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  • 1
    Online Resource
    Online Resource
    Closer to a Uniform Language in Colposcopy: Study on the Potential Application of 2011 International Federation for Cervical Pathology and Colposcopy Terminology in Clinical Practice
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-10
    Abstract: As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011 IFCPC classification in 525 patients, reviewed by 13 trained colposcopists. Results show that colposcopic diagnoses are in 64.95% perfect agreement with cervical pathology, with 63.64% sensitivity and 96.01% specificity for high-grade squamous intraepithelial lesion (HSIL+). And the accuracy is reproducible across different experienced examiners. Many individual findings, especially the two new signs, inner border sign and ridge sign, are proved to have good predictive accuracy, while iodine negativity demonstrates an inferior performance. However, the distribution of three cervical transformation zone (TZ) types is heterogeneous in examiners. A comparison was also made of the findings of another two colposcopists without nomenclature training according to the Reid Colposcopic Index (RCI), modified RCI, and Swede Score. Results show that colposcopic accuracies in them are lower than in those nomenclature trained colposcopists. The 2011 IFCPC nomenclature improves colposcopic accuracy in trained colposcopists, like speaking the same language. However, the reproducibility of TZ and the predictive value of a few signs remain to be discussed.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/8984516
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury
    Hindawi Limited ; 2023
    In:  Mediators of Inflammation Vol. 2023 ( 2023-7-13), p. 1-15
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2023 ( 2023-7-13), p. 1-15
    Abstract: Interstitial inflammation is an important mechanism of pathological damage in renal injury caused by hyperuricemia. Protease-activated receptor-2 (PAR2) is a class of targets that act upstream of the PI3K/AKT/NF-κB pathway and is involved in various inflammatory diseases. We induced a hyperuricemia model in rats by adenine and ethambutol gavage in an in vivo experiment. We demonstrated that PAR2 and PI3K/AKT/NF-κB pathway expression were significantly upregulated in renal tissues, with massive inflammatory cell infiltration in the renal interstitium and renal tissue injury. Treating hyperuricemic rats with AZ3451, a selective metabotropic antagonist of PAR2, we demonstrated that PAR2 antagonism inhibited the PI3K/AKT/NF-κB pathway and attenuated tubular dilation and tubulointerstitial inflammatory cell infiltration. The phospholipid metabolism profiles provided a perfect separation between the normal and hyperuricemic rats. In addition, we also found that AZ3451 can affect phospholipid metabolism. Our work suggests that PAR2 may mediate hyperuricemia-mediated renal injury by activating the PI3K/AKT/NF-κB pathway. The PAR2 antagonist AZ3451 may be a promising therapeutic strategy for hyperuricemia-induced inflammatory responses.
    Type of Medium: Online Resource
    ISSN: 1466-1861 , 0962-9351
    URL: Article
    DOI: 10.1155/2023/5007488
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2008065-7
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  • 3
    Online Resource
    Online Resource
    Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-10-7), p. 1-24
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-10-7), p. 1-24
    Abstract: Hypoxic pulmonary hypertension (HPH) is a progressive cardiopulmonary system disease characterized by pulmonary vascular remodeling. Its occurrence and progression are closely related to oxidative stress. Lycopene, extracted from red vegetables and fruits, exhibits a particularly high antioxidant capacity that is beneficial for cardiovascular diseases. Nevertheless, the role and mechanism of lycopene in HPH remain unknown. Here, we found that lycopene reversed the elevated right ventricular systolic pressure (RVSP), right ventricular hypertrophy, and pulmonary vascular remodeling induced by hypoxia in rats. In vitro, lycopene caused lower proliferation and migration of PASMCs, with higher apoptosis. Consistent with the antiproliferative result of lycopene on hypoxic PASMCs, the hippo signaling pathway associated with cell growth was activated. Furthermore, lycopene reduced malondialdehyde (MDA) levels and enhanced superoxide dismutase (SOD) activity in the lungs and serum of rats under hypoxia conditions. The expression of NOX4 in the lungs was also significantly decreased. Hypoxic PASMCs subjected to lycopene showed decreased reactive oxygen species (ROS) production and NOX4 expression. Importantly, lycopene repressed HIF-1α expression both in the lungs and PASMCs in response to hypoxia in the absence of a significant change of HIF-1α mRNA. Compared with 2ME2 (a HIF-1α inhibitor) alone treatment, lycopene treatment did not significantly change PASMC proliferation, NOX4 expression, and ROS production after 2ME2 blocked HIF-1α, suggesting the inhibitory effect of lycopene on HIF-1α-NOX4-ROS axis and the targeted effect on HIF-1α. After CHX blocked protein synthesis, lycopene promoted the protein degradation of HIF-1α. MG-132, a proteasome inhibitor, notably reversed the decrease in HIF-1α protein level induced by lycopene in response to hypoxia. Therefore, lycopene suppressed hypoxia-induced oxidative stress through HIF-1α-NOX4-ROS axis, thereby alleviating HPH. Our findings will provide a new research direction for clinical HPH therapies.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/9179427
