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  • 1
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    TO EXAMINE THE CLINICAL CHARACTERISTICS, PARACLINICAL SIGNS OF PATIENTS WITH LIVER CANCER AND EVALUATE THE RESULTS OF TREATMENT OF LIVER CANCER BY GAMMA KNIFE
    Hue University of Medicine and Pharmacy ; 2012
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Objective: To examine the clinical characteristics, paraclinical signs of patients with liver cancer and evaluate the results of treatment of liver cancer by gamma knife. Material and Methods: 95 patients were diagnosed liver cancer that treated with Gamma Knife in Hue University Hospital from January 2011 to May 2012. Daily monitoring of patients in treatment process and after treatment for 1 month, 3 months, 6 months...The data on clinical monitoring, images are recorded. Results and discussion: (i) Most patients with a history of hepatitis B, C (66.3%), what has not been previously treated (78.9%). Common clinical symptoms are right lower ribs pain (62.1%), poor diet (47.4%), enlarged liver (41.1%), weight loss (36.8%), fatigue (30,5%). The majority of liver tumors located in the right liver (74.8%) and usually have two or more tumors (91.6%). Large tumor size mostly bigger than 6 cm (48.4%), 43.2% of patients with tumor size 3-6cm. Hepatic enzyme increased 15.9%, 22.1% Billirubin increase, accounting for 26.3% of AFP increase. (ii) Gamma treatment with focus of more than 20 at a rate 47.4%, primarily radiation time longer than 15 minutes (58.9%). Most patients reported no abnormalities in the proces of treatment (57.9%), only a few patients have a feeling of fullness, indigestion (26.3%), pain (28.4%), dizziness (3.2%). The main clinical symptoms improved after treatment. (iii) The paraclinical biochemics, after 1-6 months of treatment patients with paraclinical signs improved. Tumor size after 1-6 months of treatment accounted for 66.3% reduction, not reduced to 22.1%, increase in size accounted for only 11.6%. Conclusion: after Gamma Knife treatment from 1 to 6 months, most patients respond well and are quite good. After one month, this rate is 84.2%. After 3-6 months, this rate is 73.1%. Keywords: liver cancer, treatment, Gamma Knife Key words: liver cancer, treatment, Gamma Knife
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2012.4.8
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2012
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  • 2
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    Application of the real-time PCR Taqman allelic discrimination assay for the detection of Isoniazid and/or Rifampicin resistant Mycobacterium Tuberculosis from clinical samples
    Hue University of Medicine and Pharmacy ; 2023
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Background: Drug-resistant Tuberculosis (DR-TB) is challenging public health problem in countries with high tuberculosis ​​prevalence and limited resources. Developing and applying the most appropriate and effective methods for diagnosing DR-TB from clinical samples is necessary, allowing a more rapid detection method for large-scale screening. Methods: Applying real-time PCR Taqman allelic discrimination with a PCR Taqman probes panel to identifying the DR-TB associated mutations in rpoB and katG of Mycobacterium Tuberculosis from isolates and clinical samples. Results: Comparing results of the real-time PCR allelic and DNA sequencing results, the sensitivity and specificity for Isoniazid resistance detection by analysing katG were found 95%(75.1 - 99.8) and 100%, Rifampicin resistance determining region (RRDR) of rpoB were found 95.5(77.16 - 99.88) and 100%, respectively. The real-time PCR TaqMan allelic discrimination also showed the sensitivities 100% for both katG and rpoB, and the specificities were 93.55% (78.58 - 99.21) for the rpoB and 93.94% (79.77 - 99.26) for the katG from clinical samples. Conclusions: This study showed that the real-time PCR taqman allelic discrimination assay is useful for detection of TB and DR-TB because of an accurate and rapid diagnosis in the early stages. Key words: rug-resistant, Tuberculosis, clinical samples, real-time PCR taqman allelic discrimination assay, Mycobacterium tuberculosis.
