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  • Hindawi Limited  (93)
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  • 1
    Online Resource
    Online Resource
    Yiqihuoxuejiedu Formula Inhibits Vascular Remodeling by Reducing Proliferation and Secretion of Adventitial Fibroblast after Balloon Injury
    Hindawi Limited ; 2014
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2014 ( 2014), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
    Abstract: Vascular remodeling occurs in atherosclerosis, hypertension, and restenosis after percutaneous coronary intervention. Adventitial remodeling may be a potential therapeutic target. Yiqihuoxuejiedu formula uses therapeutic principles from Chinese medicine to supplement Qi, activate blood circulation, and resolve toxin and it has been shown to inhibit vascular stenosis. To investigate effects and mechanisms of the formula on inhibiting vascular remodeling, especially adventitial remodeling, rats with a balloon injury to their common carotid artery were used and were treated for 7 or 28 days after injury. The adventitial area and α -SMA expression increased at 7 days after injury, which indicated activation and proliferation of adventitial fibroblasts. Yiqihuoxuejiedu formula reduced the adventitial areas at 7 days, attenuated the neointima and vessel wall area, stenosis percent, and α -SMA expression in the neointima, and reduced collagen content and type I/III collagen ratio in the adventitia at 28 days. Yiqihuoxuejiedu formula had more positive effects than Captopril in reducing intimal proliferation and diminishing stenosis, although Captopril lowered neointimal α -SMA expression and reduced the collagen content at 28 days. Yiqihuoxuejiedu formula has inhibitory effects on positive and negative remodeling by reducing adventitial and neointimal proliferation, reducing content, and elevating adventitial compliance.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2014/849167
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    p ‐Synephrine exhibits anti‐adipogenic activity by activating the Akt/GSK3β signaling pathway in 3T3‐L1 adipocytes
    Hindawi Limited ; 2019
    In:  Journal of Food Biochemistry Vol. 43, No. 11 ( 2019-11)
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 43, No. 11 ( 2019-11)
    Type of Medium: Online Resource
    ISSN: 0145-8884 , 1745-4514
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.v43.11
    DOI: 10.1111/jfbc.13033
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2174913-9
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  • 3
    Online Resource
    Online Resource
    Strain Incremental Adjustment Method of Cable Force of Composite Saddle Anchor Span of Single-Tower Single-Span Ground-Anchored Suspension Bridge
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-11-30), p. 1-13
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-11-30), p. 1-13
    Abstract: To improve the efficiency of cable force adjustment of composite saddle anchor span of single-tower single-span ground-anchored suspension bridge, a strain incremental adjustment method is proposed. The analytical calculation model is established according to the relative spatial position of the cable strand and the saddle groove of the composite saddle, and the target cable force of the cable strands is calculated by the target position of the composite saddle in the cable-stayed bridge and construction phases. Considering the coupling relationship between the cable strand and the composite saddle, the calculation formula of the change in main span main cable force and anchor span cable force after the adjustment of a single cable strand is derived. Based on the condition of equilibrium of forces along the slip surface of the composite saddle, the slip amount of composite saddle after a round of cable strand adjustment is obtained, then the adjustment amount of actual construction of the cable strands is also obtained through the strain incremental adjustment method. With the help of a numerical simulation platform, the calculation program of the cable force adjustment of composite saddle anchor span is established by an iterative solution method. In this paper, taking the Jinsha River Bridge at Hutiao Gorge as a research object, the adjustment of cable force of composite saddle anchor span is analyzed and calculated. The research results indicate that the calculated cable force is obtained by the strain incremental adjustment method, and it is similar to the measured cable force. The cable strand adjustment and optimization method avoids excessive repeated stretching and relaxation of a single cable strand in the process of multiple rounds of cable strand adjustment and reduces the amount of construction adjustment. This method can effectively reduce the times of cable strand adjustment and improve the efficiency of adjusting the anchor span cable force.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/2956496