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 4
    Online Resource
    Online Resource
    Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-7-21), p. 1-12
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-7-21), p. 1-12
    Abstract: Previous studies on the relationship between the circulating level of interleukin-17 (IL-17) and disease activity in systemic lupus erythematosus (SLE) were contradictory. This study is aimed at quantitatively assessing the correlation between the circulating IL-17 level and disease activity in SLE patients. A systematic search for related literature was conducted via PubMed, Web of Science, EMBASE, and Cochrane Library (up to January 26, 2021). The relationship between circulating IL-17 levels and SLE activity was evaluated using Fisher’s z value, which was then converted to r . The standardized mean difference (SMD) and its 95% confidence interval (CI) were used to describe the difference between the circulating IL-17 level in patients with active and inactive SLE. STATA 16.0 was used to perform statistical analysis. Random-effects model was performed to synthesize data. Twenty-six studies involving 1,560 SLE patients were included in this review. The pooled r value was 0.38 (95% CI: 0.25-0.50; I 2 = 83.8 %, P 〈 0.001 ) between the SLE activity and circulating level of IL-17. Patients with active SLE had higher level of circulating IL-17 than that of inactive ( pooled   SMD = 0.95 , 95% CI: 0.38-1.53; I 2 = 90.5 %, P 〈 0.001 ). The subgroup analysis suggested that the region and detection method of circulating IL-17 might not be a source of heterogeneity. No significant publication bias was found. In summary, circulating IL-17 level has a low positive relationship with SLE activity. It is necessary to carefully consider the use of circulating IL-17 as a biomarker of the disease activity in SLE patients. The relationship between the circulating level of IL-17 and SLE activity should be further confirmed in randomized controlled studies.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/9952463
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 5
    Online Resource
    Online Resource
    Serum Neuropeptide Y: A Potential Prognostic Marker of Intracerebral Hemorrhage
    Hindawi Limited ; 2021
    In:  Disease Markers Vol. 2021 ( 2021-8-10), p. 1-6
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2021 ( 2021-8-10), p. 1-6
    Abstract: Objective. Neuropeptide Y (NPY), a 36-amino acid neuromodulator, is mainly secreted by neurons in the central and peripheral nervous systems, which participate in the regulation of a series of physiological processes. However, there are few studies on its correlation with intracranial hemorrhage (ICH). The purpose of this study is to determine whether the serum NPY level is related to the prognosis of ICH. Methods. 364 patients diagnosed with ICH were included in the current study. The demographics, anthropometrics, medical history, clinical severity, and laboratory data are collected. Enzyme-linked immunoassay (ELISA) was used to detect the serum NPY level of each patient upon admission. Three months after the occurrence of ICH, we used the modified Rankin scale (mRS) to evaluate the prognosis of patients, and mRS 〉 2 was defined as a poor prognosis. Results. A total of 364 patients with ICH were included in the study, including 140 patients with a good prognosis and 224 patients with a poor prognosis. Compared with patients with a poor prognosis, ICH patients with a good prognosis have a lower baseline National Institutes of Health Stroke Scale (NIHSS) score ( p = 0.036 ) and smaller hematoma volume ( p = 0.039 ). The results of ELISA showed that compared with patients with a poor prognosis, ICH patients with a good prognosis had lower serum NPY levels ( 19.4 ± 3.7 vs. 27.6 ± 3.3  ng/ml, p 〈 0.001 ). Linear correlation analysis showed that the serum NPY level of ICH patients was significantly positively correlated with the baseline NIHSS score ( r = 0.413 , p = 0.041 ) and hematoma volume ( r = 0.308 , p = 0.026 ). Receiver operating characteristic (ROC) curve analysis showed that the sensitivity of the serum NPY level to predict the prognosis of ICH was 70.9%, the specificity was 72.6%, and the cut-off value was 24.2 ng/ml. Conclusions. The serum NPY level may be used as a predictor of ICH prognosis.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2021/7957013
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2033253-1
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  • 6
    Online Resource
    Online Resource
    Effect of feeding scheme and prey density on survival and development of Chinese mitten crab Eriocheir sinensis zoea larvae
    Hindawi Limited ; 2008
    In:  Aquaculture Research Vol. 39, No. 6 ( 2008-04), p. 568-576
