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  • MDPI AG  (25)
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  • MDPI AG  (25)
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  • 1
    Online-Ressource
    Online-Ressource
    Is No. 12a Lymph Node Dissection Compliance Necessary in Patients Who Undergo D2 Gastrectomy for Gastric Adenocarcinomas? A Population-Based Retrospective Propensity Score Matching Study
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 3 ( 2023-01-25), p. 749-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 3 ( 2023-01-25), p. 749-
    Kurzfassung: LN dissection is essential for accurately staging and improving GC patient prognosis. However, the compliance rate for No. 12a LND in practice is low, and its necessity is controversial. Data from GC patients who underwent total gastrectomy (TG)/distal gastrectomy (DG) plus D2 lymphadenectomy between January 2000 and December 2017 at West China Hospital, Sichuan University were reviewed. No. 12a LND noncompliance’s effect on the long-term prognosis of patients with GC after D2 gastrectomy was explored. Of the 2788 patients included, No. 12a LND noncompliance occurred in 1753 patients (62.9%). Among 1035 patients with assessable LNs from station 12a, 98 (9.5%) had positive LNs detected at station 12a. No. 12a LN metastasis patients (stage IV not included) had significantly better overall survival (OS) than TNM stage IV patients (p = 0.006). Patients with No. 12a LND compliance had a significantly higher OS than those without, both before (p 〈 0.001) and after (p 〈 0.001) PSM. Cox multivariate analysis confirmed that No. 12a LND noncompliance was an independent prognostic factor before (HR 1.323, 95% CI 1.171–1.496, p 〈 0.001) and after (HR 1.353, 95% CI 1.173–1.560, p 〈 0.001) PSM. In conclusion, noncompliance with No. 12a LND compromised the long-term survival of patients who underwent D2 gastrectomy for GC.
    Materialart: Online-Ressource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15030749
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2527080-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Revisiting the Phylogenetic Relationship and Evolution of Gargarini with Mitochondrial Genome (Hemiptera: Membracidae: Centrotinae)
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 24, No. 1 ( 2022-12-30), p. 694-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 1 ( 2022-12-30), p. 694-
    Kurzfassung: In this study, we newly sequenced and analyzed the complete mitochondrial genomes of five genera and six species in Gargarini: Antialcidas floripennae, Centrotoscelus davidi, Kotogargara minuta, Machaerotypus stigmosus, Tricentrus fulgidus, and Tricentrus gammamaculatus. The mitochondrial genomes contain 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and a control region. The lengths of the mitochondrial genomes are 15,253 bp to 15,812 bp, and the AT contents of the obtained mitogenomes indicate a strong AT bias, ranging from 75.8% to 78.5%. The start codons of all PCGs show that most start with a typical ATN (ATA/T/G/C) codon and less start with T/GTG; the stop codon TAA is frequently used, and TAG and a single T are less used. In Gargarini mitogenomes, all tRNA genes can be folded into the canonical cloverleaf secondary structure, except for trnaS1, which lacks a stable dihydrouridine (DHU) stem and is replaced by a simple loop. At the same time, the phylogenetic analysis of the tribe Gargarini based on sequence data of 13 PCGs from 18 treehopper species and four outgroups revealed that the 10 Gargarini species form a steady group with strong support and form a sister group with Leptocentrini, Hypsauchenini, Centrotini, and Leptobelini. Diversification within Gargarini is distinguished by a Later Cretaceous divergence that led to the rapid diversification of the species. Moreover, the ancestral state reconstructions analysis showed the absence of the suprahumeral horn, which was confirmed as the ancestor characteristic of the treehopper, which has evolved from simple to complex. Our results shed new light specifically on the molecular and phylogenetic evolution of the pronotum in Gargarini.
