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  • Hindawi Limited  (40)
  • 1
    Online Resource
    Online Resource
    Effects of Working Medium Gases on Emission Spectral and Temperature Characteristics of a Plasma Igniter
    Hindawi Limited ; 2019
    In:  Journal of Spectroscopy Vol. 2019 ( 2019-08-29), p. 1-10
    Details
    In: Journal of Spectroscopy, Hindawi Limited, Vol. 2019 ( 2019-08-29), p. 1-10
    Abstract: Ar, N 2 , O 2 , and N 2 -O 2 mixture under different O 2 components were separately used as the working medium gas of a plasma igniter to study the influence of working-medium-gas type and O 2 concentration on emission spectral and temperature characteristics of a direct-current arc plasma igniter. The emission spectra of the plasma jet were also analyzed using the optical emission spectroscopy method, and the influence rule of working medium gas and O 2 concentration on electron temperature and vibrational temperature of the plasma jet was calculated and analyzed. The experimental results show that the emission spectra of the plasma jet had significant differences when diverse working gases were used as the working medium of the igniter. With increasing O 2 concentration in the working medium gas, the spectral line intensity of oxygen-containing particles in emission spectra of the plasma jet was significantly enhanced, and the spectral intensities of nitrogen-containing particles, NO molecular bands, the second positive system of N 2 C 3 ∏ u − B 3 ∏ g , and the first negative system of N 2 + B 2 ∑ u + − X 2 ∑ u + were also enhanced obviously. Both electron and vibrational temperature of the plasma jet increased gradually with increasing O 2 concentration in the working medium gas, and first increased and then decreased with increasing axial distance from the plasma jet.
    Type of Medium: Online Resource
    ISSN: 2314-4920 , 2314-4939
    URL: Article
    DOI: 10.1155/2019/5395914
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2068433-2
    SSG: 11
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  • 2
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    Online Resource
    Effect of Transcatheter Arterial Chemoembolization Combined with Radiofrequency Ablation on Liver Function and Immune Function in Patients with Hepatocellular Carcinoma
    Hindawi Limited ; 2022
    In:  Emergency Medicine International Vol. 2022 ( 2022-9-27), p. 1-5
    Details
    In: Emergency Medicine International, Hindawi Limited, Vol. 2022 ( 2022-9-27), p. 1-5
    Abstract: Objectives. To investigate the effects of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) on liver function and immune function in patients with hepatocellular carcinoma (HCC). Methods. From December 2016 to January 2019, patients with primary liver cancer who could not be operated on were selected as the study subjects. 170 patients were randomly divided into two groups. The control group was treated with transcatheter arterial chemoembolization (n = 85). The patients in the observation group were treated with transcatheter arterial chemoembolization combined with radiofrequency ablation (n = 85). The clinical effects of the two groups were analyzed. The changes of liver function and immune function were detected by automatic biochemical analyzer before and after treatment. The changes of hypoxia inducible factor-1 (HIF1) alpha and vascular endothelial growth factor (VEGF) levels before and after treatment were analyzed by enzyme-linked immunosorbent assay (ELISA). Results. The total effective rate in the observation group was significantly higher than that in the control group ( P 〈 0.05 ). After treatment, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), CD8+, HIF1 alpha, and VEGF decreased significantly ( P 〈 0.05 ), while levels of total bilirubin, direct bilirubin, indirect bilirubin, CD3+, CD4+, and CD4+/CD8+ increased significantly ( P 〈 0.05 ). The changes of the above indexes in the observation group were more significant than those in the control group ( P 〈 0.05 ). Conclusion. Hepatic arterial chemoembolization combined with radiofrequency ablation has a significant effect on liver function and immune function in patients with liver cancer, which may be related to the abnormal levels of HIF1α and vascular endothelial growth factor.
