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  • 1
    Electronic Resource
    Electronic Resource
    Structure of the blue copper(II) complex {[7R(S),14R(S)]-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane}nitratocopper(II) perchlorate, [Cu(NO3)(C16H36N4)](ClO4) (1984)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 40 (1984), S. 641-644 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270184005175
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of tripotassium hexahydrogenhexamolybdoaluminate(III) heptahydrate (1991)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 1959-1961 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270191002159
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  • 3
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    Chronic Obstructive Pulmonary Disease: Lobe-based Visual Assessment of Volumetric CT by Using Standard Images--Comparison with Quantitative CT and Pulmonary Function Test in the COPDGene Study [Thoracic Imaging] (2013)
    The Radiological Society of North America (RSNA)
    In: Radiology
    Details
    Publication Date: 2013-01-30
    Description: Purpose: To provide a new detailed visual assessment scheme of computed tomography (CT) for chronic obstructive pulmonary disease (COPD) by using standard reference images and to compare this visual assessment method with quantitative CT and several physiologic parameters. Materials and Methods: This research was approved by the institutional review board of each institution. CT images of 200 participants in the COPDGene study were evaluated. Four thoracic radiologists performed independent, lobar analysis of volumetric CT images for type (centrilobular, panlobular, and mixed) and extent (on a six-point scale) of emphysema, the presence of bronchiectasis, airway wall thickening, and tracheal abnormalities. Standard images for each finding, generated by two radiologists, were used for reference. The extent of emphysema, airway wall thickening, and luminal area were quantified at the lobar level by using commercial software. Spearman rank test and simple and multiple regression analyses were performed to compare the results of visual assessment with physiologic and quantitative parameters. Results: The type of emphysema, determined by four readers, showed good agreement ( = 0.63). The extent of the emphysema in each lobe showed good agreement (mean weighted = 0.70) and correlated with findings at quantitative CT ( r = 0.75), forced expiratory volume in 1 second (FEV 1 ) ( r = –0.68), FEV 1 /forced vital capacity (FVC) ratio ( r = –0.74) ( P 〈 .001). Agreement for airway wall thickening was fair (mean = 0.41), and the number of lobes with thickened bronchial walls correlated with FEV 1 ( r = –0.60) and FEV 1 /FVC ratio ( r = –0.60) ( P 〈 .001). Conclusion: Visual assessment of emphysema and airways disease in individuals with COPD can provide reproducible, physiologically substantial information that may complement that provided by quantitative CT assessment. © RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120385/-/DC1
    Keywords: Chest Radiology
    Print ISSN: 0033-8419
    Electronic ISSN: 1527-1315
    Topics: Medicine
    Published by The Radiological Society of North America (RSNA)
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  • 4
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    Repeat Biopsy for Mutational Analysis of Non-Small Cell Lung Cancers Resistant to Previous Chemotherapy: Adequacy and Complications [Thoracic Imaging] (2012)
    The Radiological Society of North America (RSNA)
    In: Radiology
    Details
    Publication Date: 2012-11-22
    Description: Purpose: To evaluate the feasibility and safety of repeat biopsy for mutational analysis in patients with non–small cell lung cancer (NSCLC) who have a resistance history to previous chemotherapy. Materials and Methods: This prospective study was institutional review board approved, and written informed consent was obtained from all patients. Of 126 patients referred for repeat biopsy (hereafter, rebiopsy) with NSCLC that was resistant to conventional chemotherapy or epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors, 94 patients (31 men, 63 women; mean age ± standard deviation, 57 years ± 10.3) were selected for rebiopsy. Thirty-two patients were excluded for several reasons after strict review of the chest computed tomography (CT) images. Percutaneous transthoracic lung biopsy was performed with C-arm cone-beam CT guidance. The technical success rates for the rebiopsy and the adequacy rates of specimens for mutational analysis were evaluated. Any biopsy-related complications were recorded. Results: The technical success rate for biopsy was 100%. In 75 (80%) of 94 patients, specimens were adequate for mutational analysis. Of 75 specimens, 35 were tested for EGFR mutation, 34 for anaplastic lymphoma kinase gene (ALK) rearrangement, and six for both. The results were positive for EGFR -sensitizing mutation (exon 19 or 21) in 20, for EGFR T790M mutation in five, and for ALK rearrangement in 11. Postprocedural complications occurred in 13 (14%) of 94 patients. Conclusion: When performed by employing rigorous CT criteria, rebiopsies for the mutational analysis of NSCLCs treated previously with chemotherapy are feasible in all patients and are adequate in approximately four-fifths of patients referred for gene analysis, with acceptable rates of complications. © RSNA, 2012
