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  • Hindawi Limited  (109)
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  • Hindawi Limited  (109)
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  • 1
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2020 ( 2020-05-15), p. 1-10
    Abstract: Objective . This study is aimed at evaluating the survival of cirrhotic patients with different etiologies after endoscopic therapy for acute variceal bleeding and the effect of repeated endotherapy on patients’ prognosis. Methods . We retrospectively evaluated the clinical features and outcomes between cirrhotic patients with chronic HBV or HCV infections and other etiologies. The 3-year and 5-year survival rates and rehemorrhage rate in one year between the viral and nonviral cirrhosis patients were compared by Kaplan-Meier curves and log-rank test. Cox analysis was used to identify the impact factors that affect the long-term survival of patients with cirrhosis and variceal bleeding after endotherapy. Results . Out of 2665 patients with liver cirrhosis and variceal hemorrhage selected from our medical center between September 2008 and December 2017, a total of 1342 patients were included for analysis. The median follow-up duration was 32.9 months (range 0.16-111.4 months), the 3- and 5-year cumulative survival rates were 75.3% and 52.8%, respectively. The median survival time was significantly longer in viral cirrhosis patients (47.1 months [95% CI: 24.9-69.1]) compared with nonviral cirrhosis patients (37.0 months [95% CI: 25.0-56.0] , p = 0.001 ). The 3-year and 5-year survival rates of the viral group were higher than the nonviral group. The rehemorrhage rate at one year was higher in nonviral patients than in viral patients ( p 〈 0.001 ). Conclusion. Repeated endotherapy combined with effective antiviral therapy is helpful for long-term survival of cirrhotic population with variceal hemorrhage and HBV or HCV infection.
    Type of Medium: Online Resource
    ISSN: 1687-6121 , 1687-630X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2435460-0
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  • 2
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-6
    Abstract: Purpose . To survey the species diversity of home dust mites (HDM) in Xishuangbanna, a tropical rainforest region in Southwest China. Methods . From August 2010 to January 2011, mite-allergic patients and healthy controls were invited to participate. Dust samples from the patients’ homes were collected, and mites in the samples were isolated. Permanent slides were prepared for morphologically based species determination. Results . In total, 6316 mite specimens of morphologically identifiable species were found in 233 dust samples taken from 41 homes. The result shows that the mite family of Pyroglyphidae occupied the highest percentage of the total amount of mites collected, followed by Cheyletidae family. The most common adult Pyroglyphidae mites were Dermatophagoides ( D. ) farinae , D. pteronyssinus , and D. siboney . The most common mites found from other families were Blomia tropicalis , Tyrophagus putrescentiae , and Aleuroglyphus ovatus . Four main allergenic dust mite species D. farinae , D. pteronyssinus , D. siboney , and Blomia tropicalis were found to be coinhabiting in 6/41 homes. Conclusion . The HDM population in homes in Xishuangbanna, a tropical rainforest region in Southwest China, has its own characteristics. It has rich dust mite species and the dust mite densities do not show significant variation across seasons.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 3
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2019 ( 2019-06-12), p. 1-8
    Abstract: Background . To examine the association between morbid events and metabolic syndrome (MS) in patients with type 2 diabetes mellitus (T2DM). Methods . A prospective, longitudinal, multicenter study was conducted at 13 community health centers associated with Beijing Tongren Hospital. From 2008 to 2015, there have been 3,525 T2DM patients being managed based on the Chinese guideline for T2DM. The morbid events included macrovascular events, diabetic kidney disease, ophthalmologic events, cancer, and all-cause death. Results . At baseline, there were 2,708 people with MS and 817 without MS. After a seven-year management, there were 351 (12.96%) events in MS people and 74 (9.06%) events in people without MS ( p = 0.003 ). The prevalence of macrovascular events (6.06%) was much higher in MS people than in people without MS (3.79%, p = 0.013 ). Cox regression analysis showed an association between MS and morbid events even after adjusting for confounding variables ( adjusted   hazard   ratio = 1.44 ). MS was also associated with macrovascular events ( adjusted   hazard   ratio = 1.96 ). The occurrence of morbid events and macrovascular events was increased when the numbers of metabolic abnormalities were 1, 2, 3, and 4 ( p 〈 0.001 ). There was no continuously statistically significant difference in the cumulative prevalence of morbid events between patients with MS and patients without MS during the first five years. However, after six or seven years, the cumulative prevalence of morbid events in patients with MS was continuously significantly higher than that in patients without MS (11.00% vs. 8.20%, 12.96% vs. 9.06%, p 〈 0.05 ). Conclusions . T2DM with MS had higher incidence of morbid events, especially cardiovascular events, even after integrated management. The occurrence of morbid and macrovascular events increased as the number of metabolic abnormalities increased. MS was associated with increased risk of morbid events by 44% and macrovascular events by 96%. It would take at least six years to observe the association between MS and morbid events in T2DM.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2711897-6
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  • 4
    Online Resource
    Online Resource
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-9
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-9
    Abstract: Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma. Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP. Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides opportunities to investigate OLPs from a systematic perspective. In this paper, assuming that the OLP associated genes have functional relationships, we present a new approach to identify OLP related gene modules from gene regulatory networks. In particular, we find that the gene modules regulated by both transcription factors (TFs) and microRNAs (miRNAs) play important roles in the pathogenesis of OLP and many genes in the modules have been reported to be related to OLP in the literature.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 5
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2019 ( 2019-10-13), p. 1-9
