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  • Hindawi Limited  (10)
  • 1
    Online Resource
    Online Resource
    Computational Assessment of Thermal Conductivity of Compacted Graphite Cast Iron
    Hindawi Limited ; 2019
    In:  Advances in Materials Science and Engineering Vol. 2019 ( 2019-04-01), p. 1-7
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2019 ( 2019-04-01), p. 1-7
    Abstract: Two-dimensional FE models of CGI with different pearlite contents for thermal conductivity analysis were established according to the real metallographic images obtained by Pro/E and ANSYS. Meanwhile, thermal conductivity of CGI with different pearlite contents was tested through the laser flash method. It is indicated that the thermal conductivity of CGI declines with the increase of pearlite. When pearlite is increased from 10% to 80%, the experimental values decline from 46.63 W/m·K to 36.86 W/m·K, reducing by 21%. However, this declining tendency becomes gentle and slight when pearlite is more than 40%. In addition, the calculation results with the consideration of interfacial contact thermal conductance (ICTC) and pearlite are much close to experimental values; especially when pearlite is 80%, the difference between them is only about 2%. It can be concluded that the FE models are convenient and reasonable to analyze thermal conductivity of CGI.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2019/8562102
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2501025-6
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  • 2
    Online Resource
    Online Resource
    Inferring Functional Neural Connectivity with Phase Synchronization Analysis: A Review of Methodology
    Hindawi Limited ; 2012
    In:  Computational and Mathematical Methods in Medicine Vol. 2012 ( 2012), p. 1-13
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2012 ( 2012), p. 1-13
    Abstract: Functional neural connectivity is drawing increasing attention in neuroscience research. To infer functional connectivity from observed neural signals, various methods have been proposed. Among them, phase synchronization analysis is an important and effective one which examines the relationship of instantaneous phase between neural signals but neglecting the influence of their amplitudes. In this paper, we review the advances in methodologies of phase synchronization analysis. In particular, we discuss the definitions of instantaneous phase, the indexes of phase synchronization and their significance test, the issues that may affect the detection of phase synchronization and the extensions of phase synchronization analysis. In practice, phase synchronization analysis may be affected by observational noise, insufficient samples of the signals, volume conduction, and reference in recording neural signals. We make comments and suggestions on these issues so as to better apply phase synchronization analysis to inferring functional connectivity from neural signals.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2012/239210
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2256917-0
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  • 3
    Online Resource
    Online Resource
    Calculation of Pile Side Friction by Multiparameter Statistical Analysis
    Hindawi Limited ; 2019
    In:  Advances in Civil Engineering Vol. 2019 ( 2019-06-18), p. 1-12
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2019 ( 2019-06-18), p. 1-12
    Abstract: In this paper, a static load test and a multiparameter statistical analysis method are used to study the value of pile side friction in different soil layers in a loess region. Currently, static load testing is the most commonly used method to determine the bearing capacity of pile foundation. During the test, a vertical load is applied at the top of the pile, the data under each load level are recorded, and a Q-S curve is drawn to obtain the ultimate bearing capacity of a single pile. Reinforcement stress gauges are installed at different sections of the pile body, and then the axial force and the pile side friction of each section are calculated. Few studies have investigated the calculation of pile side friction in different soil layers using the multiparameter statistical analysis method. Obtaining accurate results using this method will provide an important supplement to the calculation of pile side friction and will also be conducive to the development of theoretical calculation of pile side friction. Therefore, taking Wuding Expressway project in loess region as an example, the lateral friction resistance of six test piles is studied through static load testing and multiparameter statistical analysis. The multiparameter statistical analysis method is compared with the static load test results, and the error is controlled within 20%. The results show that the calculation results of multiparameter statistical analysis essentially fulfill engineering requirements.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2019/2638520
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2449760-5
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  • 4
    Online Resource
    Online Resource
    Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis
    Hindawi Limited ; 2012
    In:  Clinical and Developmental Immunology Vol. 2012 ( 2012), p. 1-7
    Details
    In: Clinical and Developmental Immunology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-7
    Abstract: Follicular helper T (Tfh) cells are recognized as a distinct CD4 + helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4 + CXCR5 + ICOS high Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
    Type of Medium: Online Resource
    ISSN: 1740-2522 , 1740-2530
