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  • Hindawi Limited  (11)
  • 1
    Online-Ressource
    Online-Ressource
    Effectiveness of Gelatin-Thrombin Matrix Sealants (Floseal®) on Postoperative Spinal Epidural Hematoma during Single-Level Lumbar Decompression Using Biportal Endoscopic Spine Surgery: Clinical and Magnetic Resonance Image Study
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-07-09), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-07-09), p. 1-10
    Kurzfassung: Background . Symptomatic postoperative spinal epidural hematoma (PSEH) is a devastating complication that could develop after lumbar decompression surgery. PSEH can also develop after biportal endoscopic spine surgery (BESS), one of the recently introduced minimally invasive spine surgery techniques. Gelatin-thrombin matrix sealant (GTMS) is commonly used to prevent PSEH. This study aimed at analyzing the clinical and radiological effects of GTMS use during BESS. Methods . A total of 206 patients with spinal stenosis who underwent decompression by BESS through a posterior interlaminar approach from October 2015 to September 2018 were enrolled in this study. Postoperative magnetic resonance imaging (MRI) was performed in all patients for evaluation of PSEH. Patients in whom GTMS was not used during surgery were assigned to Group A, and those in whom GTMS was used were classified as Group B. In the clinical evaluation, the visual analog scale (VAS) of the leg and back, Oswestry Disability Index (ODI), and modified MacNab criteria were used. The incidence rate and degree of dural compression of PSEH on postoperative MRI were measured. Results . The average age of the patients was 68.1 ± 11.2 (42–89) years. The overall incidence rate of PSEH was 20.9% (43/206). The incidence rates in Groups A and B were 26.4% and 13.6%, respectively, showing a significant difference ( p = 0.023 ). The VAS-leg and ODI improvement was significantly different depending on the intraoperative use of GTMS. However, there was no statistically significant difference between the two groups in terms of the VAS-back improvement. Groups A and B showed “good” and “excellent” rates according to the modified MacNab criteria in 79.4% and 87.6% of patients, respectively, showing statistically significant difference ( p = 0.049 ). In Group A, two patients underwent revision surgery due to PSEH, while none in Group B had such event. Conclusion . Intraoperative use of GTMS during BESS may be related to reduction in the occurrence rate of PSEH. Specifically, patients with GTMS appliance showed marked decrease in the occurrence of PSEH and had better clinical outcomes.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/4801641
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes
    Hindawi Limited ; 2018
    In:  International Journal of Endocrinology Vol. 2018 ( 2018-12-24), p. 1-8
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2018 ( 2018-12-24), p. 1-8
    Kurzfassung: Background . Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored. Methods . We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study. Results . Fetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels. Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3] , P = 0.001 ) and subjects with obesity (704.1 [595.5-880.9] vs. 612.2 [547.9-802.1] , P = 0.016 ). In addition, brachial-ankle pulse wave velocity (baPWV), which reflects arterial stiffness, was higher in MA individuals compared to MH individuals. Multiple logistic regression analysis revealed that both individuals without obesity ( P for trend = 0.017) and with obesity ( P for trend = 0.028) in the higher tertiles of fetuin-A had an increased risk of MA than those in the lowest tertile. Conclusions . This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults.
    Materialart: Online-Ressource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2018/7918714
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2502951-4
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency
    Hindawi Limited ; 2018
    In:  International Journal of Endocrinology Vol. 2018 ( 2018), p. 1-7
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2018 ( 2018), p. 1-7
    Kurzfassung: Background. Limited information exists about the impact of nonalcoholic fatty liver disease (NAFLD) on mild renal insufficiency. We compared the relative influence of NAFLD, metabolic syndrome (MetS), and subclinical inflammation, alone or in combination, on mild renal insufficiency. Methods. This study included 1174 Korean adults. NAFLD was diagnosed using ultrasonography. Mild renal insufficiency was defined as an estimated glomerular filtration rate (eGFR) ≥ 60 and 〈 90 mL/min/1.73 m 2 . Results. In partial correlation analysis, several components of MetS and liver aminotransferase levels, but not high-sensitivity C-reactive protein (hsCRP), were associated with eGFR. Multivariate logistic regression analysis demonstrated the independent association of NAFLD ( P = 0.034 ) and MetS ( P = 0.018 ) with mild renal insufficiency, but not elevated hsCRP ( P = 0.885 ). Furthermore, NAFLD without the MetS group (odds ratio (95% confidence interval) = 1.56 (1.05–2.34)) or MetS without the NAFLD group (1.82 (1.11–3.00)) was associated with mild renal insufficiency after adjusting for confounding variables. However, individuals with high hsCRP showed no relationship with mild renal insufficiency, irrespective of the existence of NAFLD. Conclusions. This study demonstrated that NAFLD and MetS are independently associated with mild renal insufficiency, whereas subclinical inflammation did not affect the risk for mild renal insufficiency in Korean adults.