    Materialart: Online-Ressource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24010694
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2019364-6
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Sublethal Effects of Emamectin Benzoate on Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)
    MDPI AG ; 2022
    In:  Agriculture Vol. 12, No. 7 ( 2022-07-03), p. 959-
    Details
    In: Agriculture, MDPI AG, Vol. 12, No. 7 ( 2022-07-03), p. 959-
    Kurzfassung: Fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera: Noctuidae), is a highly invasive polyphagous pest that causes great economic losses to agricultural production. Emamectin benzoate (EMB) is one of the most popular biopesticides with high antipest, anti-parasitic and anti-nematode activities and low toxicity. The present study was conducted to determine the lethality of EMB to FAW for 24 h. Sublethal effects of EMB on FAW parental and offspring generations were also assessed. LC10, LC20 and LC50 EMB for 24 h on FAW third instar larvae were 0.0127 mg/L, 0.0589 mg/L, and 0.1062 mg/L, respectively. A low dose of sublethal concentrations of EMB could significantly influence the life cycle of FAW parental and offspring generations. Sublethal concentration (LC20) of EMB significantly prolonged the pupal period of male and increased the pupal weight of male but not of female, and significantly delayed the oviposition period and longevity of adult FAW. In the FAW offspring generation, sublethal concentrations significantly increased the mortality of offspring pupae and pre-adults, and reduced the development time of offspring larvae and pre-adult male and female. Sublethal concentrations (LC10 and LC20) of EMB significantly decreased the FAW oviposition period. However, only LC10 significantly reduced FAW F1 female fecundity. No significant difference was found in the intrinsic rates of natural increase (rm), finite rate of population increase (λ), and net reproductive rate (R0) of FAW offspring exposed to sublethal concentrations. This is the first study to determine the sublethal concentrations of EMB on the life table parameters of two FAW generations. These findings can provide important implications for the rational utilization of FAW insecticides.
    Materialart: Online-Ressource
    ISSN: 2077-0472
    URL: Article
    DOI: 10.3390/agriculture12070959
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2651678-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Propagation of Native Tree Species to Restore Subtropical Evergreen Broad-Leaved Forests in SW China
    MDPI AG ; 2016
    In:  Forests Vol. 7, No. 12 ( 2016-01-02), p. 12-
    Details
    In: Forests, MDPI AG, Vol. 7, No. 12 ( 2016-01-02), p. 12-
    Materialart: Online-Ressource
    ISSN: 1999-4907
    URL: Article
    DOI: 10.3390/f7010012
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2016
    ZDB Id: 2527081-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Right Cortical Infarction and a Reduction in Putamen Volume May Be Correlated with Empathy in Patients after Subacute Ischemic Stroke—A Multimodal Magnetic Resonance Imaging Study
    MDPI AG ; 2022
    In:  Journal of Clinical Medicine Vol. 11, No. 15 ( 2022-07-31), p. 4479-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 11, No. 15 ( 2022-07-31), p. 4479-
    Kurzfassung: Empathy has not been well studied in patients following ischemic stroke. We aimed to evaluate the relationships of multimodal neuroimaging parameters with the impairment of empathy in patients who had experienced subacute ischemic stroke. Patients who had experienced a first-event acute ischemic stroke were recruited, and we assessed their empathy using the Chinese version of the Empathy Quotient (EQ) 3 months after the index stroke. Multimodal magnetic resonance imaging (MRI) was conducted in all the participants to identify acute infarction and assess brain volumes, white matter integrity, and other preexisting abnormalities. We quantified the brain volumes of various subcortical structures, the ventricles, and cortical lobar atrophy. The microstructural integrity of the white matter was reflected in the mean fractional anisotropy (FA) and mean diffusivity (MD), and the regional mean values of FA and MD were quantified after mapping using the ICBM_DTI_81 Atlas. Twenty-three (56.1%) men and 18 (43.9%) women (mean age: 61.73 years, range: 41–77 years) were included. The median National Institutes of Health Stroke Scale (NIHSS) score at discharge was 1 (range: 0–4). On univariate analysis, the EQ was correlated with right cortical infarction (r = −0.39, p = 0.012), putamen volume (r = 0.382, p = 0.014), right putamen volume (r = 0.338, p = 0.031), and the FA value of the right sagittal stratum. EQ did not correlated with the MD value in any region of interest or pre-existing brain abnormalities. Multiple stepwise linear regression models were used to identify factors associated with EQ. After adjusting for age and the NIHSS score on admission, the frequency of right cortical infarcts negatively correlated with EQ (standardized β = −0.358, 95% confidence interval =−0.708 to −0.076, p = 0.016), and the putamen volume positively correlated with EQ (standardized β = 0.328, 95% confidence interval =0.044 to 0.676, p = 0.027). In conclusion, in patients who have experienced subacute ischemic stroke, right cortical infarction and a smaller putamen volume are associated with the impairment of empathy.
