In:
Journal of Nanomaterials, Hindawi Limited, Vol. 2011 ( 2011), p. 1-7
Abstract:
The present study explored the feasibility of using hexagonal-phase NaYF 4 :Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF 4 :Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26%), and decent MR T 1 relaxivity ( r 1 = 2.87 mM −1 s −1 ). The NaYF 4 :Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro . Meanwhile, in in vivo MR experiments on rats, the NaYF 4 :Ce,Tb,Gd NCs also significantly increased T 1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF 4 :Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.
Type of Medium:
Online Resource
ISSN:
1687-4110
,
1687-4129
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2229480-6
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