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  • Hindawi Limited  (7)
  • 1
    Online Resource
    Online Resource
    Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-5-5), p. 1-15
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-5-5), p. 1-15
    Abstract: Type 2 diabetes mellitus (T2DM) is a prevalent risk factor for cognitive impairment. Aerobic exercise can improve T2DM-related cognitive impairment; however, the possible mechanisms remain elusive. Thus, we assessed db/m mice and leptin receptor-deficient (db/db) mice that did or did not perform aerobic exercise (8 m/min, 60 min/day, and 5 days/week for 12 weeks). In this study, cognitive function was significantly impaired in the T2DM mice; aerobic exercise improved cognitive impairment through activating the AMPK/SIRT1 signalling pathway and inhibiting the JAK2/STAT3 signalling pathway in T2DM mice. However, after the application of RO8191 (JAK2 activator) or Compound C (AMPK inhibitor), the positive improvement of the exercise was evidently suppressed. Taken together, our data indicated that long-term aerobic exercise improves type 2 diabetes mellitus-related cognitive impairment by inhibiting JAK2/STAT3 and enhancing AMPK/SIRT1 pathways in mice.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/6010504
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 2
    Online Resource
    Online Resource
    Study on Steel Content Estimation of Reinforced Concrete Rectangular Pool Wall
    Hindawi Limited ; 2022
    In:  Discrete Dynamics in Nature and Society Vol. 2022 ( 2022-7-7), p. 1-11
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2022 ( 2022-7-7), p. 1-11
    Abstract: For water purification plants and sewage treatment plants, there is no reference optimal steel content for the wall of reinforced concrete water pool. Focusing on the reinforced concrete water pool, this paper explores the optimal wall thickness and optimal reinforcement area at different bending moments and identifies the optimal steel content. To solve the problem, the authors established the discrete distribution function for the engineering cost per unit length of pool wall and steel content. The theoretical model was verified by numerous data through Excel numerical simulation. The research results provide a reference optimal steel content for designers and help to save the engineering cost of pool wall.
    Type of Medium: Online Resource
    ISSN: 1607-887X , 1026-0226
    URL: Article
    DOI: 10.1155/2022/6779558
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    Nursing Analysis Based on Medical Imaging Technology before and after Coronary Angiography in Cardiovascular Medicine
    Hindawi Limited ; 2022
    In:  Applied Bionics and Biomechanics Vol. 2022 ( 2022-4-15), p. 1-8
    Details
    In: Applied Bionics and Biomechanics, Hindawi Limited, Vol. 2022 ( 2022-4-15), p. 1-8
    Abstract: With the advancement of technology, medical imaging technology has been greatly improved. This article mainly studies the nursing before and after coronary angiography in cardiovascular medicine based on medical imaging technology. This paper proposes a multimodal medical image fusion algorithm based on multiscale decomposition and convolution sparse representation. The algorithm first decomposes the preregistered source medical image by NSST, takes the subimages of different scales as training images, and optimizes the subdictionaries of different scales; then convolution and sparse the subimages on each scale encoding to obtain the sparse coefficients of different subimages; secondly, the combination of improved L1 norm and improved spatial frequency (novel sum-modified SF (NMSF)) is used for high-frequency subimage coefficients, and the fusion of low-frequency subimages improved the rule of combining the L1 norm and the regional energy; finally, the final fused image is obtained by inverse NSST of the fused low-frequency subband and high-frequency subband. Experimental analysis found that the bifurcation angle has nothing to do with the damage of the branch vessels after the main branch stent is placed. The bifurcation angle greater than 50° is an independent predictor of MACE after stent extrusion for bifurcation lesions. Experimental results show that the proposed method has good performance in contrast enhancement, detail extraction, and information retention, and it improves the quality of the fusion image.
    Type of Medium: Online Resource
    ISSN: 1754-2103 , 1176-2322
    URL: Article
    DOI: 10.1155/2022/3279068
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2179924-6
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population
    Hindawi Limited ; 2015
    In:  Journal of Ophthalmology Vol. 2015 ( 2015), p. 1-8
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Purpose . The etiology of neovascular age-related macular degeneration (nAMD) cannot be completely explained by identified environmental risk factors or single-locus gene variants. This study was to explore the potential interactions among gene variants on nAMD in Chinese population. Methods . 43 SNPs located in different genes were genotyped in 932 Chinese individuals (464 nAMD patients and 468 controls). We explored the potential interactions among gene variants using generalized multifactor dimensionality reduction (GMDR) algorithm and the method to measure the departure from the additivity model. Results . The joint effect that involved CFH rs1061170 and HTRA1 rs3793917 was shown statistically significant ( P 〈 0.001) with the highest cross-validation consistency (10/10) and the best testing balanced accuracy (64.50%). In addition, based on the method to measure the departure from the additivity model, the synergy index ( S ) was 2.63 (1.09–6.38) and the attributable proportion due to interaction (AP) was 55.7% (21.4%–89.9%), which suggested that a common pathway may exist for these genes for nAMD. Those who carried CC for rs3793917 and TC/CC for rs1061170 were at the highest risk of nAMD (OR: 9.76, 95% CI: 4.65–20.51). Conclusions . Evidence that the joint effect that involved CFH and ARMS2/HTRA1 may contribute to the risk of neovascular AMD in Chinese population was obtained.
