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  • 1
    Online Resource
    Online Resource
    Longer Time Span Air Pollution Prediction: The Attention and Autoencoder Hybrid Learning Model
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-6-2), p. 1-16
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-6-2), p. 1-16
    Abstract: Air pollution has become a critical issue in human’s life. Predicting the changing trends of air pollutants would be of great help for public health and natural environments. Current methods focus on the prediction accuracy and retain the forecasting time span within 12 hours. Shorter time span decreases the practicability of these perditions, even with higher accuracy. This study proposes an attention and autoencoder (A & A) hybrid learning approach to obtain a longer period of air pollution changing trends while holding the same high accuracy. Since pollutant concentration forecast highly relates to time changing, quite different from normal prediction problems like autotranslation, we integrate “time decay factor” into the traditional attention mechanism. The time decay factor can alleviate the impact of the value observed from a longer time before while increasing the impact of the value from a closer time point. We also utilize the hidden states in the decoder to build connection between history values and current ones. Thus, the proposed model can extract the changing trend of a longer history time span while coping with abrupt changes within a shorter time span. A set of experiments demonstrate that the A & A learning approach can obtain the changing trend of air pollutants, like PM2.5, during a longer time span of 12, 24, or even 48 hours. The approach is also tested under different pollutant concentrations and different periods and the results validate its robustness and generality.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/5515103
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Recreational Value Assessment of Urban Productive Landscape of Baguatian in Hangzhou Based on Contingent Valuation Method (CVM) and Cloud Computing
    Hindawi Limited ; 2021
    In:  Scientific Programming Vol. 2021 ( 2021-12-17), p. 1-8
    Details
    In: Scientific Programming, Hindawi Limited, Vol. 2021 ( 2021-12-17), p. 1-8
    Abstract: Cloud computing has achieved rapid development in recent years, and the use of cloud platforms to carry various large-scale services has become the general trend of the development of the information industry. This study investigates WTP of Hangzhou residents for the recreational value of Baguatian productive landscapes based on CVM and cloud computing. In this study, we did the related analysis on the social and economic characteristics and WTP of interviewees and made the monetization assessment about the recreational value of its urban productive landscapes. The result shows 62.1% of interviewees have WTP and the average payment intention (WTP) is $40.74 per year. Besides, the total recreational value of Hangzhou Baguatian productive landscapes is 354 million yuan; the relatively accepted payment mode is tax-paying and cash payment; the educational degree, occupational background, and income are the main factors influencing the tourists’ WTP and the correlation between interviewees’ origin, permanent residence, and WTP is not apparent.
    Type of Medium: Online Resource
    ISSN: 1875-919X , 1058-9244
    URL: Article
    DOI: 10.1155/2021/9276457
    RVK:
    SA 7860
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2070004-0
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  • 3
    Online Resource
    Online Resource
    Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: MicroRNAs (miRNAs) are small noncoding RNAs, which regulate numerous cell functions by targeting mRNA for cleavage or translational repression, and have been found to play an important role in Alzheimer’s disease (AD). Our study aimed to identify differentially expressed miRNAs in AD brain as a reference of potential therapeutic miRNAs or biomarkers for this disease. We used amyloid precursor protein (APP) and presenilin 1 (PS1) double transgenic mice and age-matched wild-type (WT) littermates to determine the expression of miRNAs in the brain. MiRNAs were profiled by microarray, and differentially expressed miRNAs underwent target prediction and enrichment analysis. Microarray analysis revealed 56 differentially expressed miRNAs in AD mouse brain, which involved 39 miRNAs that were significantly upregulated and 19 that were downregulated at different ages. Among those miRNAs, a total of 11 miRNAs, including miR-342-3p, miR-342-5p, miR-376c-3p, and miR-301b-3p, were not only conserved in human but also predicted to have targets and signaling pathways closely related to the pathology of AD. In conclusion, in this study, differentially expressed miRNAs were identified in AD brain and proposed as biomarkers, which may have the potential to indicate AD progression. Despite being preliminary, these results may aid in investigating pathological hallmarks and identify effective therapeutic targets.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/8030369
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 4
    Online Resource
    Online Resource
    M2-Macrophage-Derived Exosomes Promote Meningioma Progression through TGF-β Signaling Pathway
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-5-20), p. 1-20
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-5-20), p. 1-20
