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  • MDPI AG  (13)
  • 1
    Online Resource
    Online Resource
    Construction and Evaluation of a Novel MAP Immunoassay for 9 Nutrition-and-Health-Related Protein Markers Based on Multiplex Liquid Protein Chip Technique
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 6 ( 2023-03-21), p. 1522-
    Details
    In: Nutrients, MDPI AG, Vol. 15, No. 6 ( 2023-03-21), p. 1522-
    Abstract: We attempted to construct and evaluate a novel detection method to realize simultaneous detection based on a multiplex liquid protein chip technique for nine nutrition-and-health-related protein markers to meet the requirement of an accurate, simultaneous and comprehensive analysis of the proteomics of nutrition and health. The lower limits of detection, biological limits of detection and regression equations of serum ferritin (SF), soluble transferrin receptor (sTfR), c-reactive protein (CRP), retinol-binding protein4 (RBP4), apolipoprotein B (ApoB), alpha-fetoprotein (AFP), prealbumin (PA), carcino-embryonic antigen (CEA) and D-Dimmer (D-D) were determined after a series of optimal experiments. Then, the results of the methodological evaluation for this novel method indicated that the accuracies were between 70.12% and 127.07%, the within-run precisions were between 0.85% and 7.31%, the between-run precisions were between 3.53% and 19.07%, the correlation coefficients between this method and other methods were above 0.504 (p 〈 0.05), and the direct bilirubin (DBIL) of low concentration and the indirect bilirubin (IBIL) of high concentration could not interfere with the detected results of nine indicators. The novel multiplex detection method, which can increase accuracy and improve the ability of comprehensive analysis, can basically meet the requirement of detection and the diagnosis of the proteomics of nutrition and health.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu15061522
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518386-2
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  • 2
    Online Resource
    Online Resource
    Yingyangbao Reduced Anemia among Infants and Young Children Aged 6–23 Months When Delivered through a Large-Scale Nutrition Improvement Program for Children in Poor Areas in China from 2015 to 2020
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 11 ( 2023-06-05), p. 2634-
    Details
    In: Nutrients, MDPI AG, Vol. 15, No. 11 ( 2023-06-05), p. 2634-
    Abstract: The purpose of this study was to assess the effectiveness of intervention with Yingyangbao (YYB) on hemoglobin (Hb) and anemia status among infants and young children (IYC) aged 6–23 months (mo) through a large-scale Nutrition Improvement Program for Children in Poor Areas (NIPCPA) in China from 2015 to 2020. Five rounds of cross-sectional surveys were conducted using a stratified and multi-stage probability proportional to size sampling of IYC in 2015, 2017, 2018, 2019 and 2020. Multivariable regression analyses were fitted to determine the effectiveness of the YYB intervention on Hb and anemia, respectively. A total of 36,325, 40,027, 43,831, 44,375 and 46,050 IYC aged 6–23 mo were included, and the prevalence of anemia was 29.7%, 26.9%, 24.1%, 21.2% and 18.1% in 2015, 2017, 2018, 2019 and 2020, respectively. Compared with the results in 2015, the Hb concentrations significantly improved and anemia prevalence significantly decreased among IYC in 2017, 2018, 2019, and 2020 (p 〈 0.001). Regression analysis showed that higher YYB consumption was significantly associated with the increment in Hb concentration and reduction in anemia stratified by age group (p 〈 0.001). The most significant increment in Hb concentration of 2.189 mg/L and the most significant reduction in odds of anemia were observed among IYC aged 12–17 mo who consumed 270 to 359 sachets of YYB (OR: 0.671; 95% CI: 0.627, 0.719; p 〈 0.001). This study suggests that YYB intervention is a successful public health strategy for reducing the risk of anemia among IYC when delivered through a large-scale NIPCPA in China. It is necessary to continue to advance the program and increase the adherence of YYB.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu15112634
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Optimization and Application of A Bionic System of Dynamic Co-Culture with Hepatocytes and Renal Cells Based on Microfluidic Chip Technique in Evaluating Materials of Health Food
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 22 ( 2022-11-09), p. 4728-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 22 ( 2022-11-09), p. 4728-
