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  • Hindawi Limited  (15)
  • 1
    Online Resource
    Online Resource
    Fine mapping and identification of a candidate geneSSH1 in disseminated superficial actinic porokeratosis
    Hindawi Limited ; 2004
    In:  Human Mutation Vol. 24, No. 5 ( 2004-11), p. 438-438
    Details
    In: Human Mutation, Hindawi Limited, Vol. 24, No. 5 ( 2004-11), p. 438-438
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/humu.v24:5
    DOI: 10.1002/(ISSN)1098-1004
    DOI: 10.1002/humu.9283
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2004
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 2
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    Cancer SIGVAR: A semiautomated interpretation tool for germline variants of hereditary cancer‐related genes
    Hindawi Limited ; 2021
    In:  Human Mutation Vol. 42, No. 4 ( 2021-04), p. 359-372
    Details
    In: Human Mutation, Hindawi Limited, Vol. 42, No. 4 ( 2021-04), p. 359-372
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.v42.4
    DOI: 10.1002/humu.24177
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 3
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    LncRNA PVT1 Promotes Cell Proliferation, Invasion, and Migration and Inhibits Cell Apoptosis by Phosphorylating YAP
    Hindawi Limited ; 2022
    In:  Canadian Journal of Gastroenterology and Hepatology Vol. 2022 ( 2022-5-26), p. 1-10
    Details
    In: Canadian Journal of Gastroenterology and Hepatology, Hindawi Limited, Vol. 2022 ( 2022-5-26), p. 1-10
    Abstract: Gastric cancer (GC) as a serious global health problem is a threat to human longevity. Plasmacytoma variant translocation 1 (PVT1) participates in the formation and progression of various cancers, including GC. The aim of this study is to investigate the mechanism underlying the functions of PVT1 and explore a novel target for the diagnosis and treatment of GC. Analysis of the TCGA dataset using the R software identified that the lncRNA PVT1 was greatly upregulated in GC tissues. Twenty pairs of GC and adjacent normal tissues were acquired from patients with GC, and the expression of PVT1 was evaluated using RT-qPCR. Furthermore, PVT1 expression was knocked down in GC cells using siRNA, and the GC cells were divided into control, negative control (NC), and siRNA groups. Cell proliferation ability was analyzed using Cell Counting Kit-8 (CCK8) and colony formation assays, whereas cell migration and invasion ability were investigated through wound healing and Transwell assays. Moreover, Western blotting was used to analyze the expression of Yes-associated protein (YAP) and epithelial-to-mesenchymal transition (EMT) proteins. We also found that PVT1 and YAP expressions were upregulated in the GC tissues compared with those in the adjacent nontumor tissues. Knockdown of PVT1 was found to inhibit the proliferation, invasion, and migration and promote apoptosis of GC cells. Furthermore, knockdown of PVT1 downregulated YAP and promoted phosphorylation of YAP, suggesting that PVT1 exerts actions on GC cells by targeting YAP and inhibits cell apoptosis in vitro. The EMT process was also inhibited by the knockdown of PVT1. In summary, lncRNA PVT1 facilitated cell proliferation, invasion, and migration and suppressed cell apoptosis by targeting YAP. This study suggests that the expressions of PVT1 and YAP could be used for the early detection of GC and the occurrence and development of GC could be inhibited by interfering the interaction of PVT1 and YAP, which will provide new insights for the diagnosis, treatment, and prognosis of GC.
