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  • Hindawi Limited  (3)
  • 1
    Online Resource
    Online Resource
    Excessive Neutrophil Extracellular Trap Formation Aggravates Acute Myocardial Infarction Injury in Apolipoprotein E Deficiency Mice via the ROS-Dependent Pathway
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-05-21), p. 1-15
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-05-21), p. 1-15
    Abstract: Genetically human apolipoprotein E ( APOE ) ε 32 is associated with a decreased risk of ischemic heart disease. ApoE deficiency in mice impairs infarct healing after myocardial infarction (MI). After the ischemic injury, a large number of neutrophils are firstly recruited into the infarct zone and then degrade dead material and promote reparative phase transformation. The role of ApoE in inflammation response in the early stage of MI remains largely unclear. In this study, we investigated the effect of ApoE deficiency on neutrophils’ function and myocardial injury after myocardial infarction. By left coronary artery ligation in ApoE -/- and wild-type (WT) mice, we observed increased infarct size and neutrophil infiltration in ApoE -/- mice. Within the infarct zone, more neutrophil extracellular traps (NETs) were observed in ApoE -/- mice, while increased ex vivo NET formation was detected in ApoE -/- mouse-derived neutrophils through the NADPH oxidase-ROS-dependent pathway. Suppressing overproduced NETs reduced myocardial injury in ApoE -/- mice after ligation. In general, our findings reveal a critical role of apolipoprotein E in regulating Ly6G + neutrophil activation and NET formation, resulting in limiting myocardial injury after myocardial infarction. In such a process, apolipoprotein E regulates NET formation via the ROS-MAPK-MSK1 pathway.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/1209307
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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  • 2
    Online Resource
    Online Resource
    Application of Absorbable Suture in Strabismus Correction and Nursing Management Advantage of Watson Care Theory in Perioperative Period
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-3-4), p. 1-9
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-3-4), p. 1-9
    Abstract: Objectives. The article is aimed at investigating the suture effect of absorbable suture in strabismus correction and the advantage of Watson care theory. Methods. 148 children with strabismus were enrolled in this study and divided into two groups. The control group received routine nursing, and on this basis, the observation group was given Watson care theory nursing and eye muscle suture with absorbable sutures. The degree of cooperation (induction compliance checklist (ICC) score), negative emotion (modified Yale preoperative anxiety scale (m-YAPS) score), pain (face pain scale (FPS) score), quality of nursing management, parents’ satisfaction, clinical efficacy, and adverse reactions were compared. Results. After nursing and surgical treatment, all children’s strabismus symptoms were improved, and the improvement of strabismus and visual function in the observation group was more obvious. Watson care nursing can effectively improve the nursing management quality, parents’ satisfaction, children’s negative emotions, and treatment compliance. Conclusions. As a result, Watson care theory nursing is of great significance for improving the relationship between nurses and patients and building a harmonious hospital.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/8739551
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 3
    Online Resource
    Online Resource
    Application of NRS2002 in Preoperative Nutritional Screening for Patients with Liver Cancer
    Hindawi Limited ; 2021
    In:  Journal of Oncology Vol. 2021 ( 2021-08-27), p. 1-6
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2021 ( 2021-08-27), p. 1-6
    Abstract: Objective. To explore the application of NRS2002 in preoperative nutritional screening of patients with liver cancer (LC). Methods. 60 LC patients treated in the First Affiliated Hospital of Gannan Medical University (January 2018–May 2021) were chosen as the research objects, and split into group J without nutritional risk and group Q with nutritional risk according to the results of NRS2002 to compare the preoperative situation, surgery-related indexes, hematological indexes, postoperative recovery, and incidence of complications between the two groups. Results. Group J (n = 28) and group Q (n = 32) showed no obvious difference in preoperative situation, and patients’ liver function indexes were within the normal range. The duration of surgery in group J was notably shorter compared with group Q ( P 〈 0.05 ). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), direct bilirubin (DBIL), and albumin in group J were notably different from those of group Q ( P 〈 0.001 ) at 1 day after surgery. ALT and AST in group J were notably different from those of group Q at 3 days after surgery ( P 〈 0.001 ). No obvious differences were observed in the hematological indexes between the two groups at 5 days after surgery ( P 〉 0.05 ). The total amount of albumin infusion, postoperative hospitalization time, and hospitalization cost in group J were notably lower compared with group Q ( P 〈 0.001 ). The incidence of complications in group J was notably lower compared with group Q ( P 〈 0.05 ). Conclusion. Postoperative recovery of LC patients is closely related to their preoperative nutritional status, and those with poor nutritional status have a high incidence of postoperative complications and long recovery time. NRS2002 can effectively screen the nutritional status of patients and provide reference for prognosis evaluation.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2021/8943353
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2461349-6
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