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: Astragalus polysaccharide is a major component of radix astragali, a vital qi-reinforcing herb medicine with favorable immune-regulating effects. In a previous animal experiment, we demonstrated that astragalus polysaccharide effectively alleviates ischemia-reperfusion injury (IRI) of cardiac muscle through the regulation of the inflammatory reactions. However, the relationship between this herb and the cohesion molecules on the cell surface remains controversial. In this study, human cardiac microvascular endothelial cells (HCMECs) were used to validate the protective effects of astragalus under an IRI scheme simulated through hypoxia/reoxygenation in vitro. The results indicated that astragalus polysaccharide inhibited the cohesion between HCMECs and polymorphonuclear leukocyte (PMN) during IRI through the downregulation of p38 MAPK signaling and the reduction of cohesive molecule expression in HCMECs.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/280493
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    User-Characteristic-Oriented Bilateral Matching between Online Learning Service Demanders and Providers
    Hindawi Limited ; 2022
    In:  Scientific Programming Vol. 2022 ( 2022-7-20), p. 1-13
    Details
    In: Scientific Programming, Hindawi Limited, Vol. 2022 ( 2022-7-20), p. 1-13
    Abstract: Under the background of information technology and the Internet era, the matching problem in different application scenarios is becoming increasingly prominent. With respect to the matching problem in knowledge services, enabling users to choose suitable knowledge out of massive information has become an urgent demand to be satisfied. Initiating from interdisciplinary perspective, this paper proposes a matching method for online learning services according to user characteristics, which focuses on the matching of decision making for knowledge service with user relevance and characteristic under social network environment. Firstly, the complex network among users is constructed, and the user group is subcategorized into subgroups, thereby aggregating the subgroup information effectively. Secondly, the weight of the indices that evaluate the matching subject is determined by conducting the best-worst method. Thirdly, considering the difference between the expectation and actual levels of the matching subject, the cumulative prospect theory is adopted to calculate the satisfaction degree of both sides. Aiming at maximizing the satisfaction degree of the subjects, a multi-objective optimization model is established to obtain the optimal matching pairs. Finally, the validity and rationality of the proposed method are verified, offering interdisciplinary perspective and theoretical foundation for knowledge service matching and the education reform of humanities.
    Type of Medium: Online Resource
    ISSN: 1875-919X , 1058-9244
    URL: Article
    DOI: 10.1155/2022/1549899
    RVK:
    SA 7860
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2070004-0
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  • 6
    Online Resource
    Online Resource
    Organoleptic Evaluation of Amomi Fructus and Its Further Background Verified via Morphological Measurement and GC Coupled with E-Nose
    Hindawi Limited ; 2018
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2018 ( 2018), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2018 ( 2018), p. 1-9
    Abstract: The present study investigated the maneuverability and reasonability of sensory analysis, which has been applied in TCM identification for a long time. Ten assessors were trained and generated the human panel to carry out the organoleptic evaluation of twenty-five batches of Sha-Ren samples. Accordingly, samples were scored from 0 (lowest) to 10 (highest) for sensory attributes. Based on this, samples were divided into three classes: high class (Yang-Chun-Sha from Guang-Dong), moderate class (Yang-Chun-Sha samples from Yun-Nan and Guang-Xi), and low class (Lv-Qiao-Sha from marketplaces). For further background, three instrumental approaches were employed: morphological measurement with three indices (longitudinal diameter, transverse diameter, and 100-fruit weight), GC for determination of bornyl acetate contents, and E-nose for aromatic fingerprint. It is demonstrated in the results that GC and E-nose analyses were in great agreement with organoleptic evaluation. It gives insights into further studies on searching better morphological indicators and improving discriminant model of E-nose.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2018/4689767
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2148302-4
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  • 7
    Online Resource
    Online Resource
    The SCN1A Mutation Database: Updating Information and Analysis of the Relationships among Genotype, Functional Alteration, and Phenotype
    Hindawi Limited ; 2015
    In:  Human Mutation Vol. 36, No. 6 ( 2015-06), p. 573-580
    Details
    In: Human Mutation, Hindawi Limited, Vol. 36, No. 6 ( 2015-06), p. 573-580
    Type of Medium: Online Resource
    ISSN: 1059-7794
    URL: Article
    DOI: 10.1002/humu.22782
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Sexual Risk Behaviors and HIV Infection among Men Who Have Sex with Men and Women in China: Evidence from a Systematic Review and Meta-Analysis
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-12
