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  • Hindawi Limited  (5)
  • 1
    Online Resource
    Online Resource
    Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta-analysis
    Hindawi Limited ; 2023
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2023 ( 2023-4-17), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2023 ( 2023-4-17), p. 1-8
    Abstract: Objective. This study aimed to compare the clinical efficacy of continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) in patients with renal failure in intensive care unit (ICU). Methods. Relevant studies were searched in the databases including EMBASE, Cochrane Library, and MEDLINE (PubMed) from inception to January 04, 2021. The inclusion of available studies and the collection of data were independently conducted by two authors after reviewing the full text. Pooled analyses of relative risk (RR) and weighted mean difference (WMD) were performed to compare the outcomes of renal recovery, short-term mortality, length of ICU stays, and length of in-hospital stays between the two different treatment groups. Publication bias was assessed by the funnel plot. Results. A total of 11 RCT studies including 1740 patients with renal failure were eligible for final analysis. Among them, 894 patients (51.4%) underwent CRRT and 846 patients (48.6%) received IHD. Pooled analysis did not find significant differences in renal recovery and short-term mortality between the two groups. Interestingly, patients underwent CRRT showed significantly shorter length of ICU stay and in-hospital stay than those who underwent IHD (ICU stay: RR: −0.61, 95%CI: −1.10—−0.11, P 〈 0.05 ; I2 = 93.6%; in-hospital stay: RR: −0.56, 95%CI: −1.41–0.28, P 〈 0.05 ; I2 = 97.7%). No significant publication biases were observed on the funnel plots. Conclusion. Compared with IHD, CRRT had similar effects on renal recovery and short-term mortality in patients with renal failure in ICU. As a promising technique in clinical practice, CRRT could significantly reduce the length of ICU stay and in-hospital stay of patients, which was of great significance for the reduction of medical costs and the long-term benefits of patients, thereby reducing the burden on society and individuals.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2023/8688974
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    Resilient City: A Bibliometric Analysis and Visualization
    Hindawi Limited ; 2021
    In:  Discrete Dynamics in Nature and Society Vol. 2021 ( 2021-5-3), p. 1-17
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2021 ( 2021-5-3), p. 1-17
    Abstract: Resilient city has attracted global attentions as a new concept for cities to deal with risks and challenges in recent years. Numerous researchers have successively conducted in-depth studies on the resilient city from different perspectives. To acquire an overview of resilient city and grasp the current research hotspots, a bibliometric analysis and visualization of the past decade of research on the resilient city was made. The data were collected from 1249 articles published in the Web of Science database from 2010 to 2019. As the widely used bibliometric analysis tools, CiteSpace and VOSviewer were adopted in this study. The temporal distribution of resilient city research, including annual publication outputs and high-cited papers, was symmetrically analyzed. Then, the spatial distribution of resilient city research, including countries, categories, institutions, co-citation journals, author collaboration network, and author co-citation network, was investigated. Hot topics and evolution trends of resilient city were revealed. The results show that the research of resilient city experienced three periods, namely, germination, rapid diffusion, and reflection and innovation periods. Current research focuses on four aspects, including psychological resilience at the microcommunity and group levels, assessment of urban disaster resilience, multiple theoretical frameworks of urban resilience, and urban resilience promotion strategy. Therefore, this study helps scholars and practitioners to gain a comprehensive understanding of the current research progress and evolution trends of the resilient city field.
