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  • 1
    Online Resource
    Online Resource
    Epidemiology and Association Rules Analysis for Pulmonary Tuberculosis Cases with Extrapulmonary Tuberculosis from Age and Gender Perspective: A Large-Scale Retrospective Multicenter Observational Study in China
    Hindawi Limited ; 2023
    In:  International Journal of Clinical Practice Vol. 2023 ( 2023-7-31), p. 1-8
    Details
    In: International Journal of Clinical Practice, Hindawi Limited, Vol. 2023 ( 2023-7-31), p. 1-8
    Abstract: Background. Tuberculosis (TB), a multisystemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clinically, knowledge regarding concurrent PTB-EPTB is limited. Here, a large-scale multicenter observational study conducted in China aimed to study the epidemiology of concurrent PTB-EPTB cases by diagnostically defining TB types and then implementing association rules analysis. Methods. The retrospective study was conducted at 21 hospitals in 15 provinces in China and included all inpatients with confirmed TB diagnoses admitted from Jan 2011 to Dec 2017. Association rules analysis was conducted for cases with concurrent PTB and various types of EPTB using the Apriori algorithm. Results. Evaluation of 438,979TB inpatients indicated PTB was the most commonly diagnosed (82.05%) followed by tuberculous pleurisy (23.62%). Concurrent PTB-EPTB was found in 129,422 cases (29.48%) of which tuberculous pleurisy was the most common concurrent EPTB type observed. The multivariable logistic regression models demonstrated that odds ratios of concurrent PTB-EPTB cases varied by gender and age group. For PTB cases with concurrent EPTB, the strongest association was found between PTB and concurrent bronchial tuberculosis (lift = 1.09). For EPTB cases with concurrent PTB, the strongest association was found between pharyngeal/laryngeal tuberculosis and concurrent PTB (lift = 1.11). Confidence and lift values of concurrent PTB-EPTB cases varied with gender and age. Conclusions. Numerous concurrent PTB-EPTB case types were observed, with confidence and lift values varying with gender and age. Clinicians should screen for concurrent PTB-EPTB in order to improve treatment outcomes.
    Type of Medium: Online Resource
    ISSN: 1742-1241 , 1368-5031
    URL: Article
    DOI: 10.1155/2023/5562495
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2135320-7
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  • 2
    Online Resource
    Online Resource
    A COMPARISON OF MELANCHOLIC AND NONMELANCHOLIC RECURRENT MAJOR DEPRESSION IN HAN CHINESE WOMEN
    Hindawi Limited ; 2012
    In:  Depression and Anxiety Vol. 29, No. 1 ( 2012-01), p. 4-9
    Details
    In: Depression and Anxiety, Hindawi Limited, Vol. 29, No. 1 ( 2012-01), p. 4-9
    Type of Medium: Online Resource
    ISSN: 1091-4269 , 1520-6394
    URL: Issue
    URL: Article
    DOI: 10.1002/da.v29.1
    DOI: 10.1002/da.20875
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2001248-2
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Improved Surface Wettability of Water by Applying SiC/Ti6Al4V Coatings on Carbon/Carbon Composites
    Hindawi Limited ; 2013
    In:  Advances in Materials Science and Engineering Vol. 2013 ( 2013), p. 1-5
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2013 ( 2013), p. 1-5
    Abstract: SiC/Ti6Al4V coatings were applied on carbon/carbon composites to improve the surface wettability of water. SiC interlayers were preprepared by pack cementation to bond both the carbon/carbon composites and the Ti6Al4V, and then the Ti6Al4V coatings were applied by magnetron sputtering technique. The morphology and crystalline of the SiC/Ti6Al4V coatings were analyzed by scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. The surface wettability of the coatings was tested by video-based contact angle measuring device. The results showed that SiC can serve as an interlayer between the carbon/carbon composites and Ti6Al4V. The SiC/Ti6Al4V coatings covered the carbon/carbon composites uniformly with spherical morphology. The coatings improved the surface wettability of carbon/carbon composites with the contact angle of water decreasing from 85.7 ± 4.1° to 26.5 ± 0.1°.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2013/703610
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2501025-6
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  • 4
    Online Resource
    Online Resource
    A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-5-5), p. 1-21
