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  • 1
    Online Resource
    Online Resource
    Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Abstract: Aim . To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity. Methods and Results . Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group. The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification. The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF. At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR. The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value. Conclusion . NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/106252
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Curcumin-Activated Mesenchymal Stem Cells Derived from Human Umbilical Cord and Their Effects on MPTP-Mouse Model of Parkinson’s Disease: A New Biological Therapy for Parkinson’s Disease
    Hindawi Limited ; 2020
    In:  Stem Cells International Vol. 2020 ( 2020-02-17), p. 1-17
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2020 ( 2020-02-17), p. 1-17
    Abstract: Background . The aim of this study was to investigate the effects of human umbilical cord mesenchymal stem cell activated by curcumin (hUC-MSCs-CUR) on Parkinson’s disease (PD). hUC-MSCs can differentiate into many types of adult tissue cells including dopaminergic (DA) neurons. CUR could protect DA neurons from apoptosis induced by 6-hydroxydopamine (6-OHDA). Therefore, we used the hUC-MSCs activated by CUR for the treatment of PD in an animal model. Methods . The hUC-MSCs-CUR was transplanted into the MPTP-induced PD mouse models via the tail vein. We found that hUC-MSCs-CUR significantly improved the motor ability, increased the tyrosine hydroxylase (TH), dopamine (DA), and Bcl-2 levels, and reduced nitric oxide synthase, Bax, and cleaved caspase 3 expression in PD mice. The supernatant of hUC-MSCs-CUR (CM-CUR) was used to stimulate the SH-SY5Y cellular model of PD; cell proliferation, differentiation, TH, and neuronal-specific marker microtubular-associated protein 2 (MAP2) expressions were examined. Results . Our data showed that CM-CUR significantly promoted cell proliferation and gradually increased TH and MAP2 expression in SH-SY5Y PD cells. The beneficial effects could be associated with significant increase of rough endoplasmic reticulum in the hUC-MSCs-CUR, which secretes many cytokines and growth factors beneficial for PD treatment. Conclusions . Transplantation of hUC-MSCs-CUR could show promise for improving the motor recovery of PD.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2020/4636397
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2573856-2
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  • 3
    Online Resource
    Online Resource
    Biomechanical Comparison of Pedicle Screw Augmented with Different Volumes of Polymethylmethacrylate in Osteoporotic and Severely Osteoporotic Synthetic Bone Blocks in Primary Implantation: An Experimental Study
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: This study was designed to compare screw stabilities augmented with different volumes of PMMA and analyze relationship between screw stability and volume of PMMA and optimum volume of PMMA in different bone condition. Osteoporotic and severely osteoporotic synthetic bone blocks were divided into groups A0-A5 and B0-B5, respectively. Different volumes of PMMA were injected in groups A0 to A5 and B0 to B5. Axial pullout tests were performed and F m a x was measured. F m a x in groups A1-A5 were all significantly higher than group A0. Except between groups A1 and A2, A3 and A4, and A4 and A5, there were significant differences on F m a x between any other two groups. F m a x in groups B1-B5 were all significantly higher than group B0. Except between groups B1 and B2, B2 and B3, and B4 and B5, there were significant differences on F m a x between any other two groups. There was significantly positive correlation between F m a x and volume of PMMA in osteoporotic and severely osteoporotic blocks. PMMA can significantly enhance pedicle screw stability in osteoporosis and severe osteoporosis. There were positive correlations between screw stability and volume of PMMA. In this study, injection of 3 mL and 4 mL PMMA was preferred in osteoporotic and severely osteoporotic blocks, respectively.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/9627504
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 4
    Online Resource
    Online Resource
    The Impacts of SLC22A1 rs594709 and SLC47A1 rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients
    Hindawi Limited ; 2016
    In:  International Journal of Endocrinology Vol. 2016 ( 2016), p. 1-7
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