    URL: Article
    DOI: 10.1155/2012/827480
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2817541-4
    detail.hit.zdb_id: 2119272-8
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  • 5
    Online Resource
    Online Resource
    Dynamic Failure Mode and Dynamic Response of High Slope Using Shaking Table Test
    Hindawi Limited ; 2019
    In:  Shock and Vibration Vol. 2019 ( 2019-03-25), p. 1-19
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2019 ( 2019-03-25), p. 1-19
    Abstract: A shaking table test was performed to study the dynamic response and failure modes of high slope. Test results show that PGA amplification coefficients increased with increasing elevation and the PGA amplification coefficient of the concave slope was slightly larger than that of the convex slope. The slope type affected the dynamic response of the slope. The elevation amplification effect of the concave slope under seismic load was more significant than that of the convex slope; thus, the concave slope was more unstable than the convex slope. Additionally, the PGA amplification coefficient measured on the slope surface was always larger than that inside the slope, and the data show an increasing trend with the broken line. The dynamic amplification effect of the high slope was closely related to the natural frequency of the slope. Within a certain range, the higher the frequency, the more significant the amplification effect. The dynamic failure process of concave and convex slopes was studied through tests. Findings indicate that the dynamic failure modes of the concave slope are characterized by shoulder collapse, formation of the sliding surface, and integral sliding above the slope line. Dynamic failure modes of the convex slope are mainly slips in the soil layer and collapse of the slope near the slope line.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    URL: Article
    DOI: 10.1155/2019/4802740
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2070162-7
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  • 6
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    Online Resource
    Effect of TGF-β2 on the Mechanical Properties of Posterior Scleral Fibroblasts in Experimental Myopia
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-9-12), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-9-12), p. 1-8
    Abstract: Objective. The effects of TGF-β2 on mechanical properties of sclerotic desmocytes isolated from healthy and myopic guinea pigs were investigated in order to further understand the pathogenesis of myopia. To study the effect of TGF-β2 on the mechanical properties of posterior scleral fibroblasts in experimental myopia. Methods. A lens-induced myopia (LIM) animal model was developed in 12 guinea pigs, with the opposite eye serving as a self-control (SC). Five untreated guinea pigs served as normal controls. Lenses were removed 30 days after model onset. Primary scleral fibroblasts were isolated and passaged twice and then treated with vehicle control or 1, 10, or 100 ng/mL TGF-β2. After 24 h, micropipette aspiration was used to investigate the viscoelastic properties of the cells. Results. Scleral fibroblasts from LIM exhibited significantly higher equilibrium moduli and apparent viscosities relative to SC without TGF-β2 treatment. Treatment of LIM or SC scleral fibroblasts with 1 or 10 ng/mL TGF-β2 led to significantly different ( p 〈 0.05 ) equilibrium moduli and apparent viscosities compared with vehicle control, whereas no significant differences were observed upon treatment with 100 ng/mL TGF-β2. LIM cells treated with 1 and 10 ng/mL TGF-β2 exhibited lower equilibrium moduli and apparent viscosities compared with similarly treated SC cells, but LIM cells and SC cells treated with 100 ng/mL TGF-β2 had similar mechanical properties. Conclusions. The addition of 1 and 10 ng/mL TGF-β2 can lower the equilibrium modulus and apparent viscosity of scleral fibroblasts in the normal eye.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/6193876
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Quantifying Spatiotemporal Dynamics of Solar Radiation over the Northeast China Based on ACO-BPNN Model and Intensity Analysis
    Hindawi Limited ; 2017
    In:  Advances in Meteorology Vol. 2017 ( 2017), p. 1-15
    Details
    In: Advances in Meteorology, Hindawi Limited, Vol. 2017 ( 2017), p. 1-15
    Abstract: Reliable information on the spatiotemporal dynamics of solar radiation plays a crucial role in studies relating to global climate change. In this study, a new backpropagation neural network (BPNN) model optimized with an Ant Colony Optimization (ACO) algorithm was developed to generate the ACO-BPNN model, which had demonstrated superior performance for simulating solar radiation compared to traditional BPNN modelling, for Northeast China. On this basis, we applied an intensity analysis to investigate the spatiotemporal variation of solar radiation from 1982 to 2010 over the study region at three levels: interval, category, and conversion. Research findings revealed that ( 1 ) the solar radiation resource in the study region increased from the 1980s to the 2000s and the average annual rate of variation from the 1980s to the 1990s was lower than that from the 1990s to the 2000s and ( 2 ) the gains and losses of solar radiation at each level were in different conditions. The poor, normal, and comparatively abundant levels were transferred to higher levels, whereas the abundant level was transferred to lower levels. We believe our findings contribute to implementing ad hoc energy management strategies to optimize the use of solar radiation resources and provide scientific suggestions for policy planning.
