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  • Hindawi Limited  (110)
  • 1
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Journal of Applied Ichthyology Vol. 37, No. 5 ( 2021-10), p. 799-801
    In: Journal of Applied Ichthyology, Hindawi Limited, Vol. 37, No. 5 ( 2021-10), p. 799-801
    Type of Medium: Online Resource
    ISSN: 0175-8659 , 1439-0426
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 283875-8
    detail.hit.zdb_id: 2020412-7
    SSG: 21,3
    SSG: 12
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  • 2
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 2023 ( 2023-3-31), p. 1-12
    Abstract: The effect of solar drying (SD), room-temperature shaded drying (RSD), hot-air drying (HD), vacuum freeze drying (VFD), and microwave drying (MD) was compared on the sensory quality, nutrient substances, bioactive constituents, and antioxidant activities of dried Stropharia rugosoannulata. The results revealed that, in comparison with SD, RSD, HD, and MD, VFD mushrooms exhibited a better appearance with less shrinkage and an ideal colour with lower a colour difference. Meanwhile, a significantly higher content ( p 〈 0.05 ) of protein, carbohydrate, total sugar, and vitamin C was retained in VFD samples. The HD and VFD samples both had abundant total free amino acids and best met the ideal protein standard. Furthermore, VFD had advantages in terms of better preserving bioactive constituents and stronger antioxidant activities compared to other treatments. Therefore, the VFD-dried S. rugosoannulata obtained a better overall quality compared to the other four drying methods.
    Type of Medium: Online Resource
    ISSN: 1745-4549 , 0145-8892
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2175273-4
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  • 3
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: SUA is a potent antioxidant and thus may play a protective role against cancer. Many epidemiological studies have investigated this hypothesis but provided inconsistent and inconclusive findings. We aimed to precisely elucidate the association between SUA levels and cancer by pooling all available publications. Totally, 5 independent studies with 456,053 subjects and 12 with 632,472 subjects were identified after a comprehensive literature screening from PubMed, Embase, and Web of Science. The pooled RRs showed that individuals with high SUA levels were at an increased risk of total cancer incidence ( RR = 1.03 , 95% CI 1.01–1.05, P = 0.007 ). Positive association between high SUA levels and total cancer incidence was observed in males but not females (for men: RR = 1.05 , 95% CI 1.02–1.08, P = 0.002 ; for women, RR = 1.01 , 95% CI 0.98–1.04, P = 0.512 ). Besides, high SUA levels were associated with an elevated risk of total cancer mortality ( RR = 1.17 , 95% CI 1.04–1.32, P = 0.010 ), particularly in females ( RR = 1.25 , 95% CI 1.07–1.45, P = 0.004 ). The study suggests that high SUA levels increase the risk of total cancer incidence and mortality. The data do not support the hypothesis of a protective role of SUA in cancer.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2008065-7
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  • 4
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  International Journal of Genomics Vol. 2020 ( 2020-08-26), p. 1-13
    In: International Journal of Genomics, Hindawi Limited, Vol. 2020 ( 2020-08-26), p. 1-13
    Abstract: Estrogen contamination is recognized as one of the most serious environmental problems, causing widespread concern worldwide. Environmental estrogens are mainly derived from human and vertebrate excretion, drugs, and agricultural activities. The use of microorganisms is currently the most economical and effective method for biodegradation of environmental estrogens. Rhodococcus equi DSSKP-R-001 (R-001) has strong estrogen-degrading capabilities. Our study indicated that R-001 can use different types of estrogen as its sole carbon source for growth and metabolism, with final degradation rates above 90%. Transcriptome analysis showed that 720 (E1), 983 (E2), and 845 (EE2) genes were significantly upregulated in the estrogen-treated group compared with the control group, and 270 differentially expressed genes (DEGs) were upregulated across all treatment groups. These DEGs included ABC transporters; estrogen-degrading genes, including those that perform initial oxidation and dehydrogenation reactions and those that further degrade the resulting substrates into small molecules; and metabolism genes that complete the intracellular transformation and utilization of estrogen metabolites through biological processes such as amino acid metabolism, lipid metabolism, carbohydrate metabolism, and the tricarboxylic acid cycle. In summary, the biodegradation of estrogens is coordinated by a metabolic network of estrogen-degrading enzymes, transporters, metabolic enzymes, and other coenzymes. In this study, the metabolic mechanisms by which Rhodococcus equi R-001 degrades various estrogens were analyzed for the first time. A new pollutant metabolism system is outlined, providing a starting point for the construction of engineered estrogen-degrading bacteria.
