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  • MDPI AG  (120)
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  • MDPI AG  (120)
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  • 1
    In: Molecules, MDPI AG, Vol. 24, No. 21 ( 2019-10-23), p. 3816-
    Abstract: Purple sweet potato anthocyanins are kinds of natural anthocyanin red pigments extracted from the root or stem of purple sweet potato. They are stable and have the functions of anti-oxidation, anti-mutation, anti-tumor, liver protection, hypoglycemia, and anti-inflammation, which confer them a good application prospect. Nevertheless, there is not a comprehensive review of purple sweet potato anthocyanins so far. The extraction, structural characterization, stability, functional activity, application in the food, cosmetics, medicine, and other industries of anthocyanins from purple sweet potato, together with their biotransformation in vitro or by gut microorganism are reviewed in this paper, which provides a reference for further development and utilization of anthocyanins.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2008644-1
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  • 2
    In: Forests, MDPI AG, Vol. 14, No. 1 ( 2023-01-12), p. 143-
    Abstract: Root growth regulation plays a crucial role in the acclimatization of plants to their surroundings, but the molecular mechanisms underlying this process remain largely uncertain. Teosinte branched1/cycloidea/proliferating cell factor (TCP) transcription factors are crucial elements linking together plant growth and development, phytohormone signaling, and stress response. In this study, 15 TCP transcription factors were identified in the mulberry (Morus alba) genome. Gene structure, conserved motif, and phylogenetic analyses revealed the conservation and divergence of these MaTCPs, thus providing insights into their functions. A promoter analysis uncovered distinct numbers and compositions of cis-elements in MaTCP gene promoter regions that may be connected to reproductive growth and phytohormone and stress responses. An expression pattern analysis of the 15 MaTCP genes in mulberry roots indicated that transcriptional levels of MaTCP2, MaTCP4-1, MaTCP8, MaTCP9-1, and MaTCP20-2 are correlated with root development. As revealed by changes in their expressions after drought treatment, these five MaTCP genes are involved in root growth and may increase mulberry tolerance to drought. Our findings lay the foundation for future functional studies of these genes.
    Type of Medium: Online Resource
    ISSN: 1999-4907
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527081-3
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  • 3
    In: Microorganisms, MDPI AG, Vol. 10, No. 8 ( 2022-07-25), p. 1495-
    Abstract: Subacute ruminal acidosis (SARA) is a common metabolic disease in ruminants. In the early stage of SARA, ruminants do not exhibit obvious clinical symptoms. However, SARA often leads to local inflammatory diseases such as laminitis, mastitis, endometritis and hepatitis. The mechanism by which SARA leads to inflammatory diseases is largely unknown. The gut microbiota is the totality of bacteria, viruses and fungi inhabiting the gastrointestinal tract. Studies have found that the gut microbiota is not only crucial to gastrointestinal health but also involved in a variety of disease processes, including metabolic diseases, autoimmune diseases, tumors and inflammatory diseases. Studies have shown that intestinal bacteria and their metabolites can migrate to extraintestinal distal organs, such as the lung, liver and brain, through endogenous pathways, leading to related diseases. Combined with the literature, we believe that the dysbiosis of the rumen microbiota, the destruction of the rumen barrier and the dysbiosis of liver function in the pathogenesis of SARA lead to the entry of rumen bacteria and/or metabolites into the body through blood or lymphatic circulation and place the body in the “chronic low-grade” inflammatory state. Meanwhile, rumen bacteria and/or their metabolites can also migrate to the mammary gland, uterus and other organs, leading to the occurrence of related inflammatory diseases. The aim of this review is to describe the mechanism by which SARA causes inflammatory diseases to obtain a more comprehensive and profound understanding of SARA and its related inflammatory diseases. Meanwhile, it is also of great significance for the joint prevention and control of diseases.