    Materialart: Online-Ressource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm11154479
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2662592-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Chemical Constituents from Euphorbia kansui
    MDPI AG ; 2017
    In:  Molecules Vol. 22, No. 12 ( 2017-12-08), p. 2176-
    Details
    In: Molecules, MDPI AG, Vol. 22, No. 12 ( 2017-12-08), p. 2176-
    Materialart: Online-Ressource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules22122176
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2017
    ZDB Id: 2008644-1
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  • 7
    Online-Ressource
    Online-Ressource
    Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K/AKT/mTOR Signaling Pathway
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 8 ( 2022-04-09), p. 2431-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 8 ( 2022-04-09), p. 2431-
    Kurzfassung: Nigrosporins B, an anthraquinone derivative obtained from the secondary metabolites of marine fungus Nigrospora oryzae. In this study, we characterized the distinctive anti-cancer potential of Nigrosporins B in vitro and underlying molecular mechanisms in human cervical cancer Ca Ski cells for the first time. The results of MTT assay showed that Nigrosporins B significantly inhibited the proliferation of multiple tumor cells in a dose-dependent manner, especially for the Ca Ski cells with an IC50 of 1.24 µM. Nigrosporins B exerted an apoptosis induction effect on Ca Ski cells as confirmed by flow cytometry, AO/EB dual fluorescence staining, mitochondrial membrane potential analysis and western blot assay. In addition, Nigrosporins B induced obvious autophagy accompanied with the increase of autophagic vacuoles and the acceleration of autophagic flux as indicated by Cyto-ID staining, mRFP-GFP-LC3 adenovirus transfection and western blot analysis. Interestingly, the combination of Nigrosporins B with the three autophagy inhibitors all significantly enhanced the cytotoxicity of Nigrosporins B on Ca Ski cells, indicating that the autophagy induced by Nigrosporins B might protect Ca Ski cells from death. Furthermore, we found that Nigrosporins B inhibited the phosphorylation of PI3K, AKT, mTOR molecules and increased the protein expression levels of PTEN and p-AMPKα in a dose-dependent manner, suggesting that Nigrosporins B induced apoptosis and protective autophagy through the suppression of the PI3K/AKT/mTOR signaling pathway. Together, these findings revealed the anti-cervical cancer effect of Nigrosporins B and the underlying mechanism of action in Ca Ski cells, it might be as a promising alternative therapeutic agent for human cervical cancer.
    Materialart: Online-Ressource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27082431
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2008644-1
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  • 8
    Online-Ressource
    Online-Ressource
    Chamomile: A Review of Its Traditional Uses, Chemical Constituents, Pharmacological Activities and Quality Control Studies
    MDPI AG ; 2022
    In:  Molecules Vol. 28, No. 1 ( 2022-12-23), p. 133-
    Details
    In: Molecules, MDPI AG, Vol. 28, No. 1 ( 2022-12-23), p. 133-
    Kurzfassung: Matricaria chamomilla L. (MC) and Chamaemelum nobile (L.) All. (CN) are two varieties of Chamomile. These herbs have been used for thousands of years in Greece, Rome and ancient Egypt. Chamomile has been used for the treatment of stomach problems, cramps, dermatitis, and minor infections. The purpose of this study was to introduce the botanical characteristics and geographical distribution, traditional uses, chemical constituents, pharmacological activities, toxicity studies and quality control studies, and lay a theoretical foundation for the rational development and utilization of chamomile. This review powered that chemical constituents include flavonoids, coumarins, volatile oils, terpenes, organic acids, polysaccharides, and others. These compounds possess anticancer, anti-infective, anti-inflammatory, antithrombotic, antioxidant, hypolipidaemic, hypoglycaemic, antihypertensive, antidepressant, neuroprotective activities, among others. Chamomile is a widely used herb in traditional medicine. It brings great economic value due to its numerous pharmacological effects and traditional uses. However, more toxicity tests should be carried out to confirm its safety. There is need for further research to provide concrete scientific evidence and validate its medicinal properties.
