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  • Hindawi Limited  (151)
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  • Hindawi Limited  (151)
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  • 1
    Online Resource
    Online Resource
    Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain
    Hindawi Limited ; 2021
    In:  Gastroenterology Research and Practice Vol. 2021 ( 2021-1-16), p. 1-20
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2021 ( 2021-1-16), p. 1-20
    Abstract: Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that the gut microbiota plays an important role in the pathophysiology of neurological and psychiatric disorders through the microbiota-gut-brain axis. Therefore, reconstruction of the healthy gut microbiota is a promising new strategy for treating cerebral diseases. We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.).
    Type of Medium: Online Resource
    ISSN: 1687-630X , 1687-6121
    URL: Article
    DOI: 10.1155/2021/6699268
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2435460-0
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  • 2
    Online Resource
    Online Resource
    The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-11-16), p. 1-18
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-11-16), p. 1-18
    Abstract: Neuroblastoma (NB) is the most common solid tumor of the neural crest cell origin in children and has a poor prognosis in high-risk patients. The oncogene MYCN was found to be amplified at extremely high levels in approximately 20% of neuroblastoma cases. In recent years, research on the targeted hydrolysis of BRD4 to indirectly inhibit the transcription of the MYCN created by proteolysis targeting chimaera (PROTAC) technology has become very popular. dBET57 (S0137, Selleck, TX, USA) is a novel and potent heterobifunctional small molecule degrader based on PROTAC technology. The purpose of this study was to investigate the therapeutic effect of dBET57 in NB and its potential mechanism. In this study, we found that dBET57 can target BRD4 ubiquitination and disrupt the proliferation ability of NB cells. At the same time, dBET57 can also induce apoptosis, cell cycle arrest, and decrease migration. Furthermore, dBET57 also has a strong antiproliferation function in xenograft tumor models in vivo. In terms of mechanism, dBET57 targets the BET protein family and the MYCN protein family by associating with CRBN and destroys the SE landscape of NB cells. Combined with RNA-seq and ChIP-seq public database analysis, we identified the superenhancer-related genes TBX3 and ZMYND8 in NB as potential downstream targets of dBET57 and experimentally verified that they play an important role in the occurrence and development of NB. In conclusion, these results suggest that dBET57 may be an effective new therapeutic drug for the treatment of NB.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/7945884
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2817541-4
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  • 3
    Online Resource
    Online Resource
    Perovskite-Based Solar Cells: Materials, Methods, and Future Perspectives
    Hindawi Limited ; 2018
    In:  Journal of Nanomaterials Vol. 2018 ( 2018), p. 1-15
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2018 ( 2018), p. 1-15
    Abstract: A novel all-solid-state, hybrid solar cell based on organic-inorganic metal halide perovskite (CH 3 NH 3 PbX 3 ) materials has attracted great attention from the researchers all over the world and is considered to be one of the top 10 scientific breakthroughs in 2013. The perovskite materials can be used not only as light-absorbing layer, but also as an electron/hole transport layer due to the advantages of its high extinction coefficient, high charge mobility, long carrier lifetime, and long carrier diffusion distance. The photoelectric power conversion efficiency of the perovskite solar cells has increased from 3.8% in 2009 to 22.1% in 2016, making perovskite solar cells the best potential candidate for the new generation of solar cells to replace traditional silicon solar cells in the future. In this paper, we introduce the development and mechanism of perovskite solar cells, describe the specific function of each layer, and focus on the improvement in the function of such layers and its influence on the cell performance. Next, the synthesis methods of the perovskite light-absorbing layer and the performance characteristics are discussed. Finally, the challenges and prospects for the development of perovskite solar cells are also briefly presented.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2018/8148072
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2229480-6
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  • 4
    Online Resource
    Online Resource
    An Improved Genetic Algorithm-Based Traffic Scheduling Model for Airport Terminal Areas
    Hindawi Limited ; 2022
    In:  Journal of Sensors Vol. 2022 ( 2022-3-29), p. 1-13
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2022 ( 2022-3-29), p. 1-13
    Abstract: This paper takes the airport terminal area as the main research content and combines genetic algorithm with airport terminal area analysis theory to analyze and study the traffic scheduling in the airport terminal area. Based on the study of traditional traffic scheduling techniques and key techniques of genetic algorithms, this paper participates in the actual project of genetic algorithm-based traffic scheduling, analyzes the requirements of the project, focuses on the design and implementation of the traffic scheduling algorithm module in the genetic algorithm-based traffic scheduling system, and conducts further research on the pathfinding by constraints submodule. In this paper, the flight approach and departure sequencing problem and runway allocation problem are the main research objects. The dynamic optimal scheduling model of flight approach and departure is established by considering the interests and demands of airlines and airports, and a new scheduling algorithm is proposed. In this paper, a brief introduction to the airport terminal area is given, and the feasibility of the approach/departure optimal scheduling is introduced from the perspective of airlines with a long-range parallel two-runway airport as the research background. Secondly, through the analysis of the flight approach and departure process and the study of the approach and departure cooperative optimization strategy, a single-runway flight approach and departure traffic scheduling model under the joint sequencing strategy is established with the optimization objective of minimizing the total flight delay time, and the model is solved by using the sliding time window algorithm. Then, based on the single-runway scheduling model, a multirunway multiobjective flight optimal scheduling model is established with the objectives of minimizing total delay time, increasing runway throughput per unit time and fairness of flight delay time allocation, and a dynamic algorithm (STW-GA) combining sliding time window algorithm and dual-structured chromosome genetic algorithm is proposed to solve the model.
