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  • Hindawi Limited  (136)
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  • Hindawi Limited  (136)
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  • 1
    Online-Ressource
    Online-Ressource
    Blood Glucose Fluctuations in Type 2 Diabetes Patients Treated with Multiple Daily Injections
    Hindawi Limited ; 2016
    In:  Journal of Diabetes Research Vol. 2016 ( 2016), p. 1-8
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Kurzfassung: To compare blood glucose fluctuations in type 2 diabetes mellitus (T2DM) patients were treated using three procedures: insulin intensive therapy which is continuous subcutaneous insulin infusion (CSII), MDI3 (three injections daily), and MDI4 (four injections daily). T2DM patients were hospitalized and were randomly assigned to CSII, aspart 30-based MDI3, and glargine based MDI4. Treatments were maintained for 2-3 weeks after the glycaemic target was reached. After completing the baseline assessment, 6-day continuous glucose monitoring (CGM) was performed before and after completion of insulin treatment. Treatment with CSII provided a greater improvement of blood glucose fluctuations than MDI (MDI3 or MDI4) therapy either in newly diagnosed or in long-standing T2DM patients. In long-standing diabetes patients, the MDI4 treatment group had significantly greater improvement of mean amplitude glycemic excursion (MAGE) than the MDI3 treatment group. However, in patients with newly diagnosed diabetes, there were no significant differences in the improvement of MAGE between MDI3 and MDI4 groups. Glargine based MDI4 therapy provided better glucose fluctuations than aspart 30-based MDI3 therapy, especially in long-standing T2DM patients, if CSII therapy was not available.
    Materialart: Online-Ressource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2016/1028945
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2711897-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Choroidal Vascularity Index Assessment: A Potential Noninvasive Technique for Diagnosing Diabetic Nephropathy
    Hindawi Limited ; 2022
    In:  Journal of Ophthalmology Vol. 2022 ( 2022-2-24), p. 1-8
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2022 ( 2022-2-24), p. 1-8
    Kurzfassung: Aims. This study aimed to compare the accuracy of the choroidal vascularity index (CVI) and diabetic retinopathy (DR) in the diagnosis of diabetic nephropathy (DN). Methods. We performed a cross-sectional study of 117 patients with proteinuria and diabetes mellitus (DM) in which 45 patients were diagnosed with DN by renal pathology. Demographic information, clinical features, and laboratory data were collected. A total of 234 eyes underwent evaluation of DR and the CVI using enhanced depth imaging-optical coherence tomography scans. We analyzed the association between the CVI and DN and compared the CVI and DR for diagnosing DN using area under receiver operating characteristic curves (AUROCs). Results. The severe nonproliferative DR and proliferative DR groups showed a lower CVI than the no DR and mild/moderate nonproliferative DR groups ( P 〈 0.01 or P 〈 0.001 ). There was a significantly lower CVI in patients with DN stage III (63.01% ± 1.47%) compared with those in DN stages IIa (62.1% ± 1.41%, P 〈 0.001 ) and IIb (59.85% ± 1.98%, P 〈 0.01 ). The sensitivity and specificity of the CVI for diagnosing DN were 84% (71%–94%) and 95% (88%–99%), respectively, which were preferable to those of DR. The AUROCs for the CVI and DR for diagnosing DN were 0.932 and 0.831, respectively. The CVI outperformed DR for diagnosing DN ( P 〈 0.05 ). The cutoff value of the CVI was 63.13%. Conclusion. The CVI might be a reliable noninvasive technique for predicting the pathological stage of DN and is superior to DR in diagnosing DN.