    Type of Medium: Online Resource
    ISSN: 2291-2797 , 2291-2789
    URL: Article
    DOI: 10.1155/2022/5332129
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2762184-4
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  • 4
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    Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis
    Hindawi Limited ; 2022
    In:  Cardiology Research and Practice Vol. 2022 ( 2022-2-16), p. 1-10
    Details
    In: Cardiology Research and Practice, Hindawi Limited, Vol. 2022 ( 2022-2-16), p. 1-10
    Abstract: Background. Circular RNAs (circRNAs) were known to be related to the pathogenesis of many diseases through competing endogenous RNA (ceRNA) regulatory mechanisms. However, the function of circRNA in coronary artery disease (CAD) remains unclear. In this study, we aim to construct a circRNA-related competing endogenous RNA (ceRNA) network in CAD. Methods. The gene expression profiles of CAD were obtained from Gene Expression Omnibus datasets. Bioinformatics analysis was performed to construct a ceRNA regulatory network, from which the hub genes involved were identified through protein-protein interaction (PPI) networks leading to the identification of the circRNA-miRNA-hub gene subnetwork. In addition, function enrichment analysis was performed to detect the potential biological mechanism in which circRNA might be involved. Results. A total of 115 DEcircRNAs (differentially expressed circRNAs), 17 DEmiRNAs (differentially expressed microRNAs), and 790 DEmRNAs (differentially expressed mRNAs) were identified between CAD and control groups from microarray datasets. Functional enrichment analysis showed that DEmRNAs were significantly involved in inflammation-related pathways and ubiquitin-protein ligase binding. After identifying 20 DEcircRNA-DEmiRNA pairs and 561 DEmiRNA-DEmRNA pairs, we obtained a circRNA-miRNA-mRNA regulatory network. PPI network analysis showed that eight hub genes were closely related to CAD, leading to the identification of a circRNA-miRNA-hub gene subnetwork consisting of nine circRNAs (hsa_circ_0020275, hsa_circ_0020387, hsa_circ_0020417, hsa_circ_0045512, hsa_circ_0047336, hsa_circ_0069094, hsa_circ_0071326, hsa_circ_0071330, and hsa_circ_0085340), four miRNAs (hsa-miR-136-5p, hsa-miR-376c-3p, hsa-miR-411-5p, and hsa-miR-654-5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2). In addition, we discovered these hub genes were enriched in the ubiquitin-mediated proteolysis pathway, suggesting circRNAs may be involved in the pathogenesis of CAD through this pathway. Conclusions. This study may deepen our understanding of the potential role of circRNA-miRNA-mRNA regulation network in CAD and suggest novel diagnostic biomarkers and therapeutic targets for CAD.
    Type of Medium: Online Resource
    ISSN: 2090-0597 , 2090-8016
    URL: Article
    DOI: 10.1155/2022/4017082
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2506187-2
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  • 5
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    Barbituric Derivative Nanoaggregates with Aggregation-Induced Emission and Mechanofluorochromism
    Hindawi Limited ; 2019
    In:  Journal of Nanomaterials Vol. 2019 ( 2019-11-11), p. 1-10
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2019 ( 2019-11-11), p. 1-10
    Abstract: Three new nonplanar barbituric derivatives, named as TTB, TTTB, and TOB, were synthesized. The D- π -A type conjugated compounds showed obvious intramolecular charge transfer (ICT) property, which was evidenced by theoretical calculations and spectral analyses. All of them exhibited aggregation induced emission (AIE) when formed nanoaggregates. These nanoaggregates also showed reversible mechanofluorochromism (MFC). Their red light emission became deep red after grinding and then recovered with dichloromethane fuming. Hence, a strategy to fabricate mechanofluorochromic nanoaggregate phosphors via nonplanar π -skeleton and steric effect was demonstrated, and these nanophosphors possess potentials for mechanosensors and anticounterfeiting technology.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2019/7635756
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2229480-6
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  • 6
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    Exploiting the Vulnerability of Flow Table Overflow in Software-Defined Network: Attack Model, Evaluation, and Defense
    Hindawi Limited ; 2018
    In:  Security and Communication Networks Vol. 2018 ( 2018), p. 1-15
    Details
    In: Security and Communication Networks, Hindawi Limited, Vol. 2018 ( 2018), p. 1-15
    Abstract: As the most competitive solution for next-generation network, SDN and its dominant implementation OpenFlow are attracting more and more interests. But besides convenience and flexibility, SDN/OpenFlow also introduces new kinds of limitations and security issues. Of these limitations, the most obvious and maybe the most neglected one is the flow table capacity of SDN/OpenFlow switches. In this paper, we proposed a novel inference attack targeting at SDN/OpenFlow network, which is motivated by the limited flow table capacities of SDN/OpenFlow switches and the following measurable network performance decrease resulting from frequent interactions between data and control plane when the flow table is full. To the best of our knowledge, this is the first proposed inference attack model of this kind for SDN/OpenFlow. We implemented an inference attack framework according to our model and examined its efficiency and accuracy. The evaluation results demonstrate that our framework can infer the network parameters (flow table capacity and usage) with an accuracy of 80% or higher. We also proposed two possible defense strategies for the discovered vulnerability, including routing aggregation algorithm and multilevel flow table architecture. These findings give us a deeper understanding of SDN/OpenFlow limitations and serve as guidelines to future improvements of SDN/OpenFlow.
