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  • Hindawi Limited  (36)
  • 1
    Online Resource
    Online Resource
    Identification, Characterization, and Developmental Expression Pattern of Type III Interferon Receptor Gene in the Chinese Goose
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-11
    Abstract: Interferons, as the first line of defense against the viral infection, play an important role in innate immune responses. Type III interferon (IFN- λ ) was a newly identified member of IFN family, which plays IFN-like antiviral activity. Towards a better understanding of the type III interferon system in birds, type III interferon lambda receptor (IFNLR1) was first identified in the Chinese goose. In this paper, we had cloned 1952 bp for goose IFNLR1 (goIFNLR1), including an ORF of 1539 bp, encoding a 512-amino acid protein with a 20 aa predict signal peptide at its N terminal and a 23 aa transmembrane region. The predicted amino acid sequence of goIFNLR1 has 90%, 73%, and 34% identity with duck IFNLR1 (predicted sequence), chicken IFNLR1, and human IFNLR1, respectively. And the age-related tissue distribution of goIFNLR1 was identified by Real Time quantitative PCR (RT-qPCR), we found that the goIFNLR1 has a mainly expression in epithelium-rich tissues similar to other species’, such as small intestinal, lung, liver, and stomach. Moreover, a relatively high expression of goIFNLR1 was also observed in the secondary immune tissues (harderian gland and cecal tonsil). The identification and tissue distribution of goIFNLR1 will facilitate further study of the role of IFN- λ in goose antiviral defense.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/186274
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 2
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    Online Resource
    Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-14
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-14
    Abstract: Interferon γ receptor 1 (IFNGR1) and IFNGR2 are two cell membrane molecules belonging to class II cytokines, which play important roles in the IFN-mediated antiviral signaling pathway. Here, goose IFNGR1 and IFNGR2 were cloned and identified for the first time. Tissue distribution analysis revealed that relatively high levels of goose IFN γ mRNA transcripts were detected in immune tissues, including the harderian gland, cecal tonsil, cecum, and thymus. Relatively high expression levels of both IFNGR1 and IFNGR2 were detected in the cecal tonsil, which implicated an important role of IFN γ in the secondary immune system of geese. No specific correlation between IFN γ , IFNGR1, and IFNGR2 expression levels was observed in the same tissues of healthy geese. IFN γ and its cognate receptors showed different expression profiles, although they appeared to maintain a relatively balanced state. Furthermore, the agonist R848 led to the upregulation of goose IFN γ but did not affect the expression of goose IFNGR1 or IFNGR2. In summary, trends in expression of goose IFN γ and its cognate receptors showed tissue specificity, as well as an age-related dependency. These findings may help us to better understand the age-related susceptibility to pathogens in birds.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/537637
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 3
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    Online Resource
    Pharmacokinetic and Lipidomic Assessment of the In Vivo Effects of Parishin A-Isorhynchophylline in Rat Migraine Models
    Hindawi Limited ; 2020
    In:  Journal of Analytical Methods in Chemistry Vol. 2020 ( 2020-07-06), p. 1-11
    Details
    In: Journal of Analytical Methods in Chemistry, Hindawi Limited, Vol. 2020 ( 2020-07-06), p. 1-11
    Abstract: Migraine is a chronic brain disease that leads to periodic neurological attacks. Parishin A and isorhynchophylline (PI) is the active monomer component extracted from the traditional antimigraine Chinese medicinal combination of Gastrodia and Uncaria, respectively. In this study, using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) technology, we performed pharmacokinetic and lipidomic study on migraine model rats after administration of PI. For the detection of the compounds in plasma, AB Sciex Triple Quad™ 4500 was applied for quantitative analysis, and the COSMOSIL C 18 column (2.1 × 100 mm, 2.6  μ m) was used for separation. Isorhynchophylline (ISO: m / z 384.8–241.2) and its main metabolite rhynchophylline (RHY: m / z 384.8–160.2) were simultaneously detected under positive ion modes. Besides, parishin A (PA: m / z 995.1–726.9) and its main metabolite gastrodin (GAS: m / z 331.1–123.0) were simultaneously detected with negative ion modes. For the analysis of endogenous lipid components, Dionex Ultimate 3000 (UHPLC) Thermo Orbitrap Elite was applied for the detection, and the Waters UPLCRBEH C 18 column (1.7  μ m 100  ∗  2.1 mm) was used for separation. Chloroform/methanol (2 : 1, v  :  v ) was used for extraction. The results demonstrated that PI exists significant difference in metabolism between single- and coadministration and can regulate lipid levels associated with migraine.
