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  • Hindawi Limited  (21)
  • 1
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    Online Resource
    Traditional Chinese Medicine-Guided Dietary Intervention for Male Youth Undergoing Drug Detoxification: A Randomized Controlled Trial
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-12-03), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-12-03), p. 1-12
    Abstract: Objective . The aim of this study was to evaluate the effectiveness of traditional Chinese medicine- (TCM-) guided dietary interventions in improving yang-qi deficiency and yin-blood deficiency TCM syndromes according to the principles of TCM syndrome differentiation theory in male youths undergoing drug detoxification during the rehabilitation period who stayed in a compulsory isolation detoxification center. Methods . Male youths undergoing drug detoxification who met the criteria to be included in the study were randomly divided into the intervention group ( n  = 62) and the control group ( n  = 61) according to a random number table in a 1 : 1 ratio. The intervention group received a TCM-guided diet, and the control group received routine food support. Over an intervention period of 3 months, we observed changes in the TCM syndrome element scores in the two groups before and after intervention. Results . After 3 months, the qi deficiency, yin deficiency, blood deficiency, and yin-blood deficiency syndrome in the intervention group improved significantly ( P values 0.009, 0.000, 0.005, and 0.001, respectively). In the control group, yang deficiency, qi deficiency, and yang-qi deficiency syndromes worsened significantly ( P values 0.003, 0.032, and 0.009, respectively). The differences (post-pre) in yang deficiency, qi deficiency, yang-qi deficiency, yin deficiency, blood deficiency, and yin-blood deficiency syndromes between the two groups were statistically significant ( P values 0.003, 0.003, 0.003, 0.001, 0.005, and 0.002, respectively). Conclusion . A TCM-guided diet can delay the worsening of yang-qi deficiency syndrome symptoms and improve yin-blood deficiency syndrome and the prognosis of male youth undergoing drug detoxification during the rehabilitation period.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/3870316
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 2
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    Effects of different sperm sources on clinical outcomes in intracytoplasmic sperm injection cycles
    Hindawi Limited ; 2022
    In:  Andrologia Vol. 54, No. 7 ( 2022-08)
    Details
    In: Andrologia, Hindawi Limited, Vol. 54, No. 7 ( 2022-08)
    Type of Medium: Online Resource
    ISSN: 0303-4569 , 1439-0272
    URL: Issue
    URL: Article
    DOI: 10.1111/and.v54.7
    DOI: 10.1111/and.14438
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2009045-6
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  • 3
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    Development and External Validation of Web-Based Models to Predict the Prognosis of Remnant Gastric Cancer after Surgery: A Multicenter Study
    Hindawi Limited ; 2019
    In:  Journal of Oncology Vol. 2019 ( 2019-04-10), p. 1-15
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2019 ( 2019-04-10), p. 1-15
    Abstract: Background . Remnant gastric cancer (RGC) is a rare malignant tumor with poor prognosis. There is no universally accepted prognostic model for RGC. Methods . We analyzed data for 253 RGC patients who underwent radical gastrectomy from 6 centers. The prognosis prediction performances of the AJCC7th and AJCC8th TNM staging systems and the TRM staging system for RGC patients were evaluated. Web-based prediction models based on independent prognostic factors were developed to predict the survival of the RGC patients. External validation was performed using a cohort of 49 Chinese patients. Results . The predictive abilities of the AJCC8th and TRM staging systems were no better than those of the AJCC7th staging system (c-index: AJCC7th vs. AJCC8th vs. TRM, 0.743 vs. 0.732 vs. 0.744; P 〉 0.05). Within each staging system, the survival of the two adjacent stages was not well discriminated (P 〉 0.05). Multivariate analysis showed that age, tumor size, T stage, and N stage were independent prognostic factors. Based on the above variables, we developed 3 web-based prediction models, which were superior to the AJCC7th staging system in their discriminatory ability (c-index), predictive homogeneity (likelihood ratio chi-square), predictive accuracy (AIC, BIC), and model stability (time-dependent ROC curves). External validation showed predictable accuracies of 0.780, 0.822, and 0.700, respectively, in predicting overall survival, disease-specific survival, and disease-free survival. Conclusions . The AJCC TNM staging system and the TRM staging system did not enable good distinction among the RGC patients. We have developed and validated visual web-based prediction models that are superior to these staging systems.