    Type of Medium: Online Resource
    ISSN: 2314-436X , 2314-4378
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2711883-6
    SSG: 12
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  • 5
    In: Journal of Food Quality, Hindawi Limited, Vol. 2021 ( 2021-12-11), p. 1-9
    Abstract: Evaluations of the nutritional ingredients, biologically active materials, and pharmacological activities (antibacterial and antioxidant) of two types of Stropharia rugosoannulata, grown under the bamboo forest and in the greenhouse, respectively, were carried out in this study. The nutritional ingredient tests included moisture, ash, crude protein, crude fat, crude fiber, total carbohydrates, total sugar, mineral elements, vitamins, and amino acids. The biologically active material assays included total flavonoids, total polysaccharides, total triterpenoids, and reducing sugars. In addition, a broth microdilution susceptibility test was performed to evaluate antibacterial activity. The antioxidant activity was measured by ABTS+ radical scavenging, ferric-reducing power, and β-carotene bleaching assays. Results showed that two types of S. rugosoannulata were rich in protein, carbohydrate, fiber, mineral, B-group vitamins, polysaccharides, triterpenoids, and reducing sugars, with low content of fat and low Na/K ratio. Besides, they were effective in antibacterial and antioxidant activities, while S. Rugosoannulata grown under the bamboo forest was better than the greenhouse one in some respects such as higher content of protein, calcium, selenium, nicotinic acid, folic acid, polysaccharides and triterpenoids, and stronger antibacterial and antioxidant activities. They were appropriate for functional food and nutritional supplements, especially bamboo forest.
    Type of Medium: Online Resource
    ISSN: 1745-4557 , 0146-9428
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2175284-9
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2018
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2018 ( 2018), p. 1-11
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2018 ( 2018), p. 1-11
    Abstract: Purpose . To compare the efficacy of individualized herbal decoction with standard decoction for patients with stable bronchiectasis through N-of-1 trials. Methods . We conducted a single center N-of-1 trials in 17 patients with stable bronchiectasis. Each N-of-1 trial contains three cycles. Each cycle is divided into two 4-week intervention including individualized decoction and fixed decoction (control). The primary outcome was patient self-reported symptoms scores on a 1–7 point Likert scale. Secondary outcomes were 24-hour sputum volume and CAT scores. Results . Among 14 completed trials, five showed that the individualized decoction was statistically better than the control decoction on symptom scores ( P 〈 0.05 ) but was not clinically significant. The group data of all the trials showed that individualized decoction was superior to control decoction on symptom scores ( 2.13 ± 0.58 versus 2.30 ± 0.65 , P = 0.002 , mean difference and 95% CI: 0.18 (0.10, 0.25)), 24 h sputum volume ( P = 0.009 ), and CAT scores ( 9.69 ± 4.89 versus 11.64 ± 5.59 , P = 0.013 , mean difference and 95% CI: 1.95 (1.04, 2.86)) but not clinically significant. Conclusion . Optimizing the combined analysis of individual and group data and the improvement of statistical models may make contribution in establishing a method of evaluating clinical efficacy in line with the characteristics of traditional Chinese medicine individual diagnosis and treatment.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2148302-4
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  • 7
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 68, No. 6 ( 2021-11), p. 3658-3675
    Type of Medium: Online Resource
    ISSN: 1865-1674 , 1865-1682
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2414822-2
    SSG: 22
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  • 8
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  Advances in Materials Science and Engineering Vol. 2020 ( 2020-04-27), p. 1-8
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2020 ( 2020-04-27), p. 1-8
