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  • 1
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    A Simple and Safe Approach for Maxillary Sinus Augmentation with the Advanced Surgical Guide
    MDPI AG ; 2020
    In:  International Journal of Environmental Research and Public Health Vol. 17, No. 11 ( 2020-05-27), p. 3785-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 17, No. 11 ( 2020-05-27), p. 3785-
    Abstract: Objective: The development of digital dentistry has contributed to the astonishing advancement of implant dentistry. Furthermore, digital technology is expected to be applied extensively to sinus augmentation, which is an advanced technique for implant surgery. This study introduces a simple method for a safer and more precise lateral window opening for sinus augmentation using a navigation program. Methods: Five eligible patients with residual alveolar bone of 4 mm or less are presented, requiring lateral approach for sinus augmentation. Navigation system was opted for the sinus lift with simultaneous implant placement. Virtual planning started with establishing the adequate position of the lateral window based on the radiographic images and the scanned file of the dentition. The position of the window was indicated on the guide within the program. Afterwards, the virtually designed surgical guide was fabricated either with 3D printer or milling machine for the actual surgery. Results: All the patients who underwent surgery with the surgical guide showed no sign of clinical complications including pain, swelling, nausea, epistaxis, or early loss of the implants. Results of radiographic evaluation also showed adequate placement of the implants in a pre-planned position, and the sinus window was also formed in the desired location. Conclusion: Lateral window opening combined with digital navigation system is believed to be a promising technique for a more precise as well as safer sinus augmentation.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph17113785
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2175195-X
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  • 2
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    The Potential Role of Human NME1 in Neuronal Differentiation of Porcine Mesenchymal Stem Cells: Application of NB-hNME1 as a Human NME1 Suppressor
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 22 ( 2021-11-11), p. 12194-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 22 ( 2021-11-11), p. 12194-
    Abstract: This study aimed to investigate the effects of the human macrophage (MP) secretome in cellular xenograft rejection. The role of human nucleoside diphosphate kinase A (hNME1), from the secretome of MPs involved in the neuronal differentiation of miniature pig adipose tissue-derived mesenchymal stem cells (mp AD-MSCs), was evaluated by proteomic analysis. Herein, we first demonstrate that hNME1 strongly binds to porcine ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (pST8SIA1), which is a ganglioside GD3 synthase. When hNME1 binds with pST8SIA1, it induces degradation of pST8SIA1 in mp AD-MSCs, thereby inhibiting the expression of ganglioside GD3 followed by decreased neuronal differentiation of mp AD-MSCs. Therefore, we produced nanobodies (NBs) named NB-hNME1 that bind to hNME1 specifically, and the inhibitory effect of NB-hNME1 was evaluated for blocking the binding between hNME1 and pST8SIA1. Consequently, NB-hNME1 effectively blocked the binding of hNME1 to pST8SIA1, thereby recovering the expression of ganglioside GD3 and neuronal differentiation of mp AD-MSCs. Our findings suggest that mp AD-MSCs could be a potential candidate for use as an additive, such as an immunosuppressant, in stem cell transplantation.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms222212194
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 3
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    Computer-Aided Surgical Simulation for Yaw Control of the Mandibular Condyle and Its Actual Application to Orthognathic Surgery: A One-Year Follow-Up Study
    MDPI AG ; 2018
    In:  International Journal of Environmental Research and Public Health Vol. 15, No. 11 ( 2018-10-27), p. 2380-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 15, No. 11 ( 2018-10-27), p. 2380-
    Abstract: Background: Favourable occlusal interdigitation and an optimized position of the mandibular condyle after surgery are essential for obtaining favourable results. The position of the condyle is determined during the operation. However, it is difficult to maintain the condyle’s original position post-surgery despite the efforts of the surgeons. Indeed, a degree of rotation of the condyle is unavoidable, since it is difficult to verify whether the condyle is positioned correctly during surgery. Purpose: To maximize contact between the bone segments, the condyle was rotated around the vertical axis using surgical simulations. We examined changes to the condyle-fossa relationship after comparing virtual surgery to actual surgery. Methods: From 2015 to 2017, 20 patients were diagnosed with skeletal malocclusion and participated in computer-aided surgical simulation before undergoing orthognathic surgery. In the simulation, the mandibular condyles were rotated around the vertical axis, and the proximal