    Type of Medium: Online Resource
    ISSN: 2076-2607
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720891-6
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  • 4
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Applied Sciences Vol. 13, No. 10 ( 2023-05-15), p. 6047-
    In: Applied Sciences, MDPI AG, Vol. 13, No. 10 ( 2023-05-15), p. 6047-
    Abstract: When deep learning methods are used to detect rail surface defects, the training accuracy declines due to small defects and an insufficient number of samples. This paper investigates the problem of rail surface defect detection by using an improved feature pyramid network (FPN) and the metric learning approach. Firstly, the FPN is improved by adding deformable convolution and convolutional block attention modules to improve the accuracy of detecting defects of different scales, and it is pretrained on the MS COCO dataset. Secondly, a new model is established to extract network features based on the transfer learning model and learned network parameters. Thirdly, a multimodal network structure is constructed, and the distance between each modal representative and the embedded feature vector is calculated to classify the defects. Finally, experiments are carried out on the miniImageNet dataset and the rail surface defect dataset. The results show that the mAP (five-way five-shot) of our method is 73.42% on the miniImageNet dataset and 63.29% on the rail defect dataset. Our experiments show the effectiveness of the proposed method, and the results of the rail surface defect detection are satisfactory. As there are few sample classification studies of rail surface defects, this work provides a different approach and lays a foundation for further research.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704225-X
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  • 5
    In: Energies, MDPI AG, Vol. 8, No. 10 ( 2015-09-29), p. 10958-10970
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2015
    detail.hit.zdb_id: 2437446-5
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  • 6
    In: Energies, MDPI AG, Vol. 11, No. 12 ( 2018-12-11), p. 3468-
    Abstract: The design and construction of roof cutting and blasting is a key part of the roof cutting pressure releasing gob-side entry retaining (RCPRGER) technology. In the existing research, the blasting parameters of roof cutting have been primarily determined by field tests. However, the disadvantages of field tests include a complicated process, which hinders the succession of related procedures, and an unstable roof cutting effect. Therefore, in this work, the authors attempt to use a mathematical analysis method to simplify the design process of the key parameters of roof cutting blasting. First, the mechanics process mechanism of surrounding rocks with roof cutting and pressure releasing is investigated, and the stress evolution process of the surrounding rock is divided into the following six stages: original rock stress state, excavation stress state, supporting stress state, roof cutting stress state, premining stress state, and postmining stress state. Furthermore, the relationship between roof cutting and entry retaining from the perspective of Mohr’s stress circle is discussed. Next, using four typical mines, including the Tashan, Yuanlin, Jinfeng, and Hengyuan coal mines, as examples, the existing design methods of roof cutting and blasting, geological data characteristics of each mine, distribution rule of roof cutting connectivity rate, and explosive charge structure of roof cutting blasting are summarized. Based on these results, the logic of roof cutting blasting design is obtained, the key indices affecting blasting design are determined, and the blasting design is defined as a complex fuzzy problem with multiple factors. Finally, based on the study of the above mechanics mechanism and blasting rule, a three-layer back propagation (BP) neural network, including six input units, nine hidden units, and three output units, is developed with the four typical mines as the sample space. This neural network realizes the rapid determination of the three key parameters pertaining to sealing length, blasthole spacing, and the explosive charge weight of a single hole. Through training, the calculation error is less than 0.48%, which considerably simplifies the design process of the blasting parameters. The charge structure parameters can also be determined according to this method. At present, the construction of this neural network has the shortcomings of limited sample space. This problem can be overcome by supplementing the sample size in the subsequent research and practice, which will improve the efficiency and accuracy of this design method and promote the application and development of the RCPRGER technology. The interdisciplinary research reported in this paper is an attempt that uses an intelligent algorithm to simplify the design process of roof cutting blasting in RCPRGER, and it represents not only an application development of the intelligent algorithm, but also a new step regarding the intelligent design of RCPRGER technology.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2437446-5
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  • 7
    In: Energies, MDPI AG, Vol. 15, No. 15 ( 2022-07-25), p. 5374-
