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  • Hindawi Limited  (3)
  • 1
    Online-Ressource
    Online-Ressource
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-2-9), p. 1-16
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-2-9), p. 1-16
    Kurzfassung: The traveling salesman problem (TSP), a typical non-deterministic polynomial (NP) hard problem, has been used in many engineering applications. Genetic algorithms are useful for NP-hard problems, especially the traveling salesman problem. However, it has some issues for solving TSP, including quickly falling into the local optimum and an insufficient optimization precision. To address TSP effectively, this paper proposes a hybrid Cellular Genetic Algorithm with Simulated Annealing (SA) Algorithm (SCGA). Firstly, SCGA is an improved Genetic Algorithm (GA) based on the Cellular Automata (CA). The selection operation in SCGA is performed according to the state of the cell. Secondly, SCGA, combined with SA, introduces an elitist strategy to improve the speed of the convergence. Finally, the proposed algorithm is tested against 13 standard benchmark instances from the TSPLIB to confirm the performance of the three cellular automata rules. The experimental results show that, in most instances, the results obtained by SCGA using rule 2 are better and more stable than the results of using rule 1 and rule 3. At the same time, we compared the experimental results with GA, SA, and Cellular Genetic Algorithm (CGA) to verify the performance of SCGA. The comparison results show that the distance obtained by the proposed algorithm is shortened by a mean of 7% compared with the other three algorithms, which is closer to the theoretical optimal value and has good robustness.
    Materialart: Online-Ressource
    ISSN: 1563-5147 , 1024-123X
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2014442-8
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    In: Genetics Research, Hindawi Limited, Vol. 2022 ( 2022-10-15), p. 1-10
    Kurzfassung: Sepsis is a severe disease with high mortality, and liver injury is an independent risk factor for sepsis morbidity and mortality. We analyzed co-differentially expressed genes (co-DEGs) to explore potential biomarkers and therapeutic targets for sepsis-related liver injury. Three gene expression datasets (GSE60088, GSE23767, and GSE71530) were downloaded from the Gene Expression Omnibus (GEO). DEGs were screened between sepsis and control samples using GEO2R. The association of these DEGs with infection and liver disease was analyzed by using the CTD database. GO functional analysis, KEGG pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed to elucidate the potential molecular mechanism of DEGs. DEGs of different tissues in GSE60088 were analyzed again to obtain specific markers of septic liver injury. Mouse model of sepsis was also established by cecal ligation and puncture (CLP), and the expression of specific markers in liver, lung, and kidney tissues was analyzed using Western blot. Here, we identified 21 DEGs in three datasets with 8 hub genes, all of which showed higher inference scores in liver diseases than bacterial infections. Among them, only TNFRSF1A had a liver-specific differential expression. TNFRSF1A was also confirmed to be specifically reduced in septic liver tissues in mice. Therefore, TNFRSF1A may serve as a potential biomarker for septic liver injury.
    Materialart: Online-Ressource
    ISSN: 1469-5073
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2412684-6
    ZDB Id: 1472156-9
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Online-Ressource
    Online-Ressource
    Hindawi Limited ; 2022
    In:  Genetics Research Vol. 2022 ( 2022-7-22), p. 1-6
    In: Genetics Research, Hindawi Limited, Vol. 2022 ( 2022-7-22), p. 1-6
    Kurzfassung: Methylmalonic acidemia (MMA) is an autosomal recessive metabolic disorder mainly caused by mutations in the methylmalonyl coenzyme A mutase (MCM) gene (MMUT) and leads to the reduced activity of MCM. In this study, a 3-year-old girl was diagnosed with carnitine deficiency secondary to methylmalonic acidemia by tandem mass spectrometry (MS/MS) and gas chromatography/mass spectrometry (GS/MS). Whole-exome sequencing (WES) was performed on the patient and identified two compound heterozygous mutations in MMUT: c.554C 〉 T (p. S185F) and c.729–730insTT (p. D244Lfs ∗ 39). Bioinformatics analysis predicted that the rare missense mutation of c.554C 〉 T would be damaging. Moreover, this rare mutation resulted in the reduced levels of MMUT mRNA and MMUT protein. Collectively, our findings provide a greater understanding of the effects of MMUT variants and will facilitate the diagnosis and treatment of patients with MMA.
    Materialart: Online-Ressource
    ISSN: 1469-5073
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2412684-6
    ZDB Id: 1472156-9
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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