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  • Hindawi Limited  (11)
  • 1
    In: Stem Cells International, Hindawi Limited, Vol. 2022 ( 2022-5-20), p. 1-20
    Abstract: Background. MSC-derived extracellular vehicles (EVs) exhibit a protective functional role in renal ischemia/reperfusion injury (RIRI). Recent studies have revealed that mitophagy could be a potential target process in the treatment of RIRI. However, whether MSC-derived EVs are involved in the regulation of mitophagy in RIRI remains largely unknown to date. Methods. RIRI model was established in vivo in mice by subjecting them to renal ischemia/reperfusion. TCMK-1 cells were subjected to hypoxia/reoxygenation (H/R) stimulation to mimic RIRI in vitro. BMSCs and BMSC-derived EVs were isolated and identified. Renal injury was assessed using H & E staining. The qPCR and western blot analyses were conducted to detect the mRNA and protein levels. Apoptosis was evaluated using the TUNEL assay and flow cytometry analysis. The EVs, autophagosomes, and mitochondria were observed using TEM. The colocalization of autophagosomes with mitochondria was confirmed through the confocal assay. The direct binding of miR-223-3p to NLRP3 was validated through the dual-luciferase assay. Results. BMSCs and BMSC-derived EVs were successfully isolated from mice and identified. The protective effect of BMSC-derived EVs against RIRI was validated both in vitro and in vivo, which was indicated by a decrease in apoptosis and inflammasome activation and an increase in mitophagy. However, this protective effect was impaired in the miR-223-3p-depleted EVs, suggesting that miR-223-3p mediated this protective effect. Further mechanistic investigation revealed that miR-223-3p suppressed inflammasome activation to enhance mitophagy by directly targeting NLRP3. Conclusion. In conclusion, the protective role of BMSC-derived EVs and exosome-delivered miR-223-3p in RIRI was validated. Exogenous miR-223-3p directly targeted NLRP3 to attenuate inflammasome activation, thereby promoting mitophagy.
    Type of Medium: Online Resource
    ISSN: 1687-9678 , 1687-966X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2573856-2
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  • 2
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-5-20), p. 1-13
    Abstract: Objective. To analyze the impact of femoral neck cortical bone defect induced by core decompression on postoperative biomechanical stability using the finite element method. Methods. Five finite element models (FEMs) were established, including the standard operating model and four models of cortical bone defects at different portions of the femoral neck (anterior, posterior, superior, and inferior). The maximum stress of the proximal femur was evaluated during normal walking and walking downstairs. Results. Under both weight-bearing conditions, the maximum stress values of the five models were as follows: femoral neck (inferior)  〉  femoral neck (superior)  〉  femoral neck (posterior)  〉  femoral neck (anterior)  〉  standard operation. Stress concentration occurred in the areas of femoral neck cortical bone defect. Under normal walking, the maximum stress of four bone defect models and its increased percentage comparing the standard operation were as follows: anterior (17.17%), posterior (39.02%), superior (57.48%), and inferior (76.42%). The maximum stress was less than the cortical bone yield strength under normal walking conditions. Under walking downstairs, the maximum stress of four bone defect models and its increased percentage comparing the standard operation under normal walking were as follows: anterior (36.75%), posterior (67.82%), superior (83.31%), and inferior (103.65%). Under walking downstairs conditions, the maximum stress of bone defect models (anterior, posterior, and superior) was less than the yield strength of cortical bone, while the maximum stress of bone defect model (inferior) excessed yield strength value. Conclusions. The femoral neck cortical bone defect induced by core decompression can carry out normal walking after surgery. To avoid an increased risk of fracture after surgery, walking downstairs should be avoided when the cortical bone defect is inferior to the femoral neck except for the other three positions (anterior, posterior, and superior).
