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  • Hindawi Limited  (6)
  • 1
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-03-04), p. 1-8
    Abstract: Pharmacological antiarrhythmic therapy such as beta-blockers in patients with frequent premature ventricular contractions (PVCs) and concomitant bradycardia is challenging. A traditional Chinese medicine, Shensong Yangxin (SSYX), has been effective in treatment of frequent PVCs and sinus bradycardia (SB) in separate patient cohorts. This double-blind, placebo-controlled, multicentre, randomized clinical trial investigates the acute efficacy of SSYX in reducing PVCs burden in patients with concomitant SB. Patients with symptomatic, frequent PVCs, and SB, defined as mean heart rate (MHR) of 45 to 59 beats per min (bpm), were recruited at 33 medical centres in mainland China and randomly assigned by computer to either SSYX or matching placebo for eight weeks. Patients, investigators, and trial personnel were masked to treatment allocation. Primary endpoints were changes in PVCs burden and MHR as assessed by 24-hour Holter monitoring relative to baseline. Secondary efficacy endpoints were subjective symptom score, ECG, and biochemical parameters. Analysis was based on intention-to-treat principles. 333 patients were randomized, of which 166 received SSYX and 167 placebo. Baseline characteristics did not differ. SSYX reduced PVCs burden by 68.2% ( p 〈 0.001) and increased MHR by 10.9% ( p 〈 0.001) compared to 32.2% and 4.7%, respectively, in the placebo group. SSYX group experienced greater symptomatic improvement ( p 〈 0.001). No differences in reported adverse events were seen (20 versus 23). SSYX is an effective antiarrhythmic therapy for symptomatic, frequent PVCs uniquely suited patients with concomitant SB. Clinical trial number was NCT01750775 .
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    Hindawi Limited ; 2019
    In:  Complexity Vol. 2019 ( 2019-11-11), p. 1-13
    In: Complexity, Hindawi Limited, Vol. 2019 ( 2019-11-11), p. 1-13
    Abstract: As a new wireless energy transmission technology, magnetically coupled resonant wireless energy transmission system (MCRETS) is not easily affected by obstacles in the transmission process, and the transmission distance is relatively far. However, how to balance the relationship between transmission efficiency and power to achieve optimal performance is still a huge challenge. In addition, few studies have theoretically investigated the factors affecting the wireless energy transmission system to obtain an optimal solution. Here, through unprecedented theoretical analysis, we find the exact parameters of system optimization and verify them by simulation and experiments. First, the optimal topology of MCRETS is obtained through theoretical analysis and comparison of topologies. Second, to improve the transmission performance of MCRETS, its impact factors, including transmission distance, resonant frequency, relay coil, and relative position of launch and receiving coils, are analyzed in detail to get accurate parameters. Furthermore, based on the analysis, we propose an unprecedented concept for balancing optimal efficiency and power, which is named the power product. Finally, the effectiveness of the proposed method is verified through analysis and experimental results. These findings shed light on the relationship between efficiency and power and provide a comprehensive theoretical basis for subsequent research.
    Type of Medium: Online Resource
    ISSN: 1076-2787 , 1099-0526
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 3
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: We investigated the slow release of Zn ion (Zn 2+ ) from nanocoatings and compared the in vitro response of osteoblasts (MC3T3-E1) and proosteoclasts (RAW 264.7) cultured on Ca 2 ZnSi 2 O 7 nanocoated with different Zn/Ca molar ratios on a Ti-6Al-4V (i.e., Ti) substrate to optimize cell behaviors and molecule levels. Significant morphology differences were observed among samples. By comparing with pure Ti and CaSiO 3 nanocoating, the morphology of Ca 2 ZnSi 2 O 7 ceramic nanocoatings was rough and contained small nanoparticles or aggregations. Slow Zn 2+ release from nanocoatings was observed and Zn 2+ concentration was regulated by varying the Zn/Ca ratios. The cell-response results showed Ca 2 ZnSi 2 O 7 nanocoating at different Zn/Ca molar ratios for osteoblasts and osteoclasts. Compared to other nanocoatings and Ti, sample Zn/Ca (0.3) showed the highest cell viability and upregulated expression of the osteogenic differentiation genes ALP, COL-1, and OCN. Additionally, sample Zn/Ca (0.3) showed the greatest inhibition of RAW 264.7 cell growth and decreased the mRNA levels of osteoclast-related genes OAR, TRAP, and HYA1. Therefore, the optimal Zn-Ca ratio of 0.3 in Ca 2 ZnSi 2 O 7 ceramic nanocoating on Ti had a dual osteoblast-promoting and osteoclast-inhibiting effect to dynamically balance osteoblasts/osteoclasts. These optimal Zn-Ca ratios are valuable for Ca 2 ZnSi 2 O 7 ceramic nanocoating on Ti-coated implants for potential applications in bone tissue regeneration.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2229480-6
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  • 4
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-01-23), p. 1-11
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-01-23), p. 1-11
    Abstract: Objective . To investigate whether exercise preconditioning (EP) protects the rat heart from exhaustive exercise- (EE-) induced injury by inducing the PI3K-Akt signaling pathway. Methods . 84 male Sprague-Dawley rats were randomly divided into 6 groups ( n  = 14 rats per group): control group (Con), exhaustive exercise group (EE), exercise preconditioning group (EP), exercise preconditioning + exhaustive exercise group (EP + EE), LY294002 (PI3K inhibitor) + exercise preconditioning + exhaustive exercise group (LY + EP + EE), and LY294002 group (LY). The Con and LY did not exercise. The remaining groups were subjected to treadmill running. The structure of myocardial tissue and serum biomarkers of myocardial injury were observed. Hemodynamic parameters were recorded with a pressure-volume catheter. TUNEL assay was used to detect the apoptosis of cardiac myocytes, and the level of mitochondrial membrane permeability transforming pore (mPTP) in myocardium was evaluated using ELISA. Pathway and apoptosis-related proteins in myocardium were assessed using western blotting. Results . Compared to the Con group, the EE group showed remarkable myocardial injury, such as cardiac dysfunction and myocardial apoptosis. Compared to the EE group, the injuries in the EP + EE group were improved. EP increased the PI3K-Akt signaling pathway and regulated Bcl-2 family to decrease the mPTP openness level. However, the cardioprotective effects of EP were attenuated when pretreated with the LY294002. Conclusions . EP protected the heart from EE-induced injury, and it may improve the cardiac function and reduce the cardiomyocyte apoptosis by activating the PI3K-Akt signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  Journal of Nanomaterials Vol. 2020 ( 2020-02-24), p. 1-11
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2020 ( 2020-02-24), p. 1-11
    Abstract: Polysilicon nanofilm (PSNF) can provide a large gauge factor and good temperature stability, which promotes their application in piezoresistive sensing devices. Electrical trimming is necessary to further improve the stability and matching of piezoresistive resistors after sensor fabrication. The advantages of PSNF are realized by first preparing PSNF samples with different doping concentrations and deposition temperatures. By applying an incremental DC current that is higher than the threshold current of the PSNF resistors, the PSNF resistors are trimmed and the resistance changes are measured. The results of electrical trimming show that the threshold current, trimming rate, and trimming error are related to the doping concentration and deposition temperature. According to tunneling piezoresistive theory and the interstitial-vacancy pair model, the experimental results are expounded. These results are useful for the design and fabrication of PSNF piezoresistive sensors.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2229480-6
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  • 6
    In: International Journal of Energy Research, Hindawi Limited, Vol. 44, No. 11 ( 2020-09), p. 8314-8327
    Type of Medium: Online Resource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 1480879-1
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