    Type of Medium: Online Resource
    ISSN: 2090-2859 , 2090-2840
    URL: Article
    DOI: 10.1155/2022/4842370
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2596429-X
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  • 3
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    Online Resource
    IL-21 Modulates Release of Proinflammatory Cytokines in LPS-Stimulated Macrophages through Distinct Signaling Pathways
    Hindawi Limited ; 2013
    In:  Mediators of Inflammation Vol. 2013 ( 2013), p. 1-12
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2013 ( 2013), p. 1-12
    Abstract: The aim of this study was to investigate the anti-inflammatory effect of IL-21 on LPS-induced mouse peritoneal macrophages. The results showed that IL-21 significantly inhibited LPS-induced mRNA expression of IL-1 β , TNF- α , and IL-6 in macrophages, but not of IFN- γ , IL-10, CCL5, or CXCL2. ELISA analysis showed that IL-21 also suppressed LPS-induced production of TNF- α and IL-6 in culture supernatants. Western blot analysis showed that IL-21 clearly inhibited ERK and I κ B α phosphorylation and NF- κ B translocation in LPS-stimulated macrophages, but it increased STAT3 phosphorylation. Flow cytometric and Western blot analysis showed that IL-21 decreased M1 macrophages surface markers expression of CD86, iNOS, and TLR4 in LPS-stimulated cells. All results suggested that IL-21 decreases IL-6 and TNF- α production via inhibiting the phosphorylation of ERK and translocation of NF- κ B and promotes a shift from the M1 to M2 macrophage phenotype by decreasing the expression of CD86, iNOS, and TLR4 and by increasing STAT3 phosphorylation in LPS-stimulated cells.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2013/548073
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2008065-7
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  • 4
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    Online Resource
    Experimental Study on Immersion Effects of Pressure Water on the Tensile Characteristics of Sandstone Samples
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-2-1), p. 1-11
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-2-1), p. 1-11
    Abstract: In this study, Brazilian splitting tests were conducted on sandstone samples subjected to drying and immersing at water pressures of 0, 1, and 3 MPa (immersion duration of 120 h). Investigation of the immersion effects of pressure water on the tensile characteristics of the samples revealed that their tensile strengths decreased with the immersion water pressure. Relative to a sandstone sample subjected to drying alone, immersing at water pressures of 0, 1, and 3 MPa reduced the tensile strength by 12.96%, 19.03%, and 30.16%, respectively. Although the immersed samples experienced splitting failure indicative of obvious brittle failure characteristics, decreases in the postpeak stress reduction rate with immersion water pressure revealed that the intensity of brittle failure weakened with pressure. Based on the obtained data, the deformation evolution process of the sandstone samples could be divided into five stages: deformation adjustment, formation of local deformation zones, local deformation zone propagation, failure surface formation, and sample failure. The water pressure aggravated the physicochemical reactions between water and the hydrophilic minerals in the sandstone, promoting argillisation, dissolution, and loss of hydrophilic minerals and interparticle cementitious materials. As a result of these immersion micromechanisms, the deterioration of the sandstone samples increased with the immersion water pressure, with the average porosities of the fracture surfaces at 0, 1, and 3 MPa increasing by 142.86%, 368.37%, and 593.88%, respectively, relative to the dried sample. As a result of these morphological changes, the sandstone samples subjected to water pressure immersion failed at small axial stresses with low levels of applied mechanical energy.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/6694881
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 5
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    Mechanical Properties of Different Lithological Rocks: A Case Study of the Coal Measure Strata in the Eastern Margin of Ordos Basin, China
    Hindawi Limited ; 2022
    In:  Geofluids Vol. 2022 ( 2022-7-20), p. 1-11
    Details
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-7-20), p. 1-11