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 3
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2022 ( 2022-1-5), p. 1-13
    Abstract: Roll responses of the semitrailer and the tractor provide higher lead time and characterise the roll instability of the commercial vehicles subjected to directional manoeuvres at highway speeds. This paper proposes a novel rollover index based on the synthesized roll angles of the tractor and trailer. Owing to the poor measurability, the unscented Kalman filter (UKF) algorithm is used to estimate the roll angle of the track and trailer, respectively. Meanwhile, different weight coefficients are considered in the rollover index to eliminate the influence of mutual coupling between the tractor and the trailer and improve the accuracy of the warning. For the practical implementation of the algorithm, a two-stage rollover warning method triggered by the video and audio is finally proposed to reduce the possibilities of false warnings. Co-simulation is presented to prove the validity of the proposed rollover warning approach.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 4
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-09-03), p. 1-13
    Abstract: Background and Aim . The progression of liver fibrosis in chronic hepatitis B (CHB) patients is currently insufficiently controlled worldwide. The Yi Guan Jian decoction (YGJD) has been widely used in the treatment of liver fibrosis in CHB cases. Although animal studies have reported the antifibrotic effects of the decoction, the active ingredients of the YGJD remain unknown. This study aimed at identifying the potential active ingredients and exploring the mechanisms of action (MOA) of the decoction when treating CHB patients with fibrosis. Methods . Using data mining techniques and a structural clustering analysis, the potential active ingredients were determined. A network analysis of the differentially expressed genes was conducted to identify the potential targets. Selected compounds were docked to the potential targets for the compound-target interaction simulation. In vitro validation, including a cell proliferation assay and Western blot analysis, was conducted to evaluate the prediction results. Results . In the microarray data, 224 differentially expressed genes related to liver fibrosis were considered to be potential targets. Thirty active ingredients of the YGJD and 15 main targets and relevant pathways were identified. Among them, two active ingredients, methylophiopogonone A and 8-geranyloxypsoralen, were validated as exhibiting antifibrotic effects on hepatic stellate cells. Conclusions . We identified the potential active ingredients of the YGJD and proposed the possible explanation for the MOA in the treatment of CHB patients with liver fibrosis. Moreover, this study provides a methodological reference for the systematic investigation of the bioactive compounds and related MOA of a traditional Chinese medicine formula in a clinical context.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Computational Intelligence and Neuroscience Vol. 2021 ( 2021-9-29), p. 1-9
    In: Computational Intelligence and Neuroscience, Hindawi Limited, Vol. 2021 ( 2021-9-29), p. 1-9
    Abstract: A synthetic aperture radar (SAR) target recognition method based on image blocking and matching is proposed. The test SAR image is first separated into four blocks, which are analyzed and matched separately. For each block, the monogenic signal is employed to describe its time-frequency distribution and local details with a feature vector. The sparse representation-based classification (SRC) is used to classify the four monogenic feature vectors and produce the reconstruction error vectors. Afterwards, a random weight matrix with a rich set of weight vectors is used to linearly fuse the feature vectors and all the results are analyzed in a statistical way. Finally, a decision value is designed based on the statistical analysis to determine the target label. The proposed method is tested on the moving and stationary target acquisition and recognition (MSTAR) dataset and the results confirm the validity of the proposed method.
    Type of Medium: Online Resource
    ISSN: 1687-5273 , 1687-5265
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2388208-6
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2022
    In:  Journal of Sensors Vol. 2022 ( 2022-4-28), p. 1-12
    In: Journal of Sensors, Hindawi Limited, Vol. 2022 ( 2022-4-28), p. 1-12
    Abstract: Given the increasingly serious ecological and environmental problems in China, research on enterprises’ low-carbon sustainable development behavior (LCSDB) has become a heated discussion. This is also because enterprises are a primary source of carbon emissions and environmental pollution. From the perspective of the board of directors’ capital (BODC), this study considers empirical evidence from 286 enterprises listed on the Shanghai and Shenzhen stock exchanges in China from 2008 to 2016 to examine the BODC’s impact on enterprises’ LCSDB and its mechanisms. A group test is conducted using the enterprise’s property, nature of rights, and region, among other factors, to investigate the heterogeneity of the impact of board capital on enterprises’ LCSDB and its regulatory role. The research indicates (1) an increase in BODC promotes enterprises’ LCSDB. (2) An awareness of social responsibility (AOSR) plays an intermediary role in the relationship between BODC and corporate LCSDB. (3) Media attention enhances the BODC’s role in promoting enterprises’ LCSDB. (4) Government regulatory factors promote the BODC’s positive impact on LCSDB. These findings significantly impact the effectiveness of decision-makers within the company, the governance mechanism to address climate change risks, and the possible connection between corporate governance reform and carbon-related policies.
