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  • IOP Publishing  (3)
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  • IOP Publishing  (3)
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  • 1
    Online-Ressource
    Online-Ressource
    In vitro application of drug-loaded hydrogel combined with 3D-printed porous scaffolds
    IOP Publishing ; 2022
    In:  Biomedical Materials Vol. 17, No. 6 ( 2022-11-01), p. 065019-
    Details
    In: Biomedical Materials, IOP Publishing, Vol. 17, No. 6 ( 2022-11-01), p. 065019-
    Kurzfassung: Titanium mesh and three-dimensional titanium alloy scaffolds play a key role in addressing oral and maxillofacial bone defects, which can provide a specific environment and structure for bone growth and development. The two main causes of implant surgery failure are aseptic loosening and bacterial-induced implant-associated infections. To make bone defect implants effective for a long time, the ideal scaffold should take into account the two functions of osseointegration and anti-infection. Therefore, on the basis of the low-elastic-modulus Ti-10Ta-2Nb-2Zr (TTNZ) alloys developed by the research group in the early stage, this study intends to combine the vancomycin-loaded hydrogel with the 3D-printed through-hole porous titanium alloy scaffold to endow 3D-printed TTNZ scaffolds with antibacterial properties. The antibacterial properties of the complex were investigated by the zone of inhibition test and the adhesion/free antibacterial test. The effects of the composite system on osseointegration were investigated from the aspects of cell adhesion, cell proliferation and osteogenesis-related gene expression. The results showed that loading 2.5 wt.% and 5 wt.% vancomycin did not affect the structure of chitosan–hyaluronic acid hydrogel. The properties of the hydrogels were examined by scanning electron microscopy, Fourier-transform infrared, degradation experiment in vitro and vancomycin release experiment in vitro . When combined with porous scaffolds, the drug-loaded hydrogels exhibited slower drug release rates and longer release times. In addition, in vitro studies found that the TTNZ scaffolds loaded with 5 wt.% vancomycin had a certain effect on the expression of osteogenesis-related genes in cells, but the antibacterial effect was the best. The porous scaffolds loaded with 2.5 wt.% vancomycin hydrogel TTNZ scaffolds did not inhibit cell proliferation, adhesion, alkaline phosphatase activity, and osteogenesis-related gene ex-pression, but the antibacterial effect on free bacteria was not as good as that of TTNZ scaffolds loaded with 5 wt.% vancomycin. This study, complementing the advantages of the two and controlling the local release rate of vancomycin, provides a new idea for future 3D printing of titanium alloy stents for anti-infection.
    Materialart: Online-Ressource
    ISSN: 1748-6041 , 1748-605X
    URL: Article
    DOI: 10.1088/1748-605X/ac9943
    Sprache: Unbekannt
    Verlag: IOP Publishing
    Publikationsdatum: 2022
    ZDB Id: 2233169-4
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    A Review of Routing Algorithms Based on Multi-Layer Satellite Networks
    IOP Publishing ; 2021
    In:  Journal of Physics: Conference Series Vol. 2136, No. 1 ( 2021-12-01), p. 012040-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2136, No. 1 ( 2021-12-01), p. 012040-
    Kurzfassung: Compared with single layer satellite network, satellite distribution of multi-layer satellite networks in the double layer or multilayer orbital plane, combines all the advantages of engaging subjects of the satellite, therefore contains its low vulnerability, good robustness, high stability, high spectrum efficiency and system throughput, channel characteristics such as large capacity, in the satellite network is a very promising direction. Multilayer satellite network also has some inevitable disadvantages, that is, the number of nodes and the number of links is large, so it has the characteristics of frequent changes in network topology, which requires higher routing algorithm. There are many researches on routing algorithms based on multi-layer satellite networks at home and abroad. This paper introduces the general situation of multi-layer satellite network, classifies the existing routing algorithms of multi-layer satellite network according to different standards, analyzes several typical routing algorithms in detail, points out the advantages and disadvantages, and summarizes the future development trend.
    Materialart: Online-Ressource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/2136/1/012040
    Sprache: Unbekannt
    Verlag: IOP Publishing
    Publikationsdatum: 2021
    ZDB Id: 2166409-2
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Nondestructive material characterization of meteorites with synchrotron-based high energy x-ray phase micro-computed tomography
    IOP Publishing ; 2017
    In:  Journal of Physics D: Applied Physics Vol. 50, No. 5 ( 2017-02-08), p. 055301-
    Details
    In: Journal of Physics D: Applied Physics, IOP Publishing, Vol. 50, No. 5 ( 2017-02-08), p. 055301-
    Materialart: Online-Ressource
    ISSN: 0022-3727 , 1361-6463
    URL: Article
    DOI: 10.1088/1361-6463/aa4f31
    Sprache: Unbekannt
    Verlag: IOP Publishing
    Publikationsdatum: 2017
    ZDB Id: 209221-9
    ZDB Id: 1472948-9
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
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