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  • 1
    Online Resource
    Online Resource
    In Situ Metal Organic Framework (ZIF-8) and Mechanofusion-Assisted MWCNT Coating of LiFePO4/C Composite Material for Lithium-Ion Batteries
    MDPI AG ; 2023
    In:  Batteries Vol. 9, No. 3 ( 2023-03-20), p. 182-
    Details
    In: Batteries, MDPI AG, Vol. 9, No. 3 ( 2023-03-20), p. 182-
    Abstract: LiFePO4 is one of the industrial, scalable cathode materials in lithium-ion battery production, due to its cost-effectiveness and environmental friendliness. However, the electrochemical performance of LiFePO4 in high current rate operation is still limited, due to its poor ionic- and electron-conductive properties. In this study, a zeolitic imidazolate framework (ZIF-8) and multiwalled carbon nanotubes (MWCNT) modified LiFePO4/C (LFP) composite cathode materials were developed and investigated in detail. The ZIF-8 and MWCNT can be used as ionic- and electron-conductive materials, respectively. The surface modification of LFP by ZIF-8 and MWCNT was carried out through in situ wet chemical and mechanical alloy coating. The as-synthesized materials were scrutinized via various characterization methods, such as XRD, SEM, EDX, etc., to determine the material microstructure, morphology, phase, chemical composition, etc. The uniform and stable spherical morphology of LFP composites was obtained when the ZIF-8 coating was processed by the agitator [A], instead of the magnetic stirrer [MS] , condition. It was found that the (optimum of) 2 wt.% ZIF-8@LFP [A]/MWCNT composite cathode material exhibited outstanding improvement in high-rate performance; it maintained the discharge capacities of 125 mAh g−1 at 1C, 110 mAh g−1 at 3C, 103 mAh g−1 at 5C, and 91 mAh g−1 at 10C. Better cycling stability with capacity retention of 75.82% at 1C for 100 cycles, as compared to other electrodes prepared in this study, was also revealed. These excellent results were mainly obtained because of the improvement of lithium-ion transport properties, less polarization effect, and interfacial impedance of the LFP composite cathode materials derived from the synergistic effect of both ZIF-8 and MWCNT coating materials.
    Type of Medium: Online Resource
    ISSN: 2313-0105
    URL: Article
    DOI: 10.3390/batteries9030182
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2813972-0
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  • 2
    Online Resource
    Online Resource
    SrMnO3/Functionalized h-BN Composite Modified Disposable Sensor for the Voltammetric Determination of Furaltadone Antibiotic Drug
    MDPI AG ; 2022
    In:  Catalysts Vol. 12, No. 12 ( 2022-11-22), p. 1494-
    Details
    In: Catalysts, MDPI AG, Vol. 12, No. 12 ( 2022-11-22), p. 1494-
    Abstract: Improper disposal of pharmaceutical drugs, including antibiotics, can affect the ecological system and generate serious health problems for living organisms. In this work, we have developed an electrochemical sensor based on a strontium manganese oxide/functionalized hexagonal boron nitride (SrMnO3/f-BN) electrocatalyst for the detection of the antibiotic drug furaltadone (FLD). Various analytical techniques were used to characterize the physicochemical properties of the as-prepared SrMnO3/f-BN composite. The as-fabricated SrMnO3/f-BN composite electrode showed excellent sensing activity towards FLD, with a wide linear range (0.01–152.11 µM) and low detection limit (2.0 nM). The sensor exhibited good selectivity towards FLD for detection in the presence of various interfering species (nitro compounds, metal ions, and biological compounds). Interestingly, real-time analysis using the proposed SrMnO3/f-BN composite was able to determine the FLD content in human urine and wastewater samples with good recovery. Hence, the as-developed SrMnO3/f-BN modified sensor could be viable in practical applications to target the antibiotic drug FLD in both human fluids and environmental samples.
    Type of Medium: Online Resource
    ISSN: 2073-4344
    URL: Article
    DOI: 10.3390/catal12121494
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662126-5
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  • 3
    Online Resource
    Online Resource
    Enhanced Epithelial-to-Mesenchymal Transition and Chemoresistance in Advanced Retinoblastoma Tumors Is Driven by miR-181a
    MDPI AG ; 2022
    In:  Cancers Vol. 14, No. 20 ( 2022-10-19), p. 5124-
    Details
    In: Cancers, MDPI AG, Vol. 14, No. 20 ( 2022-10-19), p. 5124-
    Abstract: Advanced retinoblastoma (Rb) tumors display high metastatic spread to distant tissues, causing a potent threat to vision and life. Through transcriptomic profiling, we discovered key upregulated genes that belonged to the epithelial–mesenchymal transition (EMT) and chemotherapy resistance pathways in advanced Rb tumors. Through in vitro models, we further showed that Rb null tumor cells under prolonged chemo drug exposure, acquires a metastasis-like phenotype through the EMT program mediated by ZEB1 and SNAI2 and these cells further acquires chemotherapeutic resistance through cathepsin-L- and MDR1-mediated drug efflux mechanisms. Using a miRNA microarray, we identified miR-181a-5p as being significantly reduced in advanced Rb tumors, which was associated with an altered EMT and drug-resistance genes. We showed that enhancing miR-181a-5p levels in Rb null chemo-resistant sublines reduced the ZEB1 and SNAI2 levels and halted the mesenchymal transition switch, further reducing the drug resistance. We thus identified miR-181a-5p as a therapeutically exploitable target for EMT-triggered drug-resistant cancers that halted their invasion and migration and sensitized them to low-dose chemotherapy drugs.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers14205124
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527080-1
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  • 4
    Online Resource
    Online Resource
    Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors
    MDPI AG ; 2022
    In:  Cells Vol. 11, No. 10 ( 2022-05-18), p. 1668-
    Details
    In: Cells, MDPI AG, Vol. 11, No. 10 ( 2022-05-18), p. 1668-
    Abstract: Retinoblastoma (Rb) is a pediatric intraocular malignancy that is proposed to originate from maturing cone cell precursors in the developing retina. The molecular mechanisms underlying the biological and clinical behaviors are important to understand in order to improve the management of advanced-stage tumors. While the genetic causes of Rb are known, an integrated understanding of the gene expression and metabolic processes in tumors of human eyes is deficient. By integrating transcriptomic profiling from tumor tissues and metabolomics from tumorous eye vitreous humor samples (with healthy, age-matched pediatric retinae and vitreous samples as controls), we uncover unique functional associations between genes and metabolites. We found distinct gene expression patterns between clinically advanced and non-advanced Rb. Global metabolomic analysis of the vitreous humor of the same Rb eyes revealed distinctly altered metabolites, indicating how tumor metabolism has diverged from healthy pediatric retina. Several key enzymes that are related to cellular energy production, such as hexokinase 1, were found to be reduced in a manner corresponding to altered metabolites; notably, a reduction in pyruvate levels. Similarly, E2F2 was the most significantly elevated E2F family member in our cohort that is part of the cell cycle regulatory circuit. Ectopic expression of the wild-type RB1 gene in the Rb-null Y79 and WERI-Rb1 cells rescued hexokinase 1 expression, while E2F2 levels were repressed. In an additional set of Rb tumor samples and pediatric healthy controls, we further validated differences in the expression of HK1 and E2F2. Through an integrated omics analysis of the transcriptomics and metabolomics of Rb, we uncovered a significantly altered tumor-specific metabolic circuit that reduces its dependence on glycolytic pathways and is governed by Rb1 and HK1.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells11101668
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2661518-6
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