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  • Knowledge E DMCC  (4)
  • 1
    Online Resource
    Online Resource
    Evaluation of Reversed Administration Order of Busulfan (BU) and Cyclophosphamide (CY) as Conditioning on Liver Toxicity in Allogenic Hematopoietic Stem Cell Transplantation (ALLHSCT)
    Knowledge E DMCC ; 2020
    In:  International Journal of Hematology-Oncology and Stem Cell Research ( 2020-07-18)
    Details
    In: International Journal of Hematology-Oncology and Stem Cell Research, Knowledge E DMCC, ( 2020-07-18)
    Abstract: Background: Busulfan (BU) in combination with cyclophosphamide (CY) is used as an effective conditioning regimen in hematopoietic SCT. Busulfan, depletes glutathione level in liver and causes elevated levels of CY metabolites. Cyclophosphamide metabolites are highly toxic for sinusoidal endothelial cells and cause VOD/ SOS with high mortality rate. Materials and Methods: Between September 2013 and September 2015, all adult patients with acute leukemia who were candidates for myeloablative allogenic SCT and were admitted to Stem Cell Transplantation center were enrolled in this prospective randomized clinical trial. We tested the hypothesis that reverse administration from BU-CY (n=28) to CY-BU group (n=27) would reduce liver toxicity. Results: Liver function tests were significantly higher in the BU-CY group between day -1 and +4 (p 〈 0.05), but VOD/SOS was not diagnosed in both groups. The incidence and severity of acute GVHD was higher in the BU-CY group, but not statistically significant. Engraftment and mortality rate were not different. Conclusion: These data support the concept that CY-BU is associated with less liver toxicity, suggesting CY-BU is superior to BU-CY as conditioning.
    Type of Medium: Online Resource
    ISSN: 2008-2207
    URL: Article
    DOI: 10.18502/ijhoscr.v14i3.3725
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2020
    detail.hit.zdb_id: 2652853-8
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Association between TLR2 and TLR4 Expression and Response to Induction Therapy in Acute Myeloid Leukemia Patients
    Knowledge E DMCC ; 2018
    In:  International Journal of Hematology-Oncology and Stem Cell Research ( 2018-10-22)
    Details
    In: International Journal of Hematology-Oncology and Stem Cell Research, Knowledge E DMCC, ( 2018-10-22)
    Abstract: Background: Toll-like receptors (TLRs) are a family of transmembrane pattern-recognition receptors that play a crucial role in the realization of innate and adaptive immune response. TLRs may play a role in tumor development and growth because of expression or up-regulation of functional TLRs in some tumors and tumor cell lines. The participation of TLRs in the pathogenesis of acute myeloid leukemia (AML) remains unspecified. This study aimed to investigate the effect of TLR2 and TLR4 expression in peripheral blood mononuclear cells of AML patients in response to induction chemotherapy. Materials and Methods: Eighty- five patients with newly diagnosed AML were evaluated. Using quantitative reverse transcriptase PCR, the mRNA expression of genes TLR2 and TLR4 was measured before starting and after induction chemotherapy. The differences in the mean expression levels of TLR2 and TLR4 before and after chemotherapy were compared using a paired t-test. The mean expression levels of TLR2 and TLR4 regarding laboratory data were analyzed by one-way ANOVA and Chi-square test. Results: We found that the mRNA expression of TLR2 after induction chemotherapy was significantly lower as compared to before treatment (p=0.001). Also, we found a lower TLR4 gene expression level after chemotherapy as compared to before chemotherapy, albeit it was not statistically significant (p=0.21). Moreover, we observed significantly higher expression of TLR2 and TLR4 in AML-M3 cases compared to non-M3 AML patients. Conclusion: The decreased expression of TLR4 in leukemic samples after induction chemotherapy might indicate a novel potential prognostic role for this receptor, particularly in AML-M3 cases.
