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  • 1
    Online Resource
    Online Resource
    Efficacy and safety of rituximab biosimilars or reference product as first‐line treatment in patients with low‐tumour‐burden follicular lymphoma: A systematic review and meta‐analysis
    Hindawi Limited ; 2022
    In:  Journal of Clinical Pharmacy and Therapeutics Vol. 47, No. 12 ( 2022-12), p. 1923-1931
    Details
    In: Journal of Clinical Pharmacy and Therapeutics, Hindawi Limited, Vol. 47, No. 12 ( 2022-12), p. 1923-1931
    Type of Medium: Online Resource
    ISSN: 0269-4727 , 1365-2710
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpt.v47.12
    DOI: 10.1111/jcpt.13799
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2006678-8
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Analysis of the Effect of Laparoscopic and Open Surgical Treatment in Children with Congenital Megacolon
    Hindawi Limited ; 2022
    In:  Computational Intelligence and Neuroscience Vol. 2022 ( 2022-6-8), p. 1-5
    Details
    In: Computational Intelligence and Neuroscience, Hindawi Limited, Vol. 2022 ( 2022-6-8), p. 1-5
    Abstract: In this paper, we have compared and analyzed the effect of laparoscopic and open surgical treatments in children with congenital megacolon. To address this, a total of 64 children with congenital megacolon who underwent surgery in the hospital, particularly from April 2014 to December 2020, were selected as the research objects. They were divided into control and observation groups by the random number table method, with 32 cases in each group. The control and observation groups were treated with open surgical and laparoscopic treatments, respectively. The treatment effects of the two groups were compared. The enema time, operation time, blood loss, anal defecation time, and duration of postoperative hospital stay of the observation group were lower than those of the control group. The comparison between the two groups was statistically significant ( P 〈 0.05 ). There was no significant difference in CRP and WBC between the two groups before surgery ( P 〉 0.05 ). The CRP level and WBC of the two groups were both increased after operation, the CRP level of the observation group was lower than that of the control group, the difference was statistically significant ( P 〈 0.05 ), the WBC of the two groups was not statistically significant ( P 〉 0.05 ). The rate of excellent and good defecation in the observation group on the 7th day after surgery was higher than that in the control group, and the difference was statistically significant ( P 〈 0.05 ). There was no significant difference in Krickenbeck scores between the two groups before surgery ( P 〉 0.05 ); 6 months after the surgery, the score of Krickenbeck in both groups increased, and that of the observation group was higher than that of the control group, indicating a difference in the overall score ( P 〈 0.05 ). The total complication rate within 7 days after surgery in the observation group was lower than that in the control group, and the difference was not statistically significant ( P 〉 0.05 ). Laparoscopic treatment of congenital megacolon could improve surgical indicators and reduce stress response in children, improve defecation and anal function, reduce the risk of complications, and promote recovery.
    Type of Medium: Online Resource
    ISSN: 1687-5273 , 1687-5265
    URL: Article
    DOI: 10.1155/2022/2669294
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2388208-6
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  • 3
    Online Resource
    Online Resource
    Graphene-Assisted Goos–Hänchen Shift in a Planar Multilayer Configuration in the Visible Light Range
    Hindawi Limited ; 2020
    In:  Advances in Condensed Matter Physics Vol. 2020 ( 2020-12-15), p. 1-6
    Details
    In: Advances in Condensed Matter Physics, Hindawi Limited, Vol. 2020 ( 2020-12-15), p. 1-6
    Abstract: In this paper, the graphene-assisted Goos–Hänchen (GH) shift of the optical beam reflected from a planar multilayer configuration is investigated. The increased positive Goos–Hänchen shifts can be modulated by adjusting the Fermi energy due to graphene with unique optical properties in the visible light range. Moreover, the GH shift can be tuned by varying the layers of graphene, the thickness of the medium, incident wavelength, and so on. These results will be useful for designing the novel graphene-based optical sensing and switching.
