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  • Hindawi Limited  (7)
  • 1
    Online Resource
    Online Resource
    Initial Clinical Experience with the Biodegradable AbsnowTM Device for Percutaneous Closure of Atrial Septal Defect: A 3-Year Follow-Up
    Hindawi Limited ; 2021
    In:  Journal of Interventional Cardiology Vol. 2021 ( 2021-7-30), p. 1-10
    Details
    In: Journal of Interventional Cardiology, Hindawi Limited, Vol. 2021 ( 2021-7-30), p. 1-10
    Abstract: Objective. We reported the 3-year follow-up results of initial clinical experience with the AbsnowTM device, a novel biodegradable occluder for percutaneous closure of atrial septal defect (ASD). Background. The AbsnowTM device is a total biodegradable septal occluder with double-disc poly-L-lactic acid (PLLA) framework and PLLA membranes intergraded into the device to ensure its biodegradability, clinical safety, and efficacy. Methods. Five pediatric patients were enrolled from May to June 2018 in our institution and were followed up for 3 years. A clinical evaluation and transthoracic echocardiography were performed at 24 hr, 1 month, 3 months, 6 months, 12 months, and yearly after implantation. Primary endpoints were a composite clinical success, comprising of clinical closure success and safety at the 36-month follow-up evaluation. Secondary endpoints included technical success, procedure success, closure success, and safety at each of the follow-up visits. Results. The median subject age was 3.6 years (range 3.1–6.5 years). The mean ASD diameter was (13.7 ± 2.9) mm. The median device size was 20 mm (range 14 to 24 mm). Technical and procedure success was achieved in 100% (5/5) of the patients. At 2-year follow-up, 3 of the 5 patients developed new-onset residual shunts and 2 of them reached a moderate degree. At 3-year follow-up, the residual shunt size increased over time in all the 3 patients, and 1 of them had right ventricular enlargement. All of the 5 patients were free from serious adverse events during the 3-year follow-up, with no device embolization, thromboembolization, or reintervention to the target defect. Conclusion. This 3-year follow-up result of initial experience with the biodegradable AbsnowTM device has demonstrated acceptable safety with no procedural complications. Notably, the high rate of residual shunt significantly affected its efficacy. The long-term safety and efficacy of the device should be further evaluated in a large cohort of patients in future studies.
    Type of Medium: Online Resource
    ISSN: 1540-8183 , 0896-4327
    URL: Article
    DOI: 10.1155/2021/6369493
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2103585-4
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  • 2
    Online Resource
    Online Resource
    A Survey on HIV/AIDS-Related Knowledge, Attitudes, Risk Behaviors, and Characteristics of Men Who Have Sex with Men among University Students in Guangxi, China
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-06-15), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-06-15), p. 1-10
    Abstract: In recent years, the prevalence of human immunodeficiency virus (HIV) infection among Chinese university students has increased significantly, and HIV transmission among men who have sex with men (MSM) comprises more than half of the new cases. There is still a lack of research investigating the incidence of male-to-male sex, the attitudes towards MSM, and the awareness of HIV/AIDS among university students in Guangxi, one of the HIV high-risk areas in China. Therefore, we performed a cross-sectional investigation among 578 male students, recruited by stratified sampling, in universities in Nanning, Guangxi, between January 2016 and March 2017. Researcher-administered anonymous questionnaires were completed. Self-recognition as MSM was found in 8.48% of the subjects. Compared with non-MSM, university student MSM included more people over the age of 20 ( OR = 4.95 ), had less migration from other districts of Guangxi ( OR = 0.26 ), and the majority were nonmedical students ( OR = 8.99 ). In total, 63.25% of the male student participants reported a lack of acceptance of MSM, while 35.47% acknowledged barriers between themselves and acquaintances who were MSM. Overall, 67.30% of the subjects correctly answered questions related to AIDS knowledge. The proportion of MSM subjects who answered the AIDS-related questions completely correctly was significantly lower than that of non-MSM subjects (42.86% vs. 69. 57%, respectively, OR: 0.33), but the self-recognition risk of MSM was significantly higher than that of non-MSM ( OR = 2.59 ). Risky behaviors associated with HIV infections, including smoking, alcohol consumption, drug abuse, and inconsistent condom use, were significantly higher among the MSM participants. The percentages of student’s willingness to accept MC and PrEP were 70.93% and 77.51%, respectively. These results raise the alarm that university student MSM in Guangxi, China, require urgent public attention and more effective health education, including the education on MC and PrEP.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/7857231
