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  • IOS Press  (3)
  • 1
    Online Resource
    Online Resource
    Minimizing fuzzy makespan in a distributed assembly flow shop by using an efficient artificial bee colony algorithm
    IOS Press ; 2023
    In:  Journal of Intelligent & Fuzzy Systems Vol. 45, No. 4 ( 2023-10-04), p. 7025-7046
    Details
    In: Journal of Intelligent & Fuzzy Systems, IOS Press, Vol. 45, No. 4 ( 2023-10-04), p. 7025-7046
    Abstract: Assembly flow shop scheduling problem (AFSP) in a single factory has attracted widespread attention over the past decades; however, the distributed AFSP with DPm → 1 layout considering uncertainty is seldom investigated. In this study, a distributed assembly flow shop scheduling problem with fuzzy makespan minimization (FDAFSP) is considered, and an efficient artificial bee colony algorithm (EABC) is proposed. In EABC, an adaptive population division method based on evolutionary quality of subpopulation is presented; a competitive employed bee phase and a novel onlooker bee phase are constructed, in which diversified combinations of global search and multiple neighborhood search are executed; the historical optimization data set and a new scout bee phase are adopted. The proposed EABC is verified on 50 instances from the literature and compared with some state-of-the-art algorithms. Computational results demonstrate that EABC performs better than the comparative algorithms on over 74% instances.
    Type of Medium: Online Resource
    ISSN: 1064-1246 , 1875-8967
    URL: Article
    DOI: 10.3233/JIFS-230592
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2023
    detail.hit.zdb_id: 2070080-5
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Radiomics of contrast-enhanced spectral mammography for prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer
    IOS Press ; 2023
    In:  Journal of X-Ray Science and Technology Vol. 31, No. 4 ( 2023-07-13), p. 669-683
    Details
    In: Journal of X-Ray Science and Technology, IOS Press, Vol. 31, No. 4 ( 2023-07-13), p. 669-683
    Abstract: BACKGROUND: Neoadjuvant chemotherapy (NAC) has been regarded as one of the standard treatments for patients with locally advanced breast cancer. No previous study has investigated the feasibility of using a contrast-enhanced spectral mammography (CESM)-based radiomics nomogram to predict pathological complete response (pCR) after NAC. OBJECTIVE: To develop and validate a CESM-based radiomics nomogram to predict pCR after NAC in breast cancer. METHODS: A total of 118 patients were enrolled, which are divided into a training dataset including 82 patients (with 21 pCR and 61 non-pCR) and a testing dataset of 36 patients (with 9 pCR and 27 non-pCR). The tumor regions of interest (ROIs) were manually segmented by two radiologists on the low-energy and recombined images and radiomics features were extracted. Intraclass correlation coefficients (ICCs) were used to assess the intra- and inter-observer agreements of ROI features extraction. In the training set, the variance threshold, SelectKBest method, and least absolute shrinkage and selection operator regression were used to select the optimal radiomics features. Radiomics signature was calculated through a linear combination of selected features. A radiomics nomogram containing radiomics signature score (Rad-score) and clinical risk factors was developed. The receiver operating characteristic (ROC) curve and calibration curve were used to evaluate prediction performance of the radiomics nomogram, and decision curve analysis (DCA) was used to evaluate the clinical usefulness of the radiomics nomogram. RESULTS: The intra- and inter- observer ICCs were 0.769–0.815 and 0.786–0.853, respectively. Thirteen radiomics features were selected to calculate Rad-score. The radiomics nomogram containing Rad-score and clinical risk factor showed an encouraging calibration and discrimination performance with area under the ROC curves of 0.906 (95% confidence interval (CI): 0.840–0.966) in the training dataset and 0.790 (95% CI: 0.554–0.952) in the test dataset. CONCLUSIONS: The CESM-based radiomics nomogram had good prediction performance for pCR after NAC in breast cancer; therefore, it has a good clinical application prospect.
    Type of Medium: Online Resource
    ISSN: 0895-3996 , 1095-9114
    URL: Article
    DOI: 10.3233/XST-221349
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2023
    detail.hit.zdb_id: 2012019-9
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Scavenging Reactive Oxygen Species Decreases Amyloid-β Levels via Activation of PI3K/Akt/GLUT1 Pathway in N2a/APP695swe Cells
    IOS Press ; 2022
    In:  Journal of Alzheimer's Disease Vol. 90, No. 1 ( 2022-10-25), p. 185-198
    Details
    In: Journal of Alzheimer's Disease, IOS Press, Vol. 90, No. 1 ( 2022-10-25), p. 185-198
    Abstract: Background: Dysregulated glucose metabolism in the brain is considered to be one of the key causes of Alzheimer’s disease (AD). Abnormal glucose uptake in AD is tightly associated with decreased levels of glucose transporter 1 (GLUT1) and GLUT3 in the brain, but the underlying mechanisms remain unclear. Objective: We aimed to explore the cause and mechanism of impaired glucose uptake in AD. Methods: N2a/WT and N2a/APP695swe cells were cultured in vitro, and cellular glucose uptake and ATP content, as well as the expression of GLUT1, GLUT3, and PI3K/Akt pathway members, were detected. Intracellular reactive oxygen species (ROS) levels were detected by flow cytometry. After treatment with the ROS scavenger N-acetyl-L-cysteine (NAC), the above indicators were detected again. Results: GLUT1 expression was significantly decreased (p = 0.0138) in N2a/APP695swe cells, while GLUT3 expression was no statistical difference (p  〉  0.05). After NAC treatment, PI3K and Akt phosphorylation levels, GLUT1 expression, glucose uptake and ATP levels were remarkably increased (p = 0.0006, p = 0.0008, p = 0.0009, p = 0.0001, p = 0.0013), while Aβ levels were significantly decreased (p = 0.0058, p = 0.0066). After addition of the PI3K inhibitor LY29004, GLUT1 expression was reduced (p = 0.0008), and Aβ levels were increased (p = 0.0009, p = 0.0117). In addition, increases in glucose uptake and ATP levels induced by the Akt activator SC79 were hindered by the GLUT1 inhibitor WZB117 (p = 0.0002, p = 0.0005). Aβ levels were decreased after SC79 treatment and increased after WZB117 treatment (p = 0.0212, p = 0.0006). Conclusion: Taken together, scavenging of ROS prevents from Aβ deposition via activation of the PI3K/Akt/GLUT1 pathway, and improved the impaired glucose uptake in N2a/APP695swe cells.
    Type of Medium: Online Resource
    ISSN: 1387-2877 , 1875-8908
    URL: Article
    DOI: 10.3233/JAD-220610
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2022
    detail.hit.zdb_id: 2070772-1
    Location Call Number Limitation Availability
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