    Materialart: Online-Ressource
    ISSN: 2090-0058 , 2090-004X
    URL: Article
    DOI: 10.1155/2022/3124746
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2546525-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Revealing Potential Diagnostic Gene Biomarkers Associated with Immune Infiltration in Patients with Renal Fibrosis Based on Machine Learning Analysis
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-4-20), p. 1-20
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-4-20), p. 1-20
    Kurzfassung: Chronic kidney disease is characterized by the development of renal fibrosis. The basic mechanisms of renal fibrosis have not yet been fully investigated despite significant progress in understanding the etiology of the disease. In this work, the researchers sought to identify potential diagnostic indicators for renal fibrosis. From the GEO database, we were able to acquire two gene expression profiles with publically available data (GSE22459 and GSE76882, respectively) from human renal fibrosis and control samples. 215 renal fibrosis specimens and 124 normal specimens were examined for differentially expressed genes (DEGs). The SVM-RFE and LASSO regression models were used to discover potential markers. CIBERSORT was applied to estimate the combined cohorts’ immune cell fraction compositional trends in renal fibrosis. RT-PCR was used to examine the expression of ISG20 in renal fibrosis and healthy samples. In vitro experiments were applied to examine the function of ISG20 knockdown on the progression of renal fibrosis. In this study, we identified 24 DEGs. The result of LASSO and SVM-RFE identified nine critical genes. ROC assays confirmed the diagnostic value of the above nine genes for renal fibrosis. Immune cell infiltration analysis revealed that ISG20 and SERPINA3 were both found to be correlated with T cell follicular helper, neutrophils, T cell CD4 memory activated, eosinophils, T cell CD8, dendritic cell activated, B cell memory, monocytes, macrophage M2, plasma cells, T cell CD4 naïve, mast cell resting, B cell naïve, T cell regulatory, and NK cell activated. Finally, we observed that the expression of ISG20 and SERPINA3 was distinctly increased in renal fibrosis samples compared with normal samples. ISG20 siRNA significantly suppressed the progression of renal fibrosis in vitro. Overall, this study identified nine diagnostic biomarkers for renal fibrosis. ISG20 may be a novel therapeutic target of renal fibrosis.
    Materialart: Online-Ressource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/3027200
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2817541-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    The Effects of Lycopene on the Methylation of the GSTP1 Promoter and Global Methylation in Prostatic Cancer Cell Lines PC3 and LNCaP
    Hindawi Limited ; 2014
    In:  International Journal of Endocrinology Vol. 2014 ( 2014), p. 1-9
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-9
    Kurzfassung: DNA (cytosine-5-) methylation silencing of GSTP1 function occurs in prostate adenocarcinoma (PCa). Previous studies have shown that there is an inverse relationship between dietary lycopene intake and the risk of PCa. However, it is unknown whether lycopene reactivates the tumor suppressor gene glutathioneS-transferase- π (GSTP1) by demethylation of the hypermethylated CpGs that act to silence the GSTP1 promoter. Here, we demonstrated that lycopene treatment significantly decreased the methylation levels of the GSTP1 promoter and increased the mRNA and protein levels of GSTP1 in an androgen-independent PC-3 cell line. In contrast, lycopene treatment did not demethylate the GSTP1 promoter or increase GSTP1 expression in the androgen-dependent LNCaP cell line. DNA methyltransferase (DNMT) 3A protein levels were downregulated in PC-3 cells following lycopene treatment; however, DNMT1 and DNMT3B levels were unchanged. Furthermore, the long interspersed element (LINE-1) and short interspersed element ALU were not demethylated when treated by lycopene. In LNCaP cells, lycopene treatment did not affect any detected DNMT protein expression, and the methylation levels of LINE-1 and ALU were decreased. These results indicated that the protective effect of lycopene on the prostate is different between androgen-dependent and androgen-independent derived PCa cells. Further, in vivo studies should be conducted to confirm these promising results and to evaluate the potential role of lycopene in the protection of the prostate.
    Materialart: Online-Ressource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2014/620165
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2502951-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Interval Prediction of Photovoltaic Power Using Improved NARX Network and Density Peak Clustering Based on Kernel Mahalanobis Distance
    Hindawi Limited ; 2022
    In:  Complexity Vol. 2022 ( 2022-3-15), p. 1-22
    Details
    In: Complexity, Hindawi Limited, Vol. 2022 ( 2022-3-15), p. 1-22
    Kurzfassung: Photovoltaic (PV) power forecasting can provide strong support for the safe operation of the power system. Existing forecasting methods are ineffective for grid scheduling decisions or risk analysis. The novel multicluster interval prediction method is proposed to consider the volatility and randomness of PV power output. First, this method utilizes the sparse autoencoder (SAE) and Bayesian regularized NARX network (BRNARX) for point forecasting of PV power. Second, density peak clustering improved by kernel Mahalanobis distance (KMDDPC) is applied to classify the dataset into multiple clusters, including forecasting error and meteorological factors. Finally, the joint probability density is established by multivariate kernel density estimation (MKDE) to accomplish the PV power interval prediction. The proposed hybrid method is applied for the interval prediction of PV power at Yulara, Australia. Comparative research of point forecasting is implemented to evaluate the machine learning and deep learning methods, with the proposed SAE-BRNARX under four different periods. Results shows that the average values of nRMSE, MRE, nMAE, and R2 for the four periods are 4.45%, 0.90%, −0.15%, 3.39%, and 95.93%, respectively. Moreover, the results of interval prediction obtained by the other interval prediction approaches are compared with the proposed KMDDPC-MKDE. It shows that the average values of PICP, PINAW, ACE, and nMPICD for four periods are 93.93%, 9.50%, 3.93%, and 7.10% at 90% confidence level, respectively. Outcomes demonstrate that the proposed method can obtain more accuracy, a higher coverage rate, narrower average bandwidth, and a closer distance between the middle of interval and actual value than other methods.