    Materialart: Online-Ressource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2018/1835486
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2502951-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    The effect of renin–angiotensin system blockade on renal protection in chronic kidney disease patients with hyperkalemia
    Hindawi Limited ; 2014
    In:  Journal of the Renin-Angiotensin-Aldosterone System Vol. 15, No. 4 ( 2014-12), p. 491-497
    Details
    In: Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 15, No. 4 ( 2014-12), p. 491-497
    Materialart: Online-Ressource
    ISSN: 1470-3203 , 1752-8976
    URL: Article
    DOI: 10.1177/1470320313507122
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2261873-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Learning Curve and Clinical Outcome of Biportal Endoscopic-Assisted Lumbar Interbody Fusion
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-12-17), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-12-17), p. 1-8
    Kurzfassung: Interbody fusion is a common surgical technique for diseases of the lumbar spine. Biportal endoscopic-assisted lumbar interbody fusion (BE-LIF) is a novel minimally invasive technique that has a long learning curve, which can be a barrier for surgeons. Therefore, we analyzed the learning curve in terms of operative time and evaluated the outcomes of BE-LIF. A retrospective study of fifty-seven consecutive patients who underwent BE-LIF for degenerative lumbar disease by a single surgeon from January 2017 to December 2018 was performed. Fifty patients underwent a single-level procedure, and 7 underwent surgery at two levels. The mean follow-up period was 24 months (range, 14–38). Total operative time, postoperative drainage volume, time to ambulation, and complications were analyzed. Clinical outcome was measured using the Oswestry Disability Index (ODI), Visual Analog Scale (VAS) score for back and leg pain, and modified Macnab criteria. The learning curve was evaluated by a nonparametric regression locally weighted scatterplot smoothing curve. Cases before the stable point on the curve were designated as group A, and those after the stable point were designated group B. Operative time decreased as the number of cases increased. A stable point was noticed on the 400th day and the 34th case after the first BE-LIF was performed. All cases showed improved ODI and VAS scores at the final follow-up. Overall mean operative time was 171.74 ± 35.1   min . Mean operative time was significantly lower in group B ( 139.7 ± 11.6   min ) compared to group A ( 193.4 ± 28.3   min ). Time to ambulation was significantly lower in group B compared to group A. VAS and ODI scores did not differ between the two groups. BE-LIF is an effective minimally invasive technique for lumbar degenerative disease. In our case series, this technique required approximately 34 cases to reach an adequate performance level.
    Materialart: Online-Ressource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2020/8815432
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Precursor‐driven facile densification of Gd 0. 1 Ce 0 . 9 O 2− δ interlayer for high‐performance solid oxide fuel cells
    Hindawi Limited ; 2022
    In:  International Journal of Energy Research Vol. 46, No. 12 ( 2022-10-10), p. 17511-17520
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 46, No. 12 ( 2022-10-10), p. 17511-17520
    Materialart: Online-Ressource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v46.12
    DOI: 10.1002/er.8419
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 1480879-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Forecasting of Hazard Zone due to Storm Surge Using SIND Model
    Hindawi Limited ; 2021
    In:  Advances in Civil Engineering Vol. 2021 ( 2021-5-20), p. 1-14
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2021 ( 2021-5-20), p. 1-14
    Kurzfassung: We have developed the SIND (scientific interpolation for natural disasters) model to forecast natural hazard zone for storm surge. Most previous studies have been conducted to predict hazard zone with numerical simulations based on various scenarios. It is hard to predict hazard zone for all scenarios and to respond immediately because most numerical models are requested a long simulation time and complicated postprocess, especially in coastal engineering. Thus, in this study, the SIND model was developed to overcome these limitations. The principal developing methods are the scientific interpolation for risk grades and trial and error for parameters embedded in the governing equation. Even designed with hatch files, applying disaster characteristics such as the risk propagation, the governing equation for storm surge in coastal lines was induced from the mathematical solver, COMSOL Multiphysics software that solves partial differential equations for multiple physics using FEM method. The verification process was performed through comparison with the official reference, and the accuracy was calculated with a shape similarity indicating the geometric similarity of the hazard zone. It was composed of position, shape, and area criteria. The accuracy of about 80% in terms of shape similarity was archived. The strength of the model is high accuracy and fast calculation time. It took only less than few seconds to create a hazard map for each scenario. As future works, if the characteristics of other disasters would be understood well, it would be able to present risk propagation induced from each natural disaster in a short term, which should help the decision making for EAP.