    Type of Medium: Online Resource
    ISSN: 2090-8865 , 2090-8873
    URL: Article
    DOI: 10.1155/2020/9101598
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2654178-6
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  • 4
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    Online Resource
    Identification of sex‐specific markers and heterogametic XX/XY sex determination system by 2b‐RAD sequencing in redtail catfish ( Mystus wyckioides )
    Hindawi Limited ; 2019
    In:  Aquaculture Research Vol. 50, No. 8 ( 2019-08), p. 2251-2266
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 50, No. 8 ( 2019-08), p. 2251-2266
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.2019.50.issue-8
    DOI: 10.1111/are.14106
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 5
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    Online Resource
    Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis
    Hindawi Limited ; 2018
    In:  International Journal of Endocrinology Vol. 2018 ( 2018-06-04), p. 1-8
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2018 ( 2018-06-04), p. 1-8
    Abstract: Background. The results of previous studies on the usefulness of free triiodothyronine (FT3) to free thyroxine (FT4) are controversial. We investigated the usefulness of FT3, FT4, and FT3/FT4 ratio in differentiating Graves’ disease (GD) from destructive thyroiditis. Methods. A total of 126 patients with untreated GD, 36 with painless thyroiditis, 18 with painful subacute thyroiditis, and 63 healthy controls, were recruited. The levels of FT3 and FT4 and the FT3/FT4 ratios for the different etiologies of thyrotoxicosis were evaluated separately by receiver operating characteristic (ROC) curve analysis. The expression levels of type 1 and type 2 deiodinase ( DIO1 and DIO2 ) in thyroid tissues were also investigated. Results. The optimal cut-off values were 7.215 pmol/L for FT3, 21.71 pmol/L for FT4, and 0.4056 for the FT3/FT4 ratio. The specificity and positive predictive value of the FT3/FT4 ratio were highest for values  〉  0.4056. DIO1 mRNA expression was significantly higher in the thyroid tissue of patients with GD ( P = 0.013 ). Conclusions. We demonstrated that the FT3/FT4 ratio was useful in differentiating GD from destructive thyroiditis. In addition, a relatively high expression of type 1 deiodinase in the thyroid might be responsible for the high FT3/FT4 ratio in patients with GD.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2018/4836736
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2502951-4
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  • 6
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    Online Resource
    Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: MicroRNAs (miRNAs) are endogenous, noncoding RNAs that regulate various biological processes including adipogenesis and fat metabolism. Here, we adopted a deep sequencing approach to determine the identity and abundance of miRNAs involved in fat deposition in adipose tissues from fat-tailed (Kazakhstan sheep, KS) and thin-tailed (Tibetan sheep, TS) sheep breeds. By comparing HiSeq data of these two breeds, 539 miRNAs were shared in both breeds, whereas 179 and 97 miRNAs were uniquely expressed in KS and TS, respectively. We also identified 35 miRNAs that are considered to be putative novel miRNAs. The integration of miRNA-mRNA analysis revealed that miRNA-associated targets were mainly involved in the gene ontology (GO) biological processes concerning cellular process and metabolic process, and miRNAs play critical roles in fat deposition through their ability to regulate fundamental pathways. These pathways included the MAPK signaling pathway, FoxO and Wnt signaling pathway, and focal adhesion. Taken together, our results define miRNA expression signatures that may contribute to fat deposition and lipid metabolism in sheep.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/1857580
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 7
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    Online Resource
    Temperature and Stress Effects on the Compressive Creep Behavior of Parallel Strand Bamboo
    Hindawi Limited ; 2021
    In:  Advances in Civil Engineering Vol. 2021 ( 2021-6-3), p. 1-9
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2021 ( 2021-6-3), p. 1-9
    Abstract: Parallel strand bamboo (PSB) is an engineered bamboo product fabricated using crushed bamboo fiber bundles. Recently, this product finds applications in the civil engineering field. It is expected that the use of this composite will continue to grow because of its excellent mechanical performance, relatively low variability in material properties, and shape standardization. Modern bamboo structures made from PSB composites may be subjected to temperature variations during service. So far, however, there has been little discussion about the temperature-dependent creep. In this study, an investigation was carried out on the short-term behavior of the compressive property of PSB. A stress range of 8 to 64 MPa over a temperature range of 25°C to 75°C was considered in the 24-hour creep tests. In addition, Burgers model was adopted to describe the short-term creep behavior of PSB. Temperature and stress effects on the creep compliance of the Burgers model were also discussed.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2021/6637572
