In:
Journal of Berry Research, IOS Press, Vol. 11, No. 2 ( 2021-06-14), p. 267-277
Abstract:
BACKGROUND: Polyphenols intake increases the function of brown adipose tissue (BAT), stimulating energy expenditure (EE). Calafate (Berberis microphylla) is a polyphenol-rich Chilean native fruit. OBJECTIVE: To analyse the effect of a treatment with a Calafate extract in the thermogenic activity of mice adipose tissues. METHODS: Forty adult C57BL/6J male mice were subdivided into four groups (n=10 each): control diet, control+Calafate (extract: 50mg total polyphenols/kg weight), high-fat diet (HF) and HF+Calafate. RESULTS: Calafate prevented the increase in body weight and the decrease EE induced by HF. In BAT, Ucp-1 transcript was influenced by the interaction between diet and Calafate (p 〈 0.01), Pparα showed the same expression pattern as Ucp-1 and both, diet (p 〈 0.01) and Calafate (p 〈 0.05), induced significant effects in Sirt1. In inguinal adipose tissue, Pgc1α, Pparα, Prdm16, Sirt1, and Dio2 transcripts presented a decreased expression caused by HF, that was reversed by Calafate. In BAT, an effect of diet (p 〈 0.05) and an interaction between diet and Calafate (p 〈 0.01) was observed in UCP-1 protein levels. CONCLUSIONS: A treatment with Calafate drives less weight gain in mice fed with HF, and reverses the effects generated by it on the expression of thermogenic and browning markers.
Type of Medium:
Online Resource
ISSN:
1878-5093
,
1878-5123
Language:
Unknown
Publisher:
IOS Press
Publication Date:
2021
detail.hit.zdb_id:
2585240-1
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