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  • Hindawi Limited  (4)
  • 1
    Online Resource
    Online Resource
    Study on the Deformation of Pavement Structure with Multiplex Organic Hydraulicity Mixture under Driving Load Based on Simulation and Experiment
    Hindawi Limited ; 2021
    In:  Advances in Materials Science and Engineering Vol. 2021 ( 2021-10-11), p. 1-12
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2021 ( 2021-10-11), p. 1-12
    Abstract: With the continuous growth of global warming and traffic volume, rutting deformation is common on road surfaces. A new type of pavement mixture, a semiflexible mixture, was proposed to solve the easy deformation and low riding quality of traditional pavement mixtures. It can be divided into pouring type and mixing type according to the construction method. However, there is little research on mixed semiflexible mixtures (i.e., multiplex organic hydraulicity (MOH) mixtures) in the current literature, so the deformation of pavement under driving loads was studied based on the MOH mixture in this paper. Four types of pavement composed of the traditional mixture and MOH mixture (i.e., AC13-AC20, AC13-MOH, MOH-MOH, and MOH-AC20) were selected to achieve the purpose of the research. Based on these four types of pavement, the deformation of the pavement was studied by simulations and experiments. The results show that the deformation of the upper layer is almost the same for these four types of pavement and that the deformation of the middle layer changes substantially for these four types of pavement. In regard to the deformation, the relationship is MOH-MOH  〈  AC13-MOH  〈  MOH-AC20  〈  AC13-AC20. In addition, the contribution rate of the deformation of the middle layer is much greater than that of the upper layer. The antideforming ability of the whole pavement can be improved by using the MOH mixture as the middle layer of the pavement, which means that the performance of the MOH mixture can achieve the best performance when it is applied to the middle layer.
    Type of Medium: Online Resource
    ISSN: 1687-8442 , 1687-8434
    URL: Article
    DOI: 10.1155/2021/7073229
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2501025-6
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  • 2
    Online Resource
    Online Resource
    The PBDE-209 Exposure during Pregnancy and Lactation Impairs Immune Function in Rats
    Hindawi Limited ; 2012
    In:  Mediators of Inflammation Vol. 2012 ( 2012), p. 1-8
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2012 ( 2012), p. 1-8
    Abstract: In the present study, we assessed the treatment effects of PBDE-209 administration on the immune function in rats during pregnancy and lactation. We harvested the blood and organs for flow cytometry, viability assay, enzyme-linked immunosorbent assay, and histological evaluation. The results of this study were the PBDE-209 exposure during pregnancy and lactation impairs immune function in rats. The results may contribute to understanding the mechanism of PBDE-209 in immune function.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2012/692467
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2008065-7
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  • 3
    Online Resource
    Online Resource
    FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK-Induced c-FLIP Ubiquitination and Degradation
    Hindawi Limited ; 2022
    In:  Stem Cells International Vol. 2022 ( 2022-9-30), p. 1-18
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2022 ( 2022-9-30), p. 1-18
    Abstract: Background. The poor survival rates of transplanted mesenchymal stem cells (MSCs) in harsh microenvironments impair the efficacy of MSCs transplantation in myocardial infarction (MI). Extrinsic apoptosis pathways play an important role in the apoptosis of transplanted MSCs, and Fas apoptosis inhibitory molecule (FAIM) is involved in regulation of the extrinsic apoptosis pathway. Thus, we aimed to explore whether FAIM augmentation protects MSCs against stress-induced apoptosis and thereby improves the therapeutic efficacy of MSCs. Methods. We ligated the left anterior descending coronary artery (LAD) in the mouse heart to generate an MI model and then injected FAIM-overexpressing MSCs (MSCsFAIM) into the peri-infarction area in vivo. Moreover, FAIM-overexpressing MSCs were challenged with oxygen, serum, and glucose deprivation (OGD) in vitro, which mimicked the harsh microenvironment that occurs in cardiac infarction. Results. FAIM was markedly downregulated under OGD conditions, and FAIM overexpression protected MSCs against OGD-induced apoptosis. MSCsFAIM transplantation improved cell retention, strengthened angiogenesis, and ameliorated heart function. The antiapoptotic effect of FAIM was mediated by cellular-FLICE inhibitory protein (c-FLIP), and FAIM augmentation improved the protein expression of c-FLIP by reducing ubiquitin–proteasome-dependent c-FLIP degradation. Furthermore, FAIM inhibited the activation of JNK, and treatment with the JNK inhibitor SP600125 abrogated the reduction in c-FLIP protein expression caused by FAIM silencing. Conclusions. Overall, these results indicated that FAIM curbed the JNK-mediated, ubiquitination–proteasome-dependent degradation of c-FLIP, thereby improving the survival of transplanted MSCs and enhancing their efficacy in MI. This study may provide a novel approach to strengthen the therapeutic effect of MSC-based therapy.
    Type of Medium: Online Resource
    ISSN: 1687-9678 , 1687-966X
    URL: Article
    DOI: 10.1155/2022/3705637
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2573856-2
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  • 4
    Online Resource
    Online Resource
    Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
    Hindawi Limited ; 2013
    In:  Mediators of Inflammation Vol. 2013 ( 2013), p. 1-7
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2013 ( 2013), p. 1-7
    Abstract: Dexmedetomidine (DEX) is an α 2-adrenergic agonist. It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity. In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery. We evaluated the role of dexmedetomidine (DEX) in cytokine release during postpartum BMODS in rats. In summary, the present study demonstrated that DEX administration reduced IFN-r and IL-4 release and decreased lung injury during postpartum BMODS. It is possible that DEX administration decreased inflammatory cytokine production in BMODS by inhibiting inflammation and free radical release by leukocytes independent of the DEX dose.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2013/627831
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2008065-7
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