    Type of Medium: Online Resource
    ISSN: 1939-0114 , 1939-0122
    URL: Article
    DOI: 10.1155/2018/4760632
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2415104-X
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  • 7
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    Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
    Hindawi Limited ; 2021
    In:  Journal of Diabetes Research Vol. 2021 ( 2021-10-26), p. 1-11
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2021 ( 2021-10-26), p. 1-11
    Abstract: Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.
    Type of Medium: Online Resource
    ISSN: 2314-6753 , 2314-6745
    URL: Article
    DOI: 10.1155/2021/8746114
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2711897-6
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  • 8
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    An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration
    Hindawi Limited ; 2021
    In:  Journal of Diabetes Research Vol. 2021 ( 2021-11-10), p. 1-12
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2021 ( 2021-11-10), p. 1-12
    Abstract: Background. Diabetic retinopathy (DR) is a leading cause of blindness in working-age populations. Proper in vitro DR models are crucial for exploring pathophysiology and identifying novel therapeutic targets. This study establishes a rational in vitro diabetic retinal neuronal-endothelial dysfunction model and a comprehensive downstream validation system. Methods. Human retinal vascular endothelial cells (HRMECs) and retinal ganglion cells (RGCs) were treated with different glucose concentrations with mannitol as matched osmotic controls. Cell proliferation and viability were evaluated by the Cell Counting Kit-8. Cell migration was measured using a transwell migration assay. Cell sprouting was assessed by a tube formation assay. The VEGF expression was assessed by ELISA. RGCs were labeled by neurons and RGC markers TUJ1 and BRN3A for quantitative and morphological analysis. Apoptosis was detected using PI/Hoechst staining and TUNEL assay and quantified by ImageJ. Results. Cell proliferation and migration in HRMECs were significantly higher in the 25 mM glucose-treated group ( p 〈 0.001 ) but lower in the 50 mM and 100 mM groups ( p 〈 0.001 ). The permeability and the apoptotic index in HRMECs were statistically higher in the 25 mM, 50 mM, and 100 mM groups ( p 〈 0.05 ). The tube formation assay found that all the parameters were significantly higher in the 25 mM and 50 mM groups ( p 〈 0.001 ) concomitant with the elevated VEGFA expression in HRMECs ( p = 0.016 ). Cell viability was significantly lower in the 50 mM, 100 mM, and 150 mM groups in RGCs ( p 50 mM = 0.013 , p 100 mM = 0.019 , and p 150 mM = 0.002 ). Apoptosis was significantly elevated, but the proportion of RGCs with neurite extension was significantly lower in the 50 mM, 100 mM, and 150 mM groups ( p 50 mM 〈 0.001 , p 100 m M 〈 0.001 , and p 150 mM 〈 0.001 ). Conclusions. We have optimized glucose concentrations to model diabetic retinal endothelial (25-50 mM) or neuronal (50-100 mM) dysfunction in vitro, which have a wide range of downstream applications.
    Type of Medium: Online Resource
    ISSN: 2314-6753 , 2314-6745
    URL: Article
    DOI: 10.1155/2021/9765119
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2711897-6
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  • 9
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    New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss : XIA et al.
    Hindawi Limited ; 2017
    In:  Human Mutation Vol. 38, No. 10 ( 2017-10), p. 1421-1431
    Details
    In: Human Mutation, Hindawi Limited, Vol. 38, No. 10 ( 2017-10), p. 1421-1431
    Type of Medium: Online Resource
    ISSN: 1059-7794
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.2017.38.issue-10
    DOI: 10.1002/humu.23285
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 10
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    Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats
    Hindawi Limited ; 2022
    In:  Stem Cells International Vol. 2022 ( 2022-8-16), p. 1-10
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2022 ( 2022-8-16), p. 1-10
    Abstract: Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β-catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β-catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β-catenin and TCF4 in the Wnt/β-catenin signaling pathway to treat osteoporotic rats.
    Type of Medium: Online Resource
    ISSN: 1687-9678 , 1687-966X
    URL: Article
    DOI: 10.1155/2022/1395299
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2573856-2
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