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-5-5), p. 1-21
    Abstract: Breast cancer (BRCA) is one of the leading causes of death among women worldwide, and drug resistance often leads to a poor prognosis. Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. In this study, we established a signature basis of 7 necroptosis-related lncRNAs associated with prognosis and divided BRCA patients into high- and low-risk groups. Kaplan-Meier curves all showed an adverse prognosis for patients in the high-risk group. Cox assays confirmed that risk score was an independent prognostic factor for BRCA patients. The receiver operating characteristic (ROC) curve proved the predictive accuracy of the signature and the area under the curve (AUC) values of the risk score reached 0.722. The nomogram relatively accurately predicted the prognosis of the patients. GSEA analysis suggested that the related signaling pathways and biological processes enriched in the high- and low-risk groups may influence the tumor microenvironment (TME) of BRCA. ssGSEA showed the difference in immune cell infiltration, immune pathway activation, and immune checkpoint expression between the two risk groups, with the low-risk group more suitable for immunotherapy. According to the significant difference in IC50 between risk groups, patients can be guided for an individualized treatment plan. Overall, the authors established a prognostic signature consisting of 7 necroptosis-associated lncRNAs that can independently predict the clinical outcome of BRCA patients. The difference in the tumor immune microenvironment between the low- and high-risk populations may be the reason for the resistance to immunotherapy in some patients.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/3143511
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2817541-4
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  • 5
    Online Resource
    Online Resource
    ALT-to-Lymphocyte Ratio as a Predictor of Long-Term Mortality in Patients with Normal Liver Function Presenting Coronary Artery Disease after Undergoing PCI: A Retrospective Cohort Study
    Hindawi Limited ; 2020
    In:  Journal of Interventional Cardiology Vol. 2020 ( 2020-04-22), p. 1-7
    Details
    In: Journal of Interventional Cardiology, Hindawi Limited, Vol. 2020 ( 2020-04-22), p. 1-7
    Abstract: Background . Alanine aminotransferase (ALT) is referred as liver transaminase and predominantly expressed by hepatocytes. Previous evidences showed that high levels of ALT were reversely associated with short- and long-term outcomes in patients with myocardial infarction. Besides, low lymphocyte has been demonstrated to be significantly correlated with adverse clinical outcomes in coronary artery disease (CAD). However, evidences about the relationship between ALT-to-lymphocyte ratio (ALR) and outcomes in CAD patients with normal liver function are limited. The aim of this study was to assess the relationship between ALR and clinical outcomes in patients with CAD. Methods . This is a retrospective cohort study, and a total of 3561 patients were enrolled in Clinical Outcomes and Risk Factors of Patients with CAD after percutaneous coronary intervention (PCI), from January 2013 to December 2017. After excluding patients with liver dysfunction, we finally enrolled 2714 patients. These patients were divided into two groups according to ALR value: the lower group (ALR  〈  14.06, n  = 1804) and the higher group (ALR ≥ 14.06, n  = 910). The average follow-up time was 37.59 ± 22.24 months. Results . We found that there were significant differences between the two groups in the incidence of all-cause mortality (ACM) ( P 〈 0.001 ) and cardiac mortality (CM) ( P = 0.010 ). Kaplan–Meier survival analysis suggested that CAD patients with higher ALR tended to have an increased accumulated risk of ACM and CM (log rank P 〈 0.001 and P = 0.006 , respectively). Multivariate Cox regression analysis showed that ALR was an independent predictor of ACM (hazard ratio (HR) = 2.017 (95% confidence interval (CI): 1.289–3.158), P = 0.002 ) and CM (HR = 1.862 (95% CI: 1.047–3.313), P = 0.034 ). We did not find significant difference in the incidence of major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs) between the two groups after adjustments of confounders. Conclusion . Our results indicate that ALR is an independent predictor of long-term adverse outcomes in CAD patients who underwent PCI.
