GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Intra-Operative Electron Radiation Therapy: An Update of the Evidence Collected in 40 Years to Search for Models for Electron-FLASH Studies
    MDPI AG ; 2022
    In:  Cancers Vol. 14, No. 15 ( 2022-07-29), p. 3693-
    Details
    In: Cancers, MDPI AG, Vol. 14, No. 15 ( 2022-07-29), p. 3693-
    Abstract: Introduction: The clinical practice and outcome results of intraoperative electron radiation therapy (IOeRT) in cancer patients have been extensively reported over 4 decades. Electron beams can be delivered in the promising FLASH dose rate. Methods and Materials: Several cancer models were approached by two alternative radiobiological strategies to optimize local cancer control: boost versus exclusive IOeRT. Clinical outcomes are revisited via a bibliometric search performed for the elaboration of ESTRO/ACROP IORT guidelines. Results: In the period 1982 to 2020, a total of 19,148 patients were registered in 116 publications concerning soft tissue sarcomas (9% of patients), unresected and borderline-resected pancreatic cancer (22%), locally recurrent and locally advanced rectal cancer (22%), and breast cancer (45%). Clinical outcomes following IOeRT doses in the range of 10 to 25 Gy (with or without external beam fractionated radiation therapy) show a wide range of local control from 40 to 100% depending upon cancer site, histology, stage, and treatment intensity. Constraints for normal tissue tolerance are important to maintain tumor control combined with acceptable levels of side effects. Conclusions: IOeRT represents an evidence-based approach for several tumor types. A specific risk analysis for local recurrences supports the identification of cancer models that are candidates for FLASH studies.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers14153693
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527080-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Influence of Scoring Systems on Mental Fatigue, Physical Demands, and Tactical Behavior during Soccer Large-Sided Games
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 3 ( 2023-01-23), p. 2087-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 3 ( 2023-01-23), p. 2087-
    Abstract: Constraints are common in soccer training to develop physical, technical-tactical, and mental training concurrently. This study examined how different scoring systems influence physical, tactical, and mental demands during large-sided games in soccer. Eighteen youth-elite male (17.39 ± 1.04 y) soccer players completed three 8 vs. 8 large-sided games where the different score systems were i) official score system (OSS; i.e., 1 goal = 1 goal), ii) double the value of the goal—4 min (DVx4; i.e., 1 goal = 1 goal from 0.00 to 7.59 min, and 1 goal = 2 goals from 8.00 to 12.00 min), and iii) double the value of the goal—8 min (DVx8; i.e., 1 goal = 1 goal from 0.00 to 3.59 min, and 1 goal = 2 goals from 4.00 to 12.00 min). Physical demands and tactical behaviors were recorded during tasks using a global positioning system and video camera. Mental fatigue was recorded pre- and post-task using a visual analogue scale. Also, the ratio of perceived exertion and mental load were recorded after tasks were finished. Results reported the highest values of mental and physical demands in DVx4. Mental fatigue increased during all three large-sided games, although this increase was significantly higher in DVx4 compared with OSS (p = 0.006) and DVx8 (p = 0.027). Tactical behavior showed a trend towards more direct play during DVx4, which was less observed during DVx8, and not at all during OSS. In conclusion, changing the scoring system affects physical, tactical, and mental demands.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph20032087
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Mucosal Immune Defence Gene Polymorphisms as Relevant Players in the Pathogenesis of IgA Vasculitis?