    Type of Medium: Online Resource
    ISSN: 1687-8124 , 1687-8108
    URL: Article
    DOI: 10.1155/2020/8822273
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2501251-4
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  • 4
    Online Resource
    Online Resource
    A Real-Time Embedded Control System for Electro-Fused Magnesia Furnace
    Hindawi Limited ; 2013
    In:  Journal of Control Science and Engineering Vol. 2013 ( 2013), p. 1-12
    Details
    In: Journal of Control Science and Engineering, Hindawi Limited, Vol. 2013 ( 2013), p. 1-12
    Abstract: Since smelting process of electro-fused magnesia furnace is a complicated process which has characteristics like complex operation conditions, strong nonlinearities, and strong couplings, traditional linear controller cannot control it very well. Advanced intelligent control strategy is a good solution to this kind of industrial process. However, advanced intelligent control strategy always involves huge programming task and hard debugging and maintaining problems. In this paper, a real-time embedded control system is proposed for the process control of electro-fused magnesia furnace based on intelligent control strategy and model-based design technology. As for hardware, an embedded controller based on an industrial Single Board Computer (SBC) is developed to meet industrial field environment demands. As for software, a Linux based on Real-Time Application Interface (RTAI) is used as the real-time kernel of the controller to improve its real-time performance. The embedded software platform is also modified to support generating embedded code automatically from Simulink/Stateflow models. Based on the proposed embedded control system, the intelligent embedded control software of electro-fused magnesium furnace can be directly generated from Simulink/Stateflow models. To validate the effectiveness of the proposed embedded control system, hardware-in-the-loop (HIL) and industrial field experiments are both implemented. Experiments results show that the embedded control system works very well in both laboratory and industry environments.
    Type of Medium: Online Resource
    ISSN: 1687-5249 , 1687-5257
    URL: Article
    DOI: 10.1155/2013/719683
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2267501-2
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  • 5
    Online Resource
    Online Resource
    Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-12-11), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-12-11), p. 1-16
    Abstract: Uveal melanoma is the most common primary ocular neoplasm in adults, with many patients ending up developing liver metastasis and facing a significant reduction of their life expectancy due to the lack of efficient treatments. Artemisinin is an antimalarial drug that has been widely used in the clinic and whose anticancer properties have also been described. Its reported safety, affordability, and ability to reach the ocular tissues point that it has a potential therapeutic agent against uveal melanoma. In the present study, we found that a subantimalaria dosage of artemisinin significantly attenuated the migration and invasion potential of uveal melanoma cells, in a concentration-dependent manner. Assessment of the mechanisms underlying artemisinin anticancer action revealed that its use dramatically reduced the phosphorylation of PI3K, AKT, and mTOR in UM cells. Further inhibition of PI3K signaling, using LY294002, or of mTOR, by rapamycin, blocked the migration and invasion of UM cells similarly to artemisinin. In contrast, AKT or mTOR activator (Sc79 and MHY1485, respectively) attenuated the inhibitory effect of artemisinin on the migration and invasion abilities of UM cells, further validating that artemisinin’s anticancer effect is likely to be mediated via inhibition of the PI3K/AKT/mTOR pathway. Artemisinin also induced mitochondrial membrane potential loss and apoptosis of UM cells, having no significant toxic effect on normal retinal neuronal cells RGC-5 and epithelial cells D407. These findings and the reported safety of artemisinin’s clinical dosage strongly suggest the therapeutic potential of artemisinin in the prevention and treatment of uveal melanomas.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/9911537
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 6
    Online Resource
    Online Resource
    Fructose-1,6-Bisphosphatase 2 Inhibits Oral Squamous Cell Carcinoma Tumorigenesis and Glucose Metabolism via Downregulation of c-Myc
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-5-6), p. 1-19
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-5-6), p. 1-19