segments were fixed to the distal segments using a customized miniplate and positioning device during actual surgery. This study investigated the relationship between the condyle and fossa using cone-beam computed tomography for several different time periods (preoperative (T0), virtual surgery (Tv), postoperative three days (T1) and one year (T2)). Results: The coronal and sagittal view exhibited significant differences in the mean values between T1and T0, Tv, and T2 for all joint spaces. As a result of the distance, the mean value of T2 in both the superior joint space (JS) and the lateral JS was significantly higher than that of Tv. In contrast, the mean value of Tv in the medial JS was significantly higher than that of T2. Moreover, the mean value of T2 on the axial plane was significantly larger than the values of Tv and T1. The mean value of T0 was also significantly larger than those of Tv and T1, and the mean value of Tv was larger than that of T1. Although the condyle was rotated, it exhibited a tendency to return to its preoperative position. There was no statistically significant difference in functional evaluation between T0 and T2. Conclusion: Our method of using yaw control for the condyle during virtual surgery and transferring this technique to the actual surgery can improve the conventional surgical technique by positioning the proximal segment in a pre-planned position, thus achieving optimal results.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph15112380
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
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  • 4
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    A Novel Locus for Bakanae Disease Resistance, qBK4T, Identified in Rice
    MDPI AG ; 2022
    In:  Agronomy Vol. 12, No. 10 ( 2022-10-19), p. 2567-
    Details
    In: Agronomy, MDPI AG, Vol. 12, No. 10 ( 2022-10-19), p. 2567-
    Abstract: Bakanae disease caused by Fusarium fujikuroi causes crop failure and yield losses in the majority of rice-growing countries. In this study, we employed a joint strategy quantitative trait locus (QTL) mapping–Genome-Wide Association Study (GWAS) to investigate novel genetic loci associated with Bakanae disease resistance using a population of 143 BC1F8 RILs derived from a cross between Ilpum × Tung Tin Wan Hien1. The phenotypic data from the bioassay and the genotypic data generated using a DNA chip were utilized to perform QTL mapping and GWAS study. Our results identified a novel genetic locus qBK4T associated with Bakanae disease resistance, which was mapped on chromosome 4 and flanked by AX-116847364 (33.12 Mbp) and AX-115752415 (33.44 Mbp) markers covering a region of 324kbp. There were 34 genes in this region including Os04g55920 (encoding a zinc-finger protein, OsJAZ1), Os04g55970 (encoding AP2-like ethylene-responsive transcription factor), etc. This study proposes qBK4T as a novel locus for Bakanae disease resistance. The identification of qBK4T and its flanking marker information could be useful for marker-assisted breeding and functional characterization of resistance genes against bakanae disease.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy12102567
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 5
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    A Novel Approach Using Customized Miniplates as Skeletal Anchorage Devices in Growing Class III Patients: A Case Report
    MDPI AG ; 2020
    In:  Applied Sciences Vol. 10, No. 12 ( 2020-06-12), p. 4067-
    Details
    In: Applied Sciences, MDPI AG, Vol. 10, No. 12 ( 2020-06-12), p. 4067-
    Abstract: Facemasks using tooth-borne anchorages have been used primarily for the treatment of Class III malocclusion with maxillary undergrowth. However, when using a tooth as an anchorage, if the stability of the tooth used as an anchor is weak, the anchoring function may fail as the tooth tilts. Meanwhile, the use of skeletal anchorages such as implants, mini-implants, and mini-plates has been claimed to minimize the side effects of using dental anchorage. This case report describes the treatment of a six-year-old male patient with Class III malocclusion, presenting maxillary undergrowth and mandibular prognathism. Due to the mobility of the anchoring primary teeth, a device using dental anchorage was replaced with that using customized skeletal anchorage for the treatment. Customized guides and miniplates for the surgery were fabricated in advance through a computer-assisted system, in order to avoid possible damage to the adjacent tooth buds. The customized plates were accurately and passively placed on the intended part, showing the desired outcome.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app10124067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2704225-X
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  • 6
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    Correction: Ahn, J.W., et al. CeRNA Network Analysis Representing Characteristics of Different Tumor Environments Based on 1p/19q Codeletion in Oligodendrogliomas. Cancers 2020, 12, 2543
    MDPI AG ; 2021
    In:  Cancers Vol. 13, No. 3 ( 2021-01-27), p. 478-
    Details
    In: Cancers, MDPI AG, Vol. 13, No. 3 ( 2021-01-27), p. 478-
    Abstract: The authors wish to make the following corrections to this paper [...]