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 17 ( 2023-08-22), p. 13063-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 17 ( 2023-08-22), p. 13063-
    Abstract: ITGAM–ITGAX (rs11150612, rs11574637), VAV3 rs17019602, CARD9 rs4077515, DEFA (rs2738048, rs10086568), and HORMAD2 rs2412971 are mucosal immune defence polymorphisms, that have an impact on IgA production, described as risk loci for IgA nephropathy (IgAN). Since IgAN and Immunoglobulin-A vasculitis (IgAV) share molecular mechanisms, with the aberrant deposit of IgA1 being the main pathophysiologic feature of both entities, we assessed the potential influence of the seven abovementioned polymorphisms on IgAV pathogenesis. These seven variants were genotyped in 381 Caucasian IgAV patients and 997 matched healthy controls. No statistically significant differences were observed in the genotype and allele frequencies of these seven polymorphisms when the whole cohort of IgAV patients and those with nephritis were compared to controls. Similar genotype and allele frequencies of all polymorphisms were disclosed when IgAV patients were stratified according to the age at disease onset or the presence/absence of gastrointestinal or renal manifestations. Likewise, no ITGAM–ITGAX and DEFA haplotype differences were observed when the whole cohort of IgAV patients, along with those with nephritis and controls, as well as IgAV patients, stratified according to the abovementioned clinical characteristics, were compared. Our results suggest that mucosal immune defence polymorphisms do not represent novel genetic risk factors for IgAV pathogenesis.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms241713063
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Electrical Conductivity of a Stretching Viscoelastic Filament
    MDPI AG ; 2021
    In:  Materials Vol. 14, No. 5 ( 2021-03-08), p. 1294-
    Details
    In: Materials, MDPI AG, Vol. 14, No. 5 ( 2021-03-08), p. 1294-
    Abstract: Long polymeric chains highly stretched and aligned with the flow confer a strong mechanical anisotropy on a viscoelastic solution. The electrically-driven transport of free ions under such conditions is far from being understood. In this paper, we determine experimentally whether the above-mentioned deviation from isotropy affects the electric charge transport across the liquid. To this end, we measure the electrical conductivity in the flow (stretching) direction of the cylindrical liquid filament formed in the elasto-capillary thinning that arises during the breakup of a viscoelastic liquid bridge. First, we examine the behavior of monodisperse solutions of polyethylene oxide (PEO) in a mixture of glycerine and water. For all the concentrations and molecular weights considered, the filament conductivity remains practically the same as the isotropic conductivity measured under hydrostatic conditions. However, we observe a decrease in the electric current at the end of elasto-capillary regime which may partially be attributed to the reduction of the liquid conductivity. Then, we measure the conductivity of bidisperse solutions of PEO with very different molecular weights. In this case, a significant decrease in conductivity is observed as the filament radius decreases. This constitutes the first experimental evidence of ion mobility reduction in stretching viscoelastic filaments, a relevant effect in applications such as electrospinning.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma14051294
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2487261-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Effect of a Four-Week Soccer Training Program Using Stressful Constraints on Team Resilience and Precompetitive Anxiety
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 2 ( 2023-01-16), p. 1620-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 2 ( 2023-01-16), p. 1620-
    Abstract: The present study examined the effects of stressful constraints during soccer trainings on psychological skill development and internal load when compared with control (nonstressful) trainings. A total of 51 elite male youth soccer players (27 in the experimental group, M = 16.54 years; 24 in the control group, M = 15.44 years) participated in the study. In a 12-week longitudinal survey, team resilience, using the Spanish version of the Characteristics of Resilience in Sports Teams Inventory, and anxiety, using the Sport Anxiety Scale, were measured at baseline (after 4 weeks of regular trainings), postprotocol (after 4 weeks of control or experimental trainings), and follow-up (after 4 weeks of regular trainings). Results show that, when compared with the control group, a program with stressful constraints helped young soccer players to develop better psychological skills: specifically, increased ability to cope with impairments in resilience (both resilience characteristics and team vulnerability under pressure; p 〈 0.001). Increases in anxiety (p = 0.06) and decreases in preoccupation (p 〈 0.001) and lack of concentration (p 〈 0.001) were also observed. The adaptation of human behavior to specific trainings may explain these results. In conclusion, the regular exposure of young soccer players to stressful situations during trainings shows benefits for their psychological skill development in soccer. Then, benefits on internal load were also observed.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph20021620
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Montecarlo Simulation and HAXPES Analysis of Organosilane Segregation in Titania Xerogel Films; Towards a Generic Surface Chemofunctionalization Process
    MDPI AG ; 2020
    In:  Surfaces Vol. 3, No. 3 ( 2020-07-28), p. 352-365
    Details
    In: Surfaces, MDPI AG, Vol. 3, No. 3 ( 2020-07-28), p. 352-365
    Abstract: The formation of xerogels implies a sequence of hydrolysis and condensation reactions, which are intricate to analyze in heteromolecular sols. We analyze by probabilistic Montecarlo methods the development of hybrid organosilane–titania xerogels and illustrate how partial charges of the reacting molecules can help estimating relative probabilities for the condensation of the molecules. Since the condensation rate of Ti alkoxides is much higher than the corresponding rate of Si alkoxides (especially if bearing a non-hydrolizable group), by imposing a fast condensation process in agreement with low pH kinetics, the process leads to a surface segregation of the organosilane. The simulation results are compared with results of characterization of thin condensates of two different organosilanes within a titanium–isopropoxide matrix. Non-destructive in-depth profiles were obtained by hard x-ray photoelectron spectroscopy, which can resolve through estimation of Si and specific moieties of the organosilane molecules the progress of the condensation. These results are relevant for the generalization of chemo-functionalization processes by kinetic demixing of organosilanes, which have myriad applications in biomedicine and biotechnology.