    Type of Medium: Online Resource
    ISSN: 0896-4327 , 1540-8183
    URL: Article
    DOI: 10.1155/2020/4713591
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2103585-4
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  • 6
    Online Resource
    Online Resource
    Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-8-12), p. 1-26
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-8-12), p. 1-26
    Abstract: Acute pancreatitis (AP), an inflammatory disorder of the pancreas, can cause systemic inflammatory responses. Escin Sodium (ES), a natural mixture of triterpene saponins extracted from the dry ripe fruit of Fructus Aesculi or horse chestnut crude, has been demonstrated to have antiedematous, anti-inflammatory, and antiexudative effects. We here aim to investigate the effects of ES pretreatment on AP in vivo and in vitro and explore its potential molecular mechanism. In the present study, we demonstrated that ES pretreatment could apparently decrease amylase and lipase, downregulate inflammatory cytokines, and attenuate pancreatic damage. Additionally, the increased expression of apoptotic-related proteins and the results of flow cytometry demonstrated the effects of ES on promoting apoptosis in acinar cells. Moreover, ES could enhance mitochondrial membrane potential (MMP, ΔΨm) and reactive oxygen species (ROS) level and reduce intracellular calcium concentration, which are closely related to mitochondrial-mediated death. The effect of ES pretreatment on acinar cell apoptosis was furtherly confirmed by the regulatory pathway of the ERK/STAT3 axis. These results suggest that ES attenuates the severity of AP by enhancing cell apoptosis via suppressing the ERK/STAT3 signaling pathway. These findings provide evidence for ES which is treated as a novel and potent therapeutic for the treatment of AP.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/9921839
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 7
    Online Resource
    Online Resource
    Depth Attenuation Degree Based Visualization for Cardiac Ischemic Electrophysiological Feature Exploration
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: Although heart researches and acquirement of clinical and experimental data are progressively open to public use, cardiac biophysical functions are still not well understood. Due to the complex and fine structures of the heart, cardiac electrophysiological features of interest may be occluded when there is a necessity to demonstrate cardiac electrophysiological behaviors. To investigate cardiac abnormal electrophysiological features under the pathological condition, in this paper, we implement a human cardiac ischemic model and acquire the electrophysiological data of excitation propagation. A visualization framework is then proposed which integrates a novel depth weighted optic attenuation model into the pathological electrophysiological model. The hidden feature of interest in pathological tissue can be revealed from sophisticated overlapping biophysical information. Experiment results verify the effectiveness of the proposed method for intuitively exploring and inspecting cardiac electrophysiological activities, which is fundamental in analyzing and explaining biophysical mechanisms of cardiac functions for doctors and medical staff.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/2979081
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 8
    Online Resource
    Online Resource
    Influences of Different Preparation Conditions on Catalytic Activity of Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 for Hydrogenation of Coal Pyrolysis
    Hindawi Limited ; 2014
    In:  Journal of Spectroscopy Vol. 2014 ( 2014), p. 1-6
    Details
    In: Journal of Spectroscopy, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Abstract: A series of catalysts of Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 was prepared by equivalent volume impregnation method. The effects of the metal loading, calcination time, and calcination temperatures of Ag and Co, respectively, on the catalytic activity were investigated. The optimum preparing condition of Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 was decided, and then the influence of different preparation conditions on catalytic activity of Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 was analyzed. The results showed the following: (1) at the same preparation condition, when silver loading was 8%, the Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 showed higher catalyst activity, (2) the catalyst activity had obviously improved when the cobalt loading was 8%, while it was weaker at loadings 5% and 10%, (3) the catalyst activity was influenced by different calcination temperatures of silver, but the influences were not marked, (4) the catalyst activity can be influenced by calcination time of silver, (5) different calcination times of cobalt can also influence the catalyst activity of Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 , and (6) the best preparation conditions of the Ag 2 O-Co 3 O 4 / γ -Al 2 O 3 were silver loading of 8%, calcination temperature of silver of 450°C, and calcinations time of silver of 4 h, while at the same time the cobalt loading was 8%, the calcination temperature of cobalt was 450°C, and calcination time of cobalt was 4 h.