    Abstract: We aimed to explore the optimization and application of a bionic system of dynamic co-culture with hepatocytes and renal cells based on the microfluidic chip technique in evaluating emodin, which might replace the conventionally cytological evaluation technique of health food. After optimal experiments, the improved bionic system was composed of human hepatocellular carcinoma cells (HepG2), human renal glomerular endothelial cells (HRGECs), rat tail collagen type I, and gelatin with optimized concentrations (1.3 mg/mL + 7.5%). The applicability of the bionic system indicated that the growth stability was appropriate (CV: 7.36%), and the cell viability of that gradually decreased with the increasing of emodin concentration from 0–100 μM, which statistic significances were at 50 and 100 μM (p 〈 0.05), and the stained results of dead/live cells also showed the same trend. The LDH level appeared rising trend after decline between 0 μM and 100 μM emodi, and the level of that at 100 μM emodin was significantly higher than that at 25 μM and 50 μM emodin, respectively. The BUN level continuously and significantly declined with the increasing of emodin concentration (p 〈 0.05). Our research realized the application of this optimized bionic system in evaluating emodin, and provided a useful platform and reference for further in vitro alternative research with regard to evaluating the efficacies of health food in the future.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14224728
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Complementary Feeding and Malnutrition among Infants and Young Children Aged 6–23 Months in Rural Areas of China
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 9 ( 2022-04-26), p. 1807-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 9 ( 2022-04-26), p. 1807-
    Abstract: This study investigated the nutrition and complementary feeding (CF) of infants and young children (IYC) aged 6–23 months in rural areas of China in 2018 and explored the relationship between CF and nutritional status. We measured the length and weight, calculated the z-scores, and detected micronutrients in the hair. The status of CF was obtained from the respondents by a 24-h dietary recall. IYC were classified into clusters using a two-step cluster analysis. The CF and nutritional status of each cluster were analyzed and compared. The prevalence of stunting, wasting, and overweight in the IYC in rural Chinese areas was 7.1%, 3.0%, and 3.7%, respectively. The median levels of Ca, Fe, and Zn in hair were 550.10 µg/g, 62.94 µg/g, and 132.86 µg/g, respectively. The prevalence of meeting the requirements of minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum acceptable diet (MAD) was 68.9%, 77.9%, and 46.4%, respectively. IYC with a higher prevalence of MDD, MMF, and MAD were more inclined to maintain a healthy status. The prevalence of undernutrition and overweight of 6- to 23-month-old IYC in rural areas of China was low. However, lack of trace elements was evident, and MAD prevalence remained low.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14091807
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Soy Food Consumption Is Inversely Associated with Handgrip Strength: Results from the TCLSIH Cohort Study
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 2 ( 2023-01-12), p. 391-
    Details
    In: Nutrients, MDPI AG, Vol. 15, No. 2 ( 2023-01-12), p. 391-
    Abstract: Background: Soy foods contain high levels of soy protein or isoflavones, which can stimulate muscle protein synthesis and increase antioxidant capacity, and thus ameliorate muscle strength decline. However, data from epidemiological studies investigating the association of habitual soy food consumption with muscle strength decline among general Chinese adults are limited. Methods: This study included 29,525 participants (mean age: 41.6 years; 16,933 (53.8%) males). Soy food consumption was evaluated using a validated 100-item food frequency questionnaire. Handgrip strength (HGS) was assessed with a hand dynamometer. Analysis of covariance were performed to assess the multivariable-adjusted least square means (LSM) and 95% confidence interval (CI) for HGS. Results: The multiple adjusted LSM (95% CI) of HGS across soy food consumption were 35.5 (34.2, 37.1) kg for 〈 1 time per week, 36.1 (34.6, 37.6) kg for 1 time per week, 36.3 (34.8, 37.8) kg for 2–3 times per week, and 36.6 (35.1, 38.0) kg for ≥4 times per week (p for trend 〈 0.001). Compared to participants with soy food consumption less than one time per week, the multiple adjusted odds ratio (95% CI) of low HGS was 0.638 (0.485, 0.836) when the weekly consumption was ≥ 4 times (p for trend 〈 0.01). Conclusions: Higher habitual soy food consumption was positively associated with HGS in general Chinese adults. Consumption of soy foods may have beneficial effects on muscle health.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu15020391
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    Effects of the Duration of Ying Yang Bao Consumption on Hemoglobin Concentration in Infants and Young Children in Less Developed Areas of China