    Abstract: Understanding the internal force distribution and prejudging the weak part of tunnel supporting structure under complicated construction surroundings have become one of the important measures to ensure the safety of tunnel construction. Based on the initial parameter method and field-monitoring results of surrounding rock pressure, the theory of beam on elastic foundation is employed to derive the analytical solution of primary support internal forces. By combining the monitored data of rock pressure in one tunnel, solution of primary support internal force of a section is back analyzed and weak parts of the primary support are analyzed and evaluated. The results show that, after the tunnel excavation is completed, the internal forces of the primary support of the tunnel arch grow larger over time. When θ   〉  1.0, the internal forces change greatly. The internal force of the primary support decreased to different extents within 2 days after the primary support was applied and then gradually increased over time. Considering the situationality and changeability of the tunnel construction process, the analytical solution for the primary support internal forces of a multicenter arch tunnel proposed in this paper has a strong feasibility in tunnel construction. The conclusions obtained here could provide theoretical support for the design of supporting structure and the optimization of tunnel construction technology.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2501025-6
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  • 9
    In: Clinical and Developmental Immunology, Hindawi Limited, Vol. 2013 ( 2013), p. 1-11
    Abstract: In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. Exposure of W3 cells to LMW-HA promoted cell proliferation and migration via TLR4. Knockdown of TLR4 has provided evidence that TLR4 is essential for LMW-HA-induced CXCR7 expression, which is responsible for LMW-HA-induced proliferation and migration of W3 cells. In tumor-bearing adult nude mice, stimulation of LMW-HA on W3 cells promotes CXCR7 expression in tumor masses ( P = 0.002 ) and tumor growth ( P 〈 0.001 ). To further confirm our findings, we investigated the clinicopathologic significance of TLR4 and CXCR7 expression using immumohistochemistry in 135 human PTC tissues and 56 normal thyroid tissue samples. Higher rates of TLR4 (53%) and CXCR7 (24%) expression were found in PTC tissues than in normal tissues. Expression of TLR4 or CXCR7 is associated with tumor size and lymph node metastasis. Therefore, LMW-HA may contribute to the development of PTC via TLR4/CXCR7 pathway, which may be a novel target for PTC immunomodulatory therapy.
    Type of Medium: Online Resource
    ISSN: 1740-2522 , 1740-2530
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2817541-4
    detail.hit.zdb_id: 2119272-8
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  • 10
    Online Resource
    Online Resource
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-10-10), p. 1-7
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-10-10), p. 1-7
    Abstract: Renal impairment is affected by various mechanisms of oxidative stress, mitochondrial dysfunction, and basement membrane thickening, which are the major causes of renal dysfunction in diabetes. Of note, hyperglycemia-induced mitochondrial dysfunction has been identified as a common cause of diabetic nephropathy and renal impairment, and the decrease in PGC-1α expression brought on by hyperglycemia plays an immensurable role in both the reduction of mitochondrial biogenesis and the rise in oxidative stress. Reduced PGC-1α expression levels may occur with rising SGLT2-dependent increase of cytoplasmic sodium and protons in the renal cells of diabetes, even if the precise mechanism of hyperglycemia-induced disruption of PGC-1α expression has not been identified. Additionally, it has been observed that SGLT2 inhibitors enhance PGC-1α expression and activity and decrease cytoplasmic sodium and protons in many kidney cells, which may be helpful in reducing renal impairment brought on by diabetes. This review summarizes our and other recent studies on the function of PGC-1α in diabetic nephropathy, provides another potential mediator of the lower PGC-1α expression levels brought on by hyperglycemia in diabetics, and identifies a new pathogenesis of diabetes-related renal impairment. It also explains the mechanism underlying the protective effects of SGLT2 inhibitors on diabetic nephropathy. Therefore, it should be taken into account that SGLT2 inhibitors are an effective therapeutic strategy for reducing renal dysfunction caused by diabetes.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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