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  • 1
    Online Resource
    Online Resource
    A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Abstract: Sepsis is a global major health problem in great need for more effective therapy. For thousands of years, Rhubarb had been used for various diseases including severe infection. Pharmacological studies and trials reported that Rhubarb may be effective in treating sepsis, but the efficacy and the quality of evidence remain unclear since there is no systematic review on Rhubarb for sepsis. The present study is the first systematic review of Rhubarb used for the treatment of experimental sepsis in both English and Chinese literatures by identifying 27 studies from 7 databases. It showed that Rhubarb might be effective in reducing injuries in gastrointestinal tract, lung, and liver induced by sepsis, and its potential mechanisms might include reducing oxidative stress and inflammation, ameliorating microcirculatory disturbance, and maintaining immune balance. Yet the positive findings should be interpreted with caution due to poor methodological quality. In a word, Rhubarb might be a promising candidate that is worth further clinical and experimental trials for sepsis therapy.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/131283
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-12-28), p. 1-22
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-12-28), p. 1-22
    Abstract: Objective . Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease whose treatment strategies remain unsatisfactory. This study aims to investigate the mechanisms of Quyushengxin formula acting on UC based on network pharmacology. Methods . Ingredients of the main herbs in Quyushengxin formula were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Absorption, distribution, metabolism, and excretion properties of all ingredients were evaluated for screening out candidate bioactive compounds in Quyushengxin formula. Weighted ensemble similarity algorithm was applied for predicting direct targets of bioactive ingredients. Functional enrichment analyses were performed for the targets. In addition, compound-target network, target-disease network, and target-pathway network were established via Cytoscape 3.6.0 software. Results . A total of 41 bioactive compounds in Quyushengxin formula were selected out from the TCMSP database. These bioactive compounds were predicted to target 94 potential proteins by weighted ensemble similarity algorithm. Functional analysis suggested these targets were closely related with inflammatory- and immune-related biological progresses. Furthermore, the results of compound-target network, target-disease network, and target-pathway network indicated that the therapeutic effects of Quyushengxin on UC may be achieved through the synergistic and additive effects. Conclusion . Quyushengxin may act on immune and inflammation-related targets to suppress UC progression in a synergistic and additive manner.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/7870424
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 3
    Online Resource
    Online Resource
    A New Precursor Integral Method for Solving Space-Dependent Kinetic Equations in Neutronic and Thermal-Hydraulic Coupling System
    Hindawi Limited ; 2020
    In:  Science and Technology of Nuclear Installations Vol. 2020 ( 2020-11-2), p. 1-15
    Details
    In: Science and Technology of Nuclear Installations, Hindawi Limited, Vol. 2020 ( 2020-11-2), p. 1-15
    Abstract: The accurate prediction of the neutronic and thermal-hydraulic coupling system transient behavior is important in nuclear reactor safety analysis, where a large-scale nonlinear coupling system with strong stiffness should be solved efficiently. In order to reduce the stiffness and huge computational cost in the coupling system, the high-performance numerical techniques for solving delayed neutron precursor equation are a key issue. In this work, a new precursor integral method with an exponential approximation is proposed and compared with widely used Taylor approximation-based precursor integral methods. The truncation errors of exponential approximation and Taylor approximation are analyzed and compared. Moreover, a time control technique is put forward which is based on flux exponential approximation. The procedure is tested in a 2D neutron kinetic benchmark and a simplified high-temperature gas-cooled reactor-pebble bed module (HTR-PM) multiphysics problem utilizing the efficient Jacobian-free Newton–Krylov method. Results show that selecting appropriate flux approximation in the precursor integral method can improve the efficiency and precision compared with the traditional method. The computation time is reduced to one-ninth in the HTR-PM model under the same accuracy when applying the exponential integral method with the time adaptive technique.
    Type of Medium: Online Resource
    ISSN: 1687-6083 , 1687-6075
    URL: Article
    DOI: 10.1155/2020/8265146
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2397941-0
    SSG: 3,6
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  • 4
    Online Resource
    Online Resource
    An Improved Scheme of Frequency-Dependent AVO Inversion Method and Its Application for Tight Gas Reservoirs
    Hindawi Limited ; 2019
    In:  Geofluids Vol. 2019 ( 2019-02-03), p. 1-12
    Details
    In: Geofluids, Hindawi Limited, Vol. 2019 ( 2019-02-03), p. 1-12
    Abstract: AVO inversion is a seismic exploration methodology used to predict the earth’s elastic parameters and thus rocks and fluid properties. It is built up on elastic theory and does not consider the seismic dispersion in real strata. Recent experiments and theory of rock physics have shown that in hydrocarbon-bearing rocks, especially in gas-bearing ones, the change of seismic velocity with frequency may be pretty remarkable for fluid flow in pore space. Some scholars proposed methods about seismic dispersion, such as frequency-dependent AVO inversion, to forecast oil and gas reservoirs underground. In this paper, we demonstrate an improved scheme of frequency-dependent AVO inversion, which is based on conventional Smith-Gidlow’s AVO equation, to extract seismic dispersion and predict the hydrocarbon underground. A simple model with gas-bearing reservoir is devised to validate the inversion scheme, and further analysis indicates that our scheme is more accurate and reasonable than the previous scheme. Our new scheme applied to the tight gas reservoirs in Fenggu area of western Sichuan depression of China finds that regions with high dispersion gradients correlate well with regions with prolific gas. Analysis and case studies show that our scheme of frequency-dependent AVO inversion is an efficient approach to predict gas reservoirs underground.