    Type of Medium: Online Resource
    ISSN: 1687-8450 , 1687-8469
    URL: Article
    DOI: 10.1155/2019/6012826
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2461349-6
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  • 4
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    CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-8-17), p. 1-21
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-8-17), p. 1-21
    Abstract: Bone metabolism occurs in the entire life of an individual and is required for maintaining skeletal homeostasis. The imbalance between osteogenesis and osteoclastogenesis eventually leads to osteoporosis. Oxidative stress is considered a major cause of bone homeostasis disorder, and relieving excessive oxidative stress in bone mesenchymal stem cells (BMSCs) is a potential treatment strategy for osteoporosis. Carbon monoxide releasing molecule-3 (CORM-3), the classical donor of carbon monoxide (CO), possesses antioxidation, antiapoptosis, and anti-inflammatory properties. In our study, we found that CORM-3 could reduce reactive oxygen species (ROS) accumulation and prevent mitochondrial dysfunction thereby restoring the osteogenic potential of the BMSCs disrupted by hydrogen peroxide (H2O2) exposure. The action of CORM-3 was preliminarily considered the consequence of Nrf2/HO-1 axis activation. In addition, CORM-3 inhibited osteoclast formation in mouse primary bone marrow monocytes (BMMs) by inhibiting H2O2-induced polarization of M1 macrophages and endowing macrophages with M2 polarizating ability. Rat models further demonstrated that CORM-3 treatment could restore bone mass and enhance the expression of Nrf2 and osteogenic markers in the distal femurs. In summary, CORM-3 is a potential therapeutic agent for the treatment of osteoporosis.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/5098358
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 5
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    A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma
    Hindawi Limited ; 2018
    In:  Journal of Immunology Research Vol. 2018 ( 2018), p. 1-11
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2018 ( 2018), p. 1-11
    Abstract: Background . Inflammation is an important hallmark of cancer. Fibrinogen and albumin are both vital factors in systemic inflammation. This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative resection. Methods . HCC patients ( n = 151 ) who underwent curative resection were evaluated retrospectively. The optimal cutoff value for the fibrinogen/albumin ratio was selected by receiver operating characteristic (ROC) curve analysis. Correlations between preoperative fibrinogen/albumin ratios and clinicopathologic characteristics were analyzed by χ 2 test. The area under the receiver operating characteristic curve (AUC) was calculated to compare the prognostic value of the fibrinogen/albumin ratio with other prognostic scores (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and albumin-bilirubin (ALBI) score). The overall survival (OS) and time to recurrence (TTR) were assessed by the log-rank test and the Cox proportional hazard regression model. Results . An optimal cutoff value of the preoperative fibrinogen/albumin ratio (0.062) was determined for 151 patients who underwent curative resection for HCC via a ROC curve analysis. Fibrinogen/albumin ratio  〉  0.062 was significantly associated with microvascular invasion, an advanced BCLC stage, and ALBI grade. Multivariate analyses revealed that fibrinogen/albumin ratio was an independent predictor for OS ( P = 0.003 ) and TTR ( P = 0.035 ). The prognostic ability of fibrinogen/albumin ratio was comparable to other prognostic scores (NLR, PLR, and ALBI score) by AUC analysis. Patients with a fibrinogen/albumin ratio  〉  0.062 had lower 1-, 3-, and 5-year OS rates (66.0%, 41.8%, and 28.2% versus 81.9%, 69.3%, and 56.1%, resp., P 〈 0.001 ) and higher 1-, 3-, and 5-year recurrence rates (60.9%, 79.2%, and 90.5% versus 49.5%, 69.1%, and 77.1%, resp., P = 0.008 ) compared with patients with fibrinogen/albumin ratio ≤ 0.062. Conclusion . The preoperative fibrinogen/albumin ratio is an effective prognostic factor for HCC patients who underwent curative resection. An elevated fibrinogen/albumin ratio significantly correlates with poorer survival and a higher risk of recurrence in HCC patients.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    URL: Article
    DOI: 10.1155/2018/4925498