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 3
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    Online Resource
    Research on Seepage Characteristics of Y-Shaped Fractures under Different Fracture Roughness
    Hindawi Limited ; 2022
    In:  Geofluids Vol. 2022 ( 2022-4-1), p. 1-16
    Details
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-4-1), p. 1-16
    Abstract: Fractures are widely distributed in coal, and studying the seepage characteristics of fluids in fractures is of great significance for unconventional natural gas extraction and prevention of gas disasters. In this work, based on the W-M fractal function, a Y-shaped fracture model with different roughness is established. The seepage characteristics of Y-shaped fracture with different roughness are interpreted from two perspectives. Firstly, the seepage law of the Y-shaped fracture with the same roughness is studied. Secondly, the fluid competitive diversion capacity caused by the difference of branch fracture roughness is discussed. The results show that the fracture roughness is an important factor affecting the seepage characteristics of the fracture. When the roughness of the fracture is identical, the outlet flow rate, velocity, and Re are all positively correlated with pressure, and the flow regime is unchanged. The increase in the fracture roughness will lead to a significant flow rate and momentum loss, resulting in maximum loss up to 45.44%, besides, enhance the flow resistance of the fracture, Re increasing by 771, 713, 489, and 355, respectively, at four patterns. And there is a threshold DM between 1.1 and 1.2 so that the major influencing factor on hydraulic conductivity changes. In addition, the roughness difference between the branch fractures of the Y-shaped fracture is the key factor to control the fluid competitive diversion capacity. The larger the roughness difference, the greater difference in flow velocity, and the more significant change in flow rate proportion, which proportion differs by 4%, 44%, and 54%, respectively, and the stronger smooth branch fracture competitive diversion capacity, and the lower the rough branch fracture hydraulic conductivity. As the inlet pressure increases, the two branch fractures Re gradually increases but Eu decreases, which Eu in smooth branch fracture is smaller is 15, 19, 20, and 21 smaller than that of rough branch, respectively, and the rough branch fracture competitive diversion capacity is weakened. Both roughness difference and inlet pressure will affect the competitive diversion capacity of the Y-shaped fracture. These results are expected to provide new insights for the exploitation of underground fluid resources.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2022/7521955
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 4
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    Online Resource
    Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research
    Hindawi Limited ; 2021
    In:  International Journal of Endocrinology Vol. 2021 ( 2021-5-29), p. 1-7
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2021 ( 2021-5-29), p. 1-7
    Abstract: Objective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population. Methods. Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured. Results. Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p 〈 0.05 ). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p 〈 0.05 ). Conclusions. These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    URL: Article
    DOI: 10.1155/2021/6663553
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2502951-4
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  • 5
    Online Resource
    Online Resource
    Preoperative Predictors of Prolonged Hospital Stay in Accelerated Rehabilitation for Patients Undergoing Orthopedic Surgery
    Hindawi Limited ; 2021
    In:  Bioinorganic Chemistry and Applications Vol. 2021 ( 2021-11-19), p. 1-9
    Details
    In: Bioinorganic Chemistry and Applications, Hindawi Limited, Vol. 2021 ( 2021-11-19), p. 1-9
    Abstract: In this study, we performed a retrospective and prospective study of preoperative predictors of the length of stay (LOS) in three groups of surgical patients and conducted a clinical retrospective study of the current research status of preoperative predictors of LOS prolongation in three groups of patients under ERAS (enhanced recovery after surgery) mode, such as patient characteristics and comorbidities. Information such as patients’ exercise preferences, exercise time, frequency and duration, footwear, location of knee osteoarthritis, whether there is a past history of knee injury, and smoking and drinking history was collected, and the research data of 312 patients undergoing the three operations were analyzed by SPSS. Meniscal injury-knee arthroscopy sample included a total of 104 people. Surgical sample for anterior cruciate ligament reconstruction included a total of 100 subjects. Knee osteoarthritis-knee replacement surgery sample included 148 people who were divided into two groups in a ratio of 1 : 1: one group used Mailuo Shutong pills during hospitalization (intervention group) and the other group did not (control group). The research conclusions are as follows. Meniscal Knee Arthroscopy. (1) Samples from different causes of injury showed significant differences for all injured sites. (2) Samples with different smoking and drinking histories all showed significant differences for the causes of injury. (3) Exercise hobby, exercise frequency, duration of each exercise and duration of exercise, and warm-up time before exercise all showed positive correlation. Anterior Cruciate Ligament Reconstruction Surgery. (4) Samples from different causes of injury showed significant differences for all the injured sites. (5) Age has a significant negative influence on the wearing of shoes at ordinary times. (6) Exercise hobby: the warm-up time before exercise had a significant negative influence on the injured area. (7) Two groups of analysis items of exercise frequency, exercise duration and exercise duration, preexercise warm-up time, and exercise hobby were typically positively correlated. Total Knee Arthroplasty. (8) There was a significant difference of 0.01 between the hospitalization days of the intervention group and the control group ( p 〈 0.01 ), and the hospitalization days of the intervention group were significantly lower than those of the control group. These results indicated that Mailuo Shutong pills were of great significance for the treatment of orthopedic patients during the operation period in that it could effectively shorten the hospital stay of all orthopedic patients and strengthen the accelerated rehabilitation. (9) There was a significant positive correlation between the history of knee joint surgery and the use time of Mailuo Shutong pills. (10) There was a markable positive correlation between occupation and sports hobbies, sports time, frequency and duration, and footwear. There was a significant negative correlation between occupation and preexercise warm-up. (11) Exercise time, frequency, and duration have significant positive influence on BMI.
    Type of Medium: Online Resource
    ISSN: 1687-479X , 1565-3633
    URL: Article
    DOI: 10.1155/2021/7832216
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2213020-2
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  • 6
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    Online Resource
    Evaluating the viscoelastic properties of soy protein isolate by creep–recovery behavior
    Hindawi Limited ; 2019
    In:  Journal of Food Processing and Preservation Vol. 43, No. 11 ( 2019-11)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 43, No. 11 ( 2019-11)
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v43.11
    DOI: 10.1111/jfpp.14185
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2175273-4
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  • 7
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    A Combination of UTMD-Mediated HIF-1 α shRNA Transfection and TAE in the Treatment of Hepatic Cancer
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-02-19), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-02-19), p. 1-8
    Abstract: To explore the antitumor effect of hypoxia-inducible factor-1 α short hairpin RNA (HIF-1 α shRNA) delivered by ultrasound targeted microbubble destruction (UTMD) and transcatheter arterial embolization (TAE) on rats with hepatic cancer. After the models of transplantation hepatoma were established, Wistar rats were randomly divided into 4 groups: Control group, UTMD group, TAE group, and UTMD+TAE group. Contrast-enhanced ultrasound (CEUS) was used to monitor tumor size on day 14 after four different treatments. Western blotting and immunohistochemistry were applied to measure the protein level of HIF-1 α and VEGF in the hepatic cancer tissue. In comparison with UTMD+TAE group (21.25±10.68 days), the mean survival time was noticeably shorter in the Control group and TAE group (13.02±4.30 days and 15.03±7.32 days) (p 〈 0.05, respectively). There was no statistical difference between UTMD+TAE group and UTMD group of the mean survival time (p 〉 0.05). In addition, our results proved that the tumor sizes in UTMD+TAE group were obviously smaller than those in other groups (p 〈 0.05, respectively). By CEUS, we clearly found that the tumor size was the smallest on day 14 in the UTMD+TAE group. The western blotting and immunohistochemistry results proved that the protein levels of HIF-1 α and VEGF in UTMD+TAE group were obviously lower than those in TAE group and Control group on days 7 and 14 (p 〈 0.05, respectively). However, there was no statistical difference between UTMD+TAE group and UTMD group (p 〉 0.05). In this study we tried to explore the antitumor effect through a combination of UTMD-mediated HIF-1 α shRNA transfection and TAE on rats with hepatic cancer. Our results showed that UTMD-mediated HIF-1 α shRNA transfection and TAE can obviously silence HIF-1 α and VEGF expression, thereby successfully inhibiting the growth of the tumor.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/1937460
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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