GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MDPI AG  (78)
Material
Publisher
  • MDPI AG  (78)
Person/Organisation
Language
Years
FID
  • 1
    Online Resource
    Online Resource
    A Novel Nomogram for Predicting Prognosis and Tailoring Local Therapy Decision for Ductal Carcinoma In Situ after Breast Conserving Surgery
    MDPI AG ; 2022
    In:  Journal of Clinical Medicine Vol. 11, No. 17 ( 2022-09-01), p. 5188-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 11, No. 17 ( 2022-09-01), p. 5188-
    Abstract: Purpose: We sought to explore the role of nomogram-combined biomarkers, mammographic microcalcification and inflammatory hematologic markers in guiding local therapy decisions in ductal carcinoma in situ (DCIS) subgroups with different ipsilateral breast tumour recurrence (IBTR) risk. Methods: Between January 2009 and December 2018, consecutive patients with DCIS and breast conserving surgery (BCS) were enrolled and randomly assigned to a training cohort (n = 181) and internally validation cohort (n = 78). Multivariate analyses were performed to identify predictors of IBTR. Model performance was evaluated by the concordance index (C-index) and calibration plot. The time-to-event curves were calculated by the Kaplan–Meier methods and compared by the log-rank test. Results: In total, 259 patients were enrolled and 182 of them received whole breast irradiation (WBI). After a median follow-up of 51.02 months, 23 IBTR events occurred in the whole cohort. By multivariate analyses of training cohort, presence of microinvasion, Ki67 index 〉 14%, mammographic-clustered fine linear microcalcifications and neutrophil/lymphocyte ratio before BCS (preop-NLR), 〉 1.1 remained independent risk factors of IBTR to develop a nomogram. The C-indexes of the nomogram were 0.87 and 0.86 in the training and internal validation set, respectively. Calibration plots illustrated good agreement between the predictions and actual observations for 5-year IBTR. Cut-off values of nomogram point were identified as 53 and 115 points, which divided all patients into low-, intermediate- and high-risk groups. Significant differences in IBTR existed between low-, intermediate- and high-risk subgroups (p 〈 0.01). For the whole cohort and ER-positive tumours, the benefit of WBI was found only in the intermediate-risk subgroup, but not in those with low or high risk. Fourteen out of 23 IBTRs occurred outside the original quadrant and all occurred in the high-risk group. Conclusions: The novel nomogram demonstrated potential to separate the risk of IBTR and locations of IBTR. For the whole cohort and ER-positive tumours, the benefit of WBI was restricted to an intermediate-risk subgroup.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm11175188
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662592-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Seroprevalence of Epizootic Hemorrhagic Disease Virus in Guangdong Cattle Farms during 2013–2017, China
    MDPI AG ; 2023
    In:  Viruses Vol. 15, No. 6 ( 2023-05-28), p. 1263-
    Details
    In: Viruses, MDPI AG, Vol. 15, No. 6 ( 2023-05-28), p. 1263-
    Abstract: Epizootic hemorrhagic disease (EHD) is an infectious viral disease caused by epizootic hemorrhagic disease virus (EHDV) and EHDV frequently circulates in wild and domestic ruminants. Sporadic outbreaks of EHD have caused thousands of deaths and stillbirths on cattle farms. However, not much is known about the circulating status of EHDV in Guangdong, southern China. To estimate the seroprevalence of EHDV in Guangdong province, 2886 cattle serum samples were collected from 2013 to 2017 and tested for antibodies against EHDV using a competitive ELISA. The overall seroprevalence of EHDV reached 57.87% and was highest in autumn (75.34%). A subset of positive samples were serotyped by a serum neutralization test, showing that EHDV serotypes 1 and 5–8 were circulating in Guangdong. In addition, EHDV prevalence always peaked in autumn, while eastern Guangdong had the highest EHDV seropositivity over the five-year period, displaying apparent temporal–spatial distribution of EHDV prevalence. A binary logistic model analysis indicated a significant association between cattle with BTV infections and seroprevalence of EHDV (OR = 1.70, p 〈 0.001). The co-infection of different serotypes of EHDV and BTV raises a high risk of potential genomic reassortment and is likely to pose a significant threat to cattle, thus urging more surveillance to monitor their circulating dynamics in China.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v15061263