    Abstract: Background. Fructose-1,6-bisphosphatase 2 (FBP2), known as a rate-limiting enzyme in gluconeogenesis, is a tumor suppressor downregulated in various cancers. However, the role of FBP2 in oral squamous cell carcinoma (OSCC) remains largely unclear. Methods. The level of FBP2 in OSCC tissues and matched adjacent normal tissues was determined by western blot and RT-qPCR assays. In addition, analysis of FBP2 function in OSCC cells was assessed using both gain-of-function and loss-of-function studies. Results. In this study, we found that the expression of FBP2 was remarkably downregulated in OSCC tissues and OSCC cells. Overexpression of FBP2 suppressed the viability, proliferation, migration, and glycolysis of OSCC cells, whereas FBP2 knockdown exhibited the opposite results. Moreover, downregulation of FBP2 promoted the growth and glycolysis of OSCC cells in nude mice in a xenograft model. Specifically, FBP2 colocalizes with the c-Myc transcription factor in the nucleus. Significantly, inhibitory effects of FBP2 overexpression on the viability, proliferation, migration, and glycolysis of OSCC cells were reversed by c-Myc overexpression. Conclusion. Collectively, FBP2 could suppress the proliferation, migration and glycolysis in OSCC cells through downregulation of c-Myc. Our study revealed a FBP2-c-Myc signaling axis that regulates OSCC glycolysis and may provide a potential intervention strategy for OSCC treatment.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/6766787
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 7
    Online Resource
    Online Resource
    Predictive Value of CT-Based Radiomics in Distinguishing Renal Angiomyolipomas with Minimal Fat from Other Renal Tumors
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-5-28), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-5-28), p. 1-8
    Abstract: Objectives. This study is aimed at determining whether CT-based radiomics models can help differentiate renal angiomyolipomas with minimal fat (AMLmf) from other solid renal tumors. Methods. This retrospective study included 58 patients with a postoperative pathologically confirmed AMLmf (observation group) and 140 patients with other common renal tumors (control group). Non-contrast-enhanced CT and contrast-enhanced CT data were evaluated. Radiomics features were extracted from manually delineated volume of interest (VOIs). The least absolute shrinkage and selection operator (LASSO) regression was used for feature screening. Five classifiers, including logistic regression, multilayer perceptron (MLP), support vector machine (SVM), k -nearest neighbor (KNN), and logistic regression (LR), were used, with leave-out validation (128 training, 60 testing). The diagnostic performance of the classifier was evaluated and compared by receiver operating characteristic curve (ROC) analysis. Results. Among the 1029 extracted features, prediction models of AMLmf were composed, by 2, 10, 4, and 9 selected features for precontrast phase (PCP), corticomedullary phase (CMP), nephrographic phase (NP), and excretory phase (EP), respectively. Models of CMP and NP achieved adequate performance after using MLP classifier, with prediction accuracy of 0.767 (AUC 0.85, sensitivity 0.76, and specificity 0.78) and 0.783 (AUC 0.83, sensitivity 0.79, and specificity 0.78), respectively. MLP model of features selected from the combination of the all features had the best diagnostic performance (accuracy 0.8500, sensitivity 0.8095, specificity 0.9444, and AUC 0.9193). Conclusions. Radiomics features may help to distinguish benign AMLmf from common malignant kidney masses, which may contribute to the selection of interventions for renal tumors.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/9108129
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 8
    Online Resource
    Online Resource
    Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study
    Hindawi Limited ; 2021
    In:  International Journal of Endocrinology Vol. 2021 ( 2021-3-24), p. 1-10
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2021 ( 2021-3-24), p. 1-10
    Abstract: Objective. The endocrine function of bone in energy metabolism may be mediated by the osteocalcin (OC). We examined the association between OC and energy metabolism among Chinese postmenopausal women. Design and Setting. A cross-sectional cohort study enrolling 1635 participants was conducted using data from the Peking Vertebral Fracture study. Partial correlation analysis was performed to explore the correlation of OC, parathyroid hormone (PTH), or 25-hydroxyvitamin D (25(OH)D) with glycemic and lipid metabolic parameters. A logistic regression model was used to investigate the association of OC, PTH, or 25(OH)D with the prevalence of diabetes and dyslipidemia. Results. Serum levels of OC, PTH, and 25(OH)D were all positively correlated with serum cholesterol levels, whereas only OC was negatively associated with serum glucose level. In the logistic regression model, both OC and PTH were negatively associated with the prevalence of diabetes (odds ratio [OR], 95% confidence interval [95% CI] : 0.967, 0.948–0.986 for OC and 0.986, 0.978–0.994 for PTH). No significant association was found between 25(OH)D and diabetes. Both OC and 25(OH)D, rather than PTH, were associated with abnormalities of high cholesterol levels, such as hypercholesterolemia and high LDL-C levels. Further classifying the population based on the median value of OC and PTH, low OC and low PTH subgroup had the highest OR, 95% CI for diabetes (1.873, 1.287–2.737) and the lowest OR, 95% CI for hypercholesterolemia (0.472, 0.324–0.688) and for high LDL-C (0.538, 0.376–0.771). Conclusion. Among Chinese postmenopausal women, a lower serum level of OC was associated with a higher prevalence of diabetes and lower serum cholesterol levels, and a low PTH concentration could magnify these associations.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    URL: Article