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers13030478
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2527080-1
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  • 7
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    Explicit Thermal Resistance Model of Self-Heating Effects of AlGaN/GaN HEMTs with Linear and Non-Linear Thermal Conductivity
    MDPI AG ; 2022
    In:  Materials Vol. 15, No. 23 ( 2022-11-25), p. 8415-
    Details
    In: Materials, MDPI AG, Vol. 15, No. 23 ( 2022-11-25), p. 8415-
    Abstract: We presented an explicit empirical model of the thermal resistance of AlGaN/GaN high-electron-mobility transistors on three distinct substrates, including sapphire, SiC, and Si. This model considered both a linear and non-linear thermal resistance model of AlGaN/GaN HEMT, the thickness of the host substrate layers, and the gate length and width. The non-linear nature of channel temperature—visible at the high-power dissipation stage—along with linear dependency, was constructed within a single equation. Comparisons with the channel temperature measurement procedure (DC) and charge-control-based device modeling were performed to verify the model’s validity, and the results were in favorable agreement with the observed model data, with only a 1.5% error rate compared to the measurement data. An agile expression for the channel temperature is also important for designing power devices and monolithic microwave integrated circuits. The suggested approach provides several techniques for investigation that could otherwise be impractical or unattainable when utilizing time-consuming numerical simulations.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma15238415
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2487261-1
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  • 8
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    Molecular Characterization of Paralichthys olivaceus MAF1 and Its Potential Role as an Anti-Viral Hemorrhagic Septicaemia Virus Factor in Hirame Natural Embryo Cells
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 3 ( 2021-01-29), p. 1353-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 3 ( 2021-01-29), p. 1353-
    Abstract: MAF1 is a global suppressor of RNA polymerase III-dependent transcription, and is conserved from yeast to human. Growing evidence supports the involvement of MAF1 in the immune response of mammals, but its biological functions in fish are unknown. We isolated and characterized Maf1 from the olive flounder Paralichthys olivaceus (PoMaf1). The coding region of PoMaf1 comprised 738 bp encoding a 245-amino-acid protein. The deduced PoMAF1 amino acid sequence shared features with those of MAF1 orthologues from vertebrates. PoMaf1 mRNA was detected in all tissues examined, and the levels were highest in eye and muscle tissue. The PoMaf1 mRNA level increased during early development. In addition, the PoMaf1 transcript level decreased during viral hemorrhagic septicemia virus (VHSV) infection of flounder hirame natural embryo (HINAE) cells. To investigate the role of PoMaf1 in VHSV infection, single-cell-derived PoMaf1 knockout HINAE cells were generated using the clustered regularly interspaced short palindromic repeats/CRISPR-associated-9 (CRISPR/Cas9) system, and cell clones with complete disruption of PoMaf1 were selected. PoMaf1 disruption increased the VHSV glycoprotein (G) mRNA levels during VHSV infection of HINAE cells, implicating PoMAF1 in the immune response to VSHV infection. To our knowledge, this is the first study to characterize fish Maf1, which may play a role in the response to viral infection.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms22031353
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 9
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    Mapping of a Major QTL, qBK1Z, for Bakanae Disease Resistance in Rice
    MDPI AG ; 2021
    In:  Plants Vol. 10, No. 3 ( 2021-02-25), p. 434-
    Details
    In: Plants, MDPI AG, Vol. 10, No. 3 ( 2021-02-25), p. 434-