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2817541-4
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  • 6
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    Catastrophe Mechanism of Stress-Fissure Coupling Field in Mining Close Distance Seams in Southwest China
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-7-30), p. 1-9
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-7-30), p. 1-9
    Abstract: For the sake of studying the catastrophe mechanism of stress-fissure coupling field in mining close distance seams in southwest China, a test working face in Guizhou province in southwest China is adopted and researched by the methods of numerical calculation and similar experiment. When the working face advances to 180 m in 4# coal seam in a similar experiment, the overlying rock breaks to the central base plate of Yulongshan limestone, and the conductive fractures run through the Changxing limestone karst cave and Yulongshan limestone karst cave. When the 1402 working face advances to 350 m, the top of vertical karst caves in the middle of the model produces extrusion damage, forming a penetrating water inrush passage. When the 1402 working face advances to 480 m, the top slab of the working face comes under periodic weighting with the short step. Besides, the mining of 9# coal seam starts after 4# coal seam in mining close distance seams. When the working face in 9# coal seam advances to 340 m in numerical simulation, the maximum opening of the overburden fractures is 51.16 mm. The fractures in the roof are mainly caused by the periodic breaking and falling of the basic roof, connected with the floor fractures of 4# coal seam. When the working face in 9# coal seam advances to 500 m, the maximum opening of the overburden fracture is 93.09 mm. Specifically, as the working face advances, the opening of fracture in the roof after collapse of the basic roof periodically is mainly greater than 5 mm, and the compaction closure is mainly 1 mm-5 mm. The fractures in the gob floor are mainly 0.1 mm-1 mm, and the fracture opening of the collapsed rock mass in the gob is mainly 1 mm-5 mm and greater than 5 mm. The karst caves in the overburden reduce the periodic weighting step of working face and play a guiding role in the direction of fracture development and water inflow passage formation. The karst caves are connected to surface waterfall holes and trap pits, and atmospheric precipitation recharges the water in the caves. The research results can be treated as an important basis for the prevention and treatment for water inrush disaster in mining close distance seams in the karst area of southwest China.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/8073602
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 7
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    Antioxidation and Tyrosinase Inhibitory Ability of Coffee Pulp Extract by Ethanol
    Hindawi Limited ; 2021
    In:  Journal of Chemistry Vol. 2021 ( 2021-12-17), p. 1-8
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2021 ( 2021-12-17), p. 1-8
    Abstract: Background. Following petroleum, coffee is the second most commonly traded commodity globally. It is also a popular good with economic value, as well as value in terms of leisure and culture. However, coffee processing generates a large amount of waste, resulting in environmental concerns. Therefore, in this study, ethanol was used to extract coffee waste (coffee pulp). High-performance liquid chromatography was conducted to examine the caffeine content and chlorogenic acid content, and the antioxidant capacity (i.e., the total phenolic content, total flavonoid content, DPPH-free radical scavenging capacity, ABTS-free radical scavenging capacity, and reductive capacity) and the tyrosinase inhibition capacity of the coffee pulp extracted using ethanol were comprehensively evaluated. Results. The results showed that the coffee pulp extract obtained using 70% ethanol had the highest tyrosinase inhibition capacity, whereas that obtained using 50% ethanol had the most satisfactory antioxidant capacity (total phenolic content, total flavonoid content, DPPH-free radical scavenging capacity, ABTS-free radical scavenging capacity, and reductive capacity). Conclusion. The results revealed that coffee pulp has superior antioxidant capacity and tyrosinase inhibition capacity when extracted by ethanol. Increasing the economic value of coffee pulp can solve the environmental concerns caused by coffee waste.
