GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hindawi Limited  (11)
  • 1
    Online Resource
    Online Resource
    Network Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Qiaoshao Formula for Treatment of Premature Ejaculation
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-11-12), p. 1-13
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-11-12), p. 1-13
    Abstract: Background. Qiaoshao (QS) formula, a traditional Chinese medicine (TCM) comprising seven herbs, has been clinically proven to have a favorable treatment effect on premature ejaculation (PE). However, its underlying pharmacological mechanisms in the treatment of PE need to be further clarified. Methods. In the present study, a network pharmacology-based strategy was adopted. The active compounds of QS formula were obtained from the Chinese medicine database, and the potential targets of these compounds were collected from the DrugBank database to construct compound-compound targets network. PE-related targets were identified from human disease databases and used to construct the protein-protein interaction (PPI) networks. Compound-disease target PPI network was constructed by merging the PPI network of disease-targets and compound-targets. Cluster and enrichment analyses were performed on the PPI network of disease targets and compound-disease targets. The influence of QS formula on serum 5-HT, NO, oxytocin, and thyroid hormones of PE patients was verified. Results. Four primary pharmacological networks of QS formula were constructed, including the compound-compound targets network, PPI network of PE-related targets and compound-disease targets, and the QS-PE mechanism network. The module and pathway enrichment analyses revealed that the QS formula had the potential to affect varieties of biological process and pathways, such as nitric oxide biosynthetic process, oxytocin, thyroid hormone, TNF, PI3K-Akt, and the HIF-1 signaling pathway, that play an important role in the pathogenesis of PE. Meanwhile, the QS formula has been clinically confirmed to regulate the serum level of 5-HT, NO, oxytocin, and TT in PE patients. Conclusion. This study preliminarily discovered the potential targets and pathways of QS formula in the treatment of PE, which laid a good foundation for further experimental research.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2020/1418634
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Correlation of TET-2 Levels with Disease Evaluation in AMI Patients
    Hindawi Limited ; 2022
    In:  Contrast Media & Molecular Imaging Vol. 2022 ( 2022-7-31), p. 1-6
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2022 ( 2022-7-31), p. 1-6
    Abstract: Objective. To investigate the expression levels of Ten-Eleven Translocation-2 (TET-2) in patients with acute myocardial infarction (AMI) and correlations of TET-2 levels with disease severity. Methods. A total of 150 patients with confirmed AMI were included in this study. According to the number of coronary artery lesions, the patients were divided into a single lesion group, two lesion group, and three lesion group. According to the Gensini scores, these patients were also assigned into three groups: the low-risk group, middle-risk group, and high-risk group. 150 patients without AMI confirmed by coronary angiography were included in the control group in the same period. TET-2 and cardiac troponin T (cTNT) levels were detected by ELISA analysis and compared among different groups. Pearson’s correlation analysis was used to evaluate the correlations of TET-2 levels and cTNT levels/Gensini scores. The levels of TET-2 in AMI patients increased remarkably with the increase of disease severity. Patients in the single lesion group or low-risk group had the lowest levels of TET-2. Pearson correlation analysis indicated that TET-2 levels were positively associated with cTNT levels and Gensini scores, respectively (all P 〈 0.001 ). Conclusion. The levels of TET-2 were upregulated in AMI patients and positively correlated with cTNT levels or Gensini scores, suggesting that the examination of TET-2 expression levels could be exploited for predicting the disease severity.
    Type of Medium: Online Resource
    ISSN: 1555-4317 , 1555-4309
    URL: Article
    DOI: 10.1155/2022/9983071
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2222967-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Mechanical Energy Expenditure-based Comfort Evaluation Model for Gesture Interaction
    Hindawi Limited ; 2018
    In:  Computational Intelligence and Neuroscience Vol. 2018 ( 2018-12-30), p. 1-11
    Details
    In: Computational Intelligence and Neuroscience, Hindawi Limited, Vol. 2018 ( 2018-12-30), p. 1-11
    Abstract: As an advanced interaction mode, the gesture has been widely used for the human-computer interaction (HCI). The paper proposes a comfort evaluation model based on the mechanical energy expenditure (MEE) and the mechanical efficiency (ME) to predict the comfort of gestures. The proposed comfort evaluation model takes nineteen muscles and seven degrees of freedom into consideration based on the data of muscles and joints and is capable of simulating the MEE and the ME of both static and dynamic gestures. The comfort scores (CSs) can be therefore calculated by normalizing and assigning different decision weights to the MEE and the ME. Compared with the traditional comfort prediction methods based on measurement, on the one hand, the proposed comfort evaluation model makes it possible for providing a quantitative value for the comfort of gestures without using electromyography (EMG) or other measuring devices; on the other hand, from the ergonomic perspective, the results provide an intuitive indicator to predict which act has the higher risk of fatigue or injury for joints and muscles. Experiments are conducted to validate the effectiveness of the proposed model. According to the comparison result among the proposed comfort evaluation model, the model based on the range of motion (ROM) and the model based on the method for movement and gesture assessment (MMGA), a slight difference can be found due to the ignorance of dynamic gestures and the relative kinematic characteristics during the movements of dynamic gestures. Therefore, considering the feedback of perceived effects and gesture recognition rate in HCI, designers can achieve a better optimization for the gesture design by making use of the proposed comfort evaluation model.