    Type of Medium: Online Resource
    ISSN: 2090-004X , 2090-0058
    URL: Article
    DOI: 10.1155/2015/821918
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2546525-9
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  • 5
    Online Resource
    Online Resource
    Identifying Risk Factors for Aspiration in Patients Hospitalized with Community-Acquired Pneumonia
    Hindawi Limited ; 2023
    In:  International Journal of Clinical Practice Vol. 2023 ( 2023-7-18), p. 1-7
    Details
    In: International Journal of Clinical Practice, Hindawi Limited, Vol. 2023 ( 2023-7-18), p. 1-7
    Abstract: Background. Aspiration pneumonia (AP) is difficult to diagnose and has poor outcomes. This case-control study aimed to explore the risk factors and delineate the antibiotic usage for AP. Methods. Inpatients diagnosed with community-acquired pneumonia (CAP) from 2013 to 2017, enrolled in the urban employee basic medical insurance program in Beijing, were included and classified into the AP (N = 2,885) and non-AP (N = 53,825) groups. Risk factors were identified by logistic regression. Results. Older age (compared to 18–64 years, OR for 65–79 years: 4.3, 95% CI: 3.8–4.9; OR for 〉 80 years: 6.3, 95% CI: 5.6–7.2), male (OR: 1.4, 95% CI: 1.3–1.5), cerebrovascular disease (OR: 3.1, 95% CI: 2.8–3.5), dementia (OR: 2.0, 95% CI: 1.8–2.1), vomiting (OR: 1.4, 95% CI: 1.2–1.7), Parkinson’s disease (OR: 2.1, 95% CI: 1.8–2.4), and epilepsy (OR: 3.2, 95% CI: 2.8–3.7) were associated with an increased risk of AP. 92.8% of the AP patients received antibiotic therapy. Among them, patients treated with broad-spectrum antibiotics, antibiotics for injection, and combined antibiotics accounted for 93.3%, 97.9%, and 81.7%, respectively. Conclusions. Older age, male, and several comorbidities were independent risk factors for AP, and combined antibiotics treatments are common, which merits attention in accurate detection of AP in a high-risk population.
    Type of Medium: Online Resource
    ISSN: 1742-1241 , 1368-5031
    URL: Article
    DOI: 10.1155/2023/2198259
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2135320-7
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  • 6
    Online Resource
    Online Resource
    Serum Osteocalcin Is Associated with Inflammatory Factors in Metabolic Syndrome: A Population-Based Study in Chinese Males
    Hindawi Limited ; 2015
    In:  Mediators of Inflammation Vol. 2015 ( 2015), p. 1-8
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hyperglycemia, or metabolic syndrome, while its association with IgE was significantly observed in men with a normal metabolic profile.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2015/683739
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2008065-7
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  • 7
    Online Resource
    Online Resource
    Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China
    Hindawi Limited ; 2020
    In:  Journal of Diabetes Research Vol. 2020 ( 2020-01-13), p. 1-7
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2020 ( 2020-01-13), p. 1-7
    Abstract: Objective . The genetic variant rs2237895, located in the Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene, has been replicated to be associated with type 2 diabetes mellitus (T2DM) susceptibility, but the relationship with lipids is conflicting. Furthermore, the common genetic predisposition to T2DM and lipids was not fully detected. Methods . In total, 5839 individuals (2220 were T2DM patients) across 2885 families were included. The effect of rs2237895 on T2DM and lipids was estimated using linear regression and logistic regression models after adjustment for multiple covariates. Mediation analysis was then used to test whether KCNQ1 participated in T2DM pathogenesis via lipid-mediated pathways. Results . Per allele-C of rs2237895 was associated with 17% (11-23%, P 〈 0.001 ) increased T2DM risk. Moreover, it was correlated with 5% (1-9%, P = 0.019 ), 4% (1-7%, P = 0.019 ), 2% (0-3%, P = 0.045 ), and 2% (0-3%, P = 0.009 ) higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A, and apolipoprotein B (Apo-B) concentrations, respectively. Nevertheless, the genetic susceptibility for higher T2DM risk was correlated with higher high-density lipoprotein cholesterol (HDL-C) level (2%, 0-3%, P = 0.026 ). Mediation analysis showed only TC, LDL-C, and Apo-B had small significant mediated effects, with 2.9%, 2.3%, and 3.1% of the total effects of rs2237895 on T2DM being mediated by them, respectively. Conclusion . KCNQ1 had pleiotropic effects on lipids and T2DM, and the unexpected genetic effect on association of HDL-C with T2DM was observed, indicating the different pathways to lipids and T2DM. Further research studies are needed to verify potential biological mechanisms.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2020/8278574
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2711897-6
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