    Abstract: Bakanae disease is a fungal disease of rice (Oryza sativa L.) caused by the pathogen Gibberella fujikuroi (also known as Fusarium fujikuroi). This study was carried out to identify novel quantitative trait loci (QTLs) from an indica variety Zenith. We performed a QTL mapping using 180 F2:9 recombinant inbred lines (RILs) derived from a cross between the resistant variety, Zenith, and the susceptible variety, Ilpum. A primary QTL study using the genotypes and phenotypes of the RILs indicated that the locus qBK1z conferring bakanae disease resistance from the Zenith was located in a 2.8 Mb region bordered by the two RM (Rice Microsatellite) markers, RM1331 and RM3530 on chromosome 1. The log of odds (LOD) score of qBK1z was 13.43, accounting for 30.9% of the total phenotypic variation. A finer localization of qBK1z was delimited at an approximate 730 kb interval in the physical map between Chr01_1435908 (1.43 Mbp) and RM10116 (2.16 Mbp). Introducing qBK1z or pyramiding with other previously identified QTLs could provide effective genetic control of bakanae disease in rice.
    Type of Medium: Online Resource
    ISSN: 2223-7747
    URL: Article
    DOI: 10.3390/plants10030434
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704341-1
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  • 10
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    Tissue Expansion Improves the Outcome and Predictability for Alveolar Bone Augmentation: Prospective, Multicenter, Randomized Controlled Trial
    MDPI AG ; 2020
    In:  Journal of Clinical Medicine Vol. 9, No. 4 ( 2020-04-16), p. 1143-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 9, No. 4 ( 2020-04-16), p. 1143-
    Abstract: Objectives: The purpose of this study was to evaluate the effectiveness of the intraoral use of subperiosteally placed self-inflating tissue expanders for subsequent bone augmentation and implant integrity. Material and methods: A prospective, multicenter, randomized controlled trial was performed on patients requiring alveolar bone graft for dental implant insertion. Patients were assigned to three groups: tissue expansion and tunneling graft (TET group), tissue expansion and conventional bone graft (TEG), and control group without tissue expansion. Dimensional changes of soft tissue and radiographic vertical bone gain, retention, and peri-implant marginal bone changes were evaluated and secondary outcomes; clinical complications and thickness changes of expanded overlying tissue were assessed. Results: Among 75 patients screened, a total of 57 patients were included in the final analysis. Most patients showed uneventful soft tissue expansion without any inflammatory sign or symptoms. Ultrasonographic measurements of overlying gingiva revealed no thinning after tissue expansion (p 〉 0.05). Mean soft vertical and horizontal tissue measurements at the end of its expansion were 5.62 and 6.03 mm, respectively. Significantly higher vertical bone gain was shown in the TEG (5.71 ± 1.99 mm) compared with that in the control patients (4.32 ± 0.97 mm; p 〈 0.05). Hard tissue retention— measured by bone resorption after 6 months—showed that control group showed higher amount of vertical (2.06 ± 1.00 mm) and horizontal bone resorption (1.69 ± 0.81 mm) compared to that of the TEG group (p 〈 0.05). Conclusion: The self-inflating tissue expander effectively augmented soft tissue volume and both conventional bone graft and tunneling techniques confirmed their effectiveness in bone augmentation. With greater amount of bone gain and better 6 month hard tissue integrity, the TEG group compared to the control group—without tissue expansion—showed that the combined modality of tissue expander use and guided bone regeneration (GBR) technique may improve the outcome and predictability of hard tissue augmentation.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm9041143
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662592-1
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