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2023.4.10
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2023
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  • 3
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    Prognostic factors for severity and mortality of sepsis patients in Hue Central Hospital 2018 - 2019
    Hue University of Medicine and Pharmacy ; 2022
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Background: Sepsis has a high risk of death from septic shock and dysfunction of many organs. Diagnosis and prognosis of patients in the early stage play a very important role, helping to reduce mortality and shorten the hospital stay of patients. Aims: Study some factors for severity and mortality of sepsis adult patients. Subjects and methods: 84 patients over 15 years old were diagnosed with sepsis, treated at the Department of Tropical Diseases and Intensive Care Unit, Hue Central Hospital during the period from April 2018 to June 2019. A cross-sectional study. Results: Lactate concentrations within 24 hours of admission had a good severe prognosis value with an AUC of 0.866 (p 〈 0.001). PCT concentrations within 24 hours of admission had a good prognosis value with an AUC of 0.866 (p 〈 0.001). Comorbidities, hospital infections, creatinine, PCT, blood lactate, and SOFA and APACHE II scores were factors associated with a severe prognosis in patients sepsis with an OR of 3.33 respectively; 5.39; 1.01; 1.05; 2.52; 4.16, and 1.36. SOFA and APACHE II scores at 24 hours post-admission had AUC of 0.982 and 0.876, respectively. The factors related to mortality are comorbidities, nosocomial infections and SOFA score at 24 hours after admission with OR 99.07, respectively; 7.66 and 2.02. Conclusion: Comorbidities, nosocomial infections, an increase in serum creatinine levels, an increase in PCT, blood lactate as well as increased SOFA and APACHE II scores are risk factors associated with severe prognosis in sepsis patients. The factors related to mortality are comorbidities, nosocomial infections and SOFA score at 24 hours after admission with OR 99.07, respectively; 7.66 and 2.02. Key words: Sepsis, prognostic factor.
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2022.4.13
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2022
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  • 4
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    A PILOT STUDY OF HER-2/NEU GENE AMPLIFICATION ASSESSED BY FLUORESCENCE IN SITU HYBRIDIZATION (FISH) IN GASTRIC CANCER
    Hue University of Medicine and Pharmacy ; 2014
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Background: HER-2/neu is a predictive biomarker for treatment of gastric cancer using trastuzumab in combination with chemotherapy. This study aimed to evaluate the status of HER-2/neu gene amplification using fluorescence in situ hybridization (FISH) in gastric cancer. Patients and methods: thirty six gastric cancer patients were assessed HER-2/neu gene amplification by FISH using PathVysionTM HER-2 DNA Probe kit (including HER-2/neu probe and CEP-17 probe) with biopsy and surgical specimens. Results: The HER-2/neu gene amplification was observed in three cases (8.3%), the HER-2/neu gene amplification rate in Lauren’s intestinal-type and diffuse-type were 11.8% and 5.2%, respectively. Conclusion: We applied successfully FISH technique with gastric cancer tissue samples. This technique could be performed as routine test in gastric cancer in order to select patients that benefit from trastuzumab in combination with chemotherapy.
