In:
Acta Crystallographica Section F Structural Biology and Crystallization Communications, International Union of Crystallography (IUCr), Vol. 69, No. 4 ( 2013-04-01), p. 358-361
Abstract:
The structure of ligand-free glutaminyl cyclase (QC) from Drosophila melanogaster ( Dm QC) has been determined in a novel crystal form. The protein crystallized in space group I 4, with unit-cell parameters a = b = 122.3, c = 72.7 Å. The crystal diffracted to a resolution of 2 Å at the home source. The structure was solved by molecular replacement and was refined to an R factor of 0.169. Dm QC exhibits a typical α/β-hydrolase fold. The electron density of three monosaccharides could be localized. The accessibility of the active site will facilitate structural studies of novel inhibitor-binding modes.
Type of Medium:
Online Resource
ISSN:
1744-3091
DOI:
10.1107/S1744309113005575
Language:
Unknown
Publisher:
International Union of Crystallography (IUCr)
Publication Date:
2013
detail.hit.zdb_id:
2175956-X
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