    Abstract: Nonlinear composite materials serve to homogenize electric fields and can effectively improve the local concentration of the electric field in power systems. In order to study the nonlinear surface conductivity properties of micro-nano epoxy composites, two types of epoxy micro-nano composite specimens were prepared in the laboratory using the co-blending method. The surface conductivity of the composites was tested under different conditions using a high-voltage DC surface conductivity test system. The results show that the surface conductivity of micro-nano structured composites increases and then decreases with the rise of nanofiller doping concentration. The nonlinear coefficient was 1.781 at 4 wt% of doped nanostructured SiC, which was the most significant nonlinear coefficient compared to other doping contents. For the same doping concentration, the micro-nano structured composites doped with nanostructured SiC have more significant surface conductivity at the same test temperature with a nonlinear coefficient of 1.635. As the temperature increases, the surface conductivity of the micro-nano structured composite increases significantly, and the threshold field strength moves towards the high electric field. Along with the increase in temperature, the nonlinear coefficients of micro-nano composites after doping with nanostructured SiC showed a gradually decreasing trend. The temperature has little effect on the nonlinear coefficients of the micro-nano structured composites after doping with O-MMT.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2437446-5
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  • 8
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 19 ( 2023-09-27), p. 14639-
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 19 ( 2023-09-27), p. 14639-
    Abstract: Seminal plasma (SP) accounts for more than 90% of semen volume. It induces inflammation, regulates immune tolerance, and facilitates embryonic development and implantation in the female reproductive tract. In the physiological state, SP promotes endometrial decidualization and causes changes in immune cells such as macrophages, natural killer cells, regulatory T cells, and dendritic cells. This leads to the secretion of cytokines and chemokines and also results in the alteration of miRNA profiles and the expression of genes related to endometrial tolerance and angiogenesis. Together, these changes modulate the endometrial immune microenvironment and contribute to implantation and pregnancy. However, in pathological situations, abnormal alterations in SP due to advanced age or poor diet in men can interfere with a woman’s immune adaptation to pregnancy, negatively affecting embryo implantation and even the health of the offspring. Uterine pathologies such as endometriosis and endometritis can cause the endometrium to respond negatively to SP, which can further contribute to pathological progress and interfere with conception. The research on the mechanism of SP in the endometrium is conducive to the development of new targets for intervention to improve reproductive outcomes and may also provide new ideas for semen-assisted treatment of clinical infertility.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 14 ( 2022-07-21), p. 8836-
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 14 ( 2022-07-21), p. 8836-
    Abstract: As one of the most sensitive areas to global environmental change, especially global climate change, the Qinghai–Tibet Plateau is an ideal area for studying global climate change and ecosystems. There are few studies on the analysis of the vegetation’s driving factors on the Qinghai–Tibet Plateau based on large-scale and high-resolution data due to the incompetence of satellite sensors. In order to study the long-term vegetation spatiotemporal pattern and its driving factors, this study used the enhanced spatial and temporal adaptive reflectance fusion model (ESTARFM) to improve the spatial resolution of the GIMMS NDVI3g (8 km) data of the Qinghai–Tibet Plateau in 1990 and 1995 based on the MODIS NDVI (500 m) data. The research on the spatiotemporal pattern and driving factors of vegetation on the Qinghai–Tibet Plateau from 1990 to 2015 was carried out afterward, with combined data including topographic factors, annual average temperature, and annual precipitation. The results showed that there was a strong correlation between the actual MODIS NDVI image and the fused GIMMS NDVI3g image, which means that the accuracy of the fused GIMMS NDVI3g image is reliable and can provide basic data for the accurate evaluation of the spatial and temporal patterns of vegetation on the Qinghai–Tibet Plateau. From 1990 to 2015, the overall vegetation coverage of the Qinghai–Tibet Plateau showed a degrading trend at a rate of −0.41%, and the degradation trend of vegetation coverage was the weakest when the slope was ≥25°. Due to the influence of the policy of returning farmland to forests, the overall degradation trend has gradually weakened. The significant changes in vegetation in 2010 can be attributed to the difference in the spatial distribution of climatic factors such as temperature and precipitation. The area with reduced vegetation in the west was larger than the area with increased vegetation in the east. The effects of temperature and precipitation on the distribution, direction, and degradation level of vegetation coverage were varied by the areal differentiation in different zones.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 10
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 4 ( 2023-02-15), p. 3387-
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 4 ( 2023-02-15), p. 3387-
    Abstract: Over the past 40 years of reform and opening-up, China has achieved rapid economic and technological growth at the cost of severe air pollution. The emerging Fintech, as the result of financial institutions’ adapting to the latest digital technology, might be a solution to reduce air pollution. This paper investigates the impact of Fintech development on air pollution using a two-factor fixed effects model based on data for prefecture-level cities in China from 2011 to 2017. The findings show that Fintech development can effectively reduce air pollution emissions, and this conclusion is proved to be robust throughout a series of tests. The mechanism analysis shows that Fintech reduces air pollution by promoting digital finance and green innovation.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
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