    Type of Medium: Online Resource
    ISSN: 2314-4920 , 2314-4939
    URL: Article
    DOI: 10.1155/2014/272819
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2068433-2
    SSG: 11
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  • 9
    Online Resource
    Online Resource
    Electrical Fire Dynamic Risk Assessment for High-Rise Buildings Based on Variable Fuzzy Set Theory and Bayesian Network
    Hindawi Limited ; 2023
    In:  Mathematical Problems in Engineering Vol. 2023 ( 2023-2-22), p. 1-16
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2023 ( 2023-2-22), p. 1-16
    Abstract: High-rise buildings fires are far more harmful than ordinary fires. In this regard, fire risk assessment is an important way to control fire risk and reduce losses. This study presents a comprehensive model to electrical fire dynamic risk assessment of high-rise buildings based on a Bayesian network (BN) and a variable fuzzy set theory (VFST). Firstly, electric system, safety management, and other factors were comprehensively analyzed based on three categories: hazard sources identification (HSI), fault tree (FT) analysis, and VFST. A high-rise building electrical fire dynamic risk assessment model was established based on a BN. Secondly, the prior probability of BN root nodes was determined by VFST, and the conditional probability table (CPT) was determined by the analytic hierarchy process (AHP) and decomposition method. On that basis, the quantitative inference and sensitivity analysis can be performed on the electrical fire risks of high-rise buildings in combination with the variable fuzzy Bayesian network (VFBN) inference. Finally, a high-rise building in Wuhan, China, was used as an example for verification. The results show that the proposed method can realize dynamic risk assessment of electrical fires in high-rise buildings. This study provides a new method for fire risk assessment of high-rise buildings to reduce the possibility of fire.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2023/9068958
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
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    Online Resource
    New Wenshen Shengjing Decoction Improves Early Embryonic Development by Maintaining Low Levels of H3K4me3 in Sperm
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-2-21), p. 1-14
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-2-21), p. 1-14
    Abstract: Background. New Wenshen Shengjing Decoction (NWSSJD), a traditional Chinese compound medicine, has significant effect on spermatogenesis disorder and can significantly improve sperm quality. Many components in NWSSJD can induce epigenetic modifications of different types of cells. It is not yet known whether they can cause epigenetic modifications in sperm or early embryos. Objective. This study investigated the effect of NWSSJD on mouse early embryonic development and its regulation of H3K4me3 in mouse sperm and early embryos. Methods. Spermatogenesis disorder was induced in male mice with CPA (cyclophosphamide). NWSSJD was administrated for 30 days. Then, the male mice were mated with the female mice with superovulation, and the embryo degeneration rate of each stage was calculated. Immunofluorescence staining was used to detect the expression of H3K4me3 in sperm and embryos at various stages. Western blotting was performed to detect methyltransferase SETD1B expression. The expressions of development-related genes (OCT-4, NANOG, and CDX2) and apoptosis-related genes (BCL-2 and p53) were measured with qRT-PCR. Results. Compared with the CPA group, NWSSJD significantly reduced the H3K4me3 level in sperms, significantly increased the number of normal early embryos (2-cell embryos, 3-4-cell embryos, 8-16-cell embryos, and blastocysts) per mouse, and reduced the degeneration rate of the embryos. The expression levels of H3K4me3 and methyltransferase SETD1B in early embryos were significantly elevated by NWSSJD. Additionally, NWSSJD significantly promoted BCL-2 expression, while reducing p53 expression, thus inhibiting embryonic cell apoptosis. Moreover, the expressions of development-related genes OCT-4 and CDX2 were significantly increased by NWSSJD, but NANOG expression had no significant difference. Conclusion. NWSSJD may promote early embryonic development possibly by maintaining low H3K4me3 levels in sperms and normal H3K4me3 modification in early embryos and by inhibiting embryonic cell apoptosis.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/9775473
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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