    Type of Medium: Online Resource
    ISSN: 2571-9637
    URL: Article
    DOI: 10.3390/surfaces3030026
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 3008275-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Biologic Therapy in Refractory Non-Multiple Sclerosis Optic Neuritis Isolated or Associated to Immune-Mediated Inflammatory Diseases. A Multicenter Study
    MDPI AG ; 2020
    In:  Journal of Clinical Medicine Vol. 9, No. 8 ( 2020-08-11), p. 2608-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 9, No. 8 ( 2020-08-11), p. 2608-
    Abstract: We aimed to assess the efficacy of biologic therapy in refractory non-Multiple Sclerosis (MS) Optic Neuritis (ON), a condition more infrequent, chronic and severe than MS ON. This was an open-label multicenter study of patients with non-MS ON refractory to systemic corticosteroids and at least one conventional immunosuppressive drug. The main outcomes were Best Corrected Visual Acuity (BCVA) and both Macular Thickness (MT) and Retinal Nerve Fiber Layer (RNFL) using Optical Coherence Tomography (OCT). These outcome variables were assessed at baseline, 1 week, and 1, 3, 6 and 12 months after biologic therapy initiation. Remission was defined as the absence of ON symptoms and signs that lasted longer than 24 h, with or without an associated new lesion on magnetic resonance imaging with gadolinium contrast agents for at least 3 months. We studied 19 patients (11 women/8 men; mean age, 34.8 ± 13.9 years). The underlying diseases were Bechet’s disease (n = 5), neuromyelitis optica (n = 3), systemic lupus erythematosus (n = 2), sarcoidosis (n = 1), relapsing polychondritis (n = 1) and anti-neutrophil cytoplasmic antibody -associated vasculitis (n = 1). It was idiopathic in 6 patients. The first biologic agent used in each patient was: adalimumab (n = 6), rituximab (n = 6), infliximab (n = 5) and tocilizumab (n = 2). A second immunosuppressive drug was simultaneously used in 11 patients: methotrexate (n = 11), azathioprine (n = 2), mycophenolate mofetil (n = 1) and hydroxychloroquine (n = 1). Improvement of the main outcomes was observed after 1 year of therapy when compared with baseline data: mean ± SD BCVA (0.8 ± 0.3 LogMAR vs. 0.6 ± 0.3 LogMAR; p = 0.03), mean ± SD RNFL (190.5 ± 175.4 μm vs. 183.4 ± 139.5 μm; p = 0.02), mean ± SD MT (270.7 ± 23.2 μm vs. 369.6 ± 137.4 μm; p = 0.03). Besides, the median (IQR) prednisone-dose was also reduced from 40 (10–61.5) mg/day at baseline to. 2.5 (0–5) mg/day after one year of follow-up; p = 0.001. After a mean ± SD follow-up of 35 months, 15 patients (78.9%) achieved ocular remission, and 2 (10.5%) experienced severe adverse events. Biologic therapy is effective in patients with refractory non-MS ON.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm9082608
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662592-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Mental Load and Fatigue Assessment Instruments: A Systematic Review
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 1 ( 2021-12-31), p. 419-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 1 ( 2021-12-31), p. 419-
    Abstract: Mental load and fatigue are important causes of performance decreases and accidents in different activities. However, a robust systematic review, detailing the instruments used to quantify them, is currently lacking. The purpose of this study was to summarize and classify by derivations the validated instruments used to quantify mental load and fatigue. The most representative electronic databases in the scope of this review, PubMed, WOS, Scopus, SPORTDiscus, and PsycINFO (until September 2020) were searched for studies that included instruments to analyze mental load and fatigue. The quality of the selected studies was scored using a quality assessment checklist. A total of 40 papers were included. Most of the papers used subjective scales (75%) to quantify mental load and fatigue, with a small presence of behavioral (n = 5) and objective techniques (n = 5). Less is known about the analysis of mental load and fatigue using a combination of derivations. Despite the high cost and complexity of objective techniques, research that applies these measures is important for further analysis of brain processes in mental load and fatigue. The design of a battery of tests that include the three types of derivations also seems necessary.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19010419
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175195-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...