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  • 1
    Online Resource
    Online Resource
    Epigenome-Wide Association Study Reveals Differential Methylation Sites and Association of Gene Expression Regulation with Ischemic Moyamoya Disease in Adults
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-3-24), p. 1-13
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-3-24), p. 1-13
    Abstract: Background. The association of DNA methylation with the pathogenesis of adult ischemic moyamoya disease (MMD) is unknown. Here, we investigated the genome-wide DNA methylation profiles in patients with MMD and identified the genes related to the pathogenesis of MMD. Methods. Whole blood samples were collected from 20 individuals, including 10 patients with ischemic moyamoya disease without any underlying disease and 10 healthy individuals. Genome-wide DNA methylation analysis was performed using Illumina 850K microarrays. Transcriptional correlation was verified using quantitative reverse transcription-polymerase chain reaction. In vitro experiments were used to analyze the association of functional defects with candidate epigenetic markers. Results. The genome-wide methylation level in the whole blood of adults with ischemic MMD was higher than that in the healthy individuals. In total, 759 methylation probes differed significantly between the case and control. The hypermethylated regions were mostly concentrated in the gene spacer regions. Among genes with the highest degree of the differential expression, KCNMA1 and GALNT2 were upregulated, whereas SOX6 and RBM33 were downregulated. Conclusions. This is the first study showing that the low expression of genes associated with epigenetic regulation, such as SOX6 and RBM33, may be related to vascular occlusion in MMD, whereas the overexpression of KCNMA1 and GALNT2 may be related to the vascular hyperplasia. The results suggest that DNA methylation was involved in the pathogenesis of MMD, and new pathogenic genes were proposed as biological markers.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/7192060
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 2
    Online Resource
    Online Resource
    Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-07-17), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-07-17), p. 1-8
    Abstract: Background . Hyperuricemia has long been associated with increased cardiovascular risk, and arterial stiffness is proposed as a mediator. The present study is aimed at examining the associations of uric acid (UA) in blood and urine with arterial stiffness in a Chinese cohort. Methods . A total of 2296 participants (mean age: 43.0 years) from our previously established cohort of Hanzhong Adolescent Hypertension Study were included. The participants were classified as subjects with or without arterial stiffness, which was defined as brachial-ankle pulse wave velocity baPWV ≥ 1400   cm / s and/or carotid intima-media thickness CIMT ≥ 0.9   mm . Multivariate regression analyses were used to examine the relationship between serum and urinary UA and the risk of arterial stiffness after adjusting for age, gender, systolic blood pressure, fasting glucose, BMI, heart rate, total cholesterol, and triglycerides. Results . baPWV was positively correlated with urinary uric acid/creatinine ratio (uUA/Cre) ( β = 0.061 , P 〈 0.001 ), while CIMT was correlated with uUA/Cre ( β = 0.085 , P 〈 0.001 ) and fractional excretion of uric acid (FEUA) ( β = 0.044 , P = 0.033 ) in all subjects. In addition, uUA/Cre was significantly associated with the risk of high baPWV [1.032 (1.019-1.045)] and arterial stiffness [1.028 (1.016-1.040)] . Conclusion . Our study showed that urinary UA excretion was significantly associated with the risk of arterial stiffness in Chinese adults. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of arterial stiffness in otherwise healthy subjects.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2020/1638515
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
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  • 3
    Online Resource
    Online Resource
    Effect of adjuvant drug therapy after varicocelectomy on fertility outcome in males with varicocele-associated infertility: Systematic review and meta-analysis
    Hindawi Limited ; 2018
    In:  Andrologia Vol. 50, No. 8 ( 2018-10), p. e13070-
    Details
    In: Andrologia, Hindawi Limited, Vol. 50, No. 8 ( 2018-10), p. e13070-
    Type of Medium: Online Resource
    ISSN: 0303-4569
    URL: Issue
    URL: Article
    DOI: 10.1111/and.2018.50.issue-8
    DOI: 10.1111/and.13070
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2009045-6
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  • 4
    Online Resource
    Online Resource
    Model Optimization of Shale Gas Reservoir Volume Fracturing Dissolved Gas Simulation Adsorbed Gas
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-2-18), p. 1-15
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-2-18), p. 1-15