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 21 ( 2022-10-28), p. 4539-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 21 ( 2022-10-28), p. 4539-
    Abstract: Ying Yang Bao (YYB) is conventionally prescribed as a nutritional supplement to infants and young children (IYC) in less developed areas of China. However, whether 18-month YYB consumption is reasonable needs assessment. This study examined the influence of the duration of YYB consumption on hemoglobin (Hb) levels and anemia prevalence. Data from the Nutrition Improvement Project on Children in Poor Areas of China in 2018–2019 were used. Questionnaires were used to collect information on basic characteristics, dietary status, and YYB consumption. Propensity score matching (PSM) was used to balance confounders. Hb levels and anemia prevalence in IYC with different durations of YYB consumption were compared. After PSM, all covariates were well-balanced, and 1151 pairs of IYC were included in subsequent analyses. During the 1st–9th months of intervention, YYB effectively increased Hb levels and reduced anemia prevalence in the intervention group. During the 10th–18th months of intervention, Hb levels in the control group increased and anemia prevalence decreased, while Hb levels and anemia prevalence fluctuated in the intervention group. In conclusion, YYB was effective in improving nutritional status of infants, but had a limited effect in young children. Nutritional supplements with different quantities or nutrients should be considered for young children.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14214539
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Appropriate Donor-Acceptor Phase Separation Structure for the Enhancement of Charge Generation and Transport in Polymer Solar Cells
    MDPI AG ; 2018
    In:  Polymers Vol. 10, No. 3 ( 2018-03-18), p. 332-
    Details
    In: Polymers, MDPI AG, Vol. 10, No. 3 ( 2018-03-18), p. 332-
    Abstract: The morphology of active layer for polymer solar cells is critical to enhance the performance especially for fill factor of the devices. To investigate the relationship between active layer morphology and performance of polymer solar cells (PSCs), 1,8-diiodooctane (DIO) additive, and [6,6]-phenyl-C71-butyric acid methyl ester (PC71BM) electron acceptor were used to regulate the aggregation morphology of copolymer poly(thieno[3,4-b] -thiophene/benzodithiophene) (PTB7) electron donor from solution state to solid state. Atom force microscopy (AFM), steady-state absorption (UV-Vis), time-resolved absorption (TA), spectroelectrochemistry (SEC) and current-voltage (J-V) measurements were employed to characterize the morphology, optical and electrical characteristics of active layers and to reveal the relationship among the morphology, photophysical property, and performance of PTB7-based devices. The results show that DIO can refine the aggregation scale of PTB7 during the dissolution process, whereas both the aggregation scale and aggregation behaviors of PTB7 donor are affected by PC71BM acceptor molecules. Furthermore, the bulk heterojunction structure (BHJ) morphology of active layer can be optimized during the DIO evaporation process. TA kinetic data indicate that the population and lifetime of charged species are improved in the DIO-treated BHJ active layer. Moreover, the active layers with DIO treatment have a relative low highest occupied molecular orbital (HOMO) energy level, which makes hole transport more easily in PTB7 donor phase. As a result, the performance of PTB7-based PSCs is enhanced.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym10030332
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2527146-5
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  • 8
    Online Resource
    Online Resource
    Relation between Polygenic Risk Score, Vitamin D Status and BMI-for-Age z Score in Chinese Preschool Children
    MDPI AG ; 2024
    In:  Nutrients Vol. 16, No. 6 ( 2024-03-11), p. 792-
    Details
    In: Nutrients, MDPI AG, Vol. 16, No. 6 ( 2024-03-11), p. 792-