    Type of Medium: Online Resource
    ISSN: 1687-5265 , 1687-5273
    URL: Article
    DOI: 10.1155/2018/9861697
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2388208-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Comparison of fluoxetine with other selective serotonin reuptake inhibitors in the treatment of premature ejaculation: A systematic review and meta‐analysis
    Hindawi Limited ; 2022
    In:  Andrologia Vol. 54, No. 8 ( 2022-09)
    Details
    In: Andrologia, Hindawi Limited, Vol. 54, No. 8 ( 2022-09)
    Type of Medium: Online Resource
    ISSN: 0303-4569 , 1439-0272
    URL: Issue
    URL: Article
    DOI: 10.1111/and.v54.8
    DOI: 10.1111/and.14500
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2009045-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Fructus Aurantii Extracts Ameliorate Intestinal Inflammation and Regulate the Intestinal Barrier through Fc Epsilon RI Signaling Pathway
    Hindawi Limited ; 2023
    In:  Journal of Food Biochemistry Vol. 2023 ( 2023-3-20), p. 1-17
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 2023 ( 2023-3-20), p. 1-17
    Abstract: Fructus Aurantii (FA) is the dry and immature fruit of Citrus aurantium L. and its rutaceous cultivars. FA has been widely used to treat digestive system diseases since ancient China, and it promotes gastrointestinal (GI) motility in functional dyspepsia (FD), but its potential therapeutic mechanisms remain unclear. We examined the effects of FA ethanol extracts in an iodoacetamide (IA)-induced FD rat model. Firstly, key FA therapy targets for FD were gathered using systematic pharmacology. Combined with systemic pharmacological analyses, plasma metabolomics based on UPLC-QTOF-MS were conducted. Then, MetaboAnalyst was used to jointly analyze systemic pharmacology targets and metabolomic metabolites to select key metabolic pathways. Finally, the key path is verified by experiments. FA exerted distinct therapeutic effects in anti-inflammation and promoting gastrointestinal motility in our IA-induced FD rat model. When compared with the model group, FA down-regulated the inflammatory factors interleukin 1β and tumor necrosis factor-α. At the same time, FA up-regulated tight junction proteins in the intestinal epithelial barrier. Through the integrated analysis of metabolomics and systemic pharmacology, we conducted experimental verification on Fc epsilon RI signaling pathway. When compared with the model group, FA down-regulatedphospho-mitogen activated protein kinase, phospho-extracellular signal regulated kinase1/2, myosin light chain kinase, and phospho-myosin regulatory light chain protein levels. Thus, FA ameliorated FD by regulating the Fc epsilon RI signaling pathway. Our integrated strategy identified underlying FA mechanisms toward FD treatment and provided a foundation for FA development as a clinical agent for FD.
    Type of Medium: Online Resource
    ISSN: 1745-4514 , 0145-8884
    URL: Article
    DOI: 10.1155/2023/8812517
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2174913-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Base Detection Research of Drilling Robot System by Using Visual Inspection
    Hindawi Limited ; 2018
    In:  Journal of Robotics Vol. 2018 ( 2018), p. 1-9
    Details
    In: Journal of Robotics, Hindawi Limited, Vol. 2018 ( 2018), p. 1-9
    Abstract: This paper expounds the principle and method of calibration and base detection by using the visual measurement system for detection and correction of installation error between workpiece and the robot drilling system. This includes the use of Cognex Insight 5403 high precision industrial camera, a light source, and the KEYENCE coaxial IL-300 laser displacement sensor. The three-base holes method and two-base holes method are proposed to analyze the transfer relation between the basic coordinate system of the actual hole drilling robot and the basic coordinate system of the theoretical hole drilling robot. The corresponding vision coordinates calibration and the base detection experiments are examined and the data indicate that the result of base detection is close to the correct value.