    Abstract: Shale reservoirs have some natural fractures with a certain density and connectivity. The basic percolation model of shale gas reservoir: the black oil model of gas-water phase is used as the basic model, and the dissolved gas is used to simulate adsorbed gas. Accurate description of natural fractures: random distributed discrete fracture model is used as the basic model to describe natural fractures. By comparing the calculation results of single medium (including random distributed discrete fracture model) and double medium model, the model for predicting shale gas productivity is optimized.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/6631994
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 5
    Online Resource
    Online Resource
    Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer’s Disease via Intranasal Administration
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-1-25), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-1-25), p. 1-16
    Abstract: Osthole (OST) is a natural coumarin compound that exerts multiple pharmacologic effects. However, the poor water solubility and the low oral absorption of OST limit its clinical application for the treatment of neurologic diseases. A suitable preparation needs to be tailored to evade these unfavourable properties of OST. In this study, an OST nanoemulsion (OST-NE) was fabricated according to the pseudoternary phase diagram method, which was generally used to optimize the prescription in light of the solubility of OST in surfactants and cosurfactants. The final composition of OST-NE was 3.6% of ethyl oleate as oil phase, 11.4% of the surfactant (polyethylene glycol ester of 15-hydroxystearic acid: polyoxyethylene 35 castor oil = 1 : 1 ), 3% of polyethylene glycol 400 as cosurfactant, and 82% of the aqueous phase. The pharmacokinetic study of OST-NE showed that the brain-targeting coefficient of OST was larger by the nasal route than that by the intravenous route. Moreover, OST-NE inhibited cell death, decreased the apoptosis-related proteins (Bax and caspase-3), and enhanced the activity of antioxidant enzymes (superoxide dismutase and glutathione) in L-glutamate-induced SH-SY5Y cells. OST-NE improved the spatial memory ability, increased the acetylcholine content in the cerebral cortex, and decreased the activity of acetylcholinesterase in the hippocampus of Alzheimer’s disease model mice. In conclusion, this study indicates that the bioavailability of OST was improved by using the OST-NE via the nasal route. A low dose of OST-NE maintained the neuroprotective effects of OST, such as inhibiting apoptosis and oxidative stress and regulating the cholinergic system. Therefore, OST-NE can be used as a possible alternative to improve its bioavailability in the prevention and treatment of Alzheimer’s disease.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/8844455
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 6
    Online Resource
    Online Resource
    Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis
    Hindawi Limited ; 2020
    In:  Stem Cells International Vol. 2020 ( 2020-12-19), p. 1-11
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2020 ( 2020-12-19), p. 1-11
    Abstract: Asherman’s Syndrome (AS) is an uncommon, acquired, and refractory gynecological disorder. Current treatment was still limited, and stem cell-based therapy has been proposed as a novel strategy for management of AS. Here, we conducted a meta-analysis of self-controlled clinical trials to assess the effectiveness and safety of stem cell-based therapy in Asherman syndrome patients who have failed in conventional treatment. We systematically searched PubMed, Embase, Cochrane, and Web of Science database (published up to October 3, 2020). Our main evaluation outcomes were menses improvement, endometrial thickness changes, pregnancy outcome, and side effects. All analyses were performed by using RevMan5.4 software. 427 studies were identified, eight of which were eligible and included in our analysis. Stem cell combined hormone therapy achieved a higher likelihood of improving menstruation (risk ratio [RR] 22.43, 95% CI: 8.03 to 62.68, P 〈 0.00001 ), an enhancement of pregnancy outcome (risk ratio [RR] 11.1, 95% CI: 3.58 to 34.38, P 〈 0.0001 ), and a mean increase of 3-month endometrial thickness (standardized mean difference [SMD] 2.43, 95% CI: 1.72 to 3.13, P 〈 0.00001 ). Subgroup analysis also indicated that 6-month and 9-month endometrial thickness increased significantly with the stem cell-based treatment. Moreover, no obvious and severe adverse reactions were observed during the process of stem cell therapy. There were 3 patients (3.57%) reported with lost appetite, mild gastritis, vomiting, or abdominal cramps, whereas, these symptoms relieved subsequently. This meta-analysis systematically reviewed and synthesized the outcomes of stem cell-based therapy in treating Asherman syndrome, which suggest that stem cell and hormone combination therapy was safe and more effective in improving menstruation duration, pregnancy outcome, and endometrial thickness. However, further trials with large sample sizes are needed to establish more solid evidence for administrating this therapy in clinic.