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Abstract: Objectives . To understand the current risk of HIV infection and transmission and further elucidate the underlying risk factors among men who have sex with men and women (MSMW) in China. Methods . Following PRISMA guidelines, we conducted a systematic review and meta-analysis of searching through Chinese and English available literature databases between January 2000 and June 2014 to identify articles. Results . Thirty-six articles (including 19,730 MSMW and 53,536 MSMO) met the selection criteria and the aggregated results found that MSMW have significantly higher HIV prevalence than MSMO (6.6% versus 5.4%, OR = 1.27, 95% CI = 1.01–1.58). A higher proportion of MSMW had commercial male partners in the past 6 months (18.3% versus 12.2%, OR = 1.56, 95% CI = 1.01–2.42). Additionally, substance use in the past 6 months was significantly more frequent among MSMW than MSMO (alcohol use: 27.1% versus 13.1%, OR = 2.53, 95% CI = 2.14–2.99; illicit drug use: 5.3% versus 2.5%, OR = 2.09, 95% CI = 1.48–2.95). Conclusion . A higher proportion of commercial sex and substance use among MSMW may be a potentially indicative factor for significantly higher HIV prevalence compared to MSMO. Targeted interventions should aim at increasing the frequency of HIV/STIs screening and preventing high risk commercial sex and substance use among MSMW to decrease their HIV transmission to the general population.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/850132
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 9
    Online Resource
    Online Resource
    Disruption of MAP7D1 Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-7-15), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-7-15), p. 1-9
    Abstract: Doxorubicin is a cornerstone chemotherapeutic drug widely used to treat various cancers; its dose-dependent cardiomyopathy, however, is one of the leading causes of treatment-associated mortality in cancer survivors. Patients’ threshold doses leading to doxorubicin-induced cardiomyopathy (DIC) and heart failure are highly variable, mostly due to genetic variations in individuals’ genomes. However, genetic susceptibility to DIC remains largely unidentified. Here, we combined a genetic approach in the zebrafish (Danio rerio) animal model with a genome-wide association study (GWAS) in humans to identify genetic susceptibility to DIC and heart failure. We firstly reported the cardiac and skeletal muscle-specific expression and sarcomeric localization of the microtubule-associated protein 7 domain-containing protein 1b (Map7d1b) in zebrafish, followed by expression validation in mice. We then revealed that disruption of the map7d1b gene function exaggerated DIC effects in adult zebrafish. Mechanistically, the exacerbated DIC are likely conveyed by impaired autophagic degradation and elevated protein aggregation. Lastly, we identified 2 MAP7D1 gene variants associated with cardiac functional decline and heart failure in cancer patients who received doxorubicin therapy. Together, this study identifies MAP7D1 as a clinically relevant susceptibility gene to DIC and heart failure, providing useful information to stratify cancer patients with a high risk of incurring severe cardiomyopathy and heart failure after receiving chemotherapy.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/8569921
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 10
    Online Resource
    Online Resource
    Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-04-03), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-04-03), p. 1-16
    Abstract: Oxidative stress is implicated in the pathogenesis of neurodegeneration and other aging-related diseases. Previous studies have found that the whole herb of Centipeda minima has remarkable antioxidant activities. However, there have been no reports on the neuroprotective effects of C. minima , and the underlying mechanism of its antioxidant properties is unclear. Here, we examined the underlying mechanism of the antioxidant activities of the ethanol extract of C. minima (ECM) both in vivo and in vitro and found that ECM treatment attenuated glutamate and tert-butyl hydroperoxide (tBHP)-induced neuronal death, reactive oxygen species (ROS) production, and mitochondria dysfunction. tBHP-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinases (JNK) was reduced by ECM, and ECM sustained phosphorylation level of extracellular signal regulated kinase (ERK) in SH-SY5Y and PC12 cells. Moreover, ECM induced the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and the upregulation of phase II detoxification enzymes, including heme oxygenase-1 (HO-1), superoxide dismutase-2 (SOD2), and NAD(P)H quinone oxidoreductase-1 (NQO-1) in both two cell types. In a D-galactose (D-gal) and aluminum muriate (AlCl 3 )-induced neurodegenerative mouse model, administration of ECM improved the learning and memory of mice in the Morris water maze test and ameliorated the effects of neurodegenerative disorders. ECM sustained the expression level of postsynaptic density 95 (PSD95) and synaptophysin (SYN), activated the Nrf2 signaling pathway, and restored the levels of cellular antioxidants in the hippocampus of mice. In addition, four sesquiterpenoids were isolated from C. minima to identify the bioactive components responsible for the antioxidant activity of C. minima ; 6- O -angeloylplenolin and arnicolide D were found to be the active compounds responsible for the activation of the Nrf2 signaling pathway and inhibition of ROS production. Our study examined the mechanism of C. minima and its active components in the amelioration of oxidative stress, which holds the promise for the treatment of neurodegenerative disease.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/9421037
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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