    Materialart: Online-Ressource
    ISSN: 1099-0526 , 1076-2787
    URL: Article
    DOI: 10.1155/2022/8169510
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2004607-8
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Comparison of the Effects of TIPS versus BRTO on Bleeding Gastric Varices: A Meta-Analysis
    Hindawi Limited ; 2020
    In:  Canadian Journal of Gastroenterology and Hepatology Vol. 2020 ( 2020-02-11), p. 1-9
    Details
    In: Canadian Journal of Gastroenterology and Hepatology, Hindawi Limited, Vol. 2020 ( 2020-02-11), p. 1-9
    Kurzfassung: Background and Aim . Upper gastrointestinal bleeding is a threat to patients with gastric varices (GVs). Previous studies have concluded that both transjugular intrahepatic portosystemic shunt (TIPS) and balloon-occluded retrograde transvenous obliteration (BRTO) are effective treatments for patients with GV. We aimed to compare the efficiency and outcomes of these two procedures in GV patients through meta-analysis. Methods . The PubMed, Cochrane Library, EMBASE, and Web of Science databases were searched using the keywords: GV, bleeding, TIPS, and BRTO to identify relevant randomized controlled trials and cohort studies. The overall survival (OS) rate, imminent haemostasis rate, rebleeding rate, technical success rate, procedure complication rate (hepatic encephalopathy and aggravated ascites), and Child-Pugh score were evaluated. Randomized clinical trials and cohort studies comparing TIPS and BRTO for GV due to portal hypertension were included in our meta-analysis. Two independent reviewers performed data extraction and assessed the study quality. A meta-analysis was performed to calculate risk ratios (RRs), mean differences (MDs), and 95% CIs using random effects models. Results . A total of nine studies fulfilled the inclusion criteria. There was a significant difference between TIPS and BRTO in the OS rate (RR, 0.81 (95% CI, 0.66 to 0.98); P = 0.03 ) and rebleeding rate (RR, 2.61 (95% CI, 1.75 to 3.90); P 〈 0.00001 ). TIPS had a higher incidence rate of hepatic encephalopathy (RR, 16.11 (95% CI, 7.13 to 36.37); P 〈 0.00001 ). There was no significant difference between TIPS and BRTO in the immediate haemostasis rate (RR, 0.99 (95% CI, 0.89 to 1.10); P = 0.84 ), technical success rate (RR, 1.06 (95% CI, 0.98 to 1.16); P = 0.16 ), aggravated ascites rate (RR, 0.60 (95% CI, 0.33 to 1.09); P = 0.10 ), or Child-Pugh change (MD, 0.22 (95% CI, −0.21 to 0.65); P = 0.31 ). Conclusions . In this meta-analysis, BRTO brought more benefits to patients, with a higher OS rate and lower rebleeding rate. BRTO is a feasible method for GVB.
