GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hindawi Limited  (7)
  • 1
    Online Resource
    Online Resource
    GLP-1 Gene-Modified Human Umbilical Cord Mesenchymal Stem Cell Line Improves Blood Glucose Level in Type 2 Diabetic Mice
    Hindawi Limited ; 2019
    In:  Stem Cells International Vol. 2019 ( 2019-12-27), p. 1-9
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2019 ( 2019-12-27), p. 1-9
    Abstract: Type 2 diabetes constitutes a serious threat to the health of patients, but there is currently no ideal treatment in the clinic. Glucagon-like peptide-1 and human umbilical cord mesenchymal stem cells have been confirmed to have antidiabetic effects, but both of them have certain defects in the process of antidiabetes, which cannot meet the need of clinical treatment. We hypothesized that human umbilical cord mesenchymal stem cells can be used as a vector to construct a novel cell line that expresses GLP-1 in vivo for a long time. And this cell strain results in lowering blood glucose in type 2 diabetic mice. The results showed that after 3 weeks of intramuscular injection of the new cell line, the fasting blood glucose of type 2 diabetic mice returned to the normal range, and the hypoglycemic effect was maintained within 3 weeks after putting an end to the drug. At the same time, during the administration, the mice lost weight, the food intake decreased, the half-life of GLP-1 in the body prolonged, the IR reduced, and the pancreatic function recovered. The results of this study indicate that the novel cell line can prolong the half-life of GLP-1 in vivo and effectively lower blood sugar, which is a feasible method to improve type 2 diabetes.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2019/4961865
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2573856-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Characteristics of Evoked Potential Multiple EEG Recordings in Patients with Chronic Pain by Means of Parallel Factor Analysis
    Hindawi Limited ; 2012
    In:  Computational and Mathematical Methods in Medicine Vol. 2012 ( 2012), p. 1-10
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2012 ( 2012), p. 1-10
    Abstract: This paper presents an alternative method, called as parallel factor analysis (PARAFAC) with a continuous wavelet transform, to analyze of brain activity in patients with chronic pain in the time-frequency-channel domain and quantifies differences between chronic pain patients and controls in these domains. The event related multiple EEG recordings of the chronic pain patients and non-pain controls with somatosensory stimuli (pain, random pain, touch, random touch) are analyzed. Multiple linear regression (MLR) is applied to describe the effects of aging on the frequency response differences between patients and controls. The results show that the somatosensory cortical responses occurred around 250 ms in both groups. In the frequency domain, the neural response frequency in the pain group (around 4 Hz) was less than that in the control group (around 5.5 Hz) under the somatosensory stimuli. In the channel domain, cortical activation was predominant in the frontal region for the chronic pain group and in the central region for controls. The indices of active ratios were statistical significant between the two groups in the frontal and central regions. These findings demonstrate that the PARAFAC is an interesting method to understanding the pathophysiological characteristics of chronic pain.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2012/279560
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2256917-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Influence of Wheel Eccentricity on Vertical Vibration of Suspended Monorail Vehicle: Experiment and Simulation
    Hindawi Limited ; 2017
    In:  Shock and Vibration Vol. 2017 ( 2017), p. 1-10
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2017 ( 2017), p. 1-10
    Abstract: This paper investigates the influence of wheel eccentricity on vertical vibration of suspended monorail vehicle based on experiment and simulation. Two sets of tests are conducted in the first Chinese suspended monorail, and the tested acceleration is analyzed and exhibited. A multibody dynamic model of the suspended monorail vehicle is established to simulate the vertical vibration of car body excited by wheel eccentricity. The results show that there are three factors which may cause an abnormal vibration considering the track and the vehicle system. The influence of wheel eccentricity on the car body vibration was firstly analyzed. Simulated acceleration of car body has a great accordance with test. The wheel eccentricity could excite the resonance of car body at the speed of 21 km/h, and the vertical acceleration would increase considerably. Decreasing the secondary stiffness can effectively reduce the vertical vibration caused by wheel eccentricity, especially at the resonant speed. In the secondary test, the peak of car body acceleration at speed of 20 km/h is not appearing when only renewing the wheels, and the acceleration is decreasing obviously at the domain frequency. It is further determined that the abnormal vibration is mainly caused by the wheel eccentricity.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    URL: Article
    DOI: 10.1155/2017/1367683
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2070162-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    TiC 0.5 N 0.5 -Based Cermets with Varied Amounts of Si 3 N 4 Nanopowders Prepared by Spark Plasma Sintering
    Hindawi Limited ; 2015
    In:  Advances in Materials Science and Engineering Vol. 2015 ( 2015), p. 1-7
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: TiCN-based cermets with varied fractions of Si 3 N 4 nanopowder (0–5 wt.%) were prepared by spark plasma sintering. The microstructural and mechanical properties of these cermets were investigated. In general, with increasing addition amount of Si 3 N 4 nanopowder the relative density as well as mechanical properties of the as-prepared TiCN cermets increased first and then decreased. The samples containing 2 wt.% Si 3 N 4 nanopowder presented the best performance with the relative density of about 98%, bending strength of 1000 MPa, and Vickers microhardness of about 1810 HV 10 .