    Type of Medium: Online Resource
    ISSN: 1687-9678 , 1687-966X
    URL: Article
    DOI: 10.1155/2020/8820538
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2573856-2
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  • 7
    Online Resource
    Online Resource
    Spatiotemporal Relationship between Ecosystem Service Value and Ecological Risk in Disaster-Prone Mountainous Areas: Taking the Upper Reaches of the Minjiang River as an Example
    Hindawi Limited ; 2022
    In:  Journal of Environmental and Public Health Vol. 2022 ( 2022-10-7), p. 1-11
    Details
    In: Journal of Environmental and Public Health, Hindawi Limited, Vol. 2022 ( 2022-10-7), p. 1-11
    Abstract: Mountainous areas are susceptible to disasters; the frequent occurrence of disasters drives the changes in ecosystem service value (ESV) and also brings certain ecological risk, which further increases the incidence of disasters. However, few scholars have investigated the spatiotemporal correlation between the ESV of disaster-prone mountainous areas and ecological risk index (ERI) with basin as the unit. This paper aims to clarify the spatial relationship between ESV and ERI under the changes of land use. Taking the upper reaches of the Minjiang River as the study area, the authors collected the land use data of 2000–2020, estimated ESV by the value equivalent factor per unit area method, and constructed the ERI. On this basis, the relationship between ESV and ERI was investigated in details. The results show the following: (1) From 2000 to 2020, the total ESV exhibited a fluctuating upward trend. The spatial distribution of ESV was greatly affected by slope and altitude; an important reason for the rising ESV in the study area is the increase of forest area and water area. (2) The upper reaches of the Minjiang River had a generally low ERI and relatively good overall ecoenvironment. After 2010, however, the ecological risk continued to rise. Most of the strongly high risk areas are areas with frequent human activities, such as low-altitude areas and river banks. (3) There is a spatial correlation and coupling between ESV and ERI in the study area; i.e., the strongly high ESV areas generally had a low ecological risk. The correlation intensified with the elapse of time. The changes in the service value of regional ecosystems driven by unreasonable land use will have a great impact on the ecoenvironment. By clarifying the spatiotemporal relationship between ESV and ERI, this research provides theoretical basis and data support to the formulation of ecoenvironmental restoration and protection plans for the upper reaches of the Minjiang River and to the coordinated development between society, economy, and ecoenvironment in the region.