    Abstract: Background: Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age z score (zBMI) in Chinese preschool children. Methods: A total of 1046 participants aged 3.7 to 6.6 years old from the Long-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack (LHEAPITNP) were included in this study. The polygenic risk score (PRS) was established based on 55 BMI-related single nucleotide polymorphisms (SNPs) derived from a published genome-wide association study (GWAS) for BMI. Serum 25(OH)D was used as an index of vitamin D status and measured with liquid chromatography-tandem mass spectrometry (LC/MS-MS) assay. The Wilcoxon test or Kruskal–Wallis test was used to compare the differences of variables between different groups and Spearman correlation analysis was used for analyzing the correlations between the PRS, 25(OH)D levels, and zBMI. Results: The PRS showed a positive relation to zBMI (rs = 0.0953, p = 0.0022) and 25(OH)D showed a negative relation to zBMI (rs = −0.1082, p = 0.0005) in the full-adjustment model. In addition, the differences in zBMI at different vitamin D statuses in the low-risk PRS group and the intermediate-risk PRS group were both statistically significant (plow = 0.0308, pintermediate = 0.0121), the median zBMI was both higher at vitamin D insufficiency status. And the difference in zBMI between different genetic risk groups was also statistically significant at vitamin D sufficiency status (p = 0.0077). Furthermore, genetic risk showed a positive relation to zBMI at vitamin D sufficiency status, and the p for trend was 0.0028. Conclusions: Our findings suggested that vitamin D was related to zBMI negatively in Chinese preschoolers and maintaining adequate vitamin D levels may only contribute to lower the zBMI in preschoolers with low and intermediate genetic susceptibility.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu16060792
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
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  • 9
    Online Resource
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    Prevalence and Temporal Trend (2016–2018) of Anaemia among 6–23-Month-Old Infants and Young Children in China
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 18, No. 4 ( 2021-02-19), p. 2041-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 4 ( 2021-02-19), p. 2041-
    Abstract: Anaemia is a public health problem that can lead to various harmful effects on physical and neurodevelopment in infants and young children (IYC). This study aimed to investigate trends of anaemia and haemoglobin concentration among 6- to 23-month-old Chinese IYC from 2016 to 2018. We used data from the China Nutrition Improvement Project on Children in Poor Areas (CNIPCPA), conducted in 142 national-level poor counties of 20 provinces, autonomous regions, and municipalities from 2016 to 2018. Our study included 103,621 6- to 23-month-old IYC selected by a stratified multistage cluster sampling design. There were 26,303, 33,443, and 43,875 IYC in the survey in 2016, 2017, and 2018, respectively. The overall prevalence of anaemia was 27.0% in the three years. The prevalence of anaemia was 28.0%, 27.2%, and 26.2%, and the mean haemoglobin (Hb) was 11.82, 11.81, and 11.88 g/dL in 2016, 2017, and 2018, respectively. The prevalence of anaemia was highest in 6- to 11-month-olds, and declined with age. There was a gap in the education level between parents. However, the percentage of education improved in the rural areas of China. The prevalence of anaemia decreased significantly in the three years, which shows that prevention and control actions achieved the initial results.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph18042041
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175195-X
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  • 10
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    Online Resource
    Prevalence of Malnutrition and Associated Factors of Stunting among 6–23-Month-Old Infants in Central Rural China in 2019
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 18, No. 15 ( 2021-08-02), p. 8165-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 15 ( 2021-08-02), p. 8165-
    Abstract: This study aimed to evaluate the prevalence of malnutrition and to investigate the associated factors of stunting among 6–23-month-old infants in poor rural areas of central China. The China Nutrition Improvement Project on Children in Poor Areas was conducted in 56 national-level poor counties of seven provinces in 2019. We performed a multivariate binary logistic regression analysis to determine the associated factors of stunting. This cross-sectional study included 17,193 infants. The overall prevalence of stunting was the highest (3.9%), followed by overweight (3.0%), underweight (2.1%), wasting (2.0%), and obesity (0.5%). Girls [OR = 0.55, 95% CI (0.46, 0.65)], infants meeting requirements of minimum diversity diet [OR = 0.81, 95% CI (0.67, 0.98)] , and mothers with middle-school or high-school education and above decreased the prevalence of stunting. Infants with diarrhea in two weeks [OR = 1.26,95% CI (0.98, 1.62)] were at higher odds of stunting. The malnutrition status in the study areas was improved, and vulnerable infants were found to need additional and earlier monitoring to detect and fundamentally prevent undernutrition.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph18158165
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
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