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  • MDPI AG  (319)
  • 1
    In: Molecules, MDPI AG, Vol. 24, No. 8 ( 2019-04-22), p. 1582-
    Abstract: Walnut oligopeptides (WOPs) intake is associated with the augment of the antioxidant defense system and immune system. The chief object of this study is to evaluate the radioprotective effect of walnut oligopeptides extracted from walnut seed protein against 60Coγ-irradiation induced damage in mice. Female BALB/c mice were administered WOPs through drinking water for 14 days until a single dose of whole-body 60Coγ-irradiation. The 30-day survival test was carried out in the first group (8 Gy), and the other two groups (3.5 Gy) were sacrificed at 3 days and 14 days post-irradiation. Blood and organ samples of mice in the three groups were collected, the histopathological analysis and immunohistochemistry were conducted. The number of peripheral blood leukocytes, bone marrow DNA content, inflammatory cytokines, antioxidant capacity, and intestinal permeability were measured. We found that the administration of WOPs augmented antioxidant defense system, accelerated hematopoietic recovery and showed the significant trend toward higher survival rate and less weight loss compared with non-administrated control mice. In addition, WOPs administration appeared to be important to limit IR-induced splenocyte apoptosis and inflammatory cascade as well as reduce intestine epithelial barrier dysfunction and promote epithelial integrity. These results suggest that pre and post-treatment of WOPs may help to ameliorate acute damage, which is induced by ionizing radiation in mice and accelerate its recovery.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2008644-1
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  • 2
    In: Genes, MDPI AG, Vol. 8, No. 12 ( 2017-12-15), p. 391-
    Type of Medium: Online Resource
    ISSN: 2073-4425
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2527218-4
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  • 3
    In: Molecules, MDPI AG, Vol. 26, No. 16 ( 2021-08-15), p. 4942-
    Abstract: Ageing-related bone impairment due to exposure to hyperglycemic environment is scarcely researched. The aim was to confirm the improvement effects of undenatured type II collagen (UC II) on bone impairment in ageing db/db mice, and the ageing model was established by normal feeding for 48-week-old. Then, the ageing db/db mice were randomly assigned to UC II intervention, the ageing model, and the chondroitin sulfate + glucosamine hydrochloride control groups. After 12 weeks of treatment, femoral microarchitecture and biomechanical parameters were observed, biomarkers including bone metabolism, inflammatory cytokines, and oxidative stress were measured, and the gastrocnemius function and expressions of interleukin (IL) 1β, receptor activator of nuclear factor (NF)-κB ligand (RANKL), and tartrate-resistant acid phosphatase (TRAP) were analyzed. The results showed that the mice in the UC II intervention group showed significantly superior bone and gastrocnemius properties than those in the ageing model group, including bone mineral density (287.65 ± 72.77 vs. 186.97 ± 32.2 mg/cm3), gastrocnemius index (0.46 ± 0.07 vs. 0.18 ± 0.01%), muscle fiber diameter (0.0415 ± 0.005 vs. 0.0330 ± 0.002 mm), and cross-sectional area (0.0011 ± 0.00007 vs. 0.00038 ± 0.00004 mm2). The UC II intervention elevated bone mineralization and formation and decreased bone resorption, inflammatory cytokines, and the oxidative stress. In addition, lower protein expression of IL-1β, RANKL, and TRAP in the UC II intervention group was observed. These findings suggested that UC II improved bones impaired by T2DM during ageing, and the likely mechanism was partly due to inhibition of inflammation and oxidative stress.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2008644-1
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  • 4
    In: Molecules, MDPI AG, Vol. 27, No. 2 ( 2022-01-17), p. 571-
    Abstract: The authors would like to correct spelling mistakes (undenatured type II collagen) in the title, as well as in the main manuscript including the tables and figures in the title paper [...]