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2516098-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Fusarium graminearum ATP-Binding Cassette Transporter Gene FgABCC9 Is Required for Its Transportation of Salicylic Acid, Fungicide Resistance, Mycelial Growth and Pathogenicity towards Wheat
    MDPI AG ; 2018
    In:  International Journal of Molecular Sciences Vol. 19, No. 8 ( 2018-08-10), p. 2351-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 19, No. 8 ( 2018-08-10), p. 2351-
    Abstract: ATP-binding cassette (ABC) transporters hydrolyze ATP to transport a wide range of substrates. Fusarium graminearum is a major causal agent of Fusarium head blight, which is a severe disease in wheat worldwide. FgABCC9 (FG05_07325) encodes an ABC-C (ABC transporter family C) transporter in F. graminearum, which was highly expressed during the infection in wheat and was up-regulated by the plant defense hormone salicylic acid (SA) and the fungicide tebuconazole. The predicted tertiary structure of the FgABCC9 protein was consistent with the schematic of the ABC exporter. Deletion of FgABCC9 resulted in decreased mycelial growth, increased sensitivity to SA and tebuconazole, reduced accumulation of deoxynivalenol (DON), and less pathogenicity towards wheat. Re-introduction of a functional FgABCC9 gene into ΔFgABCC9 recovered the phenotypes of the wild type strain. Transgenic expression of FgABCC9 in Arabidopsis thaliana increased the accumulation of SA in its leaves without activating SA signaling, which suggests that FgABCC9 functions as an SA exporter. Taken together, FgABCC9 encodes an ABC exporter, which is critical for fungal exportation of SA, response to tebuconazole, mycelial growth, and pathogenicity towards wheat.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms19082351
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    The Predictive Value of Different Nutritional Indices Combined with the GRACE Score in Predicting the Risk of Long-Term Death in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
    MDPI AG ; 2022
    In:  Journal of Cardiovascular Development and Disease Vol. 9, No. 10 ( 2022-10-17), p. 358-
    Details
    In: Journal of Cardiovascular Development and Disease, MDPI AG, Vol. 9, No. 10 ( 2022-10-17), p. 358-
    Abstract: Nutritional status is associated with prognosis in acute coronary syndrome (ACS) patients. Although the Global Registry of Acute Coronary Events (GRACE) risk score is regarded as a relevant risk predictor for the prognosis of ACS patients, nutritional variables are not included in the GRACE score. This study aimed to compare the prognostic ability of the Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) in predicting long-term all-cause death in ACS patients undergoing percutaneous coronary intervention (PCI) and to determine whether the GNRI or PNI could improve the predictive value of the GRACE score. A total of 799 patients with ACS who underwent PCI from May 2018 to December 2019 were included and regularly followed up. The performance of the PNI in predicting all-cause death was better than that of the GNRI [C-index, 0.677 vs. 0.638, p = 0.038]. The addition of the PNI significantly improved the predictive value of the GRACE score for all-cause death [increase in C-index from 0.722 to 0.740; IDI 0.006; NRI 0.095; p 〈 0.05]. The PNI was superior to the GNRI in predicting long-term all-cause death in ACS patients undergoing PCI. The addition of the PNI to the GRACE score could significantly improve the prediction of long-term all-cause death.