    Materialart: Online-Ressource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules28010133
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2008644-1
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  • 9
    Online-Ressource
    Online-Ressource
    Petrogenesis of Alkaline Complex of the Longbaoshan Rare Earth Element Deposit in the Luxi Block, North China Craton, China
    MDPI AG ; 2022
    In:  Minerals Vol. 12, No. 12 ( 2022-11-28), p. 1524-
    Details
    In: Minerals, MDPI AG, Vol. 12, No. 12 ( 2022-11-28), p. 1524-
    Kurzfassung: The alkaline complex in the southwest region of Luxi Terrane of the North China Craton is spatially correlated with the newly discovered Longbaoshan REE deposit. Its petrogenesis, however, remains ambiguous. In this study, we present an integrated petrology, whole-rock geochemistry, sphene U-Pb and rare earth element data from the Longbaoshan alkaline complex to investigate the petrogenesis, magma source and tectonic evolution. The Longbaoshan alkaline complex consists of mafic to intermediate rocks of hornblende diorite and alkaline hornblende syenite porphyry, biotite monzonite porphyry and aegirine diorite porphyrite. The hornblende diorites show a composition of low SiO2, high MgO, Fe2O3 and moderate Na2O, CaO and are metaluminous and medium-to-high-K calc-alkaline. The hornblende syenite porphyries, biotite monzonites and argirine diorite porphyrites display a relatively higher content of SiO2, Na2O, K2O and Al2O3 and lower contents of MgO, Fe2O3 and CaO and are metaluminous, peralkaline, high-K calcic-alkaline and shoshonite. The sphene U-Pb data shows that the parent magma of the hornblende diorite was emplaced at ca. 120 Ma. All these samples show a common depletion in Th, Nb-Ta and Zr-Hf and enrichment in large ion lithophile elements (e.g., Pb, Ba, Sr) and Light Rare Earth Elements. The magma may have experienced fractionation of pyroxene, amphibole, sphene, apatite and zircon during its evolution. The variable La content, La/Sm, Rb/Sr and (Ta/Th) N ratios indicate that the parent magma may produce by partial melting of a mantle source that was interacted with sediment-derived melts in a subduction setting. Therefore, we propose that the parent magma of the Longbaoshan alkaline complex was derived from a lithospheric mantle which was metasomatized by sediment-derived melt in a prior subduction process. The enriched magma was emplaced through an extension process and experienced subsequent fractionation and assimilation with the continental crust during the rollback of the Paleo Pacific Ocean plate.
    Materialart: Online-Ressource
    ISSN: 2075-163X
    URL: Article
    DOI: 10.3390/min12121524
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2655947-X
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  • 10
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    Online-Ressource
    Dietary Guanidine Acetic Acid Addition Improved Carcass Quality with Less Back-Fat Thickness and Remarkably Increased Meat Protein Deposition in Rapid-Growing Lambs Fed Different Forage Types
    MDPI AG ; 2023
    In:  Foods Vol. 12, No. 3 ( 2023-02-02), p. 641-
    Details
    In: Foods, MDPI AG, Vol. 12, No. 3 ( 2023-02-02), p. 641-
    Kurzfassung: The aim of this study was to investigate whether guanidine acetic acid (GAA) yields a response in rapid-growing lambs depending on forage type. In this study, seventy-two small-tailed Han lambs (initial body weights = 12 ± 1.6 kg) were used in a 120-d feeding experiment after a 7-d adaptation period. A 2 × 3 factorial experimental feeding design was applied to the lambs, which were fed a total mixed ration with two forage types (OH: oaten hay; OHWS: oaten hay plus wheat silage) and three forms of additional GAA (GAA: 0 g/kg; UGAA: Uncoated GAA, 1 g/kg; CGAA: Coated GAA, 1 g/kg). The OH diet had a greater dry matter intake, average daily gain, and hot carcass weight than the OHWS diet. The GAA supplementation increased the final body weight, hot carcass weight, dressing percentage, and ribeye area in the longissimus lumborum. Meanwhile, it decreased backfat thickness and serum triglycerides. Dietary GAA decreased the acidity of the meat and elevated the water-holding capacity in mutton. In addition, the crude protein content in mutton increased with GAA addition. Dietary GAA (UGAA or CGAA) might be an effective additive in lamb fed by different forage types, as it has potential to improve growth performance and meat quality.
    Materialart: Online-Ressource
    ISSN: 2304-8158
    URL: Article
    DOI: 10.3390/foods12030641
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2704223-6
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