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2449760-5
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  • 8
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    Online Resource
    Extension of Chinese Water Chestnut : EFFECTS OF ANTIOXIDANT ON SHELF LIFE
    Hindawi Limited ; 2017
    In:  Journal of Food Processing and Preservation Vol. 41, No. 5 ( 2017-10), p. e13109-
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 41, No. 5 ( 2017-10), p. e13109-
    Type of Medium: Online Resource
    ISSN: 0145-8892
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.2017.41.issue-5
    DOI: 10.1111/jfpp.13109
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2175273-4
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  • 9
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    Online Resource
    miR-451 on Myocardial Ischemia-Reperfusion in Rats by Regulating AMPK Signaling Pathway
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-7-6), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-7-6), p. 1-9
    Abstract: Myocardial infarction is the main cause of death in patients with coronary heart disease. At present, the main method to treat cardiovascular disease is perfusion therapy. Myocardial ischemia-reperfusion will inevitably lead to reperfusion injury, which is also a major problem in the treatment of cardiovascular diseases. It has been reported that mir-451 in microRNA family participates in the protection of myocardial ischemia-reperfusion by regulating AMPK. The aim of this study was to investigate the effect of mir-451 on myocardial ischemia-reperfusion in rats by regulating AMPK signaling pathway. Sixty adult male rats were selected to establish myocardial ischemia-reperfusion animal model by ligating and loosening coronary artery. The expression level of mir-451 was regulated by injection of mir-451 virus vector and antibody, and the effect of increased or decreased mir-451 expression level on the activity of AMPK signaling pathway was detected. The myocardial infarct area and apoptosis rate of myocardial tissue were detected after 75 min ischemia-reperfusion. The results showed that when the expression level of mir-451 decreased by 15.7%, the activity index of AMPK signaling pathway was increased by 18.3%, the infarct area was reduced by 22.4%, and the apoptosis rate of myocardial cells was decreased by 25.2%. At the same time, the pathological structure of myocardial tissue was improved. Therefore, mir-451 is an inhibitor gene of AMPK signaling pathway. Reducing the expression of mir-451 can enhance the activity of AMPK signal pathway, and the increase of AMPK signal pathway activity is beneficial to reduce myocardial ischemia-reperfusion injury.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/9933998
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 10
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    Serum VEGF: Diagnostic Value of Acute Coronary Syndrome from Stable Angina Pectoris and Prognostic Value of Coronary Artery Disease
    Hindawi Limited ; 2020
    In:  Cardiology Research and Practice Vol. 2020 ( 2020-01-10), p. 1-8
    Details
    In: Cardiology Research and Practice, Hindawi Limited, Vol. 2020 ( 2020-01-10), p. 1-8
    Abstract: Background . Although the level of serum vascular endothelial growth factor (VEGF) is elevated in coronary artery disease (CAD) patients, its potential role in acute coronary syndrome (ACS) or stable angina pectoris (SAP) patients remains unclear. Objectives . To evaluate diagnostic accuracy of serum VEGF in determining ACS patients from SAP and analyze the association of serum VEGF with coronary artery lesions in SAP or the GRACE score in ACS, which is involved in the poor prognosis of low serum VEGF. Methods . 248 CAD patients and 48 healthy subjects were enrolled in this study. Serum VEGF levels were detected by using ELISA. The Gensini score or GRACE score was calculated among SAP or ACS patients. All the patients were followed up for a period of 12 months (mean: 10.77 months). Results . VEGF serum concentrations were higher in the ACS subgroup than in the SAP subgroup ( P 〈 0.001 ) with diagnostic accuracy of ACS from SAP (AUC: 0.667, sensitivity: 68.5%, specificity: 60.1%, P 〈 0.001 ). Patients with high risk of Gensini score showed reduced VEGF levels ( P 〈 0.001 ) accompanied by a negative correlation ( r  = −0.396, P 〈 0.001 ). Patients with a higher GRACE score indicated lower VEGF levels ( P 〈 0.001 ). Low serum VEGF was one of the potential risk factors with adjusted HR of 0.531 ( P = 0.048 ). Conclusion . Serum VEGF exhibits efficient diagnostic value for detection of ACS from SAP with a cutoff value of 648.75 pg/mL. Low serum VEGF indicates severe coronary artery lesions and a higher GRACE score, which suggests poor clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 2090-8016 , 2090-0597
    URL: Article
    DOI: 10.1155/2020/6786302
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2506187-2
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