    Type of Medium: Online Resource
    ISSN: 1687-7268 , 1687-725X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397931-8
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  • 7
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-8-31), p. 1-14
    Abstract: In order to study the seepage law of broken coal seams affected by multiple mining operations, a cyclic loading and unloading seepage experiment was carried out. For this purpose, the seepage law of broken samples with different coal and rock ratios was analyzed. The results of our study demonstrated that the permeability of the broken samples showed a decreasing trend. After a loading and unloading cycle, the permeability was significantly reduced. The impact of the loading stage on the broken sample was higher than that of the unloading phase. When the proportion of coal particles in the mixed samples of broken coal and rock was 50%, the irreversible permeability loss rate and permeability loss rate of the samples showed the highest values. The irreversible permeability loss rate and permeability loss rate of the broken rock mass were greater than those displayed by the broken coal mass. The stress sensitivity coefficient curves of the 5 types of broken coal and rock masses presented the same changes. The stress sensitivity coefficient curve and the effective stress displayed an exponential relationship.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 8
    In: Aquaculture Research, Hindawi Limited, Vol. 50, No. 4 ( 2019-04), p. 1117-1130
    Type of Medium: Online Resource
    ISSN: 1355-557X
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 9
    Online Resource
    Online Resource
    Hindawi Limited ; 2022
    In:  Scientific Programming Vol. 2022 ( 2022-9-28), p. 1-17
    In: Scientific Programming, Hindawi Limited, Vol. 2022 ( 2022-9-28), p. 1-17
    Abstract: The comprehensive reasons for the cross-regional flow of enterprises in their own economy are studied in this paper. Most traditional enterprise migration research focuses on the impact of a single factor. Even the research on the influence of multiple factors often ignores the interaction of various factors. Therefore, this paper proposes and logicalises the “push and pull” mechanism of enterprise migration to address the limitations of previous research. Through bibliometric analysis and investigation, we systematically think about the factors that affect the corporate migration mechanism and improve the Push-Pull Theory. Besides, by deploying a conceptual system dynamics model, this paper explains how various factors affect enterprise migration. In addition, we discussed how to adopt systems thinking to promote the development of emerging economies. We selected and tested 6 companies that migrated in China, and the results are in line with reality. The conclusion supports the theory that systematic thinking and decision-making influence corporate behaviour.
    Type of Medium: Online Resource
    ISSN: 1875-919X , 1058-9244
    RVK:
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2070004-0
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  • 10
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Advances in Civil Engineering Vol. 2021 ( 2021-3-24), p. 1-13
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2021 ( 2021-3-24), p. 1-13
    Abstract: Based on the strength reduction method, the laws of slope displacement and the changing positions of the sliding surface during the filling process are studied. The model of multistage fill slope is established by the finite element software PLAXIS. The difference is compared between the slope with no reinforcement and with reinforcement under the same working condition. Sensitivity analysis is carried out from two aspects which are internal factors and external factors. The finite element analysis shows that the settlement of the multistage fill slope with no reinforcement is mainly concentrated on the right side of the slope and gradually decreases with the increase of the filling height. The position of the sliding outlet is located at the joint of the first and the second grade of the slope. The effect of the reinforcement on the sliding surface is ideal. It is obvious that the reinforcement can supply the slope with a better position of the sliding surface, which is beneficial to the stability of the slope. The sensitivity analysis shows that unit weight, ratio of slope, and height of each grade are negatively correlated with the safety factor. At the same time, the platform width, cohesion, and internal friction angle are positively correlated with the safety factor. The internal friction angle has the greatest influence on the stability of the slope. Besides, the platform width and the height of each grade should be controlled at about 4 m. The sensitivity analysis provides a reference for the design of the multistage filling slope.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2449760-5
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