    Type of Medium: Online Resource
    ISSN: 1687-7268 , 1687-725X
    URL: Article
    DOI: 10.1155/2022/7926335
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397931-8
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  • 5
    Online Resource
    Online Resource
    Wideband Low-Profile 8 × 8 MIMO Antenna Based IFA Pair for Ultrathin 5G Smartphones
    Hindawi Limited ; 2022
    In:  International Journal of Antennas and Propagation Vol. 2022 ( 2022-5-14), p. 1-10
    Details
    In: International Journal of Antennas and Propagation, Hindawi Limited, Vol. 2022 ( 2022-5-14), p. 1-10
    Abstract: In this paper, a wideband 8 × 8 MIMO antenna is proposed. The proposed antenna can realize the low profile of 4 mm and the 3.18–4.40 GHz broadband coverage only by adjusting the ground edge structure of the deformed inverted-F antenna. Based on the original antenna, the 5G new radio (NR) band n77 (3.3–4.2 GHz) can be covered without adding any structure. In addition, the coupling between the antenna elements has also been improved, decreasing from −9.7 dB to −13.37 dB. A dual-element IFA pair is simulated, fabricated, and measured, the results show the bandwidth of 3.07–4.43 GHz, and the isolation of −13.89 dB can be achieved. An eight-element MIMO antenna is formed by placing four sets of antenna pairs along the two long edges of the substrate. The experimental results show that the bandwidth is 3.18–4.40 GHz, the isolation between any two ports is better than −12.25 dB, and the total efficiency is 61.14%–93.97%. By placing the planar antenna vertically, the ground clearance of the antenna can be reduced to zero, and the performances are similar to the planar MIMO antenna. The proposed MIMO antenna has a good profile and efficient radiation performance compared with the other works, so it has an important application value in ultrathin 5G smartphones.
    Type of Medium: Online Resource
    ISSN: 1687-5877 , 1687-5869
    URL: Article
    DOI: 10.1155/2022/5281470
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397585-4
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  • 6
    Online Resource
    Online Resource
    Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine
    Hindawi Limited ; 2012
    In:  The Scientific World Journal Vol. 2012 ( 2012), p. 1-31
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2012 ( 2012), p. 1-31
    Abstract: Berberine is one of the main alkaloids found in the Chinese herb Huang lian ( Rhizoma Coptidis ), which has been reported to have multiple pharmacological activities. This study aimed to analyze the molecular targets of berberine based on literature data followed by a pathway analysis using the PANTHER program. PANTHER analysis of berberine targets showed that the most classes of molecular functions include receptor binding, kinase activity, protein binding, transcription activity, DNA binding, and kinase regulator activity. Based on the biological process classification of in vitro berberine targets, those targets related to signal transduction, intracellular signalling cascade, cell surface receptor-linked signal transduction, cell motion, cell cycle control, immunity system process, and protein metabolic process are most frequently involved. In addition, berberine was found to interact with a mixture of biological pathways, such as Alzheimer’s disease-presenilin and -secretase pathways, angiogenesis, apoptosis signalling pathway, FAS signalling pathway, Hungtington disease, inflammation mediated by chemokine and cytokine signalling pathways, interleukin signalling pathway, and p53 pathways. We also explored the possible mechanism of action for the anti-diabetic effect of berberine. Further studies are warranted to elucidate the mechanisms of action of berberine using systems biology approach.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1100/2012/708292
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2075968-X
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  • 7
    Online Resource
    Online Resource
    Lump and Interaction Solutions to the ( 3 + 1 )-Dimensional Variable-Coefficient Nonlinear Wave Equation with Multidimensional Binary Bell Polynomials
    Hindawi Limited ; 2021
    In:  Journal of Function Spaces Vol. 2021 ( 2021-12-13), p. 1-23
    Details
    In: Journal of Function Spaces, Hindawi Limited, Vol. 2021 ( 2021-12-13), p. 1-23
    Abstract: In this paper, we study the ( 3 + 1 )-dimensional variable-coefficient nonlinear wave equation which is taken in soliton theory and generated by utilizing the Hirota bilinear technique. We obtain some new exact analytical solutions, containing interaction between a lump-two kink solitons, interaction between two lumps, and interaction between two lumps-soliton, lump-periodic, and lump-three kink solutions for the generalized ( 3 + 1 )-dimensional nonlinear wave equation in liquid with gas bubbles by the Maple symbolic package. Making use of Hirota’s bilinear scheme, we obtain its general soliton solutions in terms of bilinear form equation to the considered model which can be obtained by multidimensional binary Bell polynomials. Furthermore, we analyze typical dynamics of the high-order soliton solutions to show the regularity of solutions and also illustrate their behavior graphically.