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2014.3.2
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2014
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  • 5
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    EVALUATE THE RESULTS OF SNORING BY ADENOTONSILLECTOMY
    Hue University of Medicine and Pharmacy ; 2018
    In:  Journal of Medicine and Pharmacy Vol. 8, No. 6 ( 2018-12), p. 172-177
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy, Vol. 8, No. 6 ( 2018-12), p. 172-177
    Abstract: Aims: To study outcomes of snoring by adenotonsillectomy, expecting least equipments, good result, price rationalization. Methods: Prospective, intervention. Including 49 patients treated by adenotonsillectomy. Assessment had been made after 3 months post-op. Results: The common symtoms are snoring (100%), sniff breath (98%), sore throat (67.3%), rhinorrhea (59.2%), nasal obstruction, cough (49%). There are 49 patients with snoring, mostly over grade II (44.9%). Adenoid hypertrophy mostly is grade II and tonsil hypertrophy is grade III. After 3 months, the grade of snoring presented good or great results in (93.9%) of patients. VAS: patient’s contentment was (100%). Conclusions: The study showed that adenotonsillectomy presented good result are (93.9%) after 3 months. Key words: snoring, snoring grade, adenoid hypertrophy, tonsil hypertrophy, adenotonsillectomy
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Issue
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp.2018
    DOI: 10.34071/jmp.2018.6
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2018.6.23
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2018
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  • 6
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    PRENATAL DIAGNOSIS FOR TRISOMY 21, 18 AND 13 BY QUANTITATIVE FLUORESCENT POLYMERASE CHAIN REACTION AMONG PREGNANT WOMEN WITH HIGH RISK
    Hue University of Medicine and Pharmacy ; 2018
    In:  Journal of Medicine and Pharmacy Vol. 8, No. 4 ( 2018-8), p. 88-95
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy, Vol. 8, No. 4 ( 2018-8), p. 88-95
    Abstract: Introduction: Prenatal diagnosis of trisomy 21, 18 and 13 plays a very important role in the improving population quality. This study was aimed at (1) Identifying the prevalence of trisomy 21, 18 and 13 by QFPCR from amniotic cells of high-risk pregnancies; and (2) Evaluating the association between diagnosed trisomies and some characteristics of mother and fetus. Objectives and methods: 170 pregnant women with high risk of having trisomy 21, 18 or 13 fetuses during first trimester screening (gestation age from 11 weeks to 13 weeks 6 days). DNA was extracted from amniocytes for prenatal diagnosis using QF-PCR. Results: The prevalence of trisomies was 9.4%, among which trisomy 21 and trisomy 18 accounted for 68.8% and 31.2%, respectively; none of them was trisomy 13. There was the significant association between diagnosed trisomies and maternal age (cut-off 30.5 years old) and nuchal translucency thickness (cut-off 1.95 mm). MoM median of free β-hCG increased in trisomy 21 group (4.35, p = 0.021) and decreased in trisomy 18 group (0.13, p 〈 0.001) as compared to the non-trisomy group (2.28). MoM median of serum PAPP-A decreased in trisomy 18 group (0.14, p = 0.004) as compared to the non-trisomy group (0.54). Conclusion: Prenatal diagnosis by QF-PCR detected remarkable prevalence of fetuses with trisomy 21 và 18. There was the significant association between diagnosed trisomies and maternal age, nuchal translucency thickness, free β-hCG and serum PAPP-A. Key words: prenatal diagnosis, trisomy, QF-PCR
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Issue
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp.2018
    DOI: 10.34071/jmp.2018.4
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2018.4.13
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2018
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  • 7
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    Relationship of antibiotic resistance to results of treatment in sepsis patients in Hue Central Hospital 2017 – 2018
    Hue University of Medicine and Pharmacy ; 2019
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Sepsis is a serious bacterial infection. The main treatment is using antibiotics. However, the rate of antibiotic resistance is very high and this resistance is related to the outcome of treatment. Objectives: To evaluate the situation of antibiotic resistance of some isolated bacteria in sepsis patients treated at Hue Central Hospital; to evaluate the relationship of antibiotic resistance to the treatment results in patients with sepsis. Subjects and methods: prospective study of 60 sepsis patients diagnosed according to the criteria of the 3rd International Consensus-Sepsis 3 and its susceptibility patterns from April 2017 to August 2018. Results and Conclusions: The current agents of sepsis are mainly S. suis, Burkhoderiae spp. and E. coli. E. coli is resistant to cephalosporins 3rd, 4th generation and quinolone group is over 75%; resistance to imipenem 11.1%; the ESBL rate is 60%. S. suis resistant to ampicilline 11.1%; no resistance has been recorded to ceftriaxone and vancomycine. Resistance of Burkholderiae spp. to cefepime and amoxicillin/clavulanic acid was 42.9% and 55.6%, resistant to imipenem and meropenem is 20%, resistance to ceftazidime was not recorded. The deaths were mostly dued to E. coli and K. pneumoniae. The mortality for patients infected with antibiotic-resistant bacteria are higher than for sensitive groups. Key words: Sepsis, bacterial infection, antibiotics
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2019.5.7
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2019
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