In:
Proceedings of IMPRS, IUPUI University Library, Vol. 4, No. 1 ( 2021-12-10)
Abstract:
Background and Objective: Current standard for assessing liver fibrosis is biopsy. However, its invasive nature, cost, and limited sampling are problematic for many patients. Fibroscan is a technology that utilizes transient elastography (TE) to measure liver stiffness (LSM) quickly and non-invasively. TE is a novel method in children and has shown to be a measure of fibrosis. Biomarkers for hepatic fibrosis include the APRI and FIB-4 scores, which are not well-studied in children. Our goal is to correlate APRI and FIB-4 with LSM in children who have hepatitis B (hep B) or have received liver transplants (LT). Methods: LSM scores of 26 children with hep B and 41 children with LT were retrieved from a research database at Riley Hospital for Children. We then obtained laboratory results closest to the date (+/- 1 year) of their TE. Those results were used to determine APRI and FIB-4 scores. Spearman correlation (rs) was determined between LSM/APRI, LSM/FIB-4, and APRI/FIB-4 in each disease. Results: Table 1. Spearman Correlations for LSM/APRI, LSM/FIB-4, and APRI/FIB-4 in Hep B and LT Disease Comparison Spearman Correlation (rs) Hep B LSM APRI 0.321 LSM FIB-4 0.376 APRI FIB-4 0.731* LT LSM APRI 0.303 LSM FIB-4 0.526* APRI FIB-4 0.632* *p 〈 0.05 Conclusion and Potential Impact: The moderate correlation of LSM with FIB-4 in LT shows potential for future clinical use, but the correlations of LSM with APRI in both conditions and the correlation of LSM with FIB-4 in Hep B are weaker. APRI and FIB-4 are strongly correlated in these children. However, additional studies with larger sample sizes should be completed. Because patients with LT and chronic hep B regularly need longitudinal evaluation, finding non-invasive tools are important to ensure compliance and ease.
Type of Medium:
Online Resource
ISSN:
2641-2470
Language:
Unknown
Publisher:
IUPUI University Library
Publication Date:
2021
Permalink