    Type of Medium: Online Resource
    ISSN: 2090-9071 , 2090-9063
    URL: Article
    DOI: 10.1155/2021/8649618
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
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  • 8
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    A dual‐polarized wideband gain enhancement Fabry–Perot antenna by adopting a wedge‐shaped phase correcting structure
    Hindawi Limited ; 2022
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 32, No. 12 ( 2022-12)
    Details
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 32, No. 12 ( 2022-12)
    Type of Medium: Online Resource
    ISSN: 1096-4290 , 1099-047X
    URL: Issue
    URL: Article
    DOI: 10.1002/mmce.v32.12
    DOI: 10.1002/mmce.23434
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2007326-4
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  • 9
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    Intrusion Detection System Based on Decision Tree over Big Data in Fog Environment
    Hindawi Limited ; 2018
    In:  Wireless Communications and Mobile Computing Vol. 2018 ( 2018), p. 1-10
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2018 ( 2018), p. 1-10
    Abstract: Fog computing, as the supplement of cloud computing, can provide low-latency services between mobile users and the cloud. However, fog devices may encounter security challenges as a result of the fog nodes being close to the end users and having limited computing ability. Traditional network attacks may destroy the system of fog nodes. Intrusion detection system (IDS) is a proactive security protection technology and can be used in the fog environment. Although IDS in tradition network has been well investigated, unfortunately directly using them in the fog environment may be inappropriate. Fog nodes produce massive amounts of data at all times, and, thus, enabling an IDS system over big data in the fog environment is of paramount importance. In this study, we propose an IDS system based on decision tree. Firstly, we propose a preprocessing algorithm to digitize the strings in the given dataset and then normalize the whole data, to ensure the quality of the input data so as to improve the efficiency of detection. Secondly, we use decision tree method for our IDS system, and then we compare this method with Naïve Bayesian method as well as KNN method. Both the 10% dataset and the full dataset are tested. Our proposed method not only completely detects four kinds of attacks but also enables the detection of twenty-two kinds of attacks. The experimental results show that our IDS system is effective and precise. Above all, our IDS system can be used in fog computing environment over big data.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2018/4680867
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2045240-8
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  • 10
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    Upregulation of miR-335-5p Contributes to Right Ventricular Remodeling via Calumenin in Pulmonary Arterial Hypertension
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-10-4), p. 1-16
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-10-4), p. 1-16
    Abstract: Right ventricular (RV) failure determines the prognosis in pulmonary arterial hypertension (PAH), but the underlying mechanism is still unclear. Growing evidence has shown that microRNAs participate in RV remodeling. This study is undertaken to explore the role of miR-335-5p in regulating RV remodeling induced by PAH. Two PAH models were used in the study, including the monocrotaline rat model and hypoxia/su5416 mouse model. miRNA sequencing and RT-qPCR validation identified that miR-335-5p was elevated in the RV of PAH rats. In vitro, miR-335-5p expression was increased after angiotensin II treatment, and miR-335-5p inhibition relieved angiotensin II-induced cardiomyocyte hypertrophy. The luciferase reporter assay showed that calumenin was a target gene for miR-335-5p. Pretreatment with miR-335-5p inhibitors could rescue calumenin downregulation induced by angiotensin II in H9C2 cells. Moreover, intracellular Ca2+ concentration and apoptosis were increased after angiotensin II treatment, and miR-335-5p inhibition decreased intracellular Ca2+ accumulation and apoptosis. Finally, in vivo miR-335-5p downregulation (antagomir miR-335-5p) attenuated RV remodeling and rescued calumenin downregulation under conditions of hypoxia/su5416 exposure. Our work highlights the role of miR-335-5p and calumenin in RV remodeling and may lead to the development of novel therapeutic strategies for right heart failure.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/9294148
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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