In:
Acta Crystallographica Section D Biological Crystallography, International Union of Crystallography (IUCr), Vol. 54, No. 3 ( 1998-05-01), p. 405-406
Abstract:
The Fab fragments of two monoclonal antibodies (Fab3A2, Fab6A) raised against epitopes of human chorionic gonadotrophin (hCG) have been crystallized using the vapour-diffusion technique. The Fab3A2 antibody recognises an epitope on the C-terminal peptide of the β-subunit and the Fab6A a conformational epitope of hCG. Both Fab crystals grow as hexagonal rods from ammonium sulfate solutions. The Fab3A2 crystals belong to space group P 3 1 21 with a = b = 74.84, c = 198.2 Å and diffract to 1.33 Å at the ESRF. The Fab6A crystals are in the space group P 3 2 21 with a = b = 129.53, c = 74.40 Å and diffract to 2.7 Å at the Daresbury SRS. One Fab molecule per asymmetric unit is present in both crystals.
Type of Medium:
Online Resource
ISSN:
0907-4449
DOI:
10.1107/S0907444997011074
Language:
Unknown
Publisher:
International Union of Crystallography (IUCr)
Publication Date:
1998
detail.hit.zdb_id:
2968623-4
SSG:
12
SSG:
13
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