    Type of Medium: Online Resource
    ISSN: 2308-3425
    URL: Article
    DOI: 10.3390/jcdd9100358
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2777082-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol
    MDPI AG ; 2018
    In:  International Journal of Molecular Sciences Vol. 19, No. 7 ( 2018-06-26), p. 1874-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 19, No. 7 ( 2018-06-26), p. 1874-
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms19071874
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Coastal Vulnerability to Erosion Using a Multi-Criteria Index: A Case Study of the Xiamen Coast
    MDPI AG ; 2018
    In:  Sustainability Vol. 11, No. 1 ( 2018-12-24), p. 93-
    Details
    In: Sustainability, MDPI AG, Vol. 11, No. 1 ( 2018-12-24), p. 93-
    Abstract: The assessment of coastal vulnerability to erosion is urgently needed due to increasing coastal erosion globally. Based on the coastal characteristics of the Xiamen artificial coastline, which accounts for more than 80% of the coastline in this area, this study provides an integrated approach based on a multi-criteria index. The evaluation index system of the local coastal vulnerability to the erosion of Xiamen includes 12 indexes based on natural (coastal characteristics, coastal forcing), and socio-economic factors (coastal infrastructure, disaster reduction). The spatial differentiation characteristics of the coastal vulnerability to erosion along the Xiamen coast (2018) have been quantitatively assessed with the aid of GIS (Geographic Information System) and RS (Remote Sensing) technology. The results show that the very high vulnerability, high vulnerability, medium vulnerability, low vulnerability and very low vulnerability areas of coastal erosion accounted for 4.6%, 30.5%, 51.6%, 12.5% and 0.8% of the Xiamen coast, respectively. The coastal vulnerability to erosion classes of artificial coasts is significantly higher than those of natural coasts. This difference is mainly controlled by the coastal slope and coastal buffer ability. The results of the evaluation are basically consistent with the present situation. The rationality of the index system and the applicability of the theoretical method are well explained. The evaluation model constructed in this study can be extended to other areas with high ratios of artificial coasts.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su11010093
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2518383-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Heterogeneity Impacts of Farmers’ Participation in Payment for Ecosystem Services Based on the Collective Action Framework
    MDPI AG ; 2022
    In:  Land Vol. 11, No. 11 ( 2022-11-09), p. 2007-
    Details
    In: Land, MDPI AG, Vol. 11, No. 11 ( 2022-11-09), p. 2007-
    Abstract: Payments for ecosystem services (PES) are designed to reduce the impact of human activities on eco-sensitive areas. PES programs often adopt economic-incentive and command-control strategies. Increasing the enthusiasm of farmers’ participation is crucial for the sustainability of PES programs and ecosystem restoration. The watershed ecological compensation in Xin’an River Basin is the first horizontal ecological compensation pilot in China. In this study, economic-incentive strategy and command-control strategies in living and farming are implemented simultaneously to improve water quality. Under the collective action framework, we analyze the drivers of farmers’ participation in three concurrent strategies using hierarchical linear models (HLM). The results show: (1) Overall, 81.79%, 76.26%, and 79.11% of farmers are willing to participate in economic-incentive strategy, command-control strategy in living, and command-control strategy in farming, respectively, while 18.21%, 23.74%, and 20.89% are from the village level. (2) Among statistically significant (p 〈 0.01) factors at the farmer level, social trust (β = 0.305), and social participation (β = 0.134) have positive effects on the economic-incentive strategy; the number of communication and entertainment equipment has a positive effect on the willingness to participate in command-control strategy in living (β = 0.287) and command-control strategy in farming (β = 0.336). (3) At the village level, village characteristics have a direct impact on the farmers’ willingness to participate in strategies. Village woodland area is positively correlated with strategies participation. In addition, village characteristics play a moderating role by influencing farmers’ sustainable livelihood capital. We conclude that different concurrent strategies and collective actions need to be considered in the design of PES programs, particularly in ecologically sensitive areas, which can enrich the theory of collective action and the connotation of PES.
    Type of Medium: Online Resource
    ISSN: 2073-445X
    URL: Article
    DOI: 10.3390/land11112007
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2682955-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Coastal Wetland Vegetation Classification Using Pixel-Based, Object-Based and Deep Learning Methods Based on RGB-UAV
    MDPI AG ; 2022
    In:  Land Vol. 11, No. 11 ( 2022-11-14), p. 2039-
    Details
    In: Land, MDPI AG, Vol. 11, No. 11 ( 2022-11-14), p. 2039-
    Abstract: The advancement of deep learning (DL) technology and Unmanned Aerial Vehicles (UAV) remote sensing has made it feasible to monitor coastal wetlands efficiently and precisely. However, studies have rarely compared the performance of DL with traditional machine learning (Pixel-Based (PB) and Object-Based Image Analysis (OBIA) methods) in UAV-based coastal wetland monitoring. We constructed a dataset based on RGB-based UAV data and compared the performance of PB, OBIA, and DL methods in the classification of vegetation communities in coastal wetlands. In addition, to our knowledge, the OBIA method was used for the UAV data for the first time in this paper based on Google Earth Engine (GEE), and the ability of GEE to process UAV data was confirmed. The results showed that in comparison with the PB and OBIA methods, the DL method achieved the most promising classification results, which was capable of reflecting the realistic distribution of the vegetation. Furthermore, the paradigm shifts from PB and OBIA to the DL method in terms of feature engineering, training methods, and reference data explained the considerable results achieved by the DL method. The results suggested that a combination of UAV, DL, and cloud computing platforms can facilitate long-term, accurate monitoring of coastal wetland vegetation at the local scale.
