In:
Toxicology International, Informatics Publishing Limited, ( 2023-02-07), p. 447-454
Abstract:
The in-vitrocytotoxicity was studied in a pancreatic cell line (RIN5F) using streptozotocin-induced cellular damage. The Cytotoxic dose of aqueous and hydro-alcoholic extracts of Mimosa pudica root powder before and after streptozotocin treatment was studied and protein expression was explored. Both the extracts were subjected to metabolite analysis by LCMS. Mimosa pudica root powder extracts prevented Streptozotocin-induced cellular damage. Proteomics studies indicated both aqueous and hydro-alcoholic extracts of Mimosa pudica regulate proteins related to insulin secretion, glucose uptake, and insulin resistance with marked changes in proteins involved in insulin secretion. The study first time reports cytotoxicity of Mimosa pudica in RIN5F cells and explores protein expression after Mimosa pudica treatment. It was also observed that the abundance of Mimosine is more in Hydro-alcoholic extracts as compared to aqueous extracts.
Type of Medium:
Online Resource
ISSN:
0976-5131
,
0971-6580
DOI:
10.18311/ti/2022/v29i4/29645
Language:
Unknown
Publisher:
Informatics Publishing Limited
Publication Date:
2023
detail.hit.zdb_id:
2581634-2
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