    Type of Medium: Online Resource
    ISSN: 1420-3049
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 5
    In: Viruses, MDPI AG, Vol. 14, No. 8 ( 2022-08-09), p. 1740-
    Abstract: Intensive efforts have been made to develop models of hRSV infection or disease using various animals. However, the limitations such as semi-permissiveness and short duration of infection have impeded their applications in both the pathogenesis of hRSV and therapeutics development. Here, we present a mouse model based on a Rag2 gene knockout using CRISPR/Cas9 technology. Rag2−/− mice sustained high viral loads upon intranasal inoculation with hRSV. The average peak titer rapidly reached 1 × 109.8 copies/g and 1c106 TCID50 in nasal cavity, as well as 1 × 108 copies/g and 1 × 105 TCID50 in the lungs up to 5 weeks. Mild interstitial pneumonia, severe bronchopneumonia, elevated cytokines and NK cells were seen in Rag2−/− mice. A humanized monoclonal antibody showed strong antiviral activity in this animal model, implying that Rag2−/− mice that support long-term stable infection are a useful tool for studying the transmission and pathogenesis of human RSV, as well as evaluating therapeutics.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2516098-9
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  • 6
    In: Nutrients, MDPI AG, Vol. 14, No. 23 ( 2022-11-28), p. 5059-
    Abstract: Aging-related learning and memory decline are hallmarks of aging and pose a significant health burden. The effects of walnut oligopeptides (WOPs) on learning and memory were evaluated in this study. Sixty SAMP8 mice were randomly divided into four groups (15 mice/group), including one SAMP8 age-control group and three WOP-treated groups. SAMR1 mice (n = 15) that show a normal senescence rate were used as controls. The SAMP8 and SAMR1 controls were administered ordinary sterilized water, while the WOP-intervention groups were administered 110, 220, and 440 mg/kg·bw of WOPs in water, respectively. The whole intervention period was six months. The remaining 15 SAMP8 (4-month-old) mice were used as the young control group. The results showed that WOPs significantly improved the decline in aging-related learning/memory ability. WOPs significantly increased the expression of BDNF and PSD95 and decreased the level of APP and Aβ1-42 in the brain. The mechanism of action may be related to an increase in the activity of antioxidant enzymes (SOD and GSH-Px), a reduction in the expression of inflammatory factors (TNF-α and IL-1β) in the brain and a reduction in oxidative stress injury (MDA). Furthermore, the expression of AMPK, SIRT-1, and PGC-1α was upregulated and the mitochondrial DNA content was increased in brain. These results indicated that WOPs improved aging-related learning and memory impairment. WOP supplementation may be a potential and effective method for the elderly.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
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  • 7
    In: Remote Sensing, MDPI AG, Vol. 15, No. 2 ( 2023-01-13), p. 485-
    Abstract: Several global navigation satellite systems (GNSS) broadcast overlapping frequencies to enhance interoperability, allowing tight integration with only one reference satellite for every system with the same frequency. The key to realizing tight integration is estimating and utilizing differential intersystem biases, which allows the integer characteristic of the differenced ambiguity of two satellites from different systems to be retrieved. In this study, a detailed algorithm flow of a tight integration kinematic uncalibrated phase delay (UPD)-based PPP ambiguity resolution (PPP-AR) method, which includes multiple parts, is introduced. Subsequently, PPP-AR numerical experiments were conducted in a high-shade observation environment to determine the performance. In comparison with traditional methods, our results indicate that the average success fix rate improves from 83% to 100% after using the tight integration method in an environment where only three satellites are observed for each system. Moreover, for fewer than nine satellites, the tight integration method can still consistently maintain a fixed state. However, for comparison, the traditional loose integration method could no longer be implemented.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2513863-7
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  • 8
    Online Resource
    Online Resource
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 19 ( 2022-10-10), p. 6747-
    In: Molecules, MDPI AG, Vol. 27, No. 19 ( 2022-10-10), p. 6747-