    Type of Medium: Online Resource
    ISSN: 1687-9813 , 1687-9805
    URL: Article
    DOI: 10.1155/2022/1462237
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2526611-1
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  • 8
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    Online Resource
    Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-12
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Abstract: Background . Peritoneal dialysis (PD) can induce fibrosis and functional alterations in PD patients’ peritoneal membranes, due to long-term unphysiological dialysate exposure, partially occurring via triggering of epithelial-to-mesenchymal transition (EMT) in peritoneal mesothelial cells (MCs). Vitamin D can ameliorate these negative effects; however, the mechanism remains unexplored. Therefore, we investigated its possible links to MCs EMT inhibition. Methods . Peritoneal fibrosis was established in Sprague-Dawley rats by chlorhexidine gluconate (CG) intraperitoneal injection for 21 days, with and without 1 α ,25(OH) 2 D 3 treatment. Morphological and functional evaluation and western blot analysis of EMT marker were performed upon peritoneum tissue. In vitro study was also performed in a primary human peritoneal MC culture system; MCs were incubated with transforming growth factor- β 1 (TGF- β 1) in the absence or presence of 1 α ,25(OH) 2 D 3 . EMT marker expression, migration activities, and cytoskeleton redistribution of MCs were determined. Results . 1 α ,25(OH) 2 D 3 ameliorated CG-induced morphological and functional deterioration in animal model, along with CG-induced upregulation of α -SMA and downregulation of E-cadherin expression. Meanwhile, 1 α ,25(OH) 2 D 3 also ameliorated TGF- β 1-induced decrease in E-cadherin expression, increase in Snai1 and α -SMA expression, intracellular F-actin redistribution, and migration activity in vitro . Conclusion . 1 α ,25(OH) 2 D 3 can ameliorate CG-induced peritoneal fibrosis and attenuate functional deterioration through inhibiting MC EMT.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/595030
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 9
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    Online Resource
    Downregulation of iNOS, IL-1 β , and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats
    Hindawi Limited ; 2018
    In:  Journal of Immunology Research Vol. 2018 ( 2018), p. 1-9
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2018 ( 2018), p. 1-9
    Abstract: Protease-activated receptor 4 (PAR4) is implicated in the inhibition of visceral hyperalgesia. In the present study, the effects of PAR4 activation on visceral hypersensitivity and expression of inflammatory mediators, including interleukin-1 β (IL-1 β ), P2RX7 purinergic receptor (P2X7), inducible nitric oxide synthase (iNOS), and tryptase, in mast cells (MCs) were investigated via in vivo and in vitro studies. The numbers of tryptase-positive MCs with extensive PAR4, P2X7, and iNOS expression were increased in the colons of visceral hyperalgesia rats compared with controls. Intracolonic administration of PAR4-activating peptide (PAR4-AP) significantly attenuated the visceral hypersensitivity to colorectal distention and reduced the iNOS, IL-1 β , P2X7, and tryptase protein and mRNA levels in the colonic mucosa. Treatment of rat bone marrow MCs (BMMCs) with PAR4-AP also reduced the iNOS, IL-1 β , P2X7, and tryptase protein and mRNA levels. ERK1/2 and p38 activators (t-butylhydroquinone, tBHQ, and U-46619) reversed the suppressive effect of PAR4 activation on IL-1 β and iNOS expression, whereas ERK1/2 and p38 inhibitors (PD98059 and SB203580) reversed the suppressive effect of PAR4 activation on P2X7 and tryptase expression. Our results indicate that the downregulation of inflammatory mediators, including iNOS, IL-1 β , P2X7, and tryptase, in MCs that are mediated by PAR4 activation could inhibit visceral hyperalgesia via the mitogen-activated protein kinase (MAPK) signal pathway.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    URL: Article
    DOI: 10.1155/2018/3256908
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2817541-4
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  • 10
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    Recognition of Electromagnetic Signals Based on the Spiking Convolutional Neural Network
    Hindawi Limited ; 2022
    In:  Wireless Communications and Mobile Computing Vol. 2022 ( 2022-6-24), p. 1-9
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2022 ( 2022-6-24), p. 1-9
    Abstract: Feature extraction and recognition of signals are the bases of a cognitive radio. Traditional manual extraction for signals’ features becomes difficult in the complex electromagnetic environment. Although convolutional neural networks (CNNs) can extract signal features automatically, they have low accuracy in recognizing electromagnetic signals at low signal-to-noise ratios (SNRs) due to the agility of signals. Considering the great potential of spiking neural networks (SNNs) in classification, a spiking convolution neural network (SCNN) for the recognition of electromagnetic signals is proposed in this paper. The SCNN effectively integrates the extraction ability of spatial features in CNNs and temporal features in SNNs. Since the SCNN is difficult to train, the strategy of surrogate gradient is proposed to train it. By taking the 2-dimensional time-frequency distribution of 6 signals as input, the SCNN can effectively identify different signals at low SNRs. The method proposed in this paper contributes to promote the research and application of SNNs in the recognition of electromagnetic signals.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2022/2395996
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045240-8
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