    Type of Medium: Online Resource
    ISSN: 1468-8115 , 1468-8123
    URL: Article
    DOI: 10.1155/2019/3525818
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 5
    Online Resource
    Online Resource
    A Pan-Cancer Analysis of the Oncogenic Roles of RAD51 in Human Tumors
    Hindawi Limited ; 2022
    In:  Advanced Gut & Microbiome Research Vol. 2022 ( 2022-9-17), p. 1-28
    Details
    In: Advanced Gut & Microbiome Research, Hindawi Limited, Vol. 2022 ( 2022-9-17), p. 1-28
    Abstract: Objective. RAD51 homolog 1 (RAD51) plays significant roles in DNA damage repair and apoptosis. These pathways are tightly associated with tumor initiation and progression. To unravel the roles of RAD51 in oncogenesis and progression of different cancers, herein, a comprehensive analysis of the RAD51 was carried out using multiomics datasets of 33 cancers. Methods. Raw data were obtained from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. We analyzed the correlation between RAD51 expression and drug response using datasets from CellMiner. Next, clinical characteristics and prognostic values of RAD51 were conducted based on TCGA data. The correlation between RAD51 expression and tumor immune infiltration was explored. This was followed by gene set enrichment analysis by Rsoftware. In addition, pan-cancer analysis was conducted to investigate genetic and epigenetic alterations, respectively. Results. RAD51 was upregulated in most tumors, and this was associated with poor overall survival (OS), progression-free survival (PFS), and disease-specific survival (DSS). The expression level of RAD51 is significantly associated with the IC50 of multiple antitumor drugs and the proportion of stromal and immune components in tumor microenvironment (TME). Moreover, RAD51 expression showed a positive relationship with multiple key immune checkpoint and immunosuppressive genes, including death-ligand 1 (PD-L1), cytotoxic T-lymphocyte associated protein 4 (CTLA-4), CD28, and several TNF-related immune genes. Gene set enrichment analysis uncovered that RAD51 correlated with cell cycle, cell division, and immune system pathways in diverse cancers. Our results revealed a strong link between RAD51 expression and microsatellite instability (MSI) or tumor mutation burden (TMB). Conclusions. Our pan-cancer analysis provides a comprehensive overview of the roles of RAD51 in multiple human cancers and infers that RAD51 has the potential as a biomarker for progression and immune infiltration of different tumor types.
    Type of Medium: Online Resource
    ISSN: 2755-1652
    URL: Article
    DOI: 10.1155/2022/1591377
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 3147471-8
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  • 6
    Online Resource
    Online Resource
    A broadband reconfigurable antenna with parasitic water radiation Array
    Hindawi Limited ; 2021
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 31, No. 10 ( 2021-10)
    Details
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 31, No. 10 ( 2021-10)
    Type of Medium: Online Resource
    ISSN: 1096-4290 , 1099-047X
    URL: Issue
    URL: Article
    DOI: 10.1002/mmce.v31.10
    DOI: 10.1002/mmce.22824
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2007326-4
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  • 7
    Online Resource
    Online Resource
    The analysis ofBRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives
    Hindawi Limited ; 2003
    In:  Human Mutation Vol. 22, No. 1 ( 2003-07), p. 104-104
    Details
    In: Human Mutation, Hindawi Limited, Vol. 22, No. 1 ( 2003-07), p. 104-104
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/humu.v22:1
    DOI: 10.1002/(ISSN)1098-1004
    DOI: 10.1002/humu.9156
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2003
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection
    Hindawi Limited ; 2018
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2018 ( 2018-10-02), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2018 ( 2018-10-02), p. 1-9
    Abstract: The aim of this study is to investigate traditional Chinese medicine syndrome (TCMS) patterns and their association with hepatitis B surface antigen (HBsAg) levels during the natural history of chronic hepatitis B virus infection (CHB). Patients were categorized according to the phase of CHB, as follows: immune tolerance (ITP); immune clearance (ICP); low or nonreplication (LRP); reactivation (RAP); hepatic cirrhosis (HC); and primary liver cancer (PLC). TCMS patterns were classified among the following types: spleen-kidney deficiency (SKD); liver-qi depression (LQD); damp-heat in liver-gallbladder (LGDH); liver-kidney deficiency (LKD); and blood stasis blocking collateral (BSBC). HBsAg levels and other serological indicators were quantified for all patients and their association with TCMS was statistically analyzed and determined. Two hundred and eighty-nine patients with CHB were included. During the natural history of CHB, TCMS patterns were statistically different among the different phases ( P 〈 0.001). The most frequently occurring syndromes among the six progressive phases were SKD, LGDH, LKD, LGDH, BSBC, and LGDH, respectively. The predominant patterns in the inactive stage (ITP + LRP), active stage (ICP + RAP), and late or advanced stage (HC + PLC) were SKD (31%), LGDH (51.8%) and BSBC (34.4%), respectively. Median HBsAg levels were also statistically different among the five patterns of TCMS ( P 〈 0.001). The highest HBsAg levels were observed in SKD (4.48 log 10 IU/mL). Medium levels were in LQD (3.91 log 10 IU/mL) and LGDH (3.90 log 10 IU/mL). The lowest HBsAg levels were in LKD (3.60 log 10 IU/mL) and the second lowest levels in BSBC (3.81 log 10 IU/mL). In addition, HBsAg levels in LKD and BSBC were significantly lower than those in SKD, LQD, and LGDH ( P 〈 0.05 or 0.001). TCMS was altered during the natural history of CHB and correlated with HBsAg titers. This study could provide further insight into the therapy of CHB.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2018/7482593