    Abstract: In this paper, the mechanical behaviors of different lithological rocks of coal measure strata from Shanxi Formation in the eastern margin of the Ordos Basin, China, were investigated through uniaxial compression tests, and the deformation characteristics and failure modes of different lithological rocks were investigated. On this basis, the energy evolution of different lithology rocks was also discussed. The results show that there are obvious differences in the mechanical properties of different lithology rocks in coal measure strata, resulting in different wellbore instability prevention measures and fracturing measures in different lithology strata. Under the uniaxial compression condition, the peak strain of different lithological rocks is obviously different, and the denaturation characteristics are also obviously different, and the failure modes of rocks are mainly the tensile fracture mode, suggesting that the rock samples have strong brittle characteristics. With the increase of the strain, the total energy of different lithological rocks of the coal measure strata increases, and the elastic energy first increases and then decreases rapidly, whereas the dissipated energy first increases slowly and then increases rapidly. Each energy at the peak point is different, and the average total energy of shale, silty shale, siltstone, fine sandstone, and coal is 0.022 J/cm3, 0.045 J/cm3, 0.052 J/cm3, 0.042 J/cm3, and 0.003 J/cm3, respectively, indicating that there are obvious differences in the energy evolution laws of the different lithological rocks.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2022/1356735
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 6
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    The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-5-6), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-5-6), p. 1-11
    Abstract: Background. A disintegrin and metalloproteinase 17 (ADAM17) is a transmembrane protein that is widely expressed in various tissues; it mediates the shedding of many membrane-bound molecules, involving cell-cell and cell-matrix interactions. We investigated the role of ADAM17 within mouse cardiac fibroblasts (mCFs) in heart fibrosis. Methods. mCFs were isolated from the hearts of neonatal mice. Effects of ADAM17 on the differentiation of mCFs towards myofibroblasts and their fibrotic behaviors following induction with TGF-β1 were examined. The expression levels of fibrotic proteins, such as collagen I and α-SMA, were assessed by qRT-PCR analysis and western blotting. Cell proliferation and migration were measured using the CCK-8 and wound healing assay. To identify the target gene for ADAM17, the protein levels of the components of endoplasmic reticulum (ER) stress and the PINK1/Parkin pathway were assessed following ADAM17 silencing. The effects of ADAM17 silencing or treatment with thapsigargin, a key stimulator of acute ER stress, on mCFs proliferation, migration, and collagen secretion were also examined. In vivo, we used a mouse model of cardiac fibrosis established by left anterior descending artery ligation; the mice were administered oral gavage with a selective ADAM17 inhibitor (TMI-005) for 4 weeks after the operation. Results. We found that the ADAM17 expression levels were higher in fibrosis heart tissues and TGF-β1-treated mCFs. The ADAM17-specific siRNAs decreased TGF-β1-induced increase in the collagen secretion, proliferation, and migration of mCFs. Knockdown of ADAM17 reduces the activation of mCFs by inhibiting the ATF6 branch of ER stress and further activating mitophagy. Moreover, decreased ADAM17 expression also ameliorated cardiac fibrosis and improved heart function. Conclusions. This study highlights that mCF ADAM17 expression plays a key role in cardiac fibrosis by regulating ER stress and mitophagy, thereby limiting fibrosis and improving heart function. Therefore, ADAM17 downregulation, within the physiological range, could exert protective effects against cardiac fibrosis.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/5572088
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 7
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    Feature Extraction for Evaluating the Complexity of Electromagnetic Environment Based on Adaptive Multiscale Morphological Gradient and Nonnegative Matrix Factorization
    Hindawi Limited ; 2022
    In:  Journal of Electrical and Computer Engineering Vol. 2022 ( 2022-8-8), p. 1-12
    Details
    In: Journal of Electrical and Computer Engineering, Hindawi Limited, Vol. 2022 ( 2022-8-8), p. 1-12
    Abstract: In the current battlefield space, with the massive application of electromagnetic equipment, the electromagnetic environment in the battlefield space tends to be complex, which can lead to the electromagnetic equipment and personnel in the battlefield space receiving interference from the electromagnetic environment signal. To protect the safety of personnel and equipment quality, it is necessary to evaluate the complexity of the electromagnetic environment signal research, to use the corresponding measures. However, there is still little research related to the evaluation of the complexity of electromagnetic environmental signals. In this paper, a feature extraction method for electromagnetic environmental signals based on adaptive multiscale morphological gradient filtering and a nonnegative matrix factorization algorithm is proposed. First, the electromagnetic environment signal is filtered by AMMG, and then the filtered signal is processed by NMF for feature extraction. Finally, the complex electromagnetic environment signals after feature extraction are evaluated and classified by the SVM method. The results show that the evaluation results have good classification accuracy, and this paper provides an effective feature extraction method for the complexity of electromagnetic environment signals.