    Type of Medium: Online Resource
    ISSN: 2314-8888 , 2314-8896
    URL: Article
    DOI: 10.1155/2021/4550582
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2861541-4
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  • 8
    Online Resource
    Online Resource
    Optimal Sensor Placement and Minimum Number Selection of Sensors for Health Monitoring of Transmission Towers
    Hindawi Limited ; 2020
    In:  Shock and Vibration Vol. 2020 ( 2020-12-28), p. 1-12
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2020 ( 2020-12-28), p. 1-12
    Abstract: Transmission towers are structurally complex, which makes it challenging to choose the right place and number of sensors for health monitoring. In this paper, optimal sensor placement of a cat-head-type transmission tower is conducted by using the Effective Independent Method (EIM) and a method is proposed for calculating the minimum number of sensors for structural health monitoring by combining EIM and Modal Assurance Criterion (MAC). The method for calculating the number of sensors prescribed in this paper derives a curve that shows the relationship between MAC value and the number of sensors. It is found that the MAC value decreases with increase in the number of sensors. When the number of sensors reaches a certain threshold, the curve tends to stabilize. Then, the number of sensors corresponding to the minimum MAC is proposed as the minimum number of sensors. Through calculation, the minimum number of sensors of the cat-head-type transmission tower is obtained. Also, the optimal sensor placement results show that the position of a large number of sensors includes the position of a smaller number of sensors.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2020/2375947
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2070162-7
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  • 9
    Online Resource
    Online Resource
    Comparison between Intra-Articular Injection of Infrapatellar Fat Pad (IPFP) Cell Concentrates and IPFP-Mesenchymal Stem Cells (MSCs) for Cartilage Defect Repair of the Knee Joint in Rabbits
    Hindawi Limited ; 2021
    In:  Stem Cells International Vol. 2021 ( 2021-7-27), p. 1-12
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2021 ( 2021-7-27), p. 1-12
    Abstract: Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic method in regenerative medicine. Our previous research adopted a simple nonenzymatic strategy for the preparation of a new type of ready-to-use infrapatellar fat pad (IPFP) cell concentrates. The aim of this study was to compare the therapeutic efficacy of intra-articular (IA) injection of autologous IPFP cell concentrates and allogeneic IPFP-MSCs obtained from these concentrates in a rabbit articular cartilage defect model. IPFP-MSCs sprouting from the IPFP cell concentrates were characterized via flow cytometry as well as based on their potential for differentiation into adipocytes, osteoblasts, and chondrocytes. In the rabbit model, cartilage defects were created on the trochlear groove, followed by treatment with IPFP cell concentrates, IPFP-MSCs, or normal saline IA injection. Distal femur samples were evaluated at 6 and 12 weeks posttreatment via macroscopic observation and histological assessment based on the International Cartilage Repair Society (ICRS) macroscopic scoring system as well as the ICRS visual histological assessment scale. The macroscopic score and histological score were significantly higher in the IPFP-MSC group compared to the IPFP cell concentrate group at 12 weeks. Further, both treatment groups had higher scores compared to the normal saline group. In comparison to the latter, the groups treated with IPFP-MSCs and IPFP cell concentrates showed considerably better cartilage regeneration. Overall, IPFP-MSCs represent an effective therapeutic strategy for stimulating articular cartilage regeneration. Further, due to the simple, cost-effective, nonenzymatic, and safe preparation process, IPFP cell concentrates may represent an effective alternative to stem cell-based therapy in the clinic.
    Type of Medium: Online Resource
    ISSN: 1687-9678 , 1687-966X
    URL: Article
    DOI: 10.1155/2021/9966966
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2573856-2
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  • 10
    Online Resource
    Online Resource
    Intelligent Management of Air Traffic Flow Based on Intelligent Motion Coordinate Data Model
    Hindawi Limited ; 2022
    In:  Journal of Advanced Transportation Vol. 2022 ( 2022-3-22), p. 1-12
    Details
    In: Journal of Advanced Transportation, Hindawi Limited, Vol. 2022 ( 2022-3-22), p. 1-12
    Abstract: To adapt to the intelligent management of traffic flow in modern aviation, this study improves the algorithm according to the data exercise method and establishes the mathematical model and vector model of intelligent motion coordinates. Moreover, according to the simulation test method, this study analyzes the six-degree-of-freedom equation of motion in the coordinate system of the civil aviation aircraft and uses the simulation method to regard the civil aviation as a rigid body with a certain mass and mass distribution. In addition, this study builds an intelligent model based on the demand analysis, and according to the actual demand, this study combines the simulation method to analyze the structure of the intelligent management model of air traffic flow. Finally, this study uses the experimental analysis method to verify the effect of the model proposed in this study and combines the experimental research to verify that the model proposed in this study has a certain effect.
    Type of Medium: Online Resource
    ISSN: 2042-3195 , 0197-6729
    URL: Article
    DOI: 10.1155/2022/3628798
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2553327-7
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