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2148302-4
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  • 9
    Online Resource
    Online Resource
    Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-05-12), p. 1-13
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-05-12), p. 1-13
    Abstract: Background . Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon and the rectum. Recently, some studies have shown that microorganisms in the gut play important roles in many chronic diseases such as UC. Methods . To study the candidate viruses and bacteria involved in UC and to investigate the therapeutic mechanism of Quyushengxin formula (QYSX) in UC patients, metagenomic sequencing was performed on the feces from healthy donors and UC patients before and after QYSX treatment. Results . QYSX improved the symptoms of UC. In all participants, Caudovirales and Herpesvirales were the most dominant viruses. The abundance of Caudovirales in UC patients was significantly higher than that in the normal controls, while QYSX restored Caudovirales abundance. Furthermore, the abundance of crAssphage was enhanced in UC patients compared with the normal control, while the diversity was then decreased after QYSX treatment. However, there was no significant difference ( P 〉 0.05 ). Additionally, other non- crAssphage bacteriophages including phiST , SP-10 , and phi17:2 were higher in UC patients and QYSX decreased these viruses, while the trends of MED4−213 , P-HM1 , and P−HM2 were adverse. Interestingly, PhiDP23.1 was only found in UC patients before and after QYSX treatment. In addition, Bifidobacterium , Bacteroidetes , Prevotellaceae , Actinobacteria , and Corynebacteriales were the biomarkers in UC patients after QYSX treatment due to their high abundance. GO terms and KEGG analysis showed that the identified gut microbiome was involved in many biological processes and pathways. Conclusions . QYSX could regulate disordered gut microbiome and phages, indicating that QYSX has great therapeutic potential for UC.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/5859023
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 10
    Online Resource
    Online Resource
    Construction of Carbon Audit and Verification System Framework Based on Intelligent Wireless Sensor Network
    Hindawi Limited ; 2022
    In:  Mobile Information Systems Vol. 2022 ( 2022-3-7), p. 1-13
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2022 ( 2022-3-7), p. 1-13
    Abstract: With the large amount of carbon emissions from many enterprises over the years, the global greenhouse effect is getting worse. In order to protect the climate and environment on which we depend, the world is taking active measures to reduce carbon emissions as much as possible. At present, the domestic carbon auditing and verification system is relatively late and immature, and the traditional system efficiency is relatively low. Wireless sensor network (WSN) is a particularly flexible distributed wireless communication network, which can coordinate the perception, processing, transmission, and collection of data of objects perceived within the network until the data content is transmitted to the user terminal. This paper aims to study and design an intelligent network model based on WSN so as to calculate and verify the carbon emissions of enterprises and countries. In this paper, an intelligent WSN model based on ZigBee technology is proposed to build an efficient, low-consumption, and high-precision carbon audit and verification system framework. In this paper, the system framework is referred to as ZWCA for short, that is, the carbon audit and verification system framework of WSN based on ZigBee. In addition, this paper compares the ZWCA framework with the traditional carbon audit and verification system in several groups to analyze the practical feasibility and advantages of the ZWCA framework. The test results show that the ZWCA framework proposed in this paper can audit and verify the carbon emissions of major enterprises very well, and the initial startup power of the ZWCA framework is only 1/2 of the traditional one. At the same time, its actual running power consumption is only 3/4 of that of the traditional audit and verification system framework, and the calculation accuracy is as high as 99%. Moreover, the number of node deaths has decreased, and the system stability has been significantly improved.
    Type of Medium: Online Resource
    ISSN: 1875-905X , 1574-017X
    URL: Article
    DOI: 10.1155/2022/1973370
    RVK:
    QA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2187808-0
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