    Abstract: Fluorescent imaging has been expanded, as a non-invasive diagnostic modality for cancers, in recent years. Fluorescent probes in the near-infrared window can provide high sensitivity, resolution, and signal-to-noise ratio, without the use of ionizing radiation. Some fluorescent compounds with low molecular weight, such as rhodamine B (RhB) and indocyanine green (ICG), have been used in fluorescent imaging to improve imaging contrast and sensitivity; however, since these probes are excreted from the body quickly, they possess significant restrictions for imaging. To find a potential solution to this, this work investigated the synthesis and properties of novel macromolecular fluorescent compounds. Herein, water-soluble dextran fluorescent compounds (SD-Dextran-RhB) were prepared by the attachment of RhB and sulfadiazine (SD) derivatives to dextran carrier. These fluorescent compounds were then characterized through IR, 1H NMR, 13C NMR, UV, GPC, and other methods. Assays of their cellular uptake and cell cytotoxicity and fluorescent imaging were also performed. Through this study, it was found that SD-Dextran-RhB is sensitive to acidic conditions and possesses low cell cytotoxicities compared to normal 293 cells and HepG2 and HeLa tumor cells. Moreover, SD-Dextran-RhB demonstrated good fluorescent imaging in HepG2 and HeLa cells. Therefore, SD-Dextran-RhB is suitable to be potentially applied as a probe in the fluorescent imaging of tumors.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 9
    Online Resource
    Online Resource
    MDPI AG ; 2021
    In:  Remote Sensing Vol. 13, No. 20 ( 2021-10-19), p. 4184-
    In: Remote Sensing, MDPI AG, Vol. 13, No. 20 ( 2021-10-19), p. 4184-
    Abstract: The technique of carrier phase (CP), based on the global navigation satellite system (GNSS), has proven to be a highly effective spatial tool in the field of time and frequency transfer with sub-nanosecond accuracy. The rapid development of real-time GNSS satellite orbit and clock determinations has enabled GNSS time and frequency transfer using the CP technique to be performed in real-time mode, without any issues associated with latency. In this contribution, we preliminarily built the prototype system of real-time multi-GNSS time and frequency transfer service in National Time Service Center (NTSC) of the Chinese Academy of Sciences (CAS), which undertakes the task to generate, maintains and transmits the national standard of time and frequency UTC(NTSC). The comprehensive assessment of the availability and quality of the service system were provided. First, we assessed the multi-GNSS state space representation (SSR) correction generated in real-time multi-GNSS prototype system by combining broadcast ephemeris through a comparison with the GeoForschungsZentrum (GFZ) final products. The statistical results showed that the orbit precision in three directions was smaller than 6 cm for global positioning system (GPS) and smaller than approximately 10 cm for BeiDou satellite system (BDS). The root mean square (RMS) values of clock differences for GPS were approximately 2.74 and 6.74 ns for the GEO constellation of BDS, 3.24 ns for IGSO, and 1.39 ns for MEO. The addition, the GLObal NAvigation Satellite System (GLONASS) and Galileo satellite navigation system (Galileo) were 4.34 and 1.32 ns, respectively. In order to assess the performance of real-time multi-GNSS time and frequency transfer in a prototype system, the four real-time time transfer links, which used UTC(NTSC) as the reference, were employed to evaluate the performance by comparing with the solution determined using the GFZ final products. The RMS could reach sub-nanosecond accuracy in the two solutions, either in the SSR or GFZ solution, or in GPS, BDS, GLONASS, and Galileo. The frequency stability within 10,000 s was 3.52 × 10−12 for SSR and 3.47 × 10−12 for GFZ and GPS, 3.63 × 10−12 for SSR and 3.53 × 10−12 for GFZ for BDS, 3.57 × 10−12 for SSR and 3.52 × 10−12 for GFZ for GLONASS, and 3.56 × 10−12 for SSR and 3.48 × 10−12 for GFZ for Galileo.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2513863-7
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  • 10
    Online Resource
    Online Resource
    MDPI AG ; 2016
    In:  International Journal of Environmental Research and Public Health Vol. 13, No. 9 ( 2016-09-08), p. 897-
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 13, No. 9 ( 2016-09-08), p. 897-
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2016
    detail.hit.zdb_id: 2175195-X
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