    DOI: 10.1155/2021/5585018
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2502951-4
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  • 9
    Online Resource
    Online Resource
    Dynamic Parameters and Hysteresis Loop Characteristics of Frozen Silt Clay under Different Cyclic Stress Paths
    Hindawi Limited ; 2021
    In:  Advances in Materials Science and Engineering Vol. 2021 ( 2021-6-8), p. 1-22
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2021 ( 2021-6-8), p. 1-22
    Abstract: In cold regions, the long-term stability of engineering facilities is unavoidably influenced by the negative temperature, freeze-thaw process, dry-wet process, and dynamic loading conditions induced by earthquakes and traffic loads. In order to investigate the effects of different cyclic stress paths on the evolution of dynamic mechanical properties of frozen silt clay, a series of cyclic triaxial tests with variation confining pressure (VCP) or constant confining pressure (CCP) were performed. Triaxial low-temperature apparatus (MTS-810) was taken advantage of to simulating various cyclic stress paths by changing cyclic loading conditions of axial stress and confining pressure. In this paper, the evolution features of the axial resilient modulus, damping ratios, and the shape of hysteresis loops with an increase in the number of load cycles under different dynamic stress paths are comprehensively studied. The results show that the loading angle of cyclic stress path and the phase difference between cyclic axial stress and confining pressure are the main factors that remarkably affect the development characteristics of the resilient modulus and damping ratio. With increasing of the loading angle and phase difference, the resilient modulus increases, but damping ratio increases with increasing of loading angle and with decreasing of phase difference. With the continuous increase in the number of loading cycles, the samples of frozen soil show compacting and hardening characteristics. With an increase in the number of load cycles, the shape of hysteresis loop becoming narrows, the resilient modulus decreases at the initial stage and then gradually increases, and the damping ratio stably decreases. According to contrastively analyzing the evolution of dynamic parameters and the shape features of hysteresis loops under various cyclic stress paths, it can be clearly discovered that the evolution of sample microstructure and the development of dynamic characteristics of frozen samples have obvious dependence on the cyclic stress path. Therefore, the effects of variable confining pressure (VCP) on dynamic behaviors of frozen soils are nonnegligible in practical cold region engineering.
    Type of Medium: Online Resource
    ISSN: 1687-8442 , 1687-8434
    URL: Article
    DOI: 10.1155/2021/3763181
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2501025-6
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  • 10
    Online Resource
    Online Resource
    Enhanced Reflected Group Delay with Optical Tamm State via Graphene-Dielectric Bragg Mirror Configuration
    Hindawi Limited ; 2019
    In:  Advances in Condensed Matter Physics Vol. 2019 ( 2019-01-01), p. 1-6
    Details
    In: Advances in Condensed Matter Physics, Hindawi Limited, Vol. 2019 ( 2019-01-01), p. 1-6
    Abstract: Group delay of the optical pulse reflected from the structure composed of graphene and one dimensional photonic crystal (1D PC) is studied. It is shown that the large negative group delay in this configuration can be realized due to the excitation of the optical Tamm state (OTS) at a graphene-dielectric interface. The reflected group delay can be enlarged negatively and can be switched from positive to negative or vice versa. We show that the conductivity of graphene has a significant influence on reflected group delay, making the graphene-PC structure be a good candidate for dynamic tunable optical delay device in the THz frequencies. Furthermore, the influences of the relaxation time of graphene, the incident angel, and the dispersion characteristics of top layer on group delay are clarified.
    Type of Medium: Online Resource
    ISSN: 1687-8108 , 1687-8124
    URL: Article
    DOI: 10.1155/2019/9217613
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2501251-4
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