    Abstract: Background . We aimed to investigate the distributive characteristics of SLC22A1 rs594709 and SLC47A1 rs2289669 polymorphisms and their influence on metformin efficacy in Chinese T2DM patients. Methods . The distributions of SLC22A1 rs594709 and SLC47A1 rs2289669 polymorphisms were determined in 267 T2DM patients and 182 healthy subjects. Subsequently, 53 newly diagnosed patients who received metformin monotherapy were recruited to evaluate metformin efficacy. Results . No significant difference was found between T2DM patients and healthy subjects in SLC22A1 rs594709 and SLC47A1 rs2289669 allele frequencies and genotype frequencies. After metformin treatment, SLC22A1 rs594709 GG genotype patients showed a higher increase in FINS ( p = 0.015 ) and decrease in HOMA-IS ( p = 0.001 ) and QUICKI ( p = 0.002 ) than A allele carriers. SLC47A1 rs2289669 GG genotype patients had a higher decrease in TChol ( p = 0.030 ) and LDL-C ( p = 0.049 ) than A allele carriers. Among SLC22A1 rs594709 AA genotype, patients with SLC47A1 rs2289669 AA genotype showed a higher decrease in FBG ( p = 0.015 ), PINS ( p = 0.041 ), and HOMA-IR ( p = 0.014 ) than G allele carriers. However, among SLC22A1 rs594709 G allele carriers, SLC47A1 rs2289669 AA genotype patients showed a higher decrease in TChol ( p = 0.013 ) than G allele carriers. Conclusion . Our data suggest that SLC22A1 rs594709 and SLC47A1 rs2289669 polymorphisms may influence metformin efficacy together in Chinese T2DM patients.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2016/4350712
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2502951-4
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  • 5
    Online Resource
    Online Resource
    Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: Membranous nephropathy (MN) is an autoimmune inflammatory disease in which proteins related with plenty of biological processes play an important role. However, the role of these proteins in the pathogenesis of MN is still unclear. This study aimed to screen differential proteins in kidney tissue samples from MN patients by using protein arrays and determine the pathways involved in the pathogenesis of MN. This study first tested a quantitative protein array (QAH-INF-3) and two semiquantitative protein arrays (L-493 and L-507) with normal renal tissue and identified L-493 as the most appropriate assay to compare protein levels between MN tissues and normal control tissues. The L-493 array identified 66 differentially expressed proteins (DEPs) that may be associated with MN. The gene oncology (GO) and protein-protein interaction (PPI) analyses revealed several processes potentially involved in MN, including extracellular matrix disassembly and organization, cell adhesion, cell-cell signaling, cellular protein metabolic process, and immune response ( P 〈 0.0 5 ). We suggest that these different pathways work together via protein signaling and result in the pathogenesis and progression of MN.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/7843584
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    Data-Driven Electricity Price Risk Assessment for Spot Market
    Hindawi Limited ; 2022
    In:  International Transactions on Electrical Energy Systems Vol. 2022 ( 2022-1-31), p. 1-11
    Details
    In: International Transactions on Electrical Energy Systems, Hindawi Limited, Vol. 2022 ( 2022-1-31), p. 1-11
    Abstract: Electricity price risk assessment (EPRA) is essential for spot market analysis and operation. The statistical moments (i.e., the mean and standard deviation) of the price need to be assessed to support market risk control. This paper proposes a data-driven approach for EPRA based on the Gaussian process (GP) framework. Compared with the deep learning algorithms, GP has two merits: (1) the scale of training sample required is small and (2) the time-consuming hyperparameter tuning process is avoided. However, the direct application of GP for EPRA is not tractable due to the complicated discrete relationship between the system operating status and the electricity price. To deal with that, a data-driven EPRA framework is developed that contains a GP surrogate model for the direct current optimal power flow (DC-OPF) problem and a hybrid model-data-based hybrid electricity price calculation method. To guarantee the accuracy of EPRA, an adaptability criterion and a second verification process based on the Karush–Kuhn–Tucker (KKT) condition are developed to distinguish the samples with GP learning errors. Numerical results carried out on IEEE benchmark systems demonstrate that the proposed method can achieve exactly the same EPRA results as Monte Carlo (MC) simulation, which significantly improved the computational efficiency.