    Abstract: Tumor-associated macrophages (TAMs) have been shown to be an essential component of the tumor microenvironment and facilitate the proliferation and invasion of a variety of malignancies. However, the contribution of TAMs to meningioma progression has not been characterized in detail. In this study, we aimed to discover a novel regulatory pathway by which exosome-mediated M2-polarized macrophages participate in meningioma tumorigenesis and progression. Methods. First, the distribution and functional phenotype of macrophages in meningioma tissues were assessed by immunohistochemistry. Macrophage-derived exosomes (MDEs) were characterized, and further cell coculture experiments were performed to explore the effects of M2-MDEs on the proliferation, migration, and invasion of meningioma cells. RNA sequencing was used to analyze the transcriptomic signatures in meningioma cells treated with M2-MDEs. Three-dimensional tumorspheres and xenograft tumor models were used to evaluate the effects of M2-MDEs on meningioma tumorigenesis and development. Results. We found that M2 macrophages were enriched in meningioma tissue. Coculture with meningioma cells induced the M2 polarization of macrophages. We also found that M2-MDEs were able to significantly promote cell proliferation, cell migration, cell invasion, and tumorigenesis in meningiomas. Bioinformatic analysis suggested that the TGF-β pathway was activated in meningioma cells treated with M2-MDEs. Functional experiments demonstrated that blocking the TGF-β signaling pathway could effectively reverse the tumor-promotive effects mediated by M2-MDEs. Conclusions. Overall, our study showed that M2-MDEs promoted meningioma development and invasion by activating the TGF-β signaling pathway. Targeting exosome-mediated intercellular communication in the tumor microenvironment may be a novel therapeutic strategy for meningioma patients.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/8326591
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2817541-4
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  • 5
    Online Resource
    Online Resource
    The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-9
    Abstract: We investigated the effect of Jiangya Tongluo (JYTL) formula on renal function in rats with hypertensive nephrosclerosis. A total of 21 spontaneously hypertensive rats (SHRs) were randomized into 3 groups: valsartan (10 mg/kg/d valsartan), JYTL (14.2 g/kg/d JYTL), and a model group (5 mL/kg/d distilled water); Wistar Kyoto rats comprised the control group ( n = 7, 5 mL/kg/d distilled water). Treatments were administered by gavage every day for 8 weeks. Blood pressure, 24-h urine protein, pathological changes in the kidney, serum creatinine, and blood urea nitrogen (BUN) levels were estimated. The contents of adrenomedullin (ADM) and angiotensin II (Ang II) in both the kidney and plasma were evaluated. JYTL lowered BP, 24-h urine protein, serum creatinine, and BUN. ADM content in kidneys increased and negatively correlated with BP, while Ang II decreased and negatively correlated with ADM, but there was no statistically significant difference of plasma ADM between the model and the treatment groups. Possibly, activated intrarenal renin-angiotensin system (RAS) plays an important role in hypertensive nephrosclerosis and the protective function of ADM via local paracrine. JYTL may upregulate endogenous ADM level in the kidneys and antagonize Ang II during vascular injury by dilating renal blood vessels.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/428106
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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  • 6
    Online Resource
    Online Resource
    Renoprotective Effect of Yiqi Yangyin Huayu Tongluo Formula against Diabetic Nephropathy in Diabetic Rats
    Hindawi Limited ; 2018
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2018 ( 2018-12-06), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2018 ( 2018-12-06), p. 1-10
    Abstract: Diabetic nephropathy is developed in 20-40% of patients with diabetes mellitus, and patients with diabetic nephropathy require dialysis and renal transplantation. Traditional Chinese medicine has been widely used in treating patients with diabetic nephropathy in China. However, the detailed mechanisms of traditional Chinese medicine remain unclear. Yiqi Yangyin Huayu Tongluo formula (ZY formula) is a traditional Chinese medicinal formula. Here, we demonstrated kidney protective effect of ZY formula on the rats with diabetic nephropathy. The therapeutic effect of ZY formula on the diabetic nephropathy was almost the same as that of Irbesartan, which proved to have excellent curative effects on diabetic nephropathy. We also demonstrated the mechanism of ZY formula effect on the diabetic nephropathy. First, we validated that the activation of ROS-JNK signaling pathway in diabetic rats could be reduced by ZY. Furthermore, collagen I expression could be downregulated by ZY formula treatment. Meanwhile, cell apoptosis in the kidney of diabetic rats could be alleviated by ZY formula.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2018/4276052
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2148302-4
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  • 7
    Online Resource
    Online Resource
    Effects of Modified Sang ju-Yin Decoction Combined with IFNαlb Nebulization on IL-1β and HBD2 in Children with Asthmatic Bronchitis
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-6-22), p. 1-9
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-6-22), p. 1-9