    Type of Medium: Online Resource
    ISSN: 1687-9600 , 1687-9619
    URL: Article
    DOI: 10.1155/2018/8767531
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2582988-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-10
    Abstract: Background. Convincing evidences have demonstrated the associations between HHIP and FAM13a polymorphisms and COPD in non-Asian populations. Here genetic variants in HHIP and FAM13a were investigated in Southern Han Chinese COPD. Methods. A case-control study was conducted, including 989 cases and 999 controls. The associations between SNPs genotypes and COPD were performed by a logistic regression model; for SNPs and COPD-related phenotypes such as lung function, COPD severity, pack-year of smoking, and smoking status, a linear regression model was employed. Effects of risk alleles, genotypes, and haplotypes of the 3 significant SNPs in the HHIP gene on FEV 1 /FVC were also assessed in a linear regression model in COPD. Results. The mean FEV 1 /FVC% value was 46.8 in combined COPD population. None of the 8 selected SNPs apparently related to COPD susceptibility. However, three SNPs (rs12509311, rs13118928, and rs182859) in HHIP were associated significantly with the FEV 1 /FVC% ( P m a x = 4.1 × 10 −4 ) in COPD adjusting for gender, age, and smoking pack-years. Moreover, statistical significance between risk alleles and the FEV 1 /FVC% ( P = 2.3 × 10 −4 ), risk genotypes, and the FEV 1 /FVC% ( P = 3.5 × 10 −4 ) was also observed in COPD. Conclusions. Genetic variants in HHIP were related with FEV 1 /FVC in COPD. Significant relationships between risk alleles and risk genotypes and FEV 1 /FVC in COPD were also identified.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/2756726
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Cavernous artery intima‐media thickness predicts the response to sildenafil in erectile dysfunction patients as a morphological parameter
    Hindawi Limited ; 2021
    In:  Andrologia Vol. 53, No. 8 ( 2021-09)
    Details
    In: Andrologia, Hindawi Limited, Vol. 53, No. 8 ( 2021-09)
    Type of Medium: Online Resource
    ISSN: 0303-4569 , 1439-0272
    URL: Issue
    URL: Article
    DOI: 10.1111/and.v53.8
    DOI: 10.1111/and.14149
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2009045-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Role of shear wave elastography measured in the flaccid state in predicting arteriogenic erectile dysfunction
    Hindawi Limited ; 2021
    In:  Andrologia Vol. 53, No. 4 ( 2021-05)
    Details
    In: Andrologia, Hindawi Limited, Vol. 53, No. 4 ( 2021-05)
    Type of Medium: Online Resource
    ISSN: 0303-4569 , 1439-0272
    URL: Issue
    URL: Article
    DOI: 10.1111/and.v53.4
    DOI: 10.1111/and.13996
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2009045-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Landmark-Based Facial Feature Construction and Action Unit Intensity Prediction
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-3-11), p. 1-12
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-3-11), p. 1-12
    Abstract: Human face recognition has been widely used in many fields, including biorobots, driver fatigue monitoring, and polygraph tests. However, the end-to-end models fit by most of the existing algorithms perform poorly in interpretation because complex classifiers are constructed using facial images directly. In addition, in some of the models, dynamic characteristics of subjects as individuals are not fully considered, so dynamic information is not extracted. In order to solve these problems, this paper proposes an action unit intensity prediction model. The three-dimensional coordinates of 68 landmarks of human faces are obtained based on the convolutional experts constrained local model (CE-CLM), which enables the construction of dynamic facial features. Based on the error analysis of the CE-CLM algorithm, dimension reduction of the constructed features is performed by the principal components analysis (PCA). The radial basis function (RBF) neural network is also constructed to train the action unit prediction models. The proposed method is verified by the experiments, and the overall mean square error (MSE) of the proposed method is 0.01826. Lastly, the network construction process is optimized, so that for the same training samples, the models are fitted using fewer iterations. The number of iterations is decreased by 27 on average. In summary, this paper provides a method to rapidly construct action unit (AU) intensity prediction models and constructs automatic AU intensity estimation models for facial images.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/6623239
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...