    Type of Medium: Online Resource
    ISSN: 2050-7038
    URL: Article
    DOI: 10.1155/2022/9453879
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2702272-9
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  • 7
    Online Resource
    Online Resource
    Functional connectivity between the habenula and default mode network and its association with the antidepressant effect of ketamine
    Hindawi Limited ; 2022
    In:  Depression and Anxiety Vol. 39, No. 5 ( 2022-05), p. 352-362
    Details
    In: Depression and Anxiety, Hindawi Limited, Vol. 39, No. 5 ( 2022-05), p. 352-362
    Type of Medium: Online Resource
    ISSN: 1091-4269 , 1520-6394
    URL: Issue
    URL: Article
    DOI: 10.1002/da.v39.5
    DOI: 10.1002/da.23238
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2001248-2
    SSG: 5,2
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  • 8
    Online Resource
    Online Resource
    LncRNA MBNL1-AS1 Represses Proliferation and Cancer Stem-Like Properties of Breast Cancer through MBNL1-AS1/ZFP36/CENPA Axis
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-4-26), p. 1-22
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-4-26), p. 1-22
    Abstract: Background. Emerging studies have revealed long noncoding RNAs (lncRNAs) were key regulators of cancer progression. In this research, the expression and roles of MBNL1-AS1 were explored in breast cancer (BC). Methods. In this study, the MBNL1-AS1 expression in breast cancer tissue, as well as in cell line, was studied by qRT-PCR assays. The effects of MBNL1-AS1 on proliferation and stemness were evaluated by MTT assays, colony formation assays, orthotopic breast tumor mice models, extreme limiting dilution analysis (ELDA), fluorescence in situ hybridization (FISH), flow cytometry assays, and sphere formation assays. Flexmap 3D assays were performed to show that MBNL1-AS1 downregulated the centromere protein A (CENPA) secretion in BC cells. Western blot, RNA pull-down assays, RNA immunoprecipitation (RIP) assays, and FISH were conducted to detect the mechanism. Results. The results showed that the expression levels of MBNL1-AS1 were downregulated in breast cancer tissues and cell lines. In vitro and in vivo studies demonstrated that overexpression of MBNL1-AS1 markedly inhibited BC cells proliferation and stemness. RNA pull-down assay, RIP assay, western blot assay, and qRT-PCR assay showed that MBNL1-AS1 downregulated CENPA mRNA via directly interacting with Zinc Finger Protein 36 (ZFP36) and subsequently decreased the stability of CENPA mRNA. Restoration assays also confirmed that MBNL1-AS1 suppressed the CENPA-mediated proliferation and stemness in breast cancer cells. Conclusions. The new mechanism of how MBNL1-AS1 regulates BC phenotype is elucidated, and the MBNL1-AS1/ZFP36/CENPA axis may be served as a therapeutic target for BC patients.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/9999343
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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  • 9
    Online Resource
    Online Resource
    Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
    Hindawi Limited ; 2016
    In:  Mediators of Inflammation Vol. 2016 ( 2016), p. 1-8
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF- α ) and interferon- γ (IFN- γ ) in Concanavalin A- (ConA-) induced hepatitis (CIH). DH recruited more CD11b + Gr1 + myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2016/2684321
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2008065-7
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  • 10
    Online Resource
    Online Resource
    AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells
    Hindawi Limited ; 2016
    In:  Oxidative Medicine and Cellular Longevity Vol. 2016 ( 2016), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-11
    Abstract: Recent studies suggest that the epithelial sodium channel (ENaC) is expressed in the endothelial cells. To test whether high salt affects the NO production via regulation of endothelial ENaC, human umbilical vein endothelial cells (HUVECs) were incubated in solutions containing either normal or high sodium (additional 20 mM NaCl). Our data showed that high sodium treatment significantly increased α -, β -, and γ -ENaC expression levels in HUVECs. Using the cell-attached patch-clamp technique, we demonstrated that high sodium treatment significantly increased ENaC open probability ( P O ). Moreover, nitric oxide synthase (eNOS) phosphorylation (Ser 1177) levels and NO production were significantly decreased by high sodium in HUVECs; the effects of high sodium on eNOS phosphorylation and NO production were inhibited by a specific ENaC blocker, amiloride. Our results showed that high sodium decreased AMP-activated kinase (AMPK) phosphorylation in endothelial cells. On the other hand, metformin, an AMPK activator, prevented high sodium-induced upregulation of ENaC expression and P O . Moreover, metformin prevented high salt-induced decrease in NO production and eNOS phosphorylation. These results suggest that high sodium stimulates ENaC activation by negatively modulating AMPK activity, thereby leading to reduction in eNOS activity and NO production in endothelial cells.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2016/1531392
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2455981-7
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