    Type of Medium: Online Resource
    ISSN: 1687-9309 , 1687-9317
    URL: Article
    DOI: 10.1155/2017/1042603
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2486777-9
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  • 8
    Online Resource
    Online Resource
    Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis
    Hindawi Limited ; 2012
    In:  Clinical and Developmental Immunology Vol. 2012 ( 2012), p. 1-8
    Details
    In: Clinical and Developmental Immunology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-8
    Abstract: Rheumatoid arthritis(RA) is a common autoimmune disease associated with Th17 cells, but what about the effect of high-mobility group box chromosomal protein 1 (HMGB1) and the relationship between Th17-associated factors and HMGB1 in RA remains unknown. In the present study, we investigated the mRNA levels of HMGB1, RORγt, and IL-17 in peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis by quantitative real-time PCR (RT-qPCR), and the concentrations of HMGB1, IL-17, and IL-23 in plasma were detected by ELISA. And then, the effect of HMGB1 on Th17 cells differentiation was analyzed in vitro. Our clinical studies showed that the mRNAs of HMGB1, RORγt, and IL-17 in patients were higher than that in health control ( P 〈 0.05 ), especially in active RA patients ( P 〈 0.05 ). The plasma HMGB1, IL-17, and IL-23 in RA patients were also higher than that in health control ( P 〈 0.05 ); there was a positive correlation between the expression levels of HMGB1 and the amount of CRP, ERS, and RF in plasma. In vitro , the IL-17-produced CD4 + T cells were increased with 100 ng/mL rHMGB1 for 12h, which indicated that the increased HMGB1 might contribute to Th17 cells activation in RA patients.
    Type of Medium: Online Resource
    ISSN: 1740-2522 , 1740-2530
    URL: Article
    DOI: 10.1155/2012/295081
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2817541-4
    detail.hit.zdb_id: 2119272-8
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  • 9
    Online Resource
    Online Resource
    Optimization Analysis of Settlement Parameters for Postgrouting Piles in Loess Area of Shaanxi, China
    Hindawi Limited ; 2019
    In:  Advances in Civil Engineering Vol. 2019 ( 2019-04-18), p. 1-16
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2019 ( 2019-04-18), p. 1-16
    Abstract: The settlement calculation of postgrouting piles is complex and depends on the calculation method and parameters. Static load tests were conducted to compare the settlement characteristics of nongrouting and postgrouting piles, and three vital parameters in the layer-wise summation method were revised to predict the settlement of postgrouting piles. The elastic compression coefficient was deduced based on the Mindlin–Geddes method by considering the influence of the change in the pile side resistance distribution and end resistance ratio on the elastic compression after grouting. The relationship between the compression modulus and soil gravity stress and cone penetration resistance were established, respectively, using experimental data. The optimum value of the settlement empirical coefficient was determined using regional data. Finally, we used the postgrouting pile of the Wuqi–Dingbian expressway as a practical example. The results obtained from the layer-wise summation method after parametric optimization were close to the measured values. The results of this study provide reference data and guidance for the settlement calculation of postgrouting piles in this area.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2019/7085104
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2449760-5
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  • 10
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    Computational Biology Predicts the Efficacy of Tumor Immune Checkpoint Blockade
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-9-28), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-9-28), p. 1-9
    Abstract: Tumor immunotherapy is considered as one of the most promising methods in cancer treatment in recent years. Immune checkpoint blockade (ICB) can activate immune cells to destroy tumors by relieving the inhibitory pathway of tumor cells to immune cells. In silico prediction of the ICB response is an important step toward achieving effective and personalized cancer immunotherapy. Although immune checkpoint inhibitors have shown exciting clinical effects in the treatment of many types of tumors, there are still some clinical problems in practical application, such as low response rate and large individualized differences. How to predict the efficacy of effective individualized immune checkpoint inhibitors for tumor patients based on specific biomarkers and computational models is one of the key issues in the immunotherapy of this kind of tumor. In our work, from the five levels of genome level, transcription level, epigenetic level, microbial taxonomy level, and the immune cell infiltration profile level, the biomarkers and in silico calculation methods that affect the efficacy of tumor immune checkpoint inhibitors are comprehensively summarized.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/6087751
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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