    Materialart: Online-Ressource
    ISSN: 2291-2789 , 2291-2797
    URL: Article
    DOI: 10.1155/2020/5143013
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2762184-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Drying characteristics and quality optimization of papaya crisp slices based on microwave vacuum drying
    Hindawi Limited ; 2022
    In:  Journal of Food Processing and Preservation Vol. 46, No. 5 ( 2022-05)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 46, No. 5 ( 2022-05)
    Materialart: Online-Ressource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v46.5
    DOI: 10.1111/jfpp.16506
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2175273-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Association of the NOTCH4 Gene Polymorphism rs204993 with Schizophrenia in the Chinese Han Population
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-5
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-5
    Kurzfassung: NOTCH4 regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possible susceptibility gene for schizophrenia (SCZ). The objective of this study was to examine the relationship between NOTCH4 polymorphisms and SCZ in the Chinese Han population. The rs2071287 and rs204993 polymorphisms of the NOTCH4 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent. Single SNP allele-, genotype-, and gender-specific associations were analyzed using different models (i.e., additive, dominant, and recessive models). This association study revealed that the rs204993 polymorphism is significantly associated with susceptibility for SCZ and that the AA genotype of rs204993 is associated with a higher risk for SCZ ( P = 0 . 027 ; OR = 1.460; 95% CI, 1.043–2.054). Our data are consistent with those obtained in previous studies that suggested that rs204993 is associated with SCZ and that the AA genotype of rs204993 demonstrates a higher risk. Further large-scale association analyses in Han Chinese populations are warranted.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/408096
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF- κ B Activation
    Hindawi Limited ; 2014
    In:  Mediators of Inflammation Vol. 2014 ( 2014), p. 1-12
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2014 ( 2014), p. 1-12
    Kurzfassung: β -Hydroxybutyric acid (BHBA) has neuroprotective effects, but the underlying molecular mechanisms are unclear. Microglial activation plays an important role in neurodegenerative diseases by producing several proinflammatory enzymes and proinflammatory cytokines. The current study investigates the potential mechanisms whereby BHBA affects the expression of potentially proinflammatory proteins by cultured murine microglial BV-2 cells stimulated with lipopolysaccharide (LPS). The results showed that BHBA significantly reduced LPS-induced protein and mRNA expression levels of iNOS, COX-2, TNF- α , IL-1 β , and IL-6. Blocking of GPR109A by PTX resulted in a loss of this anti-inflammatory effect in BV-2 cells. Western blot analysis showed that BHBA reduced LPS-induced degradation of I κ B- α and translocation of NF- κ B, while no effect was observed on MAPKs phosphorylation. All results imply that BHBA significantly reduces levels of proinflammatory enzymes and proinflammatory cytokines by inhibition of the NF- κ B signaling pathway but not MAPKs pathways, and GPR109A is essential to this function. Overall, these data suggest that BHBA has a potential as neuroprotective drug candidate in neurodegenerative diseases.
    Materialart: Online-Ressource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2014/983401
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2008065-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Influence of Stress Sensitivity on Water-Gas Flow in Carbonate Rocks
    Hindawi Limited ; 2020
    In:  Geofluids Vol. 2020 ( 2020-12-5), p. 1-12
    Details
    In: Geofluids, Hindawi Limited, Vol. 2020 ( 2020-12-5), p. 1-12
    Kurzfassung: Carbonate reservoirs significantly contribute to exploitation. Due to their strong heterogeneity, it is of great significance to study core seepage capacity and gas-water two-phase flow of reservoirs with various pore structures under different stresses for productivity prediction, gas reservoir development, and reservoir protection. We utilize micrometer-resolution X-ray tomography to obtain the digital rocks of porous, fractured-porous, and fractured-vuggy carbonate rocks during pressurized process and depressurization. The Lattice Boltzmann method and pore network model are used to simulate the permeability and gas-water two-phase flow under different confining pressures. We show that at the early stage of pressure increase, fractures, vugs, or large pores as the main flow channels first undergo compaction deformation, and the permeability decreases obviously. Then, many isolated small pores are extruded and deformed; thus, the permeability reduction is relatively slow. As the confining pressure increases, the equal-permeability point of fractured-porous sample moves to right. At the same confining pressure, the water saturation corresponding to equal-permeability point during depressurization is greater than that of pressurized process. It is also proved that the pore size decreases irreversibly, and the capillary force increases, which is equivalent to the enhancement of water wettability. Therefore, the irreversible closure of pores leads to the decrease of permeability and the increase of gas-phase seepage resistance, especially in carbonate rocks with fractures, vugs, and large pores. The findings of this study are helpful to better understand the gas production law of depletion development of carbonate gas reservoirs and provide support for efficient development.
    Materialart: Online-Ressource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2020/6642008
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2045012-6
    SSG: 13
    Standort Signatur Einschränkungen Verfügbarkeit
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