    Type of Medium: Online Resource
    ISSN: 2008-2207
    URL: Article
    DOI: 10.18502/ijhoscr.v12i4.109
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2018
    detail.hit.zdb_id: 2652853-8
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  • 3
    Online Resource
    Online Resource
    Burnout Comparison between Clinical and Basic Sciences Faculty of a Medical School and Evaluation of Related Factors
    Knowledge E DMCC ; 2021
    In:  Iranian Journal of Psychiatry ( 2021-09-21)
    Details
    In: Iranian Journal of Psychiatry, Knowledge E DMCC, ( 2021-09-21)
    Abstract: Objective: It has been shown that clinical practice may be a risk factor for job burnout. On the other hand, annual income may have a protective effect on job burnout. Clinical faculty in contrast to basic sciences faculty members have higher income but are involve in clinical practice. Comparison between these two groups can clarify which factors have greater influence on burnout. As a second aim for this study, reliability and validity of the Persian version of Maslach burnout inventory general survey (MBI-GS) were evaluated as well. Method: This cross-sectional study was conducted at Shiraz Medical School in Iran and a total of 241 faculty members were randomly selected and burnout was measured by the Persian version of the Maslach burnout inventory general survey (MBI-GS). Results: Comparison of burnout between the two groups indicated that clinical faculty showed significantly higher scores in the exhaustion dimension compared to the basic sciences faculty (p value = 0.017) but no significant differences were found between the two groups in other dimensions. Job satisfaction and income satisfaction were negatively correlated with exhaustion and cynicism dimensions, and job satisfaction was positively associated with professional efficacy (p value 〉 0.05). Internal consistency of the questionnaire was acceptable (α=0.77). Scaling success rate for discrimination and convergent validity were 100% except for convergent validity in the cynicism subscale. Correlation of all questions with their dimensions was equal to or more than 0.4 with the exception of item 13 in the cynicism subscale. Conclusion: Clinical faculty had higher burnout than basic sciences faculty especially in the exhaustion dimension. It has also been shown that income and job satisfaction are the most important factors which can predict professional burnout in medical faculty members. It is important for administrative and organizational decision makers to improve job engagement and decrease job abandonment. This study largely confirmed the 3-dimensional structure of the Persian version of MBI-GS.
    Type of Medium: Online Resource
    ISSN: 1735-4587 , 2008-2215
    URL: Article
    DOI: 10.18502/ijps.v16i4.7227
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2021
    detail.hit.zdb_id: 2388800-3
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  • 4
    Online Resource
    Online Resource
    Evaluating the Efficacy of Modified BeEAM (Bendamustine, Etoposide, Cytarabine, Melphalan) Regimen as Conditioning for Autologous Stem Cell Transplantation in Relapsed or Refractory Lymphoma: An Experience from Two Centers of a Developing Country
    Knowledge E DMCC ; 2023
    In:  International Journal of Hematology-Oncology and Stem Cell Research ( 2023-05-03)
    Details
    In: International Journal of Hematology-Oncology and Stem Cell Research, Knowledge E DMCC, ( 2023-05-03)
    Abstract: Background: High-dose chemotherapy followed by Autologous SCT (stem cell transplantation) is a treatment of choice for relapsed and refractory lymphoma. Due to cost, toxicity, and shortage of Carmustine, we decided to conduct a phase 2 clinical trial to evaluate the safety and efficacy of Bendamustine instead of Carmustine in a previously used BEAM-like protocol. Materials and Methods:102 patients (median age,37) with Hodgkin(n=54) and non-Hodgkin lymphoma(n=48) were recruited and transplanted in two centers. After stem cell harvesting, a modified BeEAM regimen was administered to all the patients. Overall survival and disease-free survival (DFS) at two years were calculated as the study's primary endpoints. Results: Neutrophil and platelet recovery were observed after a median of 12 and 13 days, and all the patients were engrafted. Fever was observed in 25(24.5%) with only two documented infections. The only grade III toxicities were mucositis (20%) and nausea (15.6%). No transplant-related mortality (TRM) was observed after 100 days. After a median follow-up of 37(range 25-48) months, 68(66.6%) patients were in complete remission while 21 patients were in partial response, and 16 patients(15.6%) developed progressive disease, among which 13 (12.7%) had died. The OS at two years was (89 of 102, 87.3%), and the DFS rate was 68 of 102=66.7%. Conclusion: Our study showed that modified BeEAM is a safe, effective, and feasible conditioning regimen for ASCT in lymphoma instead of the BEAM regimen.
    Type of Medium: Online Resource
    ISSN: 2008-2207
    URL: Article
    DOI: 10.18502/ijhoscr.v17i2.12647
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2023
    detail.hit.zdb_id: 2652853-8
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