    Type of Medium: Online Resource
    ISSN: 2090-0155 , 2090-0147
    URL: Article
    DOI: 10.1155/2022/4891411
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2582829-0
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  • 8
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    Involvement of Cancer Stem Cells in Chemoresistant Relapse of Epithelial Ovarian Cancer Identified by Transcriptome Analysis
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-3-31), p. 1-16
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-3-31), p. 1-16
    Abstract: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. Despite the initial resection and chemotherapeutic treatment, relapse is common, which leads to poor survival rates in patients. A primary cause of recurrence is the persistence of ovarian cancer stem cells (OCSCs) with high tumorigenicity and chemoresistance. To achieve a better therapeutic response in EOC relapse, the mechanisms underlying acquired chemoresistance associated with relapse-initiating OCSCs need to be studied. Transcriptomes of both chemosensitive primary and chemoresistant relapse EOC samples were obtained from ICGC OV-AU dataset for differential expression analysis. The upregulated genes were further studied using KEGG and GO analysis. Significantly increased expression of eighteen CSC-related genes was found in chemoresistant relapse EOC groups. Upregulation of the expression in four hub genes including WNT3A, SMAD3, KLF4, and PAX6 was verified in chemoresistant relapse samples via immunohistochemistry staining, which confirmed the existence and enrichment of OCSCs in chemoresistant relapse EOC. KEGG and GO enrichment analysis in microarray expression datasets of isolated OCSCs indicated that quiescent state, increased ability of drug efflux, and enhanced response to DNA damage may have caused the chemoresistance in relapse EOC patients. These findings demonstrated a correlation between OCSCs and acquired chemoresistance and illustrated potential underlying mechanisms of OCSC-initiated relapse in EOC patients. Meanwhile, the differentially expressed genes in OCSCs may serve as novel preventive or therapeutic targets against EOC recurrence in the future.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/6406122
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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  • 9
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    Numerical Simulation Study on Lateral Displacement of Pile Foundation and Construction Process under Stacking Loads
    Hindawi Limited ; 2018
    In:  Complexity Vol. 2018 ( 2018), p. 1-17
    Details
    In: Complexity, Hindawi Limited, Vol. 2018 ( 2018), p. 1-17
    Abstract: Lateral displacement of pile foundation is crucial to the safety of an overall structure. In this study, a numerical simulation on the lateral displacement of pile foundation under stacking loads was conducted to determine its relation with different influencing factors. Simulation results demonstrated that stacking loads at the pile side mostly influence the lateral displacement of pile foundation. The lateral displacement of pile foundation increases by one order of magnitude when the stacking loads increase from 100 kPa to 300 kPa. Other influencing factors are less important than stacking loads. Lateral displacements of the pile body and at the pile top can be reduced effectively by increasing the deformation modulus of surface soil mass, reducing the thickness of soft soil, and expanding pile diameter. Our analysis indicates that a nonlinear relationship exists between the lateral displacement at the pile top and the pile diameter. The lateral resistance of the pile body can be enhanced by coupling the stacking load along piles and the axial force at the pile top. An actual large-scale engineering project was chosen to simulate the effects of postconstructed embankment on lateral displacement and axial force of bridge pile foundation under different construction conditions and to obtain the lateral displacement of the pile body and the negative frictional resistance caused by soft soil compression under stacking loads. On the basis of the calculated results, engineering safety and stability were evaluated, and a guide for the design and construction was proposed.
    Type of Medium: Online Resource
    ISSN: 1076-2787 , 1099-0526
    URL: Article
    DOI: 10.1155/2018/2128383
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 10
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    A miniaturized three‐dimensional log periodic Koch‐dipole array antenna using T‐shaped top loading
    Hindawi Limited ; 2021
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 31, No. 7 ( 2021-07)
    Details
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 31, No. 7 ( 2021-07)
    Type of Medium: Online Resource
    ISSN: 1096-4290 , 1099-047X
    URL: Issue
    URL: Article
    DOI: 10.1002/mmce.v31.7
    DOI: 10.1002/mmce.22678
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2007326-4
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