    Keywords: Chest Radiology
    Print ISSN: 0033-8419
    Electronic ISSN: 1527-1315
    Topics: Medicine
    Published by The Radiological Society of North America (RSNA)
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  • 5
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    Solitary Pulmonary Nodular Lung Adenocarcinoma: Correlation of Histopathologic Scoring and Patient Survival with Imaging Biomarkers [Thoracic Imaging] (2012)
    The Radiological Society of North America (RSNA)
    In: Radiology
    Details
    Publication Date: 2012-08-24
    Description: Purpose: To evaluate the usefulness of histopathologic scoring for survival prediction in patients with solitary pulmonary nodular (SPN) lung adenocarcinomas and to correlate the histopathologic scoring with the results of computed tomography (CT) and fluorine 18 fluorodeoxyglucose positron emission tomography (PET)/CT. Materials and Methods: This retrospective study was institutional review board approved and the requirement for informed consent was waived. A total of 148 patients with SPN lung adenocarcinoma underwent PET/CT and CT. Correlations between histopathologic scores estimated by using two predominant histologic subtypes from each surgically resected specimen and the mass of the nodule at CT or maximum standardized uptake value (SUV max ) at PET/CT were assessed. Disease-free survival (DFS) was estimated by using the Kaplan-Meier method, and the log-rank test was used to evaluate differences in each histopathologic subtype. Results: In 135 (91%) patients, tumors had a mixed subtype. The most frequently observed histologic subtypes, in decreasing order, were acinar (51%), lepidic (18%), solid (10%), and papillary (9%). DFS rates at 5 years were higher than 90% for the group of patients with nodules that showed the lepidic growth pattern, and 50% for patients with nodules that showed the micropapillary pattern. The pathologic score proved to be a significant predictor of DFS ( P 〈 .001). Both SUV max and the mass of the nodule were closely correlated with pathologic score. Conclusion: Pathologic scoring appears to help predict DFS in patients with SPN lung adenocarcinoma and shows close correlation with imaging biomarkers including the mass of the nodule at CT and SUV max at PET/CT. © RSNA, 2012
    Keywords: Chest Radiology, Biomarkers/Quantitative Imaging
    Print ISSN: 0033-8419
    Electronic ISSN: 1527-1315
    Topics: Medicine
    Published by The Radiological Society of North America (RSNA)
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  • 6
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    Primary Postpartum Hemorrhage: Outcome of Pelvic Arterial Embolization in 251 Patients at a Single Institution [Vascular and Interventional Radiology] (2012)
    The Radiological Society of North America (RSNA)
    In: Radiology
    Details
    Publication Date: 2012-08-24
    Description: Purpose: To evaluate the safety and efficacy of pelvic arterial embolization (PAE) for the treatment of primary postpartum hemorrhage (PPH) and to determine the factors associated with clinical outcomes. Materials and Methods: This retrospective single-center study was institutional review board approved, and informed consent was waived. Outcomes were analyzed in 251 patients who underwent PAE for primary PPH between January 2000 and February 2011. Mode of delivery, causes of bleeding, detailed laboratory and treatment records, and clinical outcomes were recorded. Clinical success was defined as cessation of bleeding after initial session of PAE without the need for additional PAE or surgery. Univariate and multivariate analyses were performed to determine the factors related to clinical outcomes. Results: The clinical success rate was 86.5% (217 of 251). Among the 34 failed cases, 12 underwent repeat PAE, 16 underwent additional surgery, and three recovered with conservative management. Overall bleeding control was achieved in 98.0% (246 of 251) of the patients. Overall mortality was 2% (five of 251) after the first ( n = 3) or second ( n = 1) session of PAE or additional surgery ( n = 1). Among the 113 patients with long-term follow-up, 110 (97.3%) maintained a regular menstrual cycle and 11 had successful pregnancies. Univariate analysis showed that cesarean section delivery, disseminated intravascular coagulation (DIC), and massive transfusion of more than 10 red blood cell units were related to failed PAE. Multivariate analysis showed that DIC (odds ratio, 0.36; P = .04) and massive transfusion (odds ratio, 0.10; P 〈 .001) were significantly related to clinical failure. Conclusion: PAE is safe and effective for managing primary PPH. Patients with DIC and massive transfusion were likely to have poor results after PAE. © RSNA, 2012
    Keywords: Obstetric/Gynecologic Radiology, Interventional Radiology, Vascular Imaging
    Print ISSN: 0033-8419
    Electronic ISSN: 1527-1315
    Topics: Medicine
    Published by The Radiological Society of North America (RSNA)
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