    Materialart: Online-Ressource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2021/8852385
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2449760-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Spectrophotometric Analysis of Phosphoric Acid Leakage in High-Temperature Phosphoric Acid-Doped Polybenzimidazole Membrane Fuel Cell Application
    Hindawi Limited ; 2016
    In:  Journal of Sensors Vol. 2016 ( 2016), p. 1-8
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Kurzfassung: High-temperature proton exchange membrane fuel cells (HT-PEMFCs) utilize a phosphoric acid- (PA-) doped polybenzimidazole (PBI) membrane as a polymer electrolyte. The PA concentration in the membrane can affect fuel cell performance, as a significant amount of PA can leak from the membrane electrode assembly (MEA) by dissolution in discharged water, which is a byproduct of cell operation. Spectrophotometric analysis of PA leakage in PA-doped polybenzimidazole membrane fuel cells is described here. This spectrophotometric analysis is based on measurement of absorption of an ion pair formed by phosphomolybdic anions and the cationoid color reagent. Different color reagents were tested based on PA detection sensitivity, stability of the formed color, and accuracy with respect to the amount of PA measured. This method allows for nondestructive analysis and monitoring of PA leakage during HT-PEMFCs operation.
    Materialart: Online-Ressource
    ISSN: 1687-725X , 1687-7268
    URL: Article
    DOI: 10.1155/2016/5290510
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2397931-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Online-Ressource
    Dual Silencing of Hsp27 and c-FLIP Enhances Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-7
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-7
    Kurzfassung: We evaluated effect of dual gene silencing of Hsp27 and c-FLIP in doxazosin-induced apoptosis of PC-3 cell. After transfection using Hsp27 and c-FLIP siRNA mixture (dual silencing), doxazosin treatment was done at the concentrations of 1, 10, and 25  μ M. We checked apoptosis of PC-3 cells with and TUNEL staining. We also checked interaction between Hsp27 and C-FLIP in the process of apoptosis inhibition. Spontaneous apoptotic index was 5% under single gene silencing of Hsp27 and c-FLIP and 7% under dual silencing of Hsp27 and c-FLIP. When doxazosin treatment was added, apoptotic indices increased in a dose-dependent manner (1, 10, and 25  μ M): nonsilencing 10, 27, and 52%; Hsp27-silencing: 14, 35, and 68%; c-FLIP silencing: 21, 46, and 78%; dual silencing: 38, 76, and 92%. While c-FLIP gene expression decreased in Hsp27- silenced cells, Hsp27 gene expression showed markedly decreased pattern in the cells of c-FLIP silencing. The knockout of c-FLIP and Hsp27 genes together enhances apoptosis even under 1  μ M, rather than low concentration, of doxazosin in PC-3 cells. This finding suggests a new strategy of multiple knockout of antiapoptotic and survival factors in the treatment of late-stage prostate cancer refractory to conventional therapy.
    Materialart: Online-Ressource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/174392
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2013
    ZDB Id: 2075968-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia: Results of a Multicenter Survey Study
    Hindawi Limited ; 2016
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2016 ( 2016), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Kurzfassung: Aim . To investigate whether dyspepsia symptoms differ depending on the presence or absence of cold hypersensitivity in the hands and feet (CHHF). Methods . In all, 6044 patients were recruited and provided with a questionnaire about CHHF and dyspepsia. Based on their responses, subjects were divided into a CHHF group (persons who noted cold sensations; n = 1209 ) and a non-CHHF group (persons who noted warm or intermediate sensations; n = 1744 ). The groups were compared in terms of their usual digestion status, using chi-square tests and logistic regression analyses to calculate the propensity score and odds ratios (ORs). We analyzed the participants’ responses to questions on dyspepsia symptoms. Results . After matching, chi-square tests indicated that the CHHF group had higher frequencies of the following symptoms: bad digestion, poor appetite, discomfort in the upper abdomen, motion sickness, epigastric burning, postprandial fullness, nausea, and bloating. Additionally, CHHF was associated with an increased OR for dyspepsia (bad digestion, vomiting, motion sickness, epigastric burning, postprandial fullness, nausea, epigastric pain, and bloating) compared with the non-CHHF group. Conclusion . This study confirmed that CHHF patients have elevated frequencies of most dyspepsia symptoms.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2016/8948690
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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