    Abstract: Objective . Asthma is a syndrome that incorporates many immune phenotypes. The immunologic effects of subcutaneous immunotherapy (SCIT) exerts on allergic asthma remain still largely unknown. Here, we investigated the effects of SCIT on cytokine production and peripheral blood levels of lymphocyte subtypes in children with mite-induced moderate and severe allergic asthma. Methods . The study included 60 kids with mite-induced allergic asthma from 5 to 10 years old. All subjects had received antiasthmatic pharmacologic for 3 months at baseline. Half of the children were treated with SCIT combined with pharmacologic treatment named the SCIT group and the other half only with pharmacologic therapy named the no-SCIT group. Total asthma symptom score (TASS) and total medication score (TMS) were recorded. Flow cytometry was used to identify lymphocyte subtypes: type 2 innate lymphocytes (ILC2s), type 1 (Th1) and type 2 (Th2) helper T cells, T helper 17 (Th17) cells, and regulatory T (Treg) cells. ELISA, flow cytometry, and cytometric bead array were used to assess cytokines IL-13, IFN- γ , IL-4, IL-17, and TGF- β , at baseline and 3 and 6 months after study treatment in both groups of patients. Results . Both groups can significantly improve clinical symptoms in children with asthma. SCIT can significantly reduce asthma medication after 6 months of treatment. SCIT induced a significantly higher and progressive reduction in ILC2 percentage and IL-13 levels after 3 and 6 months of treatment compared with baseline and compared with no-SCIT patients. Significant differences were detected in the Th1/Th2 cell ratio and IFN- γ /IL-4 cytokine ratio between groups after 6 months of treatment. Similarly, the Th17/Treg ratio and IL-17/TGF- β ratio in the SCIT group were much lower than those in the no-SCIT group after 3-6 months of treatment. Conclusion . SCIT is a promising option to reduce the percentage of ILC2 and regulate Th1/Th2 and Th17/Treg immune balance in the peripheral blood of children with asthma.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2817541-4
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  • 6
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 65, No. 6 ( 2018-12), p. 1740-1748
    Type of Medium: Online Resource
    ISSN: 1865-1674
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2414822-2
    SSG: 22
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  • 7
    Online Resource
    Online Resource
    Hindawi Limited ; 2016
    In:  International Journal of Rotating Machinery Vol. 2016 ( 2016), p. 1-8
    In: International Journal of Rotating Machinery, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: The ability of the frequency slice wavelet transform (FSWT) to distinguish the fault feature is weak under the condition of strong background noise; in order to solve this problem, a fault feature extraction method combining the singular value decomposition (SVD) and FSWT was proposed. Firstly, the Hankel matrix was constructed using SVD, based on which the SVD order was determined according to the principle of the single side maximum value. Then, the denoised signal was further processed by the FSWT to obtain the time-frequency spectrum of the passband. Finally, the detailed analysis was carried out in the time-frequency area with concentrated energy, and the signal was reconstructed by the inverse-FSWT. The processing effect for the pitting corrosion and the tooth broken faults of the gears shows that the faulty feature can be extracted effectively from the envelope spectrum of the reconstructed signal, which means the proposed method is able to help obtain a qualified result and has the potential to be carried out for the practical engineering application.
    Type of Medium: Online Resource
    ISSN: 1023-621X , 1542-3034
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2032559-9
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  • 8
    Online Resource
    Online Resource
    Hindawi Limited ; 2017
    In:  Mathematical Problems in Engineering Vol. 2017 ( 2017), p. 1-11
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: In order to improve utilization rate of high dimensional data features, an ensemble learning method based on feature selection for entity resolution is developed. Entity resolution is regarded as a binary classification problem, an optimization model is designed to maximize each classifier’s classification accuracy and dissimilarity between classifiers and minimize cardinality of features. A modified multiobjective ant colony optimization algorithm is employed to solve the model for each base classifier, two pheromone matrices are set up, weighted product method is applied to aggregate values of two pheromone matrices, and feature’s Fisher discriminant rate of records’ similarity vector is calculated as heuristic information. A solution which is called complementary subset is selected from Pareto archive according to the descending order of three objectives to train the given base classifier. After training all base classifiers, their classification outputs are aggregated by max-wins voting method to obtain the ensemble classifiers’ final result. A simulation experiment is carried out on three classical datasets. The results show the effectiveness of our method, as well as a better performance compared with the other two methods.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 9
    Online Resource
    Online Resource
    Hindawi Limited ; 2023
    In:  Journal of Food Processing and Preservation Vol. 2023 ( 2023-4-18), p. 1-15
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 2023 ( 2023-4-18), p. 1-15
    Abstract: This investigation is aimed at elucidating the effects of roasting degree and extraction method on coffee beverages prepared with beans from Asia. According to the results with the improvement of the roasting degree, a decrease in titratable acidity, total phenolic compounds, the concentrations of chlorogenic acid and trigonelline, and total antioxidant capacity was observed. Cold coffee beverages showed higher total sugar and trigonelline. The volatile components, such as pyridine, furan-2-yl-methyl acetate, 2-furanemethanol, and 5-methylfurfural, were also affected by roasting degree and extraction methods. Cold brew coffee exhibited higher intensities of enzymatic flavor and sweetness. Furthermore, the principal component analysis revealed a distinct difference in coffee characterization in roasting degree in cold coffee brews than in hot ones. The results indicate that roasting degree affects physicochemical and sensory properties more than extraction temperature. Additionally, there were significant differences in coffee characteristics between cold and hot brew coffee.
    Type of Medium: Online Resource
    ISSN: 1745-4549 , 0145-8892
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2175273-4
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  • 10
    In: Aquaculture Research, Hindawi Limited, Vol. 52, No. 7 ( 2021-07), p. 3360-3370
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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