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2015/626429
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2501025-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    A Review on the Synthesis Methods of CdSeS-Based Nanostructures
    Hindawi Limited ; 2015
    In:  Journal of Nanomaterials Vol. 2015 ( 2015), p. 1-16
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2015 ( 2015), p. 1-16
    Abstract: As typical II–VI ternary alloyed chalcogenides, CdSeS nanostructures have attracted intensive worldwide attention due to their excellent tunable optical properties based on quantum confinement effect and optical nonlinear phenomenon. Because CdSeS-based nanostructures have presented a great potential for applications in biomedicine and optoelectronic devices, different synthesis methods have been proposed to prepare CdSeS-based nanostructures with divergent optical properties to meet the needs of those applications, such as fluorescent labeling, in vivo imaging, waveguides, and solar cell. In this review, the tricks, advantages, and disadvantages of all these synthesis methods were discussed, including hot-injection synthesis, one-pot noninjection synthesis, microwave irradiation, solvothermal synthesis, template-assisted electrodeposition, thermal evaporation, and pulsed laser deposition. Special emphasis was put on those methods that are safe, economic, environment-friendly, and suitable for large-scale production of alloyed CdSeS nanostructures with high photoluminescence, high stability, and low/no cytotoxicity.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2015/519385
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2229480-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Preparation of Cementitious Material Using Smelting Slag and Tailings and the Solidification and Leaching of Pb 2+
    Hindawi Limited ; 2015
    In:  Advances in Materials Science and Engineering Vol. 2015 ( 2015), p. 1-7
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: The composite cementitious materials were prepared with lead-zinc tailings, lead-zinc smelting slag, and cement clinker. The effect of material ratio on the mechanical properties, the phase analysis, and microstructures were investigated. The effect of the pH and stripping time on the leaching amount of lead ion was discussed. The results show that the additive amount of the tailings should be minimized for the cementitious materials meeting the strength requirements, controlled within 10%. The leaching amount of cementitious materials remains low in a larger range of pH, which can effectively reduce the leaching of heavy metal lead. The leaching kinetics of lead ions in the three kinds of samples could be better described by the pseudo-second-model.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2015/352567
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2501025-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Effect of SiC Nanowhisker on the Microstructure and Mechanical Properties of WC-Ni Cemented Carbide Prepared by Spark Plasma Sintering
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-8
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
    Abstract: Ultrafine tungsten carbide-nickel (WC-Ni) cemented carbides with varied fractions of silicon carbide (SiC) nanowhisker (0–3.75 wt.%) were fabricated by spark plasma sintering at 1350°C under a uniaxial pressure of 50 MPa with the assistance of vanadium carbide (VC) and tantalum carbide (TaC) as WC grain growth inhibitors. The effects of SiC nanowhisker on the microstructure and mechanical properties of the as-prepared WC-Ni cemented carbides were investigated. X-ray diffraction analysis revealed that during spark plasma sintering (SPS) Ni may react with the applied SiC nanowhisker, forming Ni 2 Si and graphite. Scanning electron microscopy examination indicated that, with the addition of SiC nanowhisker, the average WC grain size decreased from 400 to 350 nm. However, with the additional fractions of SiC nanowhisker, more and more Si-rich aggregates appeared. With the increase in the added fraction of SiC nanowhisker, the Vickers hardness of the samples initially increased and then decreased, reaching its maximum of about 24.9 GPa when 0.75 wt.% SiC nanowhisker was added. However, the flexural strength of the sample gradually decreased with increasing addition fraction of SiC nanowhisker.
    Type of Medium: Online Resource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/673276
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2075968-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...