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 39, No. 6 ( 2008-04), p. 568-576
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Article
    DOI: 10.1111/j.1365-2109.2008.01902.x
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2008
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 7
    Online Resource
    Online Resource
    Ingestion of Artemia nauplii by Chinese mitten crab Eriocheir sinensis zoea larvae
    Hindawi Limited ; 2009
    In:  Aquaculture Research Vol. 40, No. 8 ( 2009-05), p. 950-954
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 40, No. 8 ( 2009-05), p. 950-954
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.2009.40.issue-8
    DOI: 10.1111/j.1365-2109.2009.02189.x
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 8
    Online Resource
    Online Resource
    Cell-Free Strategies for Repair and Regeneration of Meniscus Injuries through the Recruitment of Endogenous Stem/Progenitor Cells
    Hindawi Limited ; 2018
    In:  Stem Cells International Vol. 2018 ( 2018-07-12), p. 1-10
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2018 ( 2018-07-12), p. 1-10
    Abstract: The meniscus plays a vital role in protecting the articular cartilage of the knee joint. The inner two-thirds of the meniscus are avascular, and injuries to this region often fail to heal without intervention. The use of tissue engineering and regenerative medicine techniques may offer novel and effective approaches to repairing meniscal injuries. Meniscal tissue engineering and regenerative medicine typically use one of two techniques, cell-based or cell-free. While numerous cell-based strategies have been applied to repair and regenerate meniscal defects, these techniques possess certain limitations including cellular contamination and an increased risk of disease transmission. Cell-free strategies attempt to repair and regenerate the injured tissues by recruiting endogenous stem/progenitor cells. Cell-free strategies avoid several of the disadvantages of cell-based techniques and, therefore, may have a wider clinical application. This review first compares cell-based to cell-free techniques. Next, it summarizes potential sources for endogenous stem/progenitor cells. Finally, it discusses important recruitment factors for meniscal repair and regeneration. In conclusion, cell-free techniques, which focus on the recruitment of endogenous stem and progenitor cells, are growing in efficacy and may play a critical role in the future of meniscal repair and regeneration.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2018/5310471
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2573856-2
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  • 9
    Online Resource
    Online Resource
    Novel genotype definition and genome characteristics of duck circovirus in central and Eastern China
    Hindawi Limited ; 2020
    In:  Transboundary and Emerging Diseases Vol. 67, No. 6 ( 2020-11), p. 2993-3004
    Details
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 67, No. 6 ( 2020-11), p. 2993-3004
    Type of Medium: Online Resource
    ISSN: 1865-1674 , 1865-1682
    URL: Issue
    URL: Article
    DOI: 10.1111/tbed.v67.6
    DOI: 10.1111/tbed.13676
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2414822-2
    SSG: 22
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  • 10
    Online Resource
    Online Resource
    A Genetic Algorithm for Multiedge Collaborative Computing Offloading Scheme
    Hindawi Limited ; 2022
    In:  Mobile Information Systems Vol. 2022 ( 2022-7-30), p. 1-9
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2022 ( 2022-7-30), p. 1-9
    Abstract: The fast popularization of the Internet of Things (IoT) has caused the data scale to increase geometrically. The data of IoT devices is processed on the cloud, but the way of processing data in the cloud center gradually causes problems, such as communication delay, latency, and privacy leakage. Edge computing sinks some cloud center services to the edge of the device so that data processing is completed in the terminal network, thereby realizing rapid data processing. At the same time, since long-distance communication is avoided, user data is processed locally, so that user privacy data can be safely protected. A genetic algorithm is a type of heuristic algorithm that is based on the genetic development of organisms in nature and has a high global optimization capability. The basic aim and objective of this paper is to study the existing edge computing framework along with computing offloading technology. The genetic algorithm is investigated using multiedge computing-oriented collaborative computing offloading, which is helpful to the IoT’s growth as well as the generation and the use of data. The use of a genetic algorithm based on a color graph for load balancing on several edge servers is also investigated. In terms of the study’s performance evaluation, it is obvious that our proposed approach produces superior results than previous studies.
    Type of Medium: Online Resource
    ISSN: 1875-905X , 1574-017X
    URL: Article
    DOI: 10.1155/2022/4341953
    RVK:
    QA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2187808-0
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