    Type of Medium: Online Resource
    ISSN: 2073-445X
    URL: Article
    DOI: 10.3390/land11112039
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2682955-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Fusarium graminearum FgCWM1 Encodes a Cell Wall Mannoprotein Conferring Sensitivity to Salicylic Acid and Virulence to Wheat
    MDPI AG ; 2019
    In:  Toxins Vol. 11, No. 11 ( 2019-10-29), p. 628-
    Details
    In: Toxins, MDPI AG, Vol. 11, No. 11 ( 2019-10-29), p. 628-
    Abstract: Fusarium graminearum causes Fusarium head blight (FHB), a devastating disease of wheat. Salicylic acid (SA) is involved in the resistance of wheat to F. graminearum. Cell wall mannoprotein (CWM) is known to trigger defense responses in plants, but its role in the pathogenicity of F. graminearum remains unclear. Here, we characterized FgCWM1 (FG05_11315), encoding a CWM in F. graminearum. FgCWM1 was highly expressed in wheat spikes by 24 h after initial inoculation and was upregulated by SA. Disruption of FgCWM1 (ΔFgCWM1) reduced mannose and protein accumulation in the fungal cell wall, especially under SA treatment, and resulted in defective fungal cell walls, leading to increased fungal sensitivity to SA. The positive role of FgCWM1 in mannose and protein accumulation was confirmed by its expression in Saccharomyces cerevisiae. Compared with wild type (WT), ΔFgCWM1 exhibited reduced pathogenicity toward wheat, but it produced the same amount of deoxynivalenol both in culture and in spikes. Complementation of ΔFgCWM1 with FgCWM1 restored the WT phenotype. Localization analyses revealed that FgCWM1 was distributed on the cell wall, consistent with its structural role. Thus, FgCWM1 encodes a CWM protein that plays an important role in the cell wall integrity and pathogenicity of F. graminearum.
    Type of Medium: Online Resource
    ISSN: 2072-6651
    URL: Article
    DOI: 10.3390/toxins11110628
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2518395-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    B-Cell-Epitope-Based Fluorescent Quantum Dot Biosensors for SARS-CoV-2 Enable Highly Sensitive COVID-19 Antibody Detection
    MDPI AG ; 2022
    In:  Viruses Vol. 14, No. 5 ( 2022-05-12), p. 1031-
    Details
    In: Viruses, MDPI AG, Vol. 14, No. 5 ( 2022-05-12), p. 1031-
    Abstract: A new antibody diagnostic assay with more rapid and robust properties is demanded to quantitatively evaluate anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity in a large population. Here, we developed a nanometer-scale fluorescent biosensor system consisting of CdSe-ZnS quantum dots (QDs) coupled with the highly sensitive B-cell epitopes of SARS-CoV-2 that could remarkably identify the corresponding antibody with a detection limit of 100 pM. Intriguingly, we found that fluorescence quenching of QDs was stimulated more obviously when coupled with peptides than the corresponding proteins, indicating that the energy transfer between QDs and peptides was more effective. Compared to the traditional enzyme-linked immunosorbent assay (ELISA), the B-cell-epitope-based QD-biosensor could robustly distinguish coronavirus disease 2019 (COVID-19) antibody-positive patients from uninfected individuals with a higher sensitivity (92.3–98.1% positive rates by QD-biosensor vs. 78.3–83.1% positive rates by ELISAs in 207 COVID-19 patients’ sera) in a more rapid (5 min) and labor-saving manner. Taken together, the ‘QD-peptides’ biosensor provided a novel real-time, quantitative, and high-throughput method for clinical diagnosis and home-use tests.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v14051031
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2516098-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...