    Abstract: Background. Breathing disease swelling of the lung tubes caused by viral infection is more and more likely to develop into related to the lung tubes breathing disease, especially repeating breathing loudly. Objective. To investigate the effect of modified Sang ju-Yin Decoction combined with Interferon (IFN)αlb nebulization on children with asthmatic bronchitis and the effects of IL-1β and β-defensin 2 (HBD2). Materials and Methods. The clinical data of 80 children with asthmatic bronchitis who were diagnosed and treated in our hospital from May 2019 to May 2021 were selected as the research objects and divided into the control group and the observation group with 40 cases in each group according to different treatment methods. Among them, the control group was nebulized with IFNαlb, and the observation group was given addition and subtraction of Sang ju-Yin Decoction based on the control group. The clinical symptoms, pulmonary function indexes, adverse reactions, and effects on serum inflammatory indexes were observed and compared between the two groups. Results. There was no significant difference in the scores of symptoms and signs between the two groups before treatment ( P 〉 0.05 ), while the scores of shortness of breath, cough, stridor, lung rales, and signs after treatment of observation group were better than those of the control group ( P 〈 0.05 ). There was no significant difference in serum inflammatory indexes and pulmonary function indexes between the two groups before treatment ( P 〉 0.05 ), while the differences in IL-6, IL-10, TNF-α, IL-1β, and HBD2 after treatment were significant between the two groups ( P 〈 0.05 ). After treatment, the RR, TV, and PEF indexes of the two groups of children were significantly improved ( P 〈 0.05 ). After treatment, the adverse reaction rate of liver function damage, dry throat discomfort, rash, nausea, and vomiting in the observation group was 7.5%, which was significantly lower than 27.5% in the control group ( P 〈 0.05 ). Conclusion. Modified Sang ju-Yin Decoction combined with IFNαlb nebulization can improve symptoms and promote the recovery of patients in the treatment of acute bronchitis.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/2802636
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 8
    Online Resource
    Online Resource
    Corrigendum to “Ethanol Extract from Ampelopsis sinica Root Exerts Anti-Hepatitis B Virus Activity via Inhibition of p53 Pathway In Vitro ”
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-1
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-1
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/603232
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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  • 9
    Online Resource
    Online Resource
    Artificial Bee Colony Algorithm Combined with Grenade Explosion Method and Cauchy Operator for Global Optimization
    Hindawi Limited ; 2015
    In:  Mathematical Problems in Engineering Vol. 2015 ( 2015), p. 1-14
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2015 ( 2015), p. 1-14
    Abstract: Artificial bee colony (ABC) algorithm is a popular swarm intelligence technique inspired by the intelligent foraging behavior of honey bees. However, ABC is good at exploration but poor at exploitation and its convergence speed is also an issue in some cases. To improve the performance of ABC, a novel ABC combined with grenade explosion method (GEM) and Cauchy operator, namely, ABCGC, is proposed. GEM is embedded in the onlooker bees’ phase to enhance the exploitation ability and accelerate convergence of ABCGC; meanwhile, Cauchy operator is introduced into the scout bees’ phase to help ABCGC escape from local optimum and further enhance its exploration ability. Two sets of well-known benchmark functions are used to validate the better performance of ABCGC. The experiments confirm that ABCGC is significantly superior to ABC and other competitors; particularly it converges to the global optimum faster in most cases. These results suggest that ABCGC usually achieves a good balance between exploitation and exploration and can effectively serve as an alternative for global optimization.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2015/739437
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
    Online Resource
    Online Resource
    Neural Adaptive Decentralized Coordinated Control with Fault-Tolerant Capability for DFIGs under Stochastic Disturbances
    Hindawi Limited ; 2017
    In:  Mathematical Problems in Engineering Vol. 2017 ( 2017), p. 1-16
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2017 ( 2017), p. 1-16
    Abstract: At present, most methodologies proposed to control over double fed induction generators (DFIGs) are based on single machine model, where the interactions from network have been neglected. Considering this, this paper proposes a decentralized coordinated control of DFIG based on the neural interaction measurement observer. An artificial neural network is employed to approximate the nonlinear model of DFIG, and the approximation error due to neural approximation has been considered. A robust stabilization technique is also proposed to override the effect of approximation error. A H 2 controller and a H ∞ controller are employed to achieve specified engineering purposes, respectively. Then, the controller design is formulated as a mixed H 2 / H ∞ optimization with constrains of regional pole placement and proportional plus integral (PI) structure, which can be solved easily by using linear matrix inequality (LMI) technology. The results of simulations are presented and discussed, which show the capabilities of DFIG with the proposed control strategy to fault-tolerant control of the maximum power point tracking (MPPT) under slight sensor faults, low voltage ride-through (LVRT), and its contribution to power system transient stability support.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2017/6271341
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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