In:
The Korean Journal of Internal Medicine, Korean Association of Internal Medicine, Vol. 37, No. 6 ( 2022-11-01), p. 1140-1152
Abstract:
Background/Aims: We aimed to investigate the oral beclomethasone dipropionate’s (BDP) efficacy as an add-on therapy and to clarify the predictive factor for response to oral BDP in Korean ulcerative colitis (UC) patients.Methods: Patients with a stable concomitant drug regimen with exposure to oral BDP (5 mg/day) within 30 days before BDP initiation were included. Partial Mayo score (pMS) was used to evaluate response to oral BDP. Clinical remission (CREM) was defined as a post-treatment pMS ≤ 1 point. Clinical response (CRES) was defined as an at least 2-point decrease in post-treatment pMS and an at least 30% decrease from baseline pMS. Patients without CREM or CRES were considered nonresponders (NRs).Results: Of all, 37 showed CREM, 19 showed CRES, and 44 were NRs. The CREM group included more patients with mild disease activity (75.7% vs. 43.2%, 〈 i 〉 p 〈 /i 〉 = 0.011) than NRs. In contrast to NRs, CREM and CRES patients showed significant improvement of post-treatment erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) (ESR with 〈 i 〉 p 〈 /i 〉 = 0.001, CRP with 〈 i 〉 p 〈 /i 〉 = 0.004, respectively). Moreover, the initial rectal bleeding subscore (RBS) was significantly different between CREM and CRES, or NR (both with 〈 i 〉 p 〈 /i 〉 〈 0.001). In multivariate analyses, initial stool frequency subscore (SFS) of 0 and RBS of 0 were predictive factors for CREM (odds ratio [OR], 15.359; 95% confidence interval [CI] , 1.085 to 217.499; 〈 i 〉 p 〈 /i 〉 = 0.043 for SFS, and OR, 11.434; 95% CI, 1.682 to 77.710; 〈 i 〉 p 〈 /i 〉 = 0.013 for RBS).Conclusions: Oral BDP is an efficacious add-on therapy in Korean UC patients. Patients with initial SFS or RBS of 0 may be particularly good candidates for oral BDP.
Type of Medium:
Online Resource
ISSN:
1226-3303
,
2005-6648
DOI:
10.3904/kjim.2022.035
Language:
English
Publisher:
Korean Association of Internal Medicine
Publication Date:
2022
detail.hit.zdb_id:
2500508-X
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