    Type of Medium: Online Resource
    ISSN: 1607-887X , 1026-0226
    URL: Article
    DOI: 10.1155/2021/5558497
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy
    Hindawi Limited ; 2017
    In:  Journal of Diabetes Research Vol. 2017 ( 2017), p. 1-10
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2017 ( 2017), p. 1-10
    Abstract: The pathological mechanisms of diabetic retinopathy (DR), a leading cause of blindness in adults with diabetes mellitus, remain incompletely understood. Because microRNAs (miRNAs) represent effective DR therapeutic targets, we identified aberrantly expressed miRNAs associated with cellular dysfunction in early DR and detected their potential targets. We exposed human retinal endothelial cells (HRECs) and a cell line of retinal pigment epithelial (RPE) cells to high glucose (25 mmol/L, 1–7 days) to mimic DR progression and used streptozotocin-injected rats (4–8 weeks) for an in vivo diabetes model. HREC/RPE viability decreased after 24 h incubation and diminished further over 6 days, and Hoechst staining revealed hyperglycemia-induced HREC/RPE apoptosis. Although miR-124/-125b expression decreased with DR progression in vitro and in vivo, miR-135b/-199a levels decreased in retinal cells under hyperglycemia exposure, but increased in diabetic retinas. Moreover, miR-145/-146a expression decreased gradually in high-glucose-treated HRECs, but increased in hyperglycemia-exposed RPE cells and in diabetic rats. Our findings suggested that aberrant miRNA expression could be involved in hyperglycemia-induced retinal-cell dysfunction, and the identified miRNAs might vary in different retinal layers, with expression changes associated with DR development. Therefore, miRNA modulation and the targeting of miRNA effects on transcription factors could represent novel and effective DR-treatment strategies.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2017/4727942
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2711897-6
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  • 4
    Online Resource
    Online Resource
    Electroacupuncture Alleviates Neuropathic Pain through Regulating miR-206-3p Targeting BDNF after CCI
    Hindawi Limited ; 2022
    In:  Neural Plasticity Vol. 2022 ( 2022-6-9), p. 1-15
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2022 ( 2022-6-9), p. 1-15
    Abstract: Background. Electroacupuncture (EA) has benefits for neuropathic pain. However, the underlying mechanisms are still unknown. The current study explores the underlying mechanisms of EA in neuropathic pain of chronic constriction injury (CCI) rats. Material/Methods. Overall, 126 Sprague-Dawley (200-250 g) rats were divided into nine groups randomly: the sham-operated, CCI, CCI+EA, CCI+sham EA, CCI+NS, CCI+AAV-NC, CCI+AAV-miR-206-3p, CCI+EA+NS, and CCI+EA+AAV-miR-206-3p groups. The animals were sacrificed 14 days postsurgery. Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) tests were used to determine differences in neurobehavioral manifestations. qPCR, western blotting, and immunofluorescence (IF) were carried out to detect the expression levels of miR-206-3p, BDNF, BAX/Bcl-2, TNF-α, and IL-6. Nissl staining was measured to observe morphological changes in neurons. Transmission electron microscopy (TEM) was employed to evaluate microscopic changes in dorsal horn synapses. Results. Hyperalgesia was reduced markedly by EA in the CCI model. The expression level of miR-206-3p was elevated, whereas the expression levels of BDNF, BAX/Bcl-2, TNF-α, and IL-6 were decreased in EA-treated CCI rats. However, a miR-206-3p inhibitor partially abrogated the analgesic effect of EA and resulted in poor behavioral performance and the BDNF, BAX/Bcl-2, TNF-α, and IL-6 expression was elevated as well. Conclusions. EA can relieve neuropathic pain by regulating the miR-206-3p/BDNF pathway, thus exerting anti-inflammatory and antiapoptotic effect.
    Type of Medium: Online Resource
    ISSN: 1687-5443 , 2090-5904
    URL: Article
    DOI: 10.1155/2022/1489841
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2236872-3
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  • 5
    Online Resource
    Online Resource
    Intraocular Foreign Bodies: Clinical Characteristics and Prognostic Factors Influencing Visual Outcome and Globe Survival in 373 Eyes
    Hindawi Limited ; 2019
    In:  Journal of Ophthalmology Vol. 2019 ( 2019-02-13), p. 1-7
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2019 ( 2019-02-13), p. 1-7
    Abstract: Aim . To describe epidemiologic and clinical characteristics and prognostic factors influencing visual outcome after intraocular foreign bodies (IOFBs) injury. Methods . Medical records of 370 patients (373 eyes) with IOFBs were reviewed to identify the factors influencing visual acuity by univariate and multivariate analyses. Results . The majority of patients (97.0%) were men, with a mean age of 38.1 years. The most common cause of ocular injury was hammering (52.6%); magnetic IOFBs occurred in 84.7% of these cases. Factors associated with poor visual outcome (defined as 〈 1.3 logMAR) included the following: age ≥50 years ( P = 0.046 ); worse presenting visual acuity ( P 〈 0.001 ); complications of retinal breaks ( P = 0.006 ) and endophthalmitis ( P = 0.032 ); vitrectomy ( P = 0.035 ); and intraocular C 3 F 8 gas tamponade ( P = 0.038 ). Excellent visual outcome (defined as ≥0.5 logMAR) was associated with age 〈 50 years ( P = 0.003 ); better presenting visual acuity (PVA) ( P 〈 0.001 ); wound length 〈 4 mm ( P = 0.005 ); absence of vitreous hemorrhage ( P = 0.026 ) and retinal breaks ( P 〈 0.001 ); nonvitrectomy surgery ( P = 0.043 ); and use of balanced saline ( P = 0.029 ). Conclusions . Multiple prognostic factors were identified that may predict visual outcome and globe survival after IOFBs injury. Age, initial presenting visual acuity, wound length, complications (vitreous hemorrhage, retinal breaks, and endophthalmitis), surgical approach, and intraocular tamponade were significant predictors of visual outcome.
    Type of Medium: Online Resource
    ISSN: 2090-004X , 2090-0058
    URL: Article
    DOI: 10.1155/2019/5208092
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2546525-9
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