In:
Bioscience, Biotechnology, and Biochemistry, Informa UK Limited, Vol. 86, No. 3 ( 2022-02-24), p. 331-339
Kurzfassung:
As one of the most common pathological changes in trauma and surgery practice, intestinal ischemia-reperfusion (I/R) injury is regarded as a major precipitating factor in the occurrence and development of fatal diseases. BRCA1–BRCA2-containing complex subunit 36 (BRCC36), a deubiquitinase, has been proved important in a variety of pathophysiological processes such as DNA repair, cell cycle regulation, tumorigenesis, and inflammatory response. However, the effect of BRCC36 on intestinal mucosal barrier injury after I/R has not been fully elucidated. Our research found that BRCC36 aggravated intestinal mucosal barrier injury caused by bone morphogenetic protein 2 after I/R by downregulating peroxisome proliferator-activated receptor-γ (PPARγ) signaling. These results suggested that BRCC36/PPARγ axis might serve as a potential therapeutic target for preventing intestinal mucosal barrier injury after I/R.
Materialart:
Online-Ressource
ISSN:
1347-6947
Sprache:
Englisch
Verlag:
Informa UK Limited
Publikationsdatum:
2022
ZDB Id:
2110940-0
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