Publication Date:
2012-02-16
Description:
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy Nature Genetics 44, 178 (2012). doi:10.1038/ng.1047 Authors: Xue-Qing Yu, Ming Li, Hong Zhang, Hui-Qi Low, Xin Wei, Jin-Quan Wang, Liang-Dan Sun, Kar-Seng Sim, Yi Li, Jia-Nee Foo, Wei Wang, Zhi-Jian Li, Xian-Yong Yin, Xue-Qing Tang, Li Fan, Jian Chen, Rong-Shan Li, Jian-Xin Wan, Zhang-Suo Liu, Tan-Qi Lou, Li Zhu, Xiao-Jun Huang, Xue-Jun Zhang, Zhi-Hong Liu & Jian-Jun Liu We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery phase and follow-up of the top 61 SNPs in an additional 2,703 cases and 3,464 controls. We identified associations at 17p13 (rs3803800, P = 9.40 × 10−11, OR = 1.21; rs4227, P = 4.31 × 10−10, OR = 1.23) and 8p23 (rs2738048, P = 3.18 × 10−14, OR = 0.79) that implicated the genes encoding tumor necrosis factor (TNFSF13) and α-defensin (DEFA) as susceptibility genes. In addition, we found multiple associations in the major histocompatibility complex (MHC) region (rs660895, P = 4.13 × 10−20, OR = 1.34; rs1794275, P = 3.43 × 10−13, OR = 1.30; rs2523946, P = 1.74 × 10−11, OR = 1.21) and confirmed a previously reported association at 22q12 (rs12537, P = 1.17 × 10−11, OR = 0.78). We also found that rs660895 was associated with clinical subtypes of IgAN (P = 0.003), proteinuria (P = 0.025) and IgA levels (P = 0.047). Our findings show that IgAN is associated with variants near genes involved in innate immunity and inflammation.
Print ISSN:
1061-4